Разработка состава и методов стандартизации капсул индапамида

There are established optimum parameters of technological process of reception and structure capsule weights indapamide. Normative parameters of quality of capsules indapamide 2,5 mg are proved. Techniques of acknowledgement of authenticity indapamide, definition of extraneous impurity, an establishment of the quantitative maintenance, definition of quantity of substance in the environment of dissolution and uniformity of batching indapamide in capsules are developed.Установлены оптимальные параметры технологического процесса получения и состав капсульной массы индапамида. Обоснованы нормативные показатели качества капсул индапамида 2,5 мг. Разработаны методики подтверждения подлинности индапамида, определение посторонних примесей, установление количественного содержания, определение количества вещества в среде растворения и однородности дозирования индапамида в капсулах

Разработка состава и технологии таблеток афобазола методом влажного гранулирования

In clause researches on development of tablets new anxiolytic agents - 2[-2(morpholino)-aethil]-thio-5-aethoxibenzimidazoli dihydrochloride-afobazol are presented. The optimum structure of auxiliary substances, for manufacture of tablets afobazolа by a method wet granulation is picked up and proved.В статье представлены исследования по разработке таблеток нового анксиолитического средства - 2[-2-(морфолино)-этил]-тио-5-этоксибензилимидазола дигидрохлорида - афобазола. Подобран и обоснован оптимальный состав вспомогательных веществ для производства таблеток афобазола методом влажного гранулирования

Разработка состава и методик анализа таблеток ладастена, полученных прямым прессованием

Ladasten is original anxiolytic medicine with the psychostimulant action that increases human resistance to unfavorable factors of the environment. As the result of the investigation the optimal composition was found and the methods of analysis were elaborated for the direct compression tablets.Ладастен - оригинальное лекарственное средство, проявляющее анксиолитическую активность, обладающее психостимулирующим действием, повышающим устойчивость организма к действию неблагоприятных факторов среды обитания и деятельности. В результате проведенных исследований разработан оптимальный состава и методики анализа таблеток ладастена, полученных прямым прессованием

Polarized parton distributions from NLO QCD analysis of world DIS and SIDIS data

The combined analysis of polarized DIS and SIDIS data is performed in NLO QCD. The new parametrization on polarized PDFs is constructed. The uncertainties on PDFs and their first moments are estimated applying the modified Hessian method. The especial attention is paid to the impact of novel SIDIS data on the polarized distributions of light sea and strange quarks. In particular, the important question of polarized sea symmetry is studied in comparison with the latest results on this subject

Azimuthal asymmetries of charged hadrons produced by high-energy muons scattered off longitudinally polarised deuterons

Azimuthal asymmetries in semi-inclusive production of positive (h^+) and negative hadrons (h^-) have been measured by scattering 160 GeV muons off longitudinally polarised deuterons at CERN. The asymmetries were decomposed in several terms according to their expected modulation in the azimuthal angle phi of the outgoing hadron. Each term receives contributions from one or several spin and transverse-momentum-dependent parton distribution and fragmentation functions. The amplitudes of all phi-modulation terms of the hadron asymmetries integrated over the kinematic variables are found to be consistent with zero within statistical errors, while the constant terms are nonzero and equal for h^+ and h^- within the statistical errors. The dependencies of the phi-modulated terms versus the Bjorken momentum fraction x, the hadron fractional momentum z, and the hadron transverse momentum p_h^T were studied. The x dependence of the constant terms for both positive and negative hadrons is in agreement with the longitudinal double-spin hadron asymmetries, measured in semi-inclusive deep-inelastic scattering. The x dependence of the sin phi-modulation term is less pronounced than that in the corresponding HERMES data. All other dependencies of the phi-modulation amplitudes are consistent with zero within the statistical errors.Comment: 12 pages, 11 Figures; revision 1 signs in Eq 5 corrected, polishe

Velocity-space sensitivity of the time-of-flight neutron spectrometer at JET

The velocity-space sensitivities of fast-ion diagnostics are often described by so-called weight functions. Recently, we formulated weight functions showing the velocity-space sensitivity of the often dominant beam-target part of neutron energy spectra. These weight functions for neutron emission spectrometry (NES) are independent of the particular NES diagnostic. Here we apply these NES weight functions to the time-of-flight spectrometer TOFOR at JET. By taking the instrumental response function of TOFOR into account, we calculate time-of-flight NES weight functions that enable us to directly determine the velocity-space sensitivity of a given part of a measured time-of-flight spectrum from TOFOR

Relationship of edge localized mode burst times with divertor flux loop signal phase in JET

A phase relationship is identified between sequential edge localized modes (ELMs) occurrence times in a set of H-mode tokamak plasmas to the voltage measured in full flux azimuthal loops in the divertor region. We focus on plasmas in the Joint European Torus where a steady H-mode is sustained over several seconds, during which ELMs are observed in the Be II emission at the divertor. The ELMs analysed arise from intrinsic ELMing, in that there is no deliberate intent to control the ELMing process by external means. We use ELM timings derived from the Be II signal to perform direct time domain analysis of the full flux loop VLD2 and VLD3 signals, which provide a high cadence global measurement proportional to the voltage induced by changes in poloidal magnetic flux. Specifically, we examine how the time interval between pairs of successive ELMs is linked to the time-evolving phase of the full flux loop signals. Each ELM produces a clear early pulse in the full flux loop signals, whose peak time is used to condition our analysis. The arrival time of the following ELM, relative to this pulse, is found to fall into one of two categories: (i) prompt ELMs, which are directly paced by the initial response seen in the flux loop signals; and (ii) all other ELMs, which occur after the initial response of the full flux loop signals has decayed in amplitude. The times at which ELMs in category (ii) occur, relative to the first ELM of the pair, are clustered at times when the instantaneous phase of the full flux loop signal is close to its value at the time of the first ELM