Feminist Pedagogy in a Time of Coronavirus Pandemic

FemTechNet, a network of scholars, artists, and students working on, with, and at the borders of technology, science, and feminism, has a great deal of experience thinking about pedagogy and technology. We have produced real intimacy, vibrant classes, and insurgent pedagogy since 2012. The principles of our signature Distributed Open Collaborative Courses (DOCCs) are crucial (see below). In this time of crisis, we believe we need to think again, drawing the most power possible from the radical knowledges, tactics, and commitments of feminist pedagogies of past experience. We write while schools, colleges, and universities have closed in a cascade of fear and also care in the hope of minimizing coronavirus infections. Mandated social distancing is critical, but difficult emotionally to sustain. At the same time, almost all campus authorities are requiring that classes be moved to an “online environment” to maintain physical distance. Most institutions are offering complicated, highly corporate, and narrow advice about how to teach online. While rapid conversion to standardized and detached Silicon Valley-type approaches is the prominent option, we have learned how quality instruction takes time, connection, careful planning, collaborative approaches, and local know-how

Comparison of Grammar in Neurodevelopmental Disorders: The Case of Binding in Williams Syndrome and Autism With and Without Language Impairment

This study investigates whether distinct neurodevelopmental disorders show distinct patterns of impairments in particular grammatical abilities and the relation of those grammatical patterns to general language delays and intellectual disabilities. We studied two disorders (autism and Williams syndrome [WS]) and two distinct properties (Principle A that governs reflexives and Principle B that, together with its associated pragmatic rule, governs pronouns) of the binding module of grammar. These properties are known to have markedly different courses of acquisition in typical development. We compare the knowledge of binding in children with autism with language impairment (ALI) and those with normal language (ALN) to that of children with WS, matched on age to the ALN group, and on age and nonverbal mental age (MA) to the ALI group, as well as to two groups of typically developing (TD) controls, matched on nonverbal MA to ALI and ALN groups. Our results reveal a remarkably different pattern of comprehension of personal pronouns and reflexives in ALI as opposed to ALN, WS, and two groups of TD controls. All five groups demonstrated an equal delay in their comprehension of personal pronouns, in line with widely reported delays in TD literature, argued to be due to delayed pragmatic abilities. However, and most strikingly, the ALI group also showed a pronounced difficulty in comprehension of reflexive pronouns, and particularly of the knowledge that the antecedent of a reflexive must c-command it. The revealed pattern confirms the existence of a particular impairment concerning Principle A in this module of grammar, unrelated to general language delays or cognitive deficits generally present in a large portion of individuals with autism as well as WS, or to general pragmatic deficits, known to be particularly prevalent in the population with autism

Total Synthesis of Clavatadine A

The first total synthesis of the potent and selective human blood coagulation factor XIa inhibitor clavatadine A (1) is described. Direct, early-stage guanidinylation enabled rapid, convergent access to an immediate clavatadine A precursor. Concomitant lactone hydrolysis and guanidine deprotection with aqueous acid cleanly provided clavatadine A (1) in only four steps (longest linear sequence, 41–43% overall yield)

Comparing the Toxicological Responses of Pulmonary Air–Liquid Interface Models upon Exposure to Differentially Treated Carbon Fibers

In recent years, the use of carbon fibers (CFs) in various sectors of industry has been increasing. Despite the similarity of CF degradation products to other toxicologically relevant materials such as asbestos fibers and carbon nanotubes, a detailed toxicological evaluation of this class of material has yet to be performed. In this work, we exposed advanced air–liquid interface cell culture models of the human lung to CF. To simulate different stresses applied to CF throughout their life cycle, they were either mechanically (mCF) or thermo-mechanically pre-treated (tmCF). Different aspects of inhalation toxicity as well as their possible time-dependency were monitored. mCFs were found to induce a moderate inflammatory response, whereas tmCF elicited stronger inflammatory as well as apoptotic effects. Furthermore, thermal treatment changed the surface properties of the CF resulting in a presumed adhesion of the cells to the fiber fragments and subsequent cell loss. Triple-cultures encompassing epithelial, macrophage, and fibroblast cells stood out with an exceptionally high inflammatory response. Only a weak genotoxic effect was detected in the form of DNA strand breaks in mono- and co-cultures, with triple-cultures presenting a possible secondary genotoxicity. This work establishes CF fragments as a potentially harmful material and emphasizes the necessity of further toxicological assessment of existing and upcoming advanced CF-containing materials

Intact Grammar in HFA? Evidence from Control and Binding

This study contributes original results to the topical issue of the degree to which grammar is intact in high-functioning children with autism (HFA). We examine the comprehension of binding and obligatory control in 26 HFA children, mean age=12;02, compared with two groups of younger typically developing (TD) children: one matched on non-verbal mental age (MA), mean age=9;09, and the other on verbal MA, mean age=8;09. On the binding task, our HFA group showed a good performance on reflexives on a par with TD matched children, in line with recent reports of intact knowledge of reflexive binding in higher but not lower-functioning children with autism. Their comprehension of personal pronouns was somewhat poorer, with no difference observed between the groups, again supporting the existing literature. Results on the control task, which probed mastery of syntactic relations never previously examined in autism, revealed that both HFA children and the two matched TD groups were at ceiling on single-complement subject control (try) and object control (persuade). However, a considerably poorer attainment on double-complement subject control (promise) was present equally in the HFA group and the verbal MA-matched TD group but not in the non-verbal MA-matched group. Performance on promise correlated with age only in the verbal MA-matched group, whilst in HFA it correlated with general cognitive and language abilities. These novel findings demonstrate that regular obligatory control and reflexive binding are preserved in HFA. We contrast these results with previous literature that has demonstrated deficiencies with passives and raising in HFA populations. The emerging bifurcation suggests different analyses for the principles underlying these constructions: whereas the latter incorporate movement, control and binding do not. The poor performance on promise supports all previous literature on this lexically and syntactically idiosyncratic construction. Its breaking of locality, which in turn results in a conflict between lexical and syntactic requirements, is exceptional and introduces an extra step of learning. This step appears to be related to maturation in TD children, and to stronger language and cognitive skills in HFA children

Macular thickness measurements in healthy Norwegian volunteers: an optical coherence tomography study

<p>Abstract</p> <p>Background</p> <p>Ethnic, intersubject, interoperator and intermachine differences in measured macular thickness seem to exist. Our purpose was to collect normative macular thickness data in Norwegians and to evaluate the association between macular thickness and age, gender, parity, and contraception status.</p> <p>Methods</p> <p>Retinal thickness was measured by Stratus Optical Coherence Tomography in healthy subjects. Mean macular thickness (MMT) was analyzed by repeated measures ANOVA with three dependent regional MMT-variables for interaction with age, gender, parity and oral contraception use. Exploratory correlation with age by the Pearson correlation test, both before and after stratification by gender was performed. Differences in MMT between older and younger subjects, between oral contraception users and non-users, as well as parous and nulliparous women were studied by post-hoc Student's t-tests.</p> <p>Results</p> <p>Central MMT in Norwegians was similar to values earlier reported in whites. MMT in central areas of 1 and 2.25 mm in diameter were higher in males than in females. In younger subjects (≤43 years) differences in MMT between genders were larger than in the mixed age group, whereas in older subjects (>43 years) the small differences did not reach the set significance level. No differences were found in minimal foveolar thickness (MMFT) between the genders in any age group.</p> <p>Mean foveal thickness (1 mm in diameter) was positively associated with age in females (r = 0.28, p = 0.03). MMFT was positively associated with age in all groups and reached significance both in females and in mixed gender group (r = 0.20, p = 0.041 and r = 0.26, p = 0.044 respectively).</p> <p>Mean foveal thickness and MMFT were significantly higher in parous than in nulliparous women, and age-adjusted ANOVA for MMFT revealed a borderline effect of parity.</p> <p>Conclusions</p> <p>Age and gender should be taken into consideration when establishing normal ranges for MMT in younger subjects. The gender difference in retinal thickness in young, but not older adults suggests a gonadal hormonal influence. The possible association between parity and retinal structure and its clinical relevance, should be studied further.</p

Genomewide association study for onset age in Parkinson disease

<p>Abstract</p> <p>Background</p> <p>Age at onset in Parkinson disease (PD) is a highly heritable quantitative trait for which a significant genetic influence is supported by multiple segregation analyses. Because genes associated with onset age may represent invaluable therapeutic targets to delay the disease, we sought to identify such genetic modifiers using a genomewide association study in familial PD. There have been previous genomewide association studies (GWAS) to identify genes influencing PD susceptibility, but this is the first to identify genes contributing to the variation in onset age.</p> <p>Methods</p> <p>Initial analyses were performed using genotypes generated with the Illumina HumanCNV370Duo array in a sample of 857 unrelated, familial PD cases. Subsequently, a meta-analysis of imputed SNPs was performed combining the familial PD data with that from a previous GWAS of 440 idiopathic PD cases. The SNPs from the meta-analysis with the lowest p-values and consistency in the direction of effect for onset age were then genotyped in a replication sample of 747 idiopathic PD cases from the Parkinson Institute Biobank of Milan, Italy.</p> <p>Results</p> <p>Meta-analysis across the three studies detected consistent association (p < 1 × 10^-5) with five SNPs, none of which reached genomewide significance. On chromosome 11, the SNP with the lowest p-value (rs10767971; p = 5.4 × 10^-7) lies between the genes <it>QSER1 </it>and <it>PRRG4</it>. Near the PARK3 linkage region on chromosome 2p13, association was observed with a SNP (rs7577851; p = 8.7 × 10^-6) which lies in an intron of the <it>AAK1 </it>gene. This gene is closely related to <it>GAK</it>, identified as a possible PD susceptibility gene in the GWAS of the familial PD cases.</p> <p>Conclusion</p> <p>Taken together, these results suggest an influence of genes involved in endocytosis and lysosomal sorting in PD pathogenesis.</p

Studies Toward the Total Synthesis of Clavatadine A

Clavatadine A, recently isolated from the marine sponge Suberea clavata, is a specific and potent inhibitor of factor XIa. Factor XIa is a component of the coagulation cascade required for the formation of blood clots and is a potential target for treatment of cardiovascular disease. Our efforts to complete the first total synthesis of clavatadine A feature the carbamoylation of a phenol, prepared by dibromination of homogentisic acid lactone, and an azidoisocyanate, derived from ethyl 5-bromovalerate. From our advanced carbamate intermediate, we envision completing the synthesis of clavatadine A by guanylation and lactone hydrolysis