On Instagram: an intimate, immediate conversation

What are the formal and political commitments of artistic and scholarly experimentation on Instagram? With the rise of affective criticism, a practice of conversation has proved to be the perfect format for us to talk affectively about such a polarizing and popular subject. With this conversation, we want to capture that same intimacy and immediacy, but challenge the idea that such conversations must always disappear or must dissolve into solo work; to contend that the meaning we create together in ephemeral ways might have its own intellectual staying power. This conversation took place at the University of York in the spring of 2019 and the transcript has been edited for length. Thank you to the Centre for Modern Studies and the Creative Dissonance: Writing Now research strand for funding this event

An Unexpected Diversity of Photoreceptor Classes in the Longfin Squid, Doryteuthis pealeii.

Cephalopods are famous for their ability to change color and pattern rapidly for signaling and camouflage. They have keen eyes and remarkable vision, made possible by photoreceptors in their retinas. External to the eyes, photoreceptors also exist in parolfactory vesicles and some light organs, where they function using a rhodopsin protein that is identical to that expressed in the retina. Furthermore, dermal chromatophore organs contain rhodopsin and other components of phototransduction (including retinochrome, a photoisomerase first found in the retina), suggesting that they are photoreceptive. In this study, we used a modified whole-mount immunohistochemical technique to explore rhodopsin and retinochrome expression in a number of tissues and organs in the longfin squid, Doryteuthis pealeii. We found that fin central muscles, hair cells (epithelial primary sensory neurons), arm axial ganglia, and sucker peduncle nerves all express rhodopsin and retinochrome proteins. Our findings indicate that these animals possess an unexpected diversity of extraocular photoreceptors and suggest that extraocular photoreception using visual opsins and visual phototransduction machinery is far more widespread throughout cephalopod tissues than previously recognized.This research was supported by the Office of Naval Research Basic Research Challenge grant number N00014-10-0989 to T.W.C and R.T.H and a Biotechnology and Biological Sciences Research Council (BBSRC) David Phillips Fellowship BB/L024667/1 to T.J.W. We gratefully acknowledge support from the Air Force Office of Scientific Research via grants numbered FA9550-09-0346 to R.T.H. and FA9550-12-1-0321 to T.W.C.This is the final version of the article. It first appeared from PLoS via http://dx.doi.org/10.1371/journal.pone.013538

Visual phototransduction components in cephalopod chromatophores suggest dermal photoreception

Author Posting. © The Author(s), 2015. This is the author's version of the work. It is posted here by permission of The Company of Biologists for personal use, not for redistribution. The definitive version was published in Journal of Experimental Biology 218 (2015): 1596-1602, doi: 10.1242/​jeb.117945.Cephalopod molluscs are renowned for their colorful and dynamic body patterns, produced by an assemblage of skin components that interact with light. These may include iridophores, leucophores, chromatophores, and (in some species) photophores. Here, we present molecular evidence suggesting that cephalopod chromatophores, small dermal pigmentary organs that reflect various colors of light, are photosensitive. RT-PCR revealed the presence of transcripts encoding rhodopsin and retinochrome within the retinas and skin of the squid Doryteuthis pealeii, and the cuttlefish Sepia officinalis and Sepia latimanus. In D. pealeii, Gqα and squid TRP channel transcripts were present in the retina and in all dermal samples. Rhodopsin, retinochrome, and Gqα transcripts were also found in RNA extracts from dissociated chromatophores isolated from D. pealeii dermal tissues. In D. pealeii, immunohistochemical staining labeled rhodopsin, retinochrome, and Gqα proteins in several chromatophore components, including pigment cell membranes, radial muscle fibers, and sheath cells. This is the first evidence that cephalopod dermal tissues, and specifically chromatophores, may possess the requisite combination of molecules required to respond to light.This research was supported by the Office of Naval Research Basic Research Challenge [grant number N00014-10-0989] via a subcontract to T.W.C. and R.T.H.2016-05-1

Knowing Outside of English : Decolonizing at York

In early 2020, Eugenia Zuroski published a short article in MAI journal's toolkit series critiquing conventional introductory exercises in the university classroom. Called ‘Where Do You Know From?’, the task ‘illustrate[s] the importance of attending conscientiously to the ways we relate to one another in the classroom as part of our pedagogical and political responsibilities’. In this piece, Alexandra Kingston-Reese and Shazia Jagot discuss where they know from and how this knowledge has impacted their teaching, research, and development of the University of York's Decolonising Network

On Instagram: an intimate, immediate conversation

What are the formal and political commitments of artistic and scholarly experimentation on Instagram? With the rise of affective criticism, a practice of conversation has proved to be the perfect format for us to talk affectively about such a polarizing and popular subject. With this conversation, we want to capture that same intimacy and immediacy, but challenge the idea that such conversations must always disappear or must dissolve into solo work; to contend that the meaning we create together in ephemeral ways might have its own intellectual staying power. This conversation took place at the University of York in the spring of 2019 and the transcript has been edited for length. Thank you to the Centre for Modern Studies and the Creative Dissonance: Writing Now research strand for funding this event

Reducing emergency hospital admissions: A population health complex intervention of an enhanced model of primary care and compassionate communities

YesBackground: Reducing emergency admissions to hospital has been a cornerstone of health care policy. There is little evidence of systematic interventions which achieved this aim across a population. We report the impact on unplanned admissions to hospital through a complex intervention over a 44 month period in Frome, Somerset. Aim: A population health complex intervention of an enhanced model of primary care and compassionate communities to improve population health and reduce emergency admissions to hospital Design: A cohort retrospective study of a complex intervention on all emergency admissions in Frome compared to Somerset from April 2013 to December 2017. Setting: Frome Medical Practice, Somerset Methods: Patients were identified using broad criteria including anyone with cause for concern. Patient centred goal setting and care planning combined with a compassionate community social approach was implemented broadly across the population of Frome. Results: There was a progressive reduction, by 7.9 cases per quarter (95% CI: 2.8, 13.1; p=0.006) in unplanned hospital admissions across the whole population of Frome, over the study period from April 2014 to December 2017. At the same time, there was sharp increase in the number of admissions per quarter, within the Somerset, with an increase in the number of unplanned admissions of 236 per quarter (95% CI: 152, 320; p<0.001). Conclusion: The complex intervention in Frome was associated with highly significant reductions in unplanned admissions to hospital with reduction of healthcare costs across the whole population of From

Evaluation of expressive writing for postpartum health: A randomized controlled trial

Pregnancy, birth and adjusting to a new baby is a potentially stressful time that can negatively affect the health of women. There is some evidence that expressive writing can have positive effects on psychological and physical health, particularly during stressful periods. The current study aimed to evaluate whether expressive writing would improve women’s postpartum health. A randomized controlled trial was conducted with three conditions: expressive writing (n=188), a control writing task (n=213), or normal care (n=163). Measures of psychological health, physical health and quality of life were measured at baseline (6-12 weeks postpartum), 1 month and 6 months later. Ratings of stress were taken before and after the expressive writing task. Intent-to-treat analyses showed no significant differences between women in the expressive writing, control writing and normal care groups on measures of physical health, anxiety, depression, mood or quality of life at 1 and 6 months. Uptake and adherence to the writing tasks was low. However, women in the expressive writing group rated their stress as significantly reduced after completing the task. Cost analysis suggest women who did expressive writing had the lowest costs in terms of healthcare service use and lowest cost per unit of improvement in quality of life. Results suggest expressive writing is not effective as a universal intervention for all women 6-12 weeks postpartum. Future research should examine expressive writing as a targeted intervention for women in high-risk groups, such as those with mild or moderate depression, and further examine cost-effectiveness

Learning biophysically-motivated parameters for alpha helix prediction

<p>Abstract</p> <p>Background</p> <p>Our goal is to develop a state-of-the-art protein secondary structure predictor, with an intuitive and biophysically-motivated energy model. We treat structure prediction as an optimization problem, using parameterizable cost functions representing biological "pseudo-energies". Machine learning methods are applied to estimate the values of the parameters to correctly predict known protein structures.</p> <p>Results</p> <p>Focusing on the prediction of alpha helices in proteins, we show that a model with 302 parameters can achieve a Q_{<it>α </it>}value of 77.6% and an SOV_{<it>α </it>}value of 73.4%. Such performance numbers are among the best for techniques that do not rely on external databases (such as multiple sequence alignments). Further, it is easier to extract biological significance from a model with so few parameters.</p> <p>Conclusion</p> <p>The method presented shows promise for the prediction of protein secondary structure. Biophysically-motivated elementary free-energies can be learned using SVM techniques to construct an energy cost function whose predictive performance rivals state-of-the-art. This method is general and can be extended beyond the all-alpha case described here.</p