63 research outputs found
Case analysis of information security risk perceptions
The scientific rationality used by experts towards risk evaluation is expressed as the product of its likelihood of occurrence with its consequences or impacts (ENISA, 2006a). This directly opposes the subjective nature of risk perception, often appearing as inconsistent if not completely irrational (Byrne, 2003). Risk perception theories are a pathway to explain the subjective nature of risk and a deeper insight into the human\u27s cognitive system. Those theories may help to explain why people see, act and plan for risks in the way that they do, the weaknesses that exist in the human decision mechanisms and their impact on risk perceptions and decisions. By questioning the existence of risk perception in the information security field of study, this research acknowledges those risk perception theories and provides a measure of their influence when rating information security risks. The research measures the existence of risk perception issues by asking a participating sample of people to rate the likelihood of ten information security risks that carried previously measured statistics. In order to archive this, an online survey was designed to capture risk-rating information from an informed sample as well as a measure of their self-assessed information security knowledge. By measuring the gaps between the participants\u27 answers and the known occurrences of those risks, the research highlighted a number of disparities revealing the existence of risk perception divergence. A statistical analysis of the results was performed with the intent of highlighting gaps in the perception of the given risks. This analysis also allowed the research to narrow down the scope of risks that may or may not have been perceived with higher or lower gaps than other risks. Further analysis specifically identified the risks affected by those gaps, their statistical significance, strength and direction. The areas displaying the highest perception gaps resided with risks that were generally rare, new and unfamiliar or were being publicised in the popular media. Finally, this research investigated whether or not the self-assessed respondents\u27 knowledge is a factor influencing people\u27s risk ratings in the online survey and thereby a factor in the way those risks are perceived. A correlation analysis was used to determine the degree of association between the participants\u27 risk ratings and their perceived and self-rated information security knowledge
Information Security Surveys: A Review of the Methodologies, the Critics and a Pragmatic Approach to their Purposes and Usage
Each year the latest information security surveys are released to the computing and business communities. Often their findings and their methodologies are subject to criticism from the information security community, professional bodies and others in the profession. This paper looks at the viewpoints of both the producers and the critics of the surveys. The criticisms cover such issues as the methodologies, the response rates, the experience of the respondents, the design of the questions and the interpretation of the results. This paper looks at these issues and discusses the validity of these criticisms, the impact of the surveys and their value to business and government. It compares the methodologies of some of the largest local and international players in the area. It discusses the issues arising from flawed methodologies, inaccurate information and poor processes, including the perceived lack of integrity and the accuracy of the measurements and methodologies. Despite the strong criticism a middle ground emerged. Data input by the participants, whether accurate or not, may be highly subjective and influenced by their environment and business profile. Furthermore, security at a business level may be extremely complex, the governance principles dictating that the organisation profile, management ideologies and core business values must be accounted for and balanced even for IT. The paper also considers the interpretation of the results and how they may be influenced by current and future products and the vendors of those products. Finally the paper takes a closer look at the use of the surveys in a business context and attempts to show that if constructively used, these surveys can be powerful metric tools used in driving information security strategies in spite of their perceived deficiencies
Analyzing drug load and release from pharmaceutical nanocarriers for the treatment of inflammatory bowel diseases
In the context of new strategy development for the treatment of inflammatory bowel diseases,
especially Crohnâs disease and ulcerative colitis, nanoparticular systems are considered as
promising alternatives to the current treatments. Indeed, because of the accumulation of
supramolecular objects in the epithelium of inflammatory bowel, a passive targeting could be
achieved using drug carriers with the aim of increasing the efficacy and the safety for the
patient.
The objective of the present dissertation is to establish appropriate analytical methods to
characterize nanocarriers and secondarily microcarriers. Two different types of formulations,
namely the lipid nanoparticles (LipidotÂź) and the poly(lactic-co-glycolic acid) (PLGA) microand
nanoparticles were investigated. Studies were performed using budesonide and
cyclosporine A as active pharmaceutical ingredients (API). In vitro drug release testing
methods based on the derivative spectrophotometry using a fiber optic system were
successfully developed for PLGA drug carriers whereas for the first time a solid phase
extraction method for nanoparticles was designed and implemented to evaluate the carrying
performances of the LipidotÂź. Furthermore, the concept of automation was strongly
considered during the selection step of analytical techniques with the following outlook:
speed up the commercialization of nanopharmaceuticals.Im Rahmen der Entwicklung von neuen Strategien fĂŒr die Behandlung von entzĂŒndlichen
Darmerkrankungen, hauptsÀchlich Morbus Crohn und Colitis ulcerosa, werden
Nanopartikularsysteme als vielversprechende Alternativen zu aktuellen Behandlungen
betrachtet. TatsÀchlich könnte, aufgrund einer Akkumulation von supramolekularen Partikeln
im Epithelium von entzĂŒndlichen Geweben, ein âpassive targetingâ mit NanotrĂ€gern erreicht
werden und somit zu einer erhöhten Wirksamkeit und gröĂeren Sicherheit fĂŒr den Patienten
fĂŒhren.
Die vorliegende Dissertation beabsichtigt geeignete analytische Methoden zu entwickeln, um
nanopartikulare/mikropartikulare TrÀger zu charakterisieren. Zwei verschiedene
Formulierungen fĂŒr den Transport von Wirkstoffen, nĂ€mlich die Lipid-Nanopartikel (LipidotÂź)
und die Poly(lactid-co-Glycolid) (PLGA) Mikro- und Nanopartikel wurden untersucht. FĂŒr die
Experimente wurden Budesonid und Cyclosporine A ausgewÀhlt. In vitro
Freisetzungsmethoden wurden fĂŒr PLGA-WirkstofftrĂ€ger mit einer Kombination aus
Ableitungsspektrophotometrie und einem Fiberoptic Freisetzungssystem erfolgreich
entwickelt. AuĂerdem, wurde erstmalig eine Festphasenextraktionsmethode fĂŒr die
Evaluierung der Beladung von LipidotÂź fĂŒr verkapselte Wirkstoffe entwickelt und
angewendet.
DarĂŒber hinaus wurde besonderer Wert auf das Konzept der Automatisierung wĂ€hrend der
Methodenentwicklung gelegt, um die Kommerzialisierung von Nanopharmazeutika zu
beschleunigen
Spatialiser la transition énergétique: Vers la production d'"écosystÚmes énergétiques territoriaux" en milieu ruralRapport intermédiaireOctobre 2014
Cette recherche vise Ă interroger la « cohĂ©rence spatiale » des logiques de substitution Ă©nergĂ©tique Ă lâĆuvre en France. On part du constat que les innovations dans ce domaine sont le plus souvent apprĂ©hendĂ©es dans une logique techniciste, se traduisant en terme dâamĂ©nagement par une banalisation et une uniformisation du territoire et des paysages. Dans ce contexte la transition Ă©nergĂ©tique reprĂ©sente un enjeu spatial de premier ordre devant ĂȘtre saisi dans toute sa complexitĂ©, par les diverses Ă©chelles dâamĂ©nagement qu'elle touche : architecturale, urbaine et paysagĂšre. A cet Ă©gard, ce dĂ©bat doit ĂȘtre impĂ©rativement relayĂ© par une rĂ©flexion critique sur les logiques d'innovation en cours, en vue d'Ă©laborer d'autres concepts et approches, pour qualifier cette transition et l'aborder en termes de projet. Les territoires ruraux de faible densitĂ© Ă dominante agricole et forestiĂšre constituent notre terrain d'Ă©tude privilĂ©giĂ©. On est parti de lâhypothĂšse que ces territoires reprĂ©sentent un enjeu de projet stratĂ©gique, tant par leurs Ă©volutions dĂ©mographiques et Ă©conomiques, que par leur potentiel de production Ă©nergĂ©tique liĂ© Ă leurs ressources naturelles. Prenant en compte ces caractĂ©ristiques, un des objectifs clefs de cette recherche sera d'identifier Ă l'Ă©chelle locale le nouveau substrat Ă©nergĂ©tique, mettant Ă profit la puissance des quatre Ă©lĂ©ments propres aux Ă©nergies renouvelables - Ă©nergie chimique contenue dans la biomasse ; Ă©nergie mĂ©canique de l'eau ou du vent ; Ă©nergie thermique de l'eau chaude du sous-sol ou du rayonnement solaire. Autrement dit, il sera question de prĂ©figurer une nouvelle « Ă©conomie de l'habiter » en milieu rural, liĂ©e Ă la mise en place de ce nouveau substrat technique et Ă©nergĂ©tique. Dans cette optique deux concepts fĂ©dĂ©rateurs sont Ă©laborĂ©s de maniĂšre hypothĂ©tique Ă cette Ă©tape de notre travail : - celui d'« Ă©cosystĂšme Ă©nergĂ©tique territorial », permettant de croiser les « Ă©chelles Ă©nergĂ©tiques » et de travailler autant au stade de « l'Ă©nergie finale » (les outils et les infrastructures influant sur la dĂ©pense d'Ă©nergie), qu'au stade de « l'Ă©nergie primaire » (les formes sous lesquelles la nature livre l'Ă©nergie)- celui de « plan local d'Ă©nergie et de paysage », permettant d'identifier les implications Ă l'Ă©chelle architecturale et territoriale, de ce nouveau substrat Ă©nergĂ©tique, Ă moyen et Ă long termes. MĂ©thodologie de recherche : Cette rĂ©ponse Ă©laborĂ©e conjointement avec des enseignants-chercheurs de lâENSAG et du rĂ©seau ERPS vise Ă poursuivre une mĂ©thode de recherche spĂ©cifique explorĂ©e prĂ©cĂ©demment fondĂ©e sur l'interdisciplinaritĂ© : la recherche par le projet. Selon cette mĂ©thode, le projet joue un double rĂŽle : heuristique et expĂ©rimental. La dimension heuristique, dĂ©veloppĂ©e dans la premiĂšre phase de la recherche consiste Ă faire Ă©merger par le projet, dans le cadre des ateliers de Master, des questions architecturales et territoriales stratĂ©giques par rapport Ă nos objectifs de recherche. TraitĂ©es d'un point de vue scientifique, ces questions permettront de formuler des hypothĂšses qui seront livrĂ©es aux concepteurs et testĂ©es dans le second temps de projet, la phase expĂ©rimentale. Le matĂ©riel produit Ă lâissue de ces phases de projet sera ensuite analysĂ© par lâĂ©quipe afin de dĂ©gager des rĂ©sultats discutĂ©s dans le cadre Ă©largi dâun sĂ©minaire international. Au travers de ces travaux en atelier, il sâagit de produire des connaissances spĂ©cifiques, susceptibles renouveler nos pratiques d'amĂ©nagement vers la construction d'une nouvelle alliance homme/territoire basĂ©e sur une redĂ©finition de notre rapport Ă l'Ă©nergie et Ă ses modes de production. En somme, de la recherche par lâaction et pour lâaction. Sa mise en application repose sur une dynamique de travail interdisciplinaire combinant activitĂ© scientifique, activitĂ© pĂ©dagogique et activitĂ© de mise en Ćuvre d'un projet expĂ©rimental, Ă partir du territoire de la commune d'Ambert situĂ©e dans le Parc naturel rĂ©gional du Livradois-Forez
Infrared Eclipses of the Strongly Irradiated Planet WASP-33b, and Oscillations of its Host Star
We observe two secondary eclipses of the strongly irradiated transiting
planet WASP-33b in the Ks band, and one secondary eclipse each at 3.6- and 4.5
microns using Warm Spitzer. This planet orbits an A5V delta-Scuti star that is
known to exhibit low amplitude non-radial p-mode oscillations at about
0.1-percent semi-amplitude. We detect stellar oscillations in all of our
infrared eclipse data, and also in one night of observations at J-band out of
eclipse. The oscillation amplitude, in all infrared bands except Ks, is about
the same as in the optical. However, the stellar oscillations in Ks band have
about twice the amplitude as seen in the optical, possibly because the
Brackett-gamma line falls in this bandpass. We use our best-fit values for the
eclipse depth, as well as the 0.9 micron eclipse observed by Smith et al., to
explore possible states of the exoplanetary atmosphere, based on the method of
Madhusudhan and Seager. On this basis we find two possible states for the
atmospheric structure of WASP-33b. One possibility is a non-inverted
temperature structure in spite of the strong irradiance, but this model
requires an enhanced carbon abundance (C/O>1). The alternative model has solar
composition, but an inverted temperature structure. Spectroscopy of the planet
at secondary eclipse, using a spectral resolution that can resolve the water
vapor band structure, should be able to break the degeneracy between these very
different possible states of the exoplanetary atmosphere. However, both of
those model atmospheres absorb nearly all of the stellar irradiance with
minimal longitudinal re-distribution of energy, strengthening the hypothesis of
Cowan et al. that the most strongly irradiated planets circulate energy poorly.
Our measurement of the central phase of the eclipse yields e*cos(omega)=0.0003
+/-0.00013, which we regard as being consistent with a circular orbit.Comment: 23 pages, 9 figures, 3 tables, accepted for the Astrophysical Journa
Three Saturn-mass planets transiting F-type stars revealed with TESS and HARPS
While the sample of confirmed exoplanets continues to increase, the
population of transiting exoplanets around early-type stars is still limited.
These planets allow us to investigate the planet properties and formation
pathways over a wide range of stellar masses and study the impact of high
irradiation on hot Jupiters orbiting such stars. We report the discovery of
TOI-615b, TOI-622b, and TOI-2641b, three Saturn-mass planets transiting main
sequence, F-type stars. The planets were identified by the Transiting Exoplanet
Survey Satellite (TESS) and confirmed with complementary ground-based and
radial velocity observations. TOI-615b is a highly irradiated (1277
) and bloated Saturn-mass planet (1.69
and 0.43) in a 4.66 day orbit transiting a 6850 K
star. TOI-622b has a radius of 0.82 and a mass of
0.30~ in a 6.40 day orbit. Despite its high
insolation flux (600 ), TOI-622b does not show any evidence
of radius inflation. TOI-2641b is a 0.37 planet in a
4.88 day orbit with a grazing transit (b = 1.04) that
results in a poorly constrained radius of 1.61.
Additionally, TOI-615b is considered attractive for atmospheric studies via
transmission spectroscopy with ground-based spectrographs and .
Future atmospheric and spin-orbit alignment observations are essential since
they can provide information on the atmospheric composition, formation and
migration of exoplanets across various stellar types.Comment: 16 pages, 17 figures, submitted to A&
A pair of Sub-Neptunes transiting the bright K-dwarf TOI-1064 characterised with CHEOPS
Funding: TGW, ACC, and KH acknowledge support from STFC consolidated grant numbers ST/R000824/1 and ST/V000861/1, and UKSA grant ST/R003203/1.We report the discovery and characterization of a pair of sub-Neptunes transiting the bright K-dwarf TOI-1064 (TIC 79748331), initially detected in the Transiting Exoplanet Survey Satellite (TESS) photometry. To characterize the system, we performed and retrieved the CHaracterising ExOPlanets Satellite (CHEOPS), TESS, and ground-based photometry, the High Accuracy Radial velocity Planet Searcher (HARPS) high-resolution spectroscopy, and Gemini speckle imaging. We characterize the host star and determine Teff,â=4734±67Kâ , Râ=0.726±0.007Rââ , and Mâ=0.748±0.032Mââ . We present a novel detrending method based on point spread function shape-change modelling and demonstrate its suitability to correct flux variations in CHEOPS data. We confirm the planetary nature of both bodies and find that TOI-1064 b has an orbital period of Pb = 6.44387 ± 0.00003 d, a radius of Rb = 2.59 ± 0.04 Râ, and a mass of Mb=13.5+1.7â1.8 Mâ, whilst TOI-1064 c has an orbital period of Pc=12.22657+0.00005â0.00004 d, a radius of Rc = 2.65 ± 0.04 Râ, and a 3Ï upper mass limit of 8.5 Mâ. From the high-precision photometry we obtain radius uncertainties of âŒ1.6 per cent, allowing us to conduct internal structure and atmospheric escape modelling. TOI-1064 b is one of the densest, well-characterized sub-Neptunes, with a tenuous atmosphere that can be explained by the loss of a primordial envelope following migration through the protoplanetary disc. It is likely that TOI-1064 c has an extended atmosphere due to the tentative low density, however further radial velocities are needed to confirm this scenario and the similar radii, different masses nature of this system. The high-precision data and modelling of TOI-1064 b are important for planets in this region of massâradius space, and it allow us to identify a trend in bulk densityâstellar metallicity for massive sub-Neptunes that may hint at the formation of this population of planets.Publisher PDFPeer reviewe
TOI-836 : a super-Earth and mini-Neptune transiting a nearby K-dwarf
Funding: TGW, ACC, and KH acknowledge support from STFC consolidated grant numbers ST/R000824/1 and ST/V000861/1, and UKSA grant ST/R003203/1.We present the discovery of two exoplanets transiting TOI-836 (TIC 440887364) using data from TESS Sector 11 and Sector 38. TOI-836 is a bright (T = 8.5 mag), high proper motion (âŒ200 mas yrâ1), low metallicity ([Fe/H]ââ0.28) K-dwarf with a mass of 0.68 ± 0.05 Mâ and a radius of 0.67 ± 0.01 Râ. We obtain photometric follow-up observations with a variety of facilities, and we use these data-sets to determine that the inner planet, TOI-836 b, is a 1.70 ± 0.07 Râ super-Earth in a 3.82 day orbit, placing it directly within the so-called âradius valleyâ. The outer planet, TOI-836 c, is a 2.59 ± 0.09 Râ mini-Neptune in an 8.60 day orbit. Radial velocity measurements reveal that TOI-836 b has a mass of 4.5 ± 0.9 Mâ, while TOI-836 c has a mass of 9.6 ± 2.6 Mâ. Photometric observations show Transit Timing Variations (TTVs) on the order of 20 minutes for TOI-836 c, although there are no detectable TTVs for TOI-836 b. The TTVs of planet TOI-836 c may be caused by an undetected exterior planet.Publisher PDFPeer reviewe
TOI-836: A super-Earth and mini-Neptune transiting a nearby K-dwarf
We present the discovery of two exoplanets transiting TOI-836 (TIC 440887364)
using data from TESS Sector 11 and Sector 38. TOI-836 is a bright (
mag), high proper motion ( mas yr), low metallicity
([Fe/H]) K-dwarf with a mass of M and a
radius of R. We obtain photometric follow-up
observations with a variety of facilities, and we use these data-sets to
determine that the inner planet, TOI-836 b, is a R
super-Earth in a 3.82 day orbit, placing it directly within the so-called
'radius valley'. The outer planet, TOI-836 c, is a R
mini-Neptune in an 8.60 day orbit. Radial velocity measurements reveal that
TOI-836 b has a mass of M , while TOI-836 c has a mass
of M. Photometric observations show Transit Timing
Variations (TTVs) on the order of 20 minutes for TOI-836 c, although there are
no detectable TTVs for TOI-836 b. The TTVs of planet TOI-836 c may be caused by
an undetected exterior planet
Transit timings variations in the three-planet system : TOI-270
We present ground- and space-based photometric observations of TOI-270 (L231-32), a system of three transiting planets consisting of one super-Earth and two sub-Neptunes discovered by TESS around a bright (K-mag = 8.25) M3V dwarf. The planets orbit near low-order mean-motion resonances (5:3 and 2:1) and are thus expected to exhibit large transit timing variations (TTVs). Following an extensive observing campaign using eight different observatories between 2018 and 2020, we now report a clear detection of TTVs for planets c and d, with amplitudes of âŒ10 min and a super-period of âŒ3 yr, as well as significantly refined estimates of the radii and mean orbital periods of all three planets. Dynamical modelling of the TTVs alone puts strong constraints on the mass ratio of planets c and d and on their eccentricities. When incorporating recently published constraints from radial velocity observations, we obtain masses of Mb=1.48±0.18Mââ , Mc=6.20±0.31Mââ , and Md=4.20±0.16Mâ for planets b, c, and d, respectively. We also detect small but significant eccentricities for all three planets : eb = 0.0167 ± 0.0084, ec = 0.0044 ± 0.0006, and ed = 0.0066 ± 0.0020. Our findings imply an Earth-like rocky composition for the inner planet, and Earth-like cores with an additional He/H2O atmosphere for the outer two. TOI-270 is now one of the best constrained systems of small transiting planets, and it remains an excellent target for atmospheric characterization
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