La colonización cisterciense en la Meseta del Duero : El ejemplo de Moreruela : Siglos XII-XIV

Tesis Universidad Complutense de Madrid, 1983.Fac. de Ciencias Políticas y SociologíaTRUEProQuestpu

Randomized phase II study of fulvestrant plus palbociclib or placebo in endocrine-sensitive, hormone receptor-positive/HER2-advanced breast cancer: GEICAM/2014-12 (FLIPPER).

Este artículo ha sido publicado en la revista European Journal of Cancer. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).Background: The potential benefit of adding palbociclib to fulvestrant as first-line treatment in hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative endocrine-sensitive advanced breast cancer (ABC) patients remains uncharacterized. Patients and methods: In this randomized (1:1), double-blind, phase II study, postmenopausal women with HR-positive, HER2-negative ABC with de novo metastatic disease or those who relapsed after >12 months of adjuvant endocrine therapy received palbociclib/fulvestrant or placebo/fulvestrant. Stratification was based on recurrent versus de novo metastatic disease and visceral involvement. The primary objective was one-year progression-free survival (PFS-1y) rate. The sample size was 190 patients. The two-sided alpha of 0.2, 80% of power to detect a difference between the arms, assuming PFS rates of 0.695 and 0.545 for palbociclib/fulvestrant and placebo/fulvestrant, respectively. Results: In total, 189 patients were randomized to palbociclib/fulvestrant ([n = 94] or placebo/fulvestrant [n = 95]). 45.5% and 60.3% of patients had de novo metastatic disease and visceral involvement, respectively. PFS-1y rates were 83.5% and 71.9% in the palbociclib/fulvestrant and placebo/fulvestrant arms, (HR 0.55, 80% CI 0.36-0.83, P = 0.064). The median PFS were 31.8 and 22.0 months for the palbociclib/fulvestrant and placebo/fulvestrant arms (aHR 0.48, 80% CI 0.37-0.64, P = 0.001). The most frequent grade 3-4 adverse events were neutropenia (68.1% vs. 0%), leucopenia (26.6% vs. 0%), anemia (3.2% vs. 0%), and lymphopenia (14.9% vs. 2.1%) for the palbociclib/fulvestrant and placebo/fulvestrant, respectively. The most frequent non-hematologic grade 3-4 adverse event was fatigue (4.3% vs. 0%). Conclusions: Palbociclib/fulvestrant demonstrated better PFS-1y rates and median PFS than placebo/fulvestrant in HR-positive/HER2-negative endocrine-sensitive ABC patients

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Formas y funciones de la renta: un estudio comparado de la fiscalidadad sectorial en la Edad Media Europea (1050-1350)

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Conflictos en el proceso de expansión de un señorío monástico

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El monacato. Zamora en la Edad media

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Feudalismo: Instituciones feudales en la Península Ibérica

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Litigios por la tierra y "malfetrías" entre la nobleza medieval castellano-leonesa

[ES] Los procesos de disputas por la tierra, manifestación más frecuente de concurrencia aristocrática, son analizados en este artículo como medio de entender aspectos importantes de la dinámica política local, considerada ésta como el conjunto de acciones dirigidas a negociar y reproducir relaciones de poder en tal esfera. Al identificar los campos donde se plantea de forma inevitable, aunque no siempre abierta, la competición y asumir como estructurales determinados antagonismos, en este caso entre los grupos dominantes, estamos igualmente en condiciones de comprender mejor no sólo las distintas formas que reviste la alianza o solidaridad entre ellos sino también la relación que puede darse entre distintas formalizaciones de la lucha política. Los cambios en la utilización de recursos jurídicos han de entenderse en relación a estos procesos y no al revés.[EN] The processes of land disputing, the inmost frequent form of aristocratic competition, are analysed in this article as a means to the understanding of important aspects of local political dynamics, this being understood as the set of actions aimed at negotiating and reproducing power relations at the local level. When we have identified the arenas in which such competition is inevitably located (even trough not always in an explicit manner), and when we have identified some pattern of antagonism as structural (that is to say, in this instance, to dominant groups) then we are in a position to understand better: not only the different forms that mutual alliance and the solidarity between aristocrats take, but also the relationships that can develop between different versions of political struggle. The change in the use of appeals to late have to be understood in the framework of these processes, and not vice versa.Peer reviewe

Labour organization in the rural work and its evolution. The Middle Ages

[ES] El objetivo de estas páginas es comentar las contribuciones que fueron presentadas a la sección sobre organización del trabajo rural durante la Edad Media en el Congreso de Historia Agraria celebrado en Bilbao (septiembre de 1999), una sobre el trabajo esclavo en la Mallorca medieval, la otra sobre el trabajo asalariado en el mundo rural castellano de Tierra de Campos. Dado que estas dos aportaciones se ocupan de dos tipos de trabajo que no se corresponden con los que se postulan como predominantes del sistema económico en el que se ubican, mis consideraciones van dirigidas a plantear algunos problemas e implicaciones derivados de otorgar centralidad a una sola forma de trabajo como característica de cualquier formación social. Son consideraciones realizadas a partir de las críticas que el modelo clásico de capitalismo ha recibido. La propuesta es que la interdisciplinaridad incluya la comunicación entre historiadores de distintos períodos[EN] This article seeks to review the papers given at the Agrarian History Conference held in Bilbao (September 1999), in the section on the organization of rural work during the Middle Ages: one paper was on slave labour in Mallorca and another on paid labour in Tierra de Campos in Castile. Both cases focus on two types of labour relations that do not agree with those considered dominant in the economic system in which they are situated. Then, my comments aim to raise some of the problems and implications of conferring central importance to one single form of work relation as characteristic of any social formation. They are considerations carried out from the critiques which the classical model of capitalism has received. The proposal is that interdisciplinarity should take into account the communication among historians of different periods.Peer reviewe

Las granjas de Moreruela. Notas para el estudio de la colonización cisterciense en la Meseta del Duero

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