Association of Helicobacter Pylori with Presence of Myocardial Infarction in Iran: A Systematic Review and Meta-Analysis

BACKGROUND: Over the past decade, cardiovascular diseases have been recognized as the leading cause of mortality worldwide. Myocardial infarction (MI) is one of the most prevalent types of cardiovascular diseases that is caused by the closure of coronary arteries and ischemic heart muscle. Numerous studies have analyzed the role of H. pylori as a possible risk factor for coronary artery diseases, in most of which the role of infection in coronary artery disease is not statistically significant.METHODS: These contradictory findings made us conduct a systematic review to analyze all relevant studies in Iran through a meta-analysis and report a comprehensive and integrated result. All published studies from September 2000 until September 2016were considered. Using reliable Latin databases like PubMed, Google Scholar, Google search, Scopus, Science Direct and Persian databases like SID, Irandoc, Iran Mede and Magiran. After quality control, these studies were entered into a meta-analysis by using the random effects model. After evaluating the studies, 11 papers were finally selected and assessed.RESULTS: A total of 2517 participants had been evaluated in these studies, including 1253 cases and 1264 controls. Based on the results of meta-analysis and using random effects model, an overall estimate of OR Helicobacter Pylori with Presence of Myocardial Infarction in Iran was OR=2.53 (CI=1.37-4.67).CONCLUSIONS: The results of this review study show that H. pylori are associated with the incidence of MI so that the odds ratio of MI in the patients with helicobacter pylori is twice greater than that of the people without H. pylori. Future studies are recommended to evaluate the mechanisms associated with relation of H. pylori with MI as well as its association with time.KEYWORDS: Myocardial infarction, H. pylori, Meta-analysis, Ira

Ankylosing Spondylitis associated with intracranial aneurysms: report of 2 cases

ABSTRACTCerebral  aneurysms  are  the  major  cause  of  subarachnoid  hemorrhage.  Common  ascribed  etiologies  arehemodynamic  factors  such  as  atherosclerosis,   hypertension,  infection,  trauma,  polycyctic   kidney  disease, connective tissue disorders like Ehlers-Danlos disease, Marfan syndrome, and familial predisposition. However, its association with ankylosing spondylitis (AS) is not clear. Here, we report 2 patients with AS who presented with subarachnoid hemorrhage which was finally confirmed to be due to cerebral aneurysms, one in posterior communicating artery and the other in basilar artery tip). The patients had no history of hypertension or any other disease. Our data may not strongly suggest that vascular changes due to AS are etiological factors for developing intracranial aneurysm, but this report may show the possibility for existence of an association between these diseases, which has to be confirmed by more genetic and pathologic studies

Spinal hydatid cyst initially diagnosed as spinal tumor: A case report and review of the literature

Key Clinical Message The spinal hydatid cyst is a benign pathology but has considerable morbidity. It should be considered as a differential diagnosis in patients having signs and symptoms of spinal compression, particularly in endemic areas

A review on potential roles of vitamins in incidence, progression, and improvement of multiple sclerosis

Multiple Sclerosis (MS) is an inflammatory and neurodegenerative disease, with unknown etiology. Vitamins, as important micronutrients playing different roles in body, seem to be important in MS pathogenesis. In vitro, in vivo and human studies, supports the protective role of some vitamins in MS occurrence or progression. Current study reviews recent insights and reports about the importance of vitamins in MS incidence or progression. In accordance, the importance of all water and fat-soluble vitamins in MS pathogenesis based on observational studies in human population and their role in the function of immune system as well as possible therapeutic opportunities are discussed in depth throughout this review. Keywords: Multiple sclerosis, Experimental autoimmune encephalomyelitis, Vitamin A, Vitamin E, Vitamin D, Folic acid, Vitamin B 12, Vitamin