The partisan ties of lobbying firms

This article examines lobbying firms as intermediaries between organized interests and legislators in the United States. It states a partisan theory of legislative subsidy in which lobbying firms are institutions with relatively stable partisan identities. Firms generate greater revenues when their clients believe that firms’ partisan ties are valued highly by members of Congress. It hypothesizes that firms that have partisan ties to the majority party receive greater revenues than do firms that do not have such ties, as well as that partisan ties with the House majority party lead to greater financial returns than do partisan ties to the Senate majority party. These hypotheses are tested using data available under the Lobbying Disclosure Act from 2008 to 2016. Panel regression analysis indicates that firms receive financial benefits when they have partisan ties with the majority party in the House but not necessarily with the Senate majority party, while controlling for firm-level covariates (number of clients, diversity, and organizational characteristics). A difference-in-differences analysis establishes that Democratically aligned lobbying firms experienced financial losses when the Republican Party reclaimed the House in 2011, but there were no significant differences between Republican and Democratic firms when the Republicans reclaimed the Senate in 2015

Interferon-β alleviates delayed tPA-induced adverse effects via modulation of MMP3/9 production in ischemic stroke

Tissue plasminogen activator (tPA) is the only US Food and Drug Administration (FDA)–approved drug for ischemic stroke. However, delayed tPA administration is associated with increased risk of blood-brain barrier (BBB) disruption and hemorrhagic transformation (HT). Interferon-β (IFNβ), an FDA-approved drug for the treatment of multiple sclerosis, is a cytokine with immunomodulatory properties. Previous studies, including ours, demonstrated that IFNβ or type I IFN receptor signaling conferred protection against ischemic stroke in preclinical models, suggesting IFNβ might have translational therapeutic potential for the treatment of ischemic stroke. Currently, whether IFNβ could be coadministered with tPA to alleviate delayed tPA-induced adverse effects remains unknown. To elucidate that, IFNβ was coadministered with delayed tPA to ischemic stroke animals, and the severity and pathology of ischemic brain injury were assessed. We found delayed tPA treatment exacerbated ischemic brain injury, manifested by aggravated BBB disruption and HT. Notably, IFNβ ameliorated delayed tPA–exacerbated brain injury and alleviated adverse effects. Mechanistic studies revealed IFNβ suppressed tPA-enhanced neuroinflammation and MMP3/9 production in the ischemic brain. Furthermore, we identified IFNβ suppressed MMP9 production in microglia and attenuated tight junction protein degradation in brain endothelial cells. Moreover, we observed that peripheral immune cells may participate to a lesser extent in delayed tPA–exacerbated brain injury during the early phase of ischemic stroke. In conclusion, we provide the first evidence that IFNβ can be coadministered with tPA to mitigate delayed tPA–induced adverse effects of BBB disruption and HT that could potentially extend the tPA therapeutic window for the treatment of ischemic stroke

Large-N Bill Positions Data from MapLight.org: What Can We Learn from Interest Groups’ Publicly Observable Legislative Positions?

The transparency organization MapLight records instances of organizations taking positions for and against legislation in Congress. The dataset comprises some 130,000 such positions taken on thousands of bills between the 109th and 115th Congresses (2005–2018). The depth and breadth of these data potentially give them wide applicability for answering questions about interest group behavior and influence as well as legislative politics more broadly. However, the coverage and content of the data are affected by aspects of MapLight’s research process. This article introduces the MapLight dataset and its potential uses, examines issues related to sampling and other aspects of MapLight’s research process, and explains how scholars can address these to make appropriate use of the data

The Science of Anterior Teeth Selection for a Completely Edentulous Patient: A Literature Review

Esthetic replacement and physiological tooth arrangement made the complete denture biologically compatible and desirable. Proper placement of tooth should be functional and esthetically pleasing to enhance the psychology of the patient. This article reviews the evolution of concepts for teeth selection and the recent techniques employed for selecting anterior teeth for complete dentures

Strategies among phytoplankton in response to alleviation of nutrient stress in a subtropical gyre

Despite generally low primary productivity and diatom abundances in oligotrophic subtropical gyres, the North Atlantic Subtropical Gyre (NASG) exhibits significant diatom-driven carbon export on an annual basis. Subsurface pulses of nutrients likely fuel brief episodes of diatom growth, but the exact mechanisms utilized by diatoms in response to these nutrient injections remain understudied within near-natural settings. Here we simulated delivery of subsurface nutrients and compare the response among eukaryotic phytoplankton using a combination of physiological techniques and metatranscriptomics. We show that eukaryotic phytoplankton groups exhibit differing levels of transcriptional responsiveness and expression of orthologous genes in response to release from nutrient limitation. In particular, strategies for use of newly delivered nutrients are distinct among phytoplankton groups. Diatoms channel new nitrate to growth-related strategies while physiological measurements and gene expression patterns of other groups suggest alternative strategies. The gene expression patterns displayed here provide insights into the cellular mechanisms that underlie diatom subsistence during chronic nitrogen-depleted conditions and growth upon nutrient delivery that can enhance carbon export from the surface ocean

Influence of diatom diversity on the ocean biological carbon pump

Diatoms sustain the marine food web and contribute to the export of carbon from the surface ocean to depth. They account for about 40% of marine primary productivity and particulate carbon exported to depth as part of the biological pump. Diatoms have long been known to be abundant in turbulent, nutrient-rich waters, but observations and simulations indicate that they are dominant also in meso- and submesoscale structures such as fronts and filaments, and in the deep chlorophyll maximum. Diatoms vary widely in size, morphology and elemental composition, all of which control the quality, quantity and sinking speed of biogenic matter to depth. In particular, their silica shells provide ballast to marine snow and faecal pellets, and can help transport carbon to both the mesopelagic layer and deep ocean. Herein we show that the extent to which diatoms contribute to the export of carbon varies by diatom type, with carbon transfer modulated by the Si/C ratio of diatom cells, the thickness of the shells and their life strategies; for instance, the tendency to form aggregates or resting spores. Model simulations project a decline in the contribution of diatoms to primary production everywhere outside of the Southern Ocean. We argue that we need to understand changes in diatom diversity, life cycle and plankton interactions in a warmer and more acidic ocean in much more detail to fully assess any changes in their contribution to the biological pump