Characterising submonolayer deposition via visibility graphs

We use visibility graphs as a tool to analyse the results of kinetic Monte Carlo (kMC) simulations of submonolayer deposition in a one-dimensional point island model. We introduce an efficient algorithm for the computation of the visibility graph resulting from a kMC simulation and show that from the properties of the visibility graph one can determine the critical island size, thus demonstrating that the visibility graph approach, which implicitly combines size and spatial data, can provide insights into island nucleation and growth processes

The inhibitory receptor LILRB4 (ILT3) modulates antigen presenting cell phenotype and, along with LILRB2 (ILT4), is upregulated in response to Salmonella infection.

BACKGROUND: Leukocyte Ig-like receptors (LILR) are a family of innate immune receptors with immunomodulatory functions. High-level expression of the receptors LILRB2 (ILT4) and LILRB4 (ILT3) is a feature of tolerogenic antigen presenting cells and has been observed in cancer and transplant situations. There are relatively few studies regarding these receptors in the context of infection and it is not yet clear how LILRB4 exerts its inhibitory effects. RESULTS: We studied the effects of LILRB4 ligation on antigen presenting cell phenotype, and the expression of LILRB2 and LILRB4 on Salmonella-infected antigen presenting cells. Ligation of LILRB4 throughout in vitro culture of dendritic cells led to an upregulation of the co-stimulatory protein CD86. Alterations in the production of IL-8 and IL-10 by LILRB4-ligated macrophages were also observed. Infection with Salmonella typhimurium or TLR stimulation with Salmonella components led to an upregulation of LILRB2 and LILRB4. CONCLUSION: Our results indicate that the inhibitory effects of LILRB4 do not result from a failure to upregulate co-stimulatory proteins. In addition to the high level expression that can render antigen presenting cells tolerogenic, there may be a role for lower level expression and activity of LILRB2 and LILRB4 in response to TLR signalling during an immune response to bacterial infection.RIGHTS : This article is licensed under the BioMed Central licence at http://www.biomedcentral.com/about/license which is similar to the 'Creative Commons Attribution Licence'. In brief you may : copy, distribute, and display the work; make derivative works; or make commercial use of the work - under the following conditions: the original author must be given credit; for any reuse or distribution, it must be made clear to others what the license terms of this work are

Interferon-I: The Pièce de Résistance of HIV-1 Transmission?

Despite the extensive viral quasispecies that develops in an individual during the course of HIV-1 infection, transmission is typically established by a single donor viral variant. Recent studies now provide insight into the phenotypic properties influencing this selection process at transmission, including the contribution of resistance to type I interferons

1,4-Bis(hex­yloxy)-2,5-diiodo­benzene

The centrosymmetric title compound, C18H28I2O2, crystallized in the monoclinic space group P21/c with the alkyl chains having extended all-trans conformations, similar to those in the centrosymmetric bromo analogue [Li et al. (2008 ▶). Acta Cryst. E64, o1930] that crystallized in the triclinic space group P . The difference between the two structures lies in the orientation of the two alkyl chains with respect to the C(aromatic)—O bond. In the title compound, the O—Calk­yl—Calk­yl—Calk­yl torsion angle is 55.8 (5)°, while in the bromo analogue this angle is −179.1 (2)°. In the title compound, the C-atoms of the alkyl chain are almost coplanar [maximum deviation of 0.052 (5) Å] and this mean plane is inclined to the benzene ring by 50.3 (3)°. In the bromo-analogue, these two mean planes are almost coplanar, making a dihedral angle of 4.1 (2)°. Another difference between the crystal structures of the two compounds is that in the title compound there are no halide⋯halide inter­actions. Instead, symmetry-related mol­ecules are linked via C—H⋯π contacts, forming a two-dimensional network

2-(2-Naphth­yl)-1,3-dioxane

The title compound, C14H14O2, crystallizes in the chiral monoclinic space group P21. This acetal is composed of a planar naphthalene ring with a 1,3-dioxane ring substituent, which has a chair conformation. In the crystal structure, symmetry-related mol­ecules are connected via a weak C—H⋯O inter­action to form a helical chain propagating in [010]. While there are no π–π stacking inter­actions present, there are weak C—H⋯π inter­actions involving the naphthalene aromatic rings, which link the helical chains to form a two-dimensional network in the (011) plane

1,4-Bis[4-(tert-butyl­diphenyl­silyl)buta-1,3-diyn­yl]benzene

The title centrosymmetric mol­ecule, C46H42Si2, is composed of a central benzene ring with buta-1,3-diynyl chains at positions 1 and 4. These chains are terminated by tert-butyl­diphenyl­silyl groups, hence the molecule is dumbbell in shape. The mol­ecules are connected via C—H⋯π inter­actions in the structure, so forming an undulating two-dimensional network in the bc plane. There is also a weak π–π inter­action involving centrosymmetrically related phenyl rings with a centroid–centroid distance of 3.8359 (11) Å

Quantifying the Performance of a Hybrid Pixel Detector with GaAs:Cr Sensor for Transmission Electron Microscopy

Hybrid pixel detectors (HPDs) have been shown to be highly effective for diffraction-based and time-resolved studies in transmission electron microscopy, but their performance is limited by the fact that high-energy electrons scatter over long distances in their thick Si sensors. An advantage of HPDs compared to monolithic active pixel sensors (MAPS) is that their sensor does not need to be fabricated from Si. We have compared the performance of the Medipix3 HPD with a Si sensor and with a GaAs:Cr sensor using primary electrons in the energy range of 60 - 300keV. We describe the measurement and calculation of the detectors' modulation transfer function (MTF) and detective quantum efficiency (DQE), which show that the performance of the GaAs:Cr device is markedly superior to that of the Si device for high-energy electrons.Comment: 15 pages + references, 13 figure

Discovery of two L & T binaries with wide separations and peculiar photometric properties

We present spatially resolved photometric and spectroscopic observations of two wide brown dwarf binaries uncovered by the SIMP near-infrared proper motion survey. The first pair (SIMP J1619275+031350AB) has a separation of 0.691" (15.2 AU) and components T2.5+T4.0, at the cooler end of the ill-understood J-band brightening. The system is unusual in that the earlier-type primary is bluer in J-Ks than the later-type secondary, whereas the reverse is expected for binaries in the late-L to T dwarf range. This remarkable color reversal can possibly be explained by very different cloud properties between the two components. The second pair (SIMP J1501530-013506AB) consists of an L4.5+L5.5 (separation 0.96", 30-47 AU) with a surprisingly large flux ratio (Delta J =1.79 mag) considering the similar spectral types of its components. The large flux ratio could be explained if the primary is itself an equal-luminosity binary, which would make it one of the first known triple brown dwarf systems. Adaptive optics observations could not confirm this hypothesis, but it remains a likely one, which may be verified by high-resolution near-infrared spectroscopy. These two systems add to the handful of known brown dwarf binaries amenable to resolved spectroscopy without the aid of adaptive optics and constitute prime targets to test brown dwarf atmosphere models.Comment: accepted for publication in Ap

Atomic resolution HOLZ-STEM imaging of atom position modulation in oxide heterostructures

It is shown that higher order Laue zone (HOLZ) rings in high energy electron diffraction are specific to individual columns of atoms, and show different strengths, structure and radii for different atom columns along the same projection in a structure. An atomic resolution 4-dimensional STEM dataset is recorded from a <110> direction in a perovskite trilayer, where only the central LaFeO3 layer should show a period doubling that gives rise to an extra HOLZ ring. Careful comparison between experiment and multislice simulations is used to understand the origins of all features in the patterns. A strong HOLZ ring is seen for the La-O columns, indicating strong La position modulation along this direction, whereas a weaker ring is seen along the O columns, and a very weak ring is seen along the Fe columns. This demonstrates that atomic resolution HOLZ-STEM is a feasible method for investigating the 3D periodicity of crystalline materials with atomic resolution