88 research outputs found
The response of the Ligurian and Tyrrhenian Seas to a summer Mistral event: A coupled atmosphereâocean approach
In this paper the effect of a summer Mistral event on the Ligurian and Tyrrhenian Seas in the northwestern Mediterranean is discussed, using a coupled numerical model and satellite and in situ observations. The focus is on the spatial and temporal distribution of the ocean mixed layer response to the strong winds, and on how this is affected by atmosphereâocean coupling. The model used is the Coupled OceanâAtmosphere Mesoscale Prediction System (COAMPSÂź1), developed at the Naval Research Laboratory. This system includes an atmospheric sigma coordinate, non-hydrostatic model, coupled to a hydrostatic sigma-z level ocean model (Naval Coastal Ocean Model), using the Earth System Modeling Framework (ESMF). The model is run at high (km scale) resolution to capture the fine structure of wind jets and surface cooling.
Two non-assimilating numerical experiments, coupled and uncoupled, are run for a 3-day period of a Mistral event, to examine more closely the impact of coupling on the surface flux and sea surface temperature (SST) fields. The cooling of SST up to 3 °C over 72 h in the coupled run significantly reduced the surface momentum and heat fluxes, relative to the uncoupled simulation, where the SST was kept fixed at the initial value. Mixed layer depths increase by as much as 30 m during the event. A heat budget analysis for the ocean is carried out to further explain and investigate the SST evolution. Shear-induced mixing in inertial waves is found to be important to the surface cooling. Effects of coupling on the atmospheric boundary layer are found to be significant, but overall the effect of coupling on the synoptic low pressure system is small
Controlling dipole-dipole frequency shifts in a lattice-based optical atomic clock
Motivated by the ideas of using cold alkaline earth atoms trapped in an
optical lattice for realization of optical atomic clocks, we investigate
theoretically the perturbative effects of atom-atom interactions on a clock
transition frequency. These interactions are mediated by the dipole fields
associated with the optically excited atoms. We predict resonance-like features
in the frequency shifts when constructive interference among atomic dipoles
occur. We theoretically demonstrate that by fine-tuning the coherent
dipole-dipole couplings in appropriately designed lattice geometries, the
undesirable frequency shifts can be greatly suppressed.Comment: 14 pages, 4 figure
Rings and bars: unmasking secular evolution of galaxies
Secular evolution gradually shapes galaxies by internal processes, in
contrast to early cosmological evolution which is more rapid. An important
driver of secular evolution is the flow of gas from the disk into the central
regions, often under the influence of a bar. In this paper, we review several
new observational results on bars and nuclear rings in galaxies. They show that
these components are intimately linked to each other, and to the properties of
their host galaxy. We briefly discuss how upcoming observations, e.g., imaging
from the Spitzer Survey of Stellar Structure in Galaxies (S4G), will lead to
significant further advances in this area of research.Comment: Invited review at "Galaxies and their Masks", celebrating Ken
Freeman's 70-th birthday, Sossusvlei, Namibia, April 2010. To be published by
Springer, New York, editors D.L. Block, K.C. Freeman, & I. Puerari; minor
change
Possible origins of macroscopic left-right asymmetry in organisms
I consider the microscopic mechanisms by which a particular left-right (L/R)
asymmetry is generated at the organism level from the microscopic handedness of
cytoskeletal molecules. In light of a fundamental symmetry principle, the
typical pattern-formation mechanisms of diffusion plus regulation cannot
implement the "right-hand rule"; at the microscopic level, the cell's
cytoskeleton of chiral filaments seems always to be involved, usually in
collective states driven by polymerization forces or molecular motors. It seems
particularly easy for handedness to emerge in a shear or rotation in the
background of an effectively two-dimensional system, such as the cell membrane
or a layer of cells, as this requires no pre-existing axis apart from the layer
normal. I detail a scenario involving actin/myosin layers in snails and in C.
elegans, and also one about the microtubule layer in plant cells. I also survey
the other examples that I am aware of, such as the emergence of handedness such
as the emergence of handedness in neurons, in eukaryote cell motility, and in
non-flagellated bacteria.Comment: 42 pages, 6 figures, resubmitted to J. Stat. Phys. special issue.
Major rewrite, rearranged sections/subsections, new Fig 3 + 6, new physics in
Sec 2.4 and 3.4.1, added Sec 5 and subsections of Sec
A replication study of genetic risk loci for ischemic stroke in a Dutch population: A case-control study
We aimed to replicate reported associations of 10 SNPs at eight distinct loci with overall ischemic stroke (IS) and its subtypes in an independent cohort of Dutch IS patients. We included 1,375 IS patients enrolled in a prospective multicenter hospital-based cohort in the Netherlands, and 1,533 population-level controls of Dutch descent. We tested these SNPs for association with overall IS and its subtypes (large artery atherosclerosis, small vessel disease and cardioembolic stroke (CE), as classified by TOAST) using an additive multivariable logistic regression model, adjusting for age and sex. We obtained odds ratios (OR) with 95% confidence intervals (95% CI) for the risk allele of each SNP analyzed and exact p-values by permutation. We confirmed the association at 4q25 (PITX2) (OR 1.43; 95% CI, 1.13-1.81, p = 0.029) and 16q22 (ZFHX3) (OR 1.62; 95% CI, 1.26-2.07, p = 0.001) as risk loci for CE. Locus 16q22 was also associated with overall IS (OR 1.24; 95% CI, 1.08-1.42, p = 0.016). Other loci previously associated with IS and/or its subtypes were not confirmed. In conclusion, we validated two loci (4q25, 16q22) associated with CE. In addition, our study may suggest that the association of locus 16q22 may not be limited to CE, but also includes overall IS
Low-mass pre--main-sequence stars in the Magellanic Clouds
[Abridged] The stellar Initial Mass Function (IMF) suggests that sub-solar
stars form in very large numbers. Most attractive places for catching low-mass
star formation in the act are young stellar clusters and associations, still
(half-)embedded in star-forming regions. The low-mass stars in such regions are
still in their pre--main-sequence (PMS) evolutionary phase. The peculiar nature
of these objects and the contamination of their samples by the evolved
populations of the Galactic disk impose demanding observational techniques for
the detection of complete numbers of PMS stars in the Milky Way. The Magellanic
Clouds, the companion galaxies to our own, demonstrate an exceptional star
formation activity. The low extinction and stellar field contamination in
star-forming regions of these galaxies imply a more efficient detection of
low-mass PMS stars than in the Milky Way, but their distance from us make the
application of special detection techniques unfeasible. Nonetheless, imaging
with the Hubble Space Telescope yield the discovery of solar and sub-solar PMS
stars in the Magellanic Clouds from photometry alone. Unprecedented numbers of
such objects are identified as the low-mass stellar content of their
star-forming regions, changing completely our picture of young stellar systems
outside the Milky Way, and extending the extragalactic stellar IMF below the
persisting threshold of a few solar masses. This review presents the recent
developments in the investigation of PMS stars in the Magellanic Clouds, with
special focus on the limitations by single-epoch photometry that can only be
circumvented by the detailed study of the observable behavior of these stars in
the color-magnitude diagram. The achieved characterization of the low-mass PMS
stars in the Magellanic Clouds allowed thus a more comprehensive understanding
of the star formation process in our neighboring galaxies.Comment: Review paper, 26 pages (in LaTeX style for Springer journals), 4
figures. Accepted for publication in Space Science Review
The solution to the Tullock rent-seeking game when R > 2: mixed-strategy equilibria and mean dissipation rates
In Tullock's rent-seeking model, the probability a player wins the game depends on expenditures raised to the power R. We show that a symmetric mixed-strategy Nash equilibrium exists when R>2, and that overdissipation of rents does not arise in any Nash equilibrium. We derive a tight lower bound on the level of rent dissipation that arises in a symmetric equilibrium when the strategy space is discrete, and show that full rent dissipation occurs when the strategy space is continuous. Our results are shown to be consistent with recent experimental evidence on the dissipation of rents.
An earlier version of this paper circulated under the title, No, Virginia, There is No Overdissipation of Rents. We are grateful to Dave Furth and Frans van Winden for stimulating conversations, and for comments provided by workshop participants from the CORE-ULB-KUL IUAP project, Purdue University, Pennsylvania State University, Rijksuniversiteit Limburg, and Washington State University. We also thank Max van de Sande Bakhuyzen and Ben Heijdra for useful discussions, and Geert Gielens for computational assistance. An earlier version of the paper was presented at the ESEM 1992 in Brussels and the Mid-West Mathematical Economics Conference in Pittsburgh. All three authors would like to thank CentER for its hospitality during the formative stages of the paper. The second author has also benefited from the financial support of the Katholieke Universitieit Leuven and the Jay N. Ross Young Faculty Scholar Award at Purdue University. The third author benefitted from visiting IGIER where part of the paper was written. The third author also benefitted from grant IUAP 26 of the Belgian Government
The sensitivity of the next generation of lunar Cherenkov observations to UHE neutrinos and cosmic rays
We present simulation results for the detection of ultra-high energy (UHE)
cosmic ray (CR) and neutrino interactions in the Moon by radio-telescopes. We
simulate the expected radio signal at Earth from such interactions, expanding
on previous work to include interactions in the sub-regolith layer for single
dish and multiple telescope systems. For previous experiments at Parkes,
Goldstone, and Kalyazin we recalculate the sensitivity to an isotropic flux of
UHE neutrinos. Our predicted sensitivity for future experiments using the
Australia Telescope Compact Array (ATCA) and the Australian SKA Pathfinder
(ASKAP) indicate these instruments will be able to detect the more optimistic
UHE neutrino flux predictions, while the Square Kilometre Array (SKA) will also
be sensitive to all bar one prediction of a diffuse `cosmogenic', or `GZK',
neutrino flux.
Current uncertainties concerning the structure and roughness of the lunar
surface prevents an accurate calculation of the sensitivity of the lunar
Cherenkov technique for UHE cosmic ray astronomy at high frequencies. However,
below 200 MHz we find that the proposed SKA low-frequency aperture array should
be able to detect events above 56 EeV at a rate about 30 times that of the
current Pierre Auger Observatory. This would allow directional analysis of UHE
cosmic rays, and investigation of correlations with putative cosmic ray source
populations, to be conducted with very high statistics.Comment: 29 pages, 9 figure
Assessing the impact of AGS-004, a dendritic cell-based immunotherapy, and vorinostat on persistent HIV-1 Infection
Approaches to deplete persistent HIV infection are needed. We investigated the combined impact of the latency reversing agent vorinostat (VOR) and AGS-004, an autologous dendritic cell immunotherapeutic, on the HIV reservoir. HIV+, stably treated participants in whom resting CD4+ T cell-associated HIV RNA (rca-RNA) increased after VOR exposure ex vivo and in vivo received 4 doses of AGS-004 every 3 weeks, followed by VOR every 72 hours for 30 days, and then the cycle repeated. Change in VOR-responsive host gene expression, HIV-specific T cell responses, low-level HIV viremia, rca-RNA, and the frequency of resting CD4+ T-cell infection (RCI) was measured at baseline and after each cycle. No serious treatment-related adverse events were observed among five participants. As predicted, VOR-responsive host genes responded uniformly to VOR dosing. Following cycles of AGS-004 and VOR, rca-RNA decreased significantly in only two participants, with a significant decrease in SCA observed in one of these participants. However, unlike other cohorts dosed with AGS-004, no uniform increase in HIV-specific immune responses following vaccination was observed. Finally, no reproducible decline of RCI, defined as a decrease of >50%, was observed. AGS-004 and VOR were safe and well-tolerated, but no substantial impact on RCI was measured. In contrast to previous clinical data, AGS-004 did not induce HIV-specific immune responses greater than those measured at baseline. More efficacious antiviral immune interventions, perhaps paired with more effective latency reversal, must be developed to clear persistent HIV infection
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