Comics in the Classroom - What\u27s at the center of the solar system?

Teaching in today’s classroom looks vastly different from 20 years ago. Today, many teachers have access to projectors, computers, smartboards, laptops and tablets, and have vast amounts of information and programs available at the click of a button. However, having access to all of these resources is not always beneficial, especially if we are not equipped to incorporate it into instruction. The 2015 Project Tomorrow Survey findings showed a number of aspects that support technology use in the classroom. Highlights of this data, related to the Center for Integrated Access Network’s (CIAN) digital comic book, include the following results (Project Tomorrow, 2016): Thirty-eight percent (38%) of students find online videos to help with their homework and 27% regularly watch videos created by their teachers. Almost two-thirds of students want to use digital games for learning in school. Teachers are using more digital content in their classroom than ever before. This year’s leader board: videos (68%), digital games (48%), online curriculum (36%), online textbooks (30%), and animations (27%). When utilized effectively, the use of digital resources in the classroom can engage students in a way print resources may not. At the Center for Integrated Access Networks (CIAN), an Engineering Research Center funded from 2008−2018 by the National Science Foundation, the education department worked to develop new and innovative digital resources to engage students in learning science content (Figure 1). One resource created, the CIAN Comic Book, focuses on educating students about optics, technology, and scientific discovery, and is well-aligned with the Next Generation Science Standards (NGSS). This article suggests one way to utilize the CIAN digital comic book by incorporating it in an Argument Driven Inquiry (ADI) lesson

Integrating contextual and online self-reported data for personalized healthcare: a tennis elbow case study

Advances in sensors and mobile technology have helped evolve the use of eHealth, especially in the field of Chronic Pain. Chronic pain is a widespread problem where self-management is important. Current studies tend to collect data at sparse intervals due to the cost involved in collecting data using traditional instruments. We demonstrate how technology enables richer data collection frequencies to analyse the influence of patients’ context on their pain levels. In this paper, we present a case study as an add-on analysis to a clinical trial for Tennis Elbow. We explore the usefulness of on-line key data collected at higher frequencies in explaining or discovering changes in pain. This dataset allowed us to learn that there are no associations with temperature and humidity to this type of pain, that patients tend to have different pain experiences, and that pain at night tends to be higher than overall or activity-related pain

Social cognition in adults with autism spectrum disorders: Validation of the Edinburgh Social Cognition Test (ESCoT).

Objective: Many existing tests of social cognition are not appropriate for clinical use, due to their length, complexity or uncertainty in what they are assessing. The Edinburgh Social Cognition Test (ESCoT) is a new test of social cognition that assesses affective and cognitive Theory of Mind as well as inter- and intrapersonal understanding of social norms using animated interactions.Method: To support the development of the ESCoT as a clinical tool, we derived cut-off scores from a neurotypical population (n = 236) and sought to validate the ESCoT in a sample of Autism Spectrum Disorder (ASD; n = 19) adults and neurotypical controls (NC; n = 38) matched on age and education. The ESCoT was administered alongside established tests and questionnaire measures of ASD, empathy, systemizing traits and intelligence.Results: Performance on the subtests of the ESCoT and ESCoT total scores correlated with performance on traditional tests, demonstrating convergent validity. ASD adults performed poorer on all measures of social cognition. Unlike the ESCoT, performance on the established tests was predicted by verbal comprehension abilities. Using a ROC curve analysis, we showed that the ESCoT was more effective than existing tests at differentiating ASD adults from NC. Furthermore, a total of 42.11% of ASD adults were impaired on the ESCoT compared to 0% of NC adults.Conclusions: Overall these results demonstrate that the ESCoT is a useful test for clinical assessment and can aid in the detection of potential difficulties in ToM and social norm understanding

Robotic-assisted unicompartmental knee arthroplasty has a greater early functional outcome when compared to manual total knee arthroplasty for isolated medial compartment arthritis

AimsThe primary aim of the study was to compare the knee-specific functional outcome of robotic unicompartmental knee arthroplasty (rUKA) with manual total knee arthroplasty (mTKA) for the management of isolated medial compartment osteoarthritis. Secondary aims were to compare length of hospital stay, general health improvement, and satisfaction between rUKA and mTKA.MethodsA powered (1:3 ratio) cohort study was performed. A total of 30 patients undergoing rUKA were propensity score matched to 90 patients undergoing mTKA for isolated medial compartment arthritis. Patients were matched for age, sex, body mass index (BMI), and preoperative function. The Oxford Knee Score (OKS) and EuroQol five-dimension questionnaire (EQ-5D) were collected preoperatively and six months postoperatively. The Forgotten Joint Score (FJS) and patient satisfaction were collected six months postoperatively. Length of hospital stay was also recorded.ResultsThere were no significant differences in the preoperative demographics (p ? 0.150) or function (p ? 0.230) between the groups. The six-month OKS was significantly greater in the rUKA group when compared with the mTKA group (difference 7.7, p < 0.001). There was also a greater six-month postoperative EQ-5D (difference 0.148, p = 0.002) and FJS (difference 24.2, p < 0.001) for the rUKA when compared to the mTKA. No patient was dissatisfied in the rUKA group and five (6%) were dissatisfied in the mTKA, but this was not significant (p = 0.210). Length of stay was significantly (p < 0.001) shorter in the rUKA group (median two days, interquartile range (IQR) 1 to 3) compared to the mTKA (median four days, IQR 3 to 5).ConclusionPatients with isolated medial compartment arthritis had a greater knee-specific functional outcome and generic health with a shorter length of hospital stay after rUKA when compared to mTKA

Wave dissipation by muddy seafloors

Author Posting. © American Geophysical Union, 2008. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geophysical Research Letters 35 (2008): L07611, doi:10.1029/2008GL033245.Muddy seafloors cause tremendous dissipation of ocean waves. Here, observations and numerical simulations of waves propagating between 5- and 2-m water depths across the muddy Louisiana continental shelf are used to estimate a frequency- and depth-dependent dissipation rate function. Short-period sea (4 s) and swell (7 s) waves are shown to transfer energy to long-period (14 s) infragravity waves, where, in contrast with theories for fluid mud, the observed dissipation rates are highest. The nonlinear energy transfers are most rapid in shallow water, consistent with the unexpected strong increase of the dissipation rate with decreasing depth. These new results may explain why the southwest coast of India offers protection for fishing (and for the 15th century Portuguese fleet) only after large waves and strong currents at the start of the monsoon move nearshore mud banks from about 5- to 2-m water depth. When used with a numerical nonlinear wave model, the new dissipation rate function accurately simulates the large reduction in wave energy observed in the Gulf of Mexico.The Office of Naval Research provided support

The Lancet Oral Health Series – implications for oral and dental research

No abstract available

Designing law and policy for the health and resilience of marine and coastal ecosystems—Lessons from (and for) Aotearoa New Zealand

Ecosystem-based approaches to marine management, which integrate marine law and policy across sectors, communities, and scales, are increasingly advocated for in international policy debates and scholarly literature. We highlight critical and timely opportunities in Aotearoa New Zealand’s evolving legal context to support an ecosystem-based approach across fisheries regulation, biodiversity conservation, environmental effects management, and Indigenous or customary rights. Given the scale of proposed law reform affecting the ocean in Aotearoa New Zealand, there are important global lessons to be elucidated from (and for) the Aotearoa New Zealand experience, revealing the potential for law to center the health of ocean ecosystems and related people in integrated marine decision making

Wave evolution across the Louisiana shelf

Author Posting. © The Author(s), 2012. This is the author's version of the work. It is posted here by permission of Elsevier B.V. for personal use, not for redistribution. The definitive version was published in Continental Shelf Research 52 (2013): 190-202, doi:10.1016/j.csr.2012.10.005.Observations and third-generation wave model hindcasts of ocean surface gravity waves propagating across the Louisiana shelf show that the effects of the mud environment on wave evolution are complex and episodic. Whereas low-frequency waves (0.04-0.20 Hz) show a consistent decay similar to earlier studies, the presence of mud also appears to suppress the development of short waves (0.20-0.25 Hz) under fetch-limited growth conditions. Significant suppression of wave development under wind-forced conditions is found to occur almost exclusively during easterly winds when satellite images show the Atchafalaya mud plume extends into the study area. These results suggest that episodic sediment suspension events with high mud concentrations in the upper water column can affect the evolution of wind waves.This work is supported by the U.S. Office of Naval Research (Littoral Geosciences and Optics Program, and Physical Oceanography Program), the National Oceanographic Partnership Program, the National Science Foundation, and a National Security Science and Engineering Faculty Fellowship

A measurement of the tau mass and the first CPT test with tau leptons

We measure the mass of the tau lepton to be 1775.1+-1.6(stat)+-1.0(syst.) MeV using tau pairs from Z0 decays. To test CPT invariance we compare the masses of the positively and negatively charged tau leptons. The relative mass difference is found to be smaller than 3.0 10^-3 at the 90% confidence level.Comment: 10 pages, 4 figures, Submitted to Phys. Letts.

Glutathione-S-transferase P promotes glycolysis in asthma in association with oxidation of pyruvate kinase M2

Background: Interleukin-1-dependent increases in glycolysis promote allergic airways disease in mice and disruption of pyruvate kinase M2 (PKM2) activity is critical herein. Glutathione-S-transferase P (GSTP) has been implicated in asthma pathogenesis and regulates the oxidation state of proteins via S-glutathionylation. We addressed whether GSTP-dependent S-glutathionylation promotes allergic airways disease by promoting glycolytic reprogramming and whether it involves the disruption of PKM2. Methods: We used house dust mite (HDM) or interleukin-1β in C57BL6/NJ WT or mice that lack GSTP. Airway basal cells were stimulated with interleukin-1β and the selective GSTP inhibitor, TLK199. GSTP and PKM2 were evaluated in sputum samples of asthmatics and healthy controls and incorporated analysis of the U-BIOPRED severe asthma cohort database. Results: Ablation of Gstp decreased total S-glutathionylation and attenuated HDM-induced allergic airways disease and interleukin-1β-mediated inflammation. Gstp deletion or inhibition by TLK199 decreased the interleukin-1β-stimulated secretion of pro-inflammatory mediators and lactate by epithelial cells. 13C-glucose metabolomics showed decreased glycolysis flux at the pyruvate kinase step in response to TLK199. GSTP and PKM2 levels were increased in BAL of HDM-exposed mice as well as in sputum of asthmatics compared to controls. Sputum proteomics and transcriptomics revealed strong correlations between GSTP, PKM2, and the glycolysis pathway in asthma. Conclusions: GSTP contributes to the pathogenesis of allergic airways disease in association with enhanced glycolysis and oxidative disruption of PKM2. Our findings also suggest a PKM2-GSTP-glycolysis signature in asthma that is associated with severe disease