4,195 research outputs found
Perturbation solutions of fifth order oscillatory nonlinear systems
Oscillatory systems play an important role in the nature. Many engineering problems and physical systems of fifth degrees of freedom are oscillatory and their governing equations are fifth order nonlinear differential equations. To investigate the solution of fifth order weakly nonlinear oscillatory systems, in this article the Krylov–Bogoliubov–Mitropolskii (KBM) method has been extended and desired solution is found. An example is solved to illustrate the method. The results obtain by the extended KBM method show good agreement with those obtained by numerical method
DAWM: cost-aware asset claim analysis approach on big data analytic computation model for cloud data centre.
The heterogeneous resource-required application tasks increase the cloud service provider (CSP) energy cost and revenue by providing demand resources. Enhancing CSP profit and preserving energy cost is a challenging task. Most of the existing approaches consider task deadline violation rate rather than performance cost and server size ratio during profit estimation, which impacts CSP revenue and causes high service cost. To address this issue, we develop two algorithms for profit maximization and adequate service reliability. First, a belief propagation-influenced cost-aware asset scheduling approach is derived based on the data analytic weight measurement (DAWM) model for effective performance and server size optimization. Second, the multiobjective heuristic user service demand (MHUSD) approach is formulated based on the CPS profit estimation model and the user service demand (USD) model with dynamic acyclic graph (DAG) phenomena for adequate service reliability. The DAWM model classifies prominent servers to preserve the server resource usage and cost during an effective resource slicing process by considering each machine execution factor (remaining energy, energy and service cost, workload execution rate, service deadline violation rate, cloud server configuration (CSC), service requirement rate, and service level agreement violation (SLAV) penalty rate). The MHUSD algorithm measures the user demand service rate and cost based on the USD and CSP profit estimation models by considering service demand weight, tenant cost, and energy cost. The simulation results show that the proposed system has accomplished the average revenue gain of 35%, cost of 51%, and profit of 39% than the state-of-the-art approaches
High index contrast photonic platforms for on-chip Raman spectroscopy
Nanophotonic waveguide enhanced Raman spectroscopy (NWERS) is a sensing technique that uses a highly confined waveguide mode to excite and collect the Raman scattered signal from molecules in close vicinity of the waveguide. The most important parameters defining the figure of merit of an NWERS sensor include its ability to collect the Raman signal from an analyte, i.e. "the Raman conversion efficiency" and the amount of "Raman background" generated from the guiding material. Here, we compare different photonic integrated circuit (PIC) platforms capable of on-chip Raman sensing in terms of the aforementioned parameters. Among the four photonic platforms under study, tantalum oxide and silicon nitride waveguides exhibit high signal collection efficiency and low Raman background. In contrast, the performance of titania and alumina waveguides suffers from a strong Raman background and a weak signal collection efficiency, respectively
The Personalization of Clopidogrel Antiplatelet Therapy: The Role of Integrative Pharmacogenetics and Pharmacometabolomics
Dual antiplatelet therapy of aspirin and clopidogrel is pivotal for patients undergoing percutaneous coronary intervention.
However, the variable platelets reactivity response to clopidogrel may lead to outcome failure and recurrence of cardiovascular
events. Although many genetic and nongenetic factors are known, great portion of clopidogrel variable platelets reactivity
remain unexplained which challenges the personalization of clopidogrel therapy. Current methods for clopidogrel personalization
include CYP2C19 genotyping, pharmacokinetics, and platelets function testing. However, these methods lack precise prediction
of clopidogrel outcome, often leading to insufficient prediction. Pharmacometabolomics which is an approach to identify
novel biomarkers of drug response or toxicity in biofluids has been investigated to predict drug response. The advantage of
pharmacometabolomics is that it does not only predict the response but also provide extensive information on the metabolic
pathways implicated with the response. Integrating pharmacogenetics with pharmacometabolomics can give insight on unknown
genetic and nongenetic factors associated with the response.This review aimed to review the literature on factors associated with
the variable platelets reactivity response to clopidogrel, as well as appraising current methods for the personalization of clopidogrel
therapy. We also aimed to review the literature on using pharmacometabolomics approach to predict drug response, as well as
discussing the plausibility of using it to predict clopidogrel outcome
Mobile station movement direction prediction (MMDP) based handover scanning for mobile WiMAX system
Mobile WiMAX is a broadband technology that is capable of delivering triple play services (voice, data, and video). However, mobility in mobile WiMAX system is still an issue when the mobile station (MS) moves and its connection is handed over between base stations (BSs). In the handover process, scanning is one of the required phases to find the target BS. During the handover scanning process, the MS must synchronize with all the advertised neighbour BSs (nBSs) to select the best BS candidate for the incoming handover action. Without terminating the connection between the SBS and MS, the SBS will schedule the scanning intervals and sleep-intervals (also called interleaving interval) to MS for the handover scanning. However, during the scanning interval period, all the coming transmissions will be paused. Therefore, the redundant or unnecessary scanning of neighbouring BS cause delay and MAC overhead which may affect real-time applications. In this paper, the MS movement direction prediction (MMDP) based handover scanning scheme is introduced to overcome the mobile WiMAX handover scanning issue. It based on dividing the BS coverage area is into zones and sectors. According to the signal quality; there are three zones, no handover (No-HO), low handover (Low-HO) and high handover (High-HO) zones respectively and six sectors. In this scheme, only two BSs can become candidates; the two that the MS moves toward them will be chosen as the candidate for the handover scanning purpose. Hence, the handover scanning process repetition will be reduced with these two shortlisted BS candidates instead of scanning all nBSs. Thus, MMDP will reduce scanning delay and the number of exchange messages during the handover scanning comparing to the conventional scanning scheme. Although, the MMDP may need an extra computational time, the prediction and scanning process will be finished before the MS reach the High-HO zone, which mean the end-user’s running application will be affected. Simulation results show that the proposed MMDP scheme reduces the total handover scanning delay and scanning interval duration by 25 and 50 % respectively. Also, the size of scanning message is reduced, which leads to reduced signalling overhead
Prospects and Evaluation of an Integrated Extension Model designed for Anthrax-free Area Development
The main purpose of this study wasto assess and evaluate anIntegrated Extension Modelto improve the overall knowledge, attitude and practice habits of community people over a sustained period.The survey questionnaire results have indicated that the various sources of anthrax message dissemination had played a significant role in the study. Among those responsible for disseminating the information, it was realized that studentsserving in the role of message disseminators played the most significant role (15%) indelivering the anthrax-related key information to the community. Majority community members (97.5%) were made aware of the nature, occurrence, public health importance, and management of the disease. Theirdangerous habits and attitudes toward slaughtering of sick animals were reduced (\u3c30%). The attention of local administration and the law enforcement agency focused distinctively on the issue of animal slaughter. Vaccination and clinical records reveal that the percentage of vaccination coverage was increased from 40% to 85% andthe percentage of farmers who can diagnose anthrax has been increased from 30% to 40%.On the other hand, their poor economic background together with the dispersed settlement nature of the farmers was the main gaps identified that continued to force them to slaughter infected animals, sell their products and to consequently concealthat information, all issues that are required to be addressed in the future. Based on the research findings, it can be concluded that this modelis an efficient, effective and suitable method to raise awareness levels in a large communitywith regards to a zoonotic disease like anthrax
Computational analysis of third-grade liquid flow with cross diffusion effects: application to entropy modeling
The key goal of this current study is to analyze the entropy generation with cross diffusion effects. The third-grade type non-Newtonian fluid model is used in this study. The current flow problem is modelled with stretching plate. Modified Fourier heat flux is replaced the classical heat flux. The appropriate transformation is availed to convert the basic boundary layers equations into ODEs and then verified by homotopy algorithm. The consequences of various physical quantities on temperature, velocity, entropy and concentration profile are illustrated graphically
Study of elastic and inelastic scattering of Be + C at 35 MeV
The elastic and inelastic scattering of Be from C have been
measured at an incident energy of 35 MeV. The inelastic scattering leading to
the 4.439 MeV excited state of C has been measured for the first time.
The experimental data cover an angular range of =
15-120. Optical model analyses were carried out with
Woods-Saxon and double-folding potential using the density dependent M3Y
(DDM3Y) effective interaction. The microscopic analysis of the elastic data
indicates breakup channel coupling effect. A coupled-channel analysis of the
inelastic scattering, based on collective form factors, show that mutual
excitation of both Be and C is significantly smaller than the single
excitation of C. The larger deformation length obtained from the DWBA
analysis could be explained by including the excitation of Be in a
coupled-channel analysis. The breakup cross section of Be is estimated to
be less than 10 of the reaction cross section. The intrinsic deformation
length obtained for the C (4.439 MeV) state is = 1.37
fm. The total reaction cross section deduced from the analysis agrees very well
with Wong's calculations for similar weakly bound light nuclei on C
target.Comment: 8 pages, 5 figure
The High Burden of Cholera in Children: Comparison of Incidence from Endemic Areas in Asia and Africa
Cholera is an often forgotten disease affecting the world's forgotten people. When a large cholera outbreak occurs, the disease appears briefly on the radar of public attention. Some unfortunate populations around the world suffer recurrent episodes of cholera but their plight goes unnoticed. We established cholera surveillance in impoverished areas in Jakarta (Indonesia), Kolkata (India), and Beira (Mozambique) where the disease is known to occur regularly. The cholera burden was calculated using the site population as the denominator and the number of cholera cases as the numerator. The lowest overall rate was in Jakarta with 0.5 cases per 1000 population per year. The incidence was three times higher in Kolkata (1.6/1000/year) and eight times higher in Beira (4.0/1000/year), adding to the growing impression of the large cholera problem in Africa. In all sites, children are the most affected. Estimates such as these are useful when considering where and among whom interventions against the disease are most needed. Improvement of water supply and sanitation is the best strategy against cholera and other diarrheal diseases but may not be achievable in these impoverished areas in the near future. Other immediate, short- to medium-term strategies such as vaccination against cholera may be useful
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