Atualização no tratamento do transtorno bipolar: o impacto da psicoeducação familiar

Abstract: Objective: to conduct a systematic review of the literature regarding the impact of family psychoeducation on the treatment of bipolar disorder. Methodology: PubMed, Lilacs, Web of A search was conducted in Science, Science Direct and Scopus using the descriptors: family psychoeducation and bipolar disorder. The last 13 years were considered. Results: 542 articles were found and after considering inclusion and exclusion criteria, 29 were selected for the study. Three other articles nominated by specialist were also used. Overall, patients diagnosed with bipolar disorder should be treated with drug therapy combined with psychotherapy. Most studies showed that the conventional treatment associated with psychoeducation reduced relapse rates and hospitalizations and that long-term programs generated better results. A comparison between supportive psychotherapy and family psychotherapy showed that it was only effective in patients who received the latter. Conclusion: although the role of pharmacological treatment is well established for the patient, (OU “ESTABLISHED IN LITERATURE”?) almost all articles consulted claim that if family psychoeducation is associated with medication, it can help with the early detection of warning signs of a crisis, reduce hospitalization rates and help reduce the number of drugs taken.Resumo: Objetivo: realizar uma revisão sistemática da literatura dos últimos 13 anos acerca do impacto da psicoeducação da família na adesão ao tratamento do paciente com perturbação bipolar. Metodologia: PubMed, Lilacs, Web of Science, Science Direct e Scopus foram pesquisados utilizando os descritores Family psychoeducation e bipolar disorder. Resultado: foram encontrados 542 artigos disponíveis, considerando critérios de inclusão e exclusão, como ano de publicação, público-alvo e tipo de intervenção; 29 foram selecionados para o estudo. Outros três artigos indicados por especialista também foram utilizados. Segundo os estudos, os pacientes com perturbação bipolar devem ser tratados com terapia medicamentosa associada à psicoterapia de apoio. A maioria dos estudos mostrou que o tratamento convencional associado à psicoeducação ocasionou redução das taxas de recaídas e internamentos, sendo que programas de longo prazo geraram melhores resultados. Na comparação entre psicoterapia de apoio e psicoterapia familiar houve benefício apenas nos pacientes que receberam esta última intervenção. Conclusão: embora o papel do tratamento farmacológico esteja bem estabelecido para o paciente na literatura, a quase totalidade dos artigos pesquisados afirma que a psicoeducação familiar, se for associada à medicação, pode auxiliar na deteção precoce dos sinais de alerta das crises, reduzir internamentos e possibilitar a diminuição das medicações utilizadas

Boneless yield of carcass of feedlot-finished young Bos indicus L. bulls

The aim of this study was to evaluate the boneless yield of the carcass of 64 feedlot-finished young Nellore bulls fed diets containing coated or uncoated urea and slaughtered at five body weights (350, 455, 485, 555, and 580 kg). A completely randomized design with a 5 × 2 factorial arrangement was used. No significant effect was detected for the interaction between slaughter weight and diet; therefore, the variables were analyzed separately, compared by polynomial contrasts and the F test, respectively. The absolute weights of the primal cuts from the fore- and hind-quarter increased linearly as the slaughter weight of the animals increased. Increasing slaughter weights elevated the percentage of rump cap in the pistola hindquarter as well as its yield. The percentages of the rump cap and rump skirt increased linearly, whereas those of knuckle, tenderloin, flank steak, rump, and outside flat decreased and the sum of prime cuts had a quadratic effect in relation to the weight of the right 1/2 carcass. Increasing slaughter weights led to a higher percentage of fat from the trimming of the hindquarter cuts relative to the weight of the 1/2 carcass. The weight of meat cuts was similar between the groups of animals fed coated and uncoated urea. Higher slaughter weights generate heavier meat cuts but lower percentages of primal cuts from the pistola hindquarter relative to the carcass weight.Objetivou-se avaliar o rendimento da desossa da carcaça de 64 tourinhos da raça Nelore, terminados em confinamento e abatidos com cinco pesos corporais: 350; 455; 485; 555 e 580 kg e alimentados com dietas contendo ureia, encapsulada ou não. O delineamento experimental utilizado foi o inteiramente casualizado em arranjo fatorial 5 x 2. Não houve efeito significativo de interação entre pesos de abate e dietas, sendo, portanto, as variáveis analisadas separadamente, comparadas por contrastes polinomiais e pelo teste F, respectivamente. Os pesos absolutos dos cortes comerciais do dianteiro e traseiro aumentaram linearmente com o incremento do peso de abate dos animais. A elevação do peso corporal ao abate aumentou a porcentagem de picanha no traseiro especial, assim como o rendimento da mesma. Verificou-se aumento linear da porcentagem dos cortes picanha e maminha, e redução do patinho, filé-mignon, fraldinha, alcatra e coxão duro, além de efeito quadrático para a soma dos cortes nobres, em relação ao peso da 1/2 carcaça direita, com o aumento do peso corporal de abate. O aumento do peso corporal ao abate promoveu maior porcentagem de gordura, em relação ao peso da 1/2 carcaça direita, durante o toalete dos cortes. Os pesos dos cortes cárneos foram semelhantes entre os animais alimentados com ureia, encapsulada ou não.El objetivo de este estudio fue evaluar el rendimiento deshuesado en canal de 64 toros jóvenes Nellore alimentados en corral con dietas que contienen urea recubierta o sin recubrir y sacrificados a cinco pesos corporales (350, 455, 485, 555 y 580 kg). Se utilizó un diseño completamente aleatorizado con un arreglo factorial de 5 × 2. No se detectó ningún efecto significativo para la interacción entre el peso de sacrificio y la dieta; por lo tanto, las variables se analizaron por separado, en comparación con los contrastes polinómicos y la prueba F, respectivamente. Los pesos absolutos de los cortes primarios del cuarto anterior y posterior aumentaron linealmente a medida que aumentaba el peso del sacrificio de los animales. El aumento de los pesos de sacrificio elevó el porcentaje de la tapa de la grupa en el cuarto trasero de la pistola, así como su rendimiento. Los porcentajes de la gorguera y la falda de la rabadilla aumentaron linealmente, mientras que los de nudillo, lomo, filete de flanco, grupa y plano exterior disminuyeron y la suma de los cortes primarios tuvo un efecto cuadrático en relación con el peso de la mitad de la carcasa. El aumento de los pesos de matanza condujo a un mayor porcentaje de grasa del recorte de los cortes del cuarto trasero en relación con el peso de la carcasa 1/2. El peso de los cortes de carne fue similar entre los grupos de animales alimentados con urea recubierta y no recubierta. Los pesos de sacrificio más altos generan cortes de carne más pesados pero porcentajes más bajos de cortes primarios del cuarto trasero de la pistola en relación con el peso de la carcasa

Possíveis abordagens terapêuticas para o tratamento do líquen plano oral: uma revisão de literatura / Possible therapeutic approaches for the treatment of oral lichen plane: a literature review

O presente estudo tem por objetivo revisar a literatura acerca das possíveis terapias para tratamento do líquen plano oral. Foi realizada uma revisão da literatura, com busca por artigos publicados no PubMed e SciELO entre 2016 a 2021, nos idiomas português, inglês e espanhol. Os artigos foram selecionados através do cruzamento dos descritores  ‘’Patologia Bucal’’,  ‘’Líquen Plano Bucal’’, ‘’Protocolos Clínicos’’, “Tratamento”, junto ao operadores booleanos ‘’AND’’ e ‘’OR’’, com seus correspondentes em inglês e espanhol, seguido pela leitura dos títulos, dos resumos e, por fim, dos artigos na íntegra. Os corticóides tópicos são a primeira escolha para o tratamento do líquen plano oral. Entretanto, seu uso a longo prazo, pode ocasionar efeitos colaterais indesejáveis. Em decorrência disso, houve a necessidade de recorrer a terapias alternativas como cirurgia nos casos de líquen plano oral mais delimitados, laserterapia como coadjuvante na diminuição da dor e aceleração no processo de cicatrização e fitoterapia como uma modalidade alternativa em casos de comprometimento sistêmico e baixo custo. A principal dificuldade para o tratamento do líquen plano oral, deve-se principalmente por não haver uma modalidade de tratamento que seja totalmente curativa. As terapias usadas limitam apenas ao controle da patologia, com isso, o tratamento requer acompanhamento a longos prazos. Segundo a literatura, é impossível alcançar a erradicação completa da doença com os métodos disponíveis. O tratamento deve visar atingir objetivos específicos, como a eliminação e redução de lesões atróficas e ulcerativas, o alívio dos sintomas e a redução do risco de transformação maligna

Incipient parallel evolution of SARS-CoV-2 Deltacron variant in South Brazil

With the coexistence of multiple lineages and increased international travel, recombination and gene flow are likely to become increasingly important in the adaptive evolution of SARS-CoV-2. These processes could result in genetic introgression and the incipient parallel evolution of multiple recombinant lineages. However, identifying recombinant lineages is challenging, and the true extent of recombinant evolution in SARS-CoV-2 may be underestimated. This study describes the first SARS-CoV-2 Deltacron recombinant case identified in Brazil. We demonstrate that the recombination breakpoint is at the beginning of the Spike gene. The 5′ genome portion (circa 22 kb) resembles the AY.101 (Delta), and the 3′ genome portion (circa 8 kb nucleotides) is most similar to the BA.1.1 (Omicron). Furthermore, evolutionary genomic analyses indicate that the new strain emerged after a single recombination event between lineages of diverse geographical locations in December 2021 in South Brazil. This Deltacron, AYBA-RS, is one of the dozens of recombinants described in 2022. The submission of only four sequences in the GISAID database suggests that this lineage had a minor epidemiological impact. However, the recent emergence of this and other Deltacron recombinant lineages (XD, XF, and XS) suggests that gene flow and recombination may play an increasingly important role in the COVID-19 pandemic. We explain the evolutionary and population genetic theory that supports this assertion, concluding that this stresses the need for continued genomic surveillance. This monitoring is vital for countries where multiple variants are present, as well as for countries that receive significant inbound international travel

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear un derstanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5–7 vast areas of the tropics remain understudied.8–11 In the American tropics, Amazonia stands out as the world’s most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepre sented in biodiversity databases.13–15 To worsen this situation, human-induced modifications16,17 may elim inate pieces of the Amazon’s biodiversity puzzle before we can use them to understand how ecological com munities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple or ganism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region’s vulnerability to environmental change. 15%–18% of the most ne glected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lostinfo:eu-repo/semantics/publishedVersio

Pervasive gaps in Amazonian ecological research

Biodiversity loss is one of the main challenges of our time,1,2 and attempts to address it require a clear understanding of how ecological communities respond to environmental change across time and space.3,4 While the increasing availability of global databases on ecological communities has advanced our knowledge of biodiversity sensitivity to environmental changes,5,6,7 vast areas of the tropics remain understudied.8,9,10,11 In the American tropics, Amazonia stands out as the world's most diverse rainforest and the primary source of Neotropical biodiversity,12 but it remains among the least known forests in America and is often underrepresented in biodiversity databases.13,14,15 To worsen this situation, human-induced modifications16,17 may eliminate pieces of the Amazon's biodiversity puzzle before we can use them to understand how ecological communities are responding. To increase generalization and applicability of biodiversity knowledge,18,19 it is thus crucial to reduce biases in ecological research, particularly in regions projected to face the most pronounced environmental changes. We integrate ecological community metadata of 7,694 sampling sites for multiple organism groups in a machine learning model framework to map the research probability across the Brazilian Amazonia, while identifying the region's vulnerability to environmental change. 15%–18% of the most neglected areas in ecological research are expected to experience severe climate or land use changes by 2050. This means that unless we take immediate action, we will not be able to establish their current status, much less monitor how it is changing and what is being lost

Boneless yield of carcass of feedlot-finished young Bos indicus L. bulls

The aim of this study was to evaluate the boneless yield of the carcass of 64 feedlot-finished young Nellore bulls fed diets containing coated or uncoated urea and slaughtered at five body weights (350, 455, 485, 555, and 580 kg). A completely randomized design with a 5 × 2 factorial arrangement was used. No significant effect was detected for the interaction between slaughter weight and diet; therefore, the variables were analyzed separately, compared by polynomial contrasts and the F test, respectively. The absolute weights of the primal cuts from the fore- and hind-quarter increased linearly as the slaughter weight of the animals increased. Increasing slaughter weights elevated the percentage of rump cap in the pistola hindquarter as well as its yield. The percentages of the rump cap and rump skirt increased linearly, whereas those of knuckle, tenderloin, flank steak, rump, and outside flat decreased and the sum of prime cuts had a quadratic effect in relation to the weight of the right 1/2 carcass. Increasing slaughter weights led to a higher percentage of fat from the trimming of the hindquarter cuts relative to the weight of the 1/2 carcass. The weight of meat cuts was similar between the groups of animals fed coated and uncoated urea. Higher slaughter weights generate heavier meat cuts but lower percentages of primal cuts from the pistola hindquarter relative to the carcass weight

Núcleos de Ensino da Unesp: artigos 2007

Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq