BEM DE FAMÍLIA, PRESSUPOSTO DE EFETIVIDADE DO DIREITO À MORADIA E GARANTIA DE UM PATRIMÔNIO MÍNIMO À LUZ DO CONSTITUCIONALISMO CONTEMPORÂNEO

O presente trabalho busca, objetivamente, demonstrar que o direito humano fundamental à moradia consagra mais do que o simples acesso a um teto que sirva à habitação, pois, de fato, é o instrumento por meio do qual outros valores se perfazem e se realizam. Nesse contexto, sustenta-se que o bem de família do fiador proprietário de único bem imóvel não pode ser objeto de constrição judicial, na medida em que tal significante tem como função essencial garantir o patrimônio mínimo, o qual por sua vez, encontra sua ratio na dignidade da pessoa humana. Ademais, propugna-se uma nova hermenêutica, em que todas as normas infraconstitucionais, bem como as relações jurídicas - públicas ou privadas - sejam interpretadas à luz da Constituição, considerando, ainda, a pessoa de carne e osso e não apenas o ser abstrato

How much do needlestick injuries cost? a systematic review of the economic evaluations of needlestick and sharps injuries among healthcare personnel

objective. To provide an overview of the economic aspects of needlestick and sharps injury (NSI) management among healthcare personnel (HCP) within a Health Technology Assessment project to evaluate the impact of safety-engineered devices on health care methods. A systematic review of economic analyses related to NSIs was performed in accordance with the PRISMA statement and by searching PubMed and Scopus databases (January 1997–February 2015). Mean costs were stratified by study approach (modeling or data driven) and type of cost (direct or indirect). Costs were evaluated using the CDC operative definition and converted to 2015 International US dollars (Int$). results. A total of 14 studies were retrieved: 8 data-driven studies and 6 modeling studies. Among them, 11 studies provided direct and indirect costs and 3 studies provided only direct costs. The median of the means for aggregate (direct + indirect) costs was Int$747 (range, Int$199–Int$1,691). The medians of the means for disaggregated costs were Int$425 (range, Int$48–Int$1,516) for direct costs (9 studies) and Int$322 (range, Int$152–Int$413) for indirect costs (6 studies). When compared with data-driven studies, modeling studies had higher disaggregated and aggregated costs, but data-driven studies showed greater variability. Indirect costs were consistent between studies, mostly referring to lost productivity, while direct costs varied widely within and between studies according to source infectivity, HCP susceptibility, and post-exposure diagnostic and prophylactic protocols. Costs of treating infections were not included, and intangible costs could equal those associated with NSI medical evaluations. conclusions. NSIs generate significant direct, indirect, potential, and intangible costs, possibly increasing over time. Economic efforts directed at preventing occupational exposures and infections, including provision of safety-engineered devices, may be offset by the savings from a lower incidence of NSIs

Tributação e sustentabilidade ambiental

- Divulgação dos SUMÁRIOS das obras recentemente incorporadas ao acervo da Biblioteca Ministro Oscar Saraiva do STJ. Em respeito à lei de Direitos Autorais, não disponibilizamos a obra na íntegra.- Localização na estante: 34:504 T822

Mechanisms of HIV-1 Nucleocapsid Protein Inhibition by Lysyl-Peptidyl-Anthraquinone Conjugates

The Nucleocapsid protein NCp7 (NC) is a nucleic acid chaperone responsible for essential steps of the HIV-1 life cycle and an attractive candidate for drug development. NC destabilizes nucleic acid structures and promotes the formation of annealed substrates for HIV-1 reverse transcription elongation. Short helical nucleic acid segments bordered by bulges and loops, such as the Trans-Activation Response element (TAR) of HIV-1 and its complementary sequence (cTAR), are nucleation elements for helix destabilization by NC and also preferred recognition sites for threading intercalators. Inspired by these observations, we have recently demonstrated that 2,6-disubstituted peptidylanthraquinone-conjugates inhibit the chaperone activities of recombinant NC in vitro, and that inhibition correlates with the stabilization of TAR and cTAR stem-loop structures. We describe here enhanced NC inhibitory activity by novel conjugates that exhibit longer peptidyl chains ending with a conserved Nterminal lysine. Their efficient inhibition of TAR/cTAR annealing mediated by NC originates from the combination of at least three different mechanisms, namely, their stabilizing effects on nucleic acids dynamics by threading intercalation, their ability to target TAR RNA substrate leading to a direct competition with the protein for the same binding sites on TAR, and, finally, their effective binding to the NC protein. Our results suggest that these molecules may represent the stepping-stone for the future development of NC-inhibitors capable of targeting the protein itself and its recognition site in RNA

ÁGUA POTÁVEL E SANEAMENTO BÁSICO: O ENCONTRO NECESSÁRIO DE DOIS DIREITOS FUNDAMENTAIS À SAÚDE DA VIDA EM GERAL

No presente texto objetiva-se trazer à discussão dois temas que estão intrinsicamente imbricados. Trata-se dos direitos à água potável e ao saneamento básico, porquanto sem o necessário implemento dos adequados serviços de coleta e tratamento de esgotos não se terá manancial hídrico com qualidade, a despeito da existência de significativo potencial de água em solo brasileiro. Sob a perspectiva metodológica, o estudo ampara-se em pesquisa exploratória, com elementos qualitativos e quantitativos

Guidelines for Tangible Preservation and Binding of PDF Scores

Guidelines for libraries that must consider printing and binding of PDF scores for physical access as part of circulating collections. These guidelines can be shared with the composer/publisher community so that they can be more aware of needs around physical access to PDF scores. Prepared by the MLA Electronic Scores Working Group - Tangible Preservation and Binding Subgroup

EL ESTADO DE COSAS INCONSTITUCIONAL COMO UN MECANISMO DE EXIGIBILIDAD DE RESPETO Y GARANTÍA DE LOS DERECHOS HUMANOS EN COLOMBIA Y SU APLICACIÓN EN BRASIL POR LA CORTE SUPREMA

Indiscutiblemente, en las últimas dos décadas la sociedad colombiana ha sido testigo y participe de las transformaciones más importantes que ha sufrido el Estado, tanto del rediseño de la estructura organizacional del poder, así como del reconocimiento progresivo de un amplio catálogo de derechos fundamentales en su carta política. En ese sentido, las transformaciones en estas dos áreas, han traído como consecuencia la existencia de un mayor parámetro de exigibilidad de respeto y garantía de los derechos humanos; para cumplir con ello, se han implementado novedosos y complejos mecanismos procesales para su defensa, tal como lo es la declaratoria del estado de cosas inconstitucional. Dicho desarrollo guarda especial relevancia, ya que sirve de modelo y guía para los países latinoamericanos, pues con ello se pretende la intervención colectiva de los poderes públicos y superar las falencias de carácter estructural de las políticas públicas, hacer frente y disminuir las violaciones masivas y sistemáticas de los derechos fundamentales y con ello reintegrar el valor máximo del ser humano que es su dignidad. Por último, se demuestra que en Brasil, aunque tímidamente, la doctrina jurisprudencial del estado de cosas inconstitucional ha sido aplicada por la Suprema Corte de aquel país

Neoplasie neuroendocrine del pancreas serotonina positive: correlazione imaging – anatomia patologica

Analisi delle caratteristiche radiologiche delle neoplasie neuroendocrine pancreatiche serotonina positive

Ablazione a radiofrequenza dell'epatocarcinoma: l'uso della texture analysis dell'area ablata per predire la recidiva

Valutare il ruolo della texture analysis nella valutazione del rischio di recidiva locale dopo radioablazione di HCC

Therapeutic aspects of Sydenham's Chorea: an update

Sydenham's Chorea (SC) is a hyperkinetic movement disorder associated with neuropsychiatric manifestations. It is believed to be caused by the autoimmune response following a group A beta-hemolytic streptococcal (GABHS) pharyngitis, and it is one of the major diagnostic criteria for Acute Rheumatic Fever (ARF) diagnosis. Despite having been known and studied for centuries, there are still no standardized therapies or official guidelines for SC treatment, so that it is necessarily left to physicians' clinical experience. Antibiotic treatment, symptomatic therapies, and immunomodulatory treatment are the three pillars upon which SC patients' management is currently based, but they still lack a solid scientific basis. The aim of this writing is precisely to review the state of the art of SC's treatment, with an overview of the advances made in the last 5 years. However, since the therapeutic uncertainties are a mere reflection of the severe gap of knowledge that concerns SC's pathogenesis and manifestations, the importance of high-quality research studies based on homogenized methodologies, instruments, and measured outcomes will also be stressed