ENSINO SUPERIOR FEDERAL NO BRASIL: POSSÍVEIS RELAÇÕES ENTRE LIDERANÇA E ESTRATÉGIA

Este artigo analisa as relações entre liderança e estratégia na Universidade Federal da Bahia, tendo como questão de pesquisa: Quais as relações entre as características de liderança dos seus reitores e a estratégia adotada no período 1946-2014? Seu referencial teórico traz reflexões acerca da estratégia e mudança estratégica, seguido de questões relativas à liderança e perfil dos líderes e suas relações com a estratégia. Metodologicamente, é um estudo de caso único, sob perspectiva longitudinal; a coleta de dados foi feita por meio de análise documental, entrevistas semiestruturadas com gestores e observação não participante. Os dados foram categorizados e analisados por meio da análise de conteúdo categorial temática baseada nas dimensões da mudança estratégica de March (1991) e da liderança do modelo de Quinn (2013). Os resultados apontam para a presença de relações entre estratégia e perfil de liderança ao longo da história desta universidade. Percebe-se ainda, confirmando os conceitos teóricos, que não haver melhor perfil de líder, já que as características da liderança devem relacionar-se ao contexto organizacional interno e externo. Entende-se que as limitações decorrentes da análise da relação estudada possam ser superadas por meio de estudos que explorem o tema em outras instituições de ensino superior públicas e privadas

The mammalian endocytic cytoskeleton

Clathrin-mediated endocytosis (CME) is the major route through which cells internalise various substances and recycle membrane components. Via the coordinated action of many proteins, the membrane bends and in-vaginates to form a vesicle that buds off-along with its contents-into the cell. The contribution of the actin cytoskeleton to this highly dynamic process in mammalian cells is not well understood. Unlike in yeast, where there is a strict requirement for actin in CME, the significance of the actin cytoskeleton to mammalian CME is variable. However, a growing number of studies have established the actin cytoskeleton as a core component of mammalian CME, and our understanding of its contribution has been increasing at a rapid pace. In this review, we summarise the state-of-the-art regarding our understanding of the endocytic cytoskeleton, its physiological significance, and the questions that remain to be answered.Peer reviewe

A kinder approach to science

Publisher Copyright: © 2021 Elsevier LtdTo be kind is to protect and promote the well-being of others. We borrow this definition from the philosophical literature to formulate a simple and powerful principle to make scientific communities and institutions healthier, fairer, and more inclusive.Non peer reviewe

Discriminating between viable and membrane-damaged cells of the plant pathogen Xylella fastidiosa.

Xylella fastidiosa is a plant pathogenic bacterium with devastating consequences to several crops of economic importance across the world. While this pathogen has been studied for over a century in the United States, several aspects of its biology remain to be investigated. Determining the physiological state of bacteria is essential to understand the effects of its interactions with different biotic and abiotic factors on cell viability. Although X. fastidiosa is culturable, its slow growing nature makes this technique cumbersome to assess the physiological state of cells present in a given environment. PMA-qPCR, i.e. the use of quantitative PCR combined with the pre-treatment of cells with the dye propidium monoazide, has been successfully used in a number of studies on human pathogens to calculate the proportion of viable cells, but has less frequently been tested on plant pathogens. We found that the use of a version of PMA, PMAxx, facilitated distinguishing between viable and non-viable cells based on cell membrane integrity in vitro and in planta. Additional experiments comparing the number of culturable, viable, and total cells in planta would help further confirm our initial results. Enhancers, intended to improve the efficacy of PMAxx, were not effective and appeared to be slightly toxic to X. fastidiosa

HSPB1 facilitates the formation of non-centrosomal microtubules

The remodeling capacity of microtubules (MT) is essential for their proper function. In mammals, MTs are predominantly formed at the centrosome, but can also originate from non-centrosomal sites, a process that is still poorly understood. We here show that the small heat shock protein HSPB1 plays a role in the control of non-centrosomal MT formation. The HSPB1 expression level regulates the balance between centrosomal and non-centrosomal MTs. The HSPB1 protein can be detected specifically at sites of de novo forming non-centrosomal MTs, while it is absent from the centrosomes. In addition, we show that HSPB1 binds preferentially to the lattice of newly formed MTs in vitro, suggesting that its function occurs by stabilizing MT seeds. Our findings open new avenues for the understanding of the role of HSPB1 in the development, maintenance and protection of cells with specialized non-centrosomal MT arrays