4,192 research outputs found
End points for sickle cell disease clinical trials: Patient-reported outcomes, pain, and the brain
Functional equivalence of genome sequencing analysis pipelines enables harmonized variant calling across human genetics projects
National characteristics and variation in Arabic handwriting
From each of four Arabic countries; Morocco, Tunisia, Jordan and Oman, 150 participants produced handwriting samples which were examined to assess whether national characteristics were discernible. Ten characters, which have different configurations depending upon their position in the word, along with one short word, were classified into distinguishable forms, and these forms recorded for each handwriting sample. Tests of independence showed that character forms used were not independent of country (p < 0.001) for all but one character-position (this was dropped from subsequent analyses). A correspondence analysis ordination plot and analysis of similarity (R = 0.326, p = 0.0002) showed that whole samples were discernibly grouped by country, and a tree analysis produced a classification which was 71% accurate for the original data and 83% accurate for 80 new handwriting samples that underwent ‘blind’ classification. When the countries were combined into two regions, North Africa and Middle East, the grouping was more marked. Thus, there appears to be some scope for narrowing down the nationality, and particularly the wider geographical region of an author based upon the character forms they use in Arabic handwriting
A strategy for building and using a human reference pangenome
In March 2019, 45 scientists and software engineers from around the world converged at the University of California, Santa Cruz for the first pangenomics codeathon. The purpose of the meeting was to propose technical specifications and standards for a usable human pangenome as well as to build relevant tools for genome graph infrastructures. During the meeting, the group held several intense and productive discussions covering a diverse set of topics, including advantages of graph genomes over a linear reference representation, design of new methods that can leverage graph-based data structures, and novel visualization and annotation approaches for pangenomes. Additionally, the participants self-organized themselves into teams that worked intensely over a three-day period to build a set of pipelines and tools for specific pangenomic applications. A summary of the questions raised and the tools developed are reported in this manuscript
Building access to care in adult sickle cell disease: Defining models of care, essential components, and economic aspects
A feasibility test of an online intervention to prevention dating violence in emerging adults
Dating violence in emerging adults is a significant problem and few prevention programs based on the developmental needs of this age group have been developed. Our research team developed an online dating violence prevention program called WISER (Writing to Improve Self-in-Relationships) for emerging adults. The program is based on narrative therapy principles and uses structured writing techniques. A single group pre-post feasibility test of WISER was conducted with 14 college women. WISER was demonstrated to be feasible and acceptable and to show promise as an effective program to decrease dating violence in this population
Effect of silicic acid and other silicon compounds on fungal growth in oligotrophic and nutrient-rich media
Mycelium grew from a spore-mycelial inoculum of Aspergillus oryzae added to ultra-pure water (upw) containing silicon compounds, but did not grow in upw alone. Growth of other fungi also occurred in upw only when silicon compounds were added. Increased growth of A. oryzae, and other fungi, also followed the addition of silicic acid and other silicon compounds to Czapek Dox. Aspergillus oryzae solubilized silicon compounds in both upw and nutrient-rich media. Although interactions between microorganisms and silicon have been generally neglected, the results show that silicon compounds can increase fungal growth under both oligotrophic and nutrient-rich conditions
Barriers and Enablers to Food Waste Recycling: A Mixed Methods Study amongst UK Citizens
We aim to identify influences on UK citizens’ household food waste recycling as a basis for designing strategies to increase household food waste collection rates via local services. Using a UK dataset (n = 1801) and the COM-B (Capability–Opportunity–Motivation–Behaviour) model as a theoretical framework, we conduct quantitative regression and supporting thematic analyses to investigate influences on citizens’ recycling of food waste. Results show that automatic motivation (e.g., emotions and habit) and psychological capability (e.g., knowledge) predict household food waste recycling. Physical opportunity (i.e., dealing with food waste in other ways such as homecomposting or feeding pets/strays, time and financial costs) was the main barrier to recycling food waste identified in thematic analyses. Participants also reported automatic motivation-related barriers such as concerns over pests, odour, hygiene and local authorities’ food waste collection capabilities. Based on findings we recommend the development of clear, consistent communications aimed at creating positive social norms relating to recycling and increasing knowledge of what can and cannot be put in food waste bins. Improved functional design and free distribution of bins and compostable caddy liners developed according to user-centred needs for cleanliness, convenience and hygiene are also needed. These will not be sufficient without a nationally uniform, efficient and reliable system of household food waste collection
Barriers and Enablers to Buying Biodegradable and Compostable Plastic Packaging
Biodegradable and compostable plastic packaging (BCPP) has the potential to reduce a global plastic waste problem. We aimed to identify influences on buying BCPP as a basis for designing strategies that enable BCPP’s environmental benefits. Using a UK-focused citizen science dataset, we thematically analysed 610 survey responses to a question exploring reasons for BCPP purchase. Themes are categorised as barriers and enablers and according to the components of the Capability, Opportunity, Motivation, and Behaviour (COM-B) model of behaviour. Key barriers concerned: psychological capability (not understanding terminology used to label packaging, not taking notice of packaging, and preferring other types of packaging and product qualities); reflective motivation (negative beliefs about BCPP’s environmental impacts and skepticism over decomposition claims), and physical opportunity (no access to appropriate waste management). Key enablers concern: reflective motivation (positive beliefs about BCPP’s environmental impact and resolve to behave pro-environmentally) and physical opportunity (access to appropriate waste management). Reducing ambiguity concerning the labels of biodegradable and compostable may reduce skepticism over environmental claims of packaging. Interventions should improve information about the source of the packaging material, how the packaging waste is processed, and how to dispose of the packaging. This will not be sufficient unless facilities for local BCPP waste collection and processing are increased
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