Conhecimento sobre COVID 19 em pacientes com CMF nº 12 e ações preventivas do trio de pesquisa

Introducción: los grandes asesinos de la historia son las bacterias y los virus, a mediados de diciembre la humanidad comenzó a ser azotada por un nuevo virus SARS-CoV-2, originando una enfermedad llamada COVID 19.Objetivo: evaluar el nivel de conocimientos y el cumplimiento de las medidas preventivas sobre la COVID-19 en los pacientes antes y después de tener la presencia en el área de salud de un caso positivo a la Covid-19.Método: se realizó un estudio descriptivo con fase de intervención a los pacientes de tres Manzanas del consultorio # 12 del policlínico Ángel Ortiz Vázquez del municipio Manzanillo, de la provincia Granma.Resultados: los resultados obtenidos fueron de 583 pacientes un 55,5 por ciento presentan factores de riesgo, antes de la intervención un 34,8% desconocen vías de trasmisión, además un 44.0 % usan el nasobuco de forma inadecuado, lo cual aumento después de la pesquisa fortalecida aumento a un 97.7%, al igual que el nivel de conocimientos que aumento a un 91.0% y satisfacción de la comunidad con las acciones educativas a un 100%.Conclusiones:   se observó después de las acciones educativas un aumento en el conocimiento de la enfermedad empoderando a la población de conocimientos y prácticas necesarias, los pacientes cumplieron adecuadamente las medidas preventivas y la satisfacción de la comunidad con el trabajo de los tríos participantes fue favorable.   Introduction: the greatest killers in history are bacteria and viruses, in mid-December humanity began to be hit by a new SARS-CoV-2 virus, causing a disease called COVID 19. Objective: to assess the level of knowledge and compliance with preventive measures on COVID-19 in patients before and after having the presence in the health area of a positive case for Covid-19.Method: a descriptive study with intervention phase was carried out on the patients of three apples from office # 12 of the Ángel Ortiz Vázquez polyclinic in the Manzanillo municipality, Granma province.Results: the results obtained were from 583 patients, 55.5 percent presented risk factors, before the intervention 34.8% were unaware of transmission routes, and 44.0% used the nasobuco improperly, which increased after the strengthened research increased to 97.7%, as did the level of knowledge that increased to 91.0% and satisfaction of the community with the educational actions to 100%.Conclusions: after the educational actions, an increase in the knowledge of the disease was observed, empowering the population with the necessary knowledge and practices, the patients adequately complied with the preventive measures and the satisfaction of the community with the work of the participating trios was favorable.Introdução: os maiores assassinos da história são bactérias e vírus. Em meados de dezembro, a humanidade começou a ser atingida por um novo vírus SARS-CoV-2, causando uma doença chamada COVID 19.Objetivo: avaliar o nível de conhecimento e a adesão às medidas preventivas do COVID-19 em pacientes antes e depois da presença na área da saúde de um caso positivo para o Covid-19. Método: foi realizado um estudo descritivo com uma fase de intervenção em pacientes de três maçãs do consultório nº 12 da policlínica Ángel Ortiz Vázquez no município de Manzanillo, província de Granma.Resultados: os resultados obtidos foram de 583 pacientes, 55,5 por cento apresentavam fatores de risco, antes da intervenção 34,8% desconheciam as vias de transmissão e 44,0% usavam indevidamente o nasobuco, que aumentava após a pesquisa reforçada aumentou para 97,7%, assim como o nível de conhecimento que aumentou para 91,0% e a satisfação da comunidade com as ações educativas para 100%.Conclusões: após as ações educativas, observou-se um aumento no conhecimento da doença, capacitando a população com os conhecimentos e práticas necessários, os pacientes cumpriram adequadamente as medidas preventivas e a satisfação da comunidade com o trabalho dos trios participantes foi favorável

A promising novel formulation for articular cartilage regeneration: Preclinical evaluation of a treatment that produces SOX9 overexpression in human synovial fluid cells

Osteoarthritis (OA) is a chronic disorder of synovial joints, in which there is progressive softening and disintegration of the articular cartilage. OA is the most common form of arthritis, and is the primary cause of disability and impaired quality of life in the elderly. Despite considerable medical necessity, no treatment has yet been proven to act as a disease‑modifying agent that may halt or reverse the structural progression of OA. The replacement of the joint with a prosthesis appears to be the best option in the advanced stages of the disease. A formulation (BIOF2) for cartilage regeneration has been recently developed. The present study evaluated the effects of BIOF2 on gene expression in human cell cultures, followed by efficacy trials in three OA animal models. Human synovial fluid cells that were exposed to the formulation exhibited increased transcription factor SOX‑9 (SOX9; chondrogenic factor) expression, and decreased mimecan (mineralization inducer) and macrophage‑stimulating protein receptor (osteoclastogenic factor) expression. The intra‑articular application of BIOF2 in the animal models significantly increased cartilage thickness from 12 to 31% at 28 days, compared with articular cartilage treated with saline solution. The articular area and number of chondrocytes additionally increased significantly, maintaining an unaltered chondrocyte/mm2 proportion. Evaluation of the histological architecture additionally displayed a decrease in the grade of articular damage in the groups treated with BIOF2. In conclusion, BIOF2 has proven to be effective for treating OA in animal models, most likely due to SOX9 overexpression in articular cells

Megaproyectos urbanos y productivos. Impactos socio-territoriales

El desarrollo de megaproyectos productivos trae consigo oportunidades para el crecimiento económico, la generación de empleos y el desarrollo regional. No obstante, en la actualidad, los grandes temas como la expansión urbana, el desarrollo industrial, las cementeras, la minería, el uso intensivo del agua y demás recursos naturales, preocupan a las comunidades por los impactos generados y porque en lo general, no consideran la racionalidad y responsabilidad ambiental y social hacia el entorno. En este contexto son diversos los estudios científicos que, en el marco de la política de económica imperante, intentan posicionarse como alternativas a proyectos económicos que confrontan los intereses particulares y comunitarios y que afectan la salud humana y ambiental. Megaproyectos urbanos y productivos. Impactos socio-territoriales, reúne veinticinco textos académicos sobre las afectaciones que éstos emprendimientos tienen para la sociedad y el entorno. Los temas expuestos recogen experiencias en el desarrollo urbano, industrial, turístico, portuario y aeroportuario, entre otros. Así mismo se retoman temas como la ética, la dialéctica, la política y la economía y su relación en el emprendimiento de megaproyectos. La búsqueda de esquemas productivos racionales y responsables con el entorno, que reivindiquen el derecho de las comunidades a un medio ambiente sano, a la preservación del territorio y sus recursos y de las formas de vida tradicionales, son los referentes para la realización del presente libro. Como elemento central se concibe el territorio como contenedor de identidad y vida, siendo preocupación y tema de estudio de la comunidad académica, las organizaciones de la sociedad civil y las redes de activistas organizados.UAEM, CONACyT, se

Gestión del conocimiento. Perspectiva multidisciplinaria. Volumen 9

El libro “Gestión del Conocimiento. Perspectiva Multidisciplinaria”, volumen 9, de la Colección Unión Global, es resultado de investigaciones. Los capítulos del libro, son resultados de investigaciones desarrolladas por sus autores. El libro es una publicación internacional, seriada, continua, arbitrada de acceso abierto a todas las áreas del conocimiento, que cuenta con el esfuerzo de investigadores de varios países del mundo, orientada a contribuir con procesos de gestión del conocimiento científico, tecnológico y humanístico que consoliden la transformación del conocimiento en diferentes escenarios, tanto organizacionales como universitarios, para el desarrollo de habilidades cognitivas del quehacer diario. La gestión del conocimiento es un camino para consolidar una plataforma en las empresas públicas o privadas, entidades educativas, organizaciones no gubernamentales, ya sea generando políticas para todas las jerarquías o un modelo de gestión para la administración, donde es fundamental articular el conocimiento, los trabajadores, directivos, el espacio de trabajo, hacia la creación de ambientes propicios para el desarrollo integral de las instituciones

SOBREEXPRESION DE HER-2/NEU EN CARCINOMAS DUCTALES DE LA GLANDULA MAMARIA

Facultad de Medicin

Suitability, Clinical Utility and Acceptability of an Online Transdiagnostic Intervention for Emotional Disorders and Stress-related Disorders in Mexican Sample: A Randomized Clinical Trial

The general objective of this study is to determine the indicators of suitability, clinical utility and satisfaction of the transdiagnostic online intervention for the treatment of emotional disorders and those derived from stress and trauma in a Mexican community sample. The specific aims are: • To Carry out a screening evaluation from the transdiagnostic model by evaluating clinical indicators (depression, anxiety, acute / post-traumatic stress, emotional regulation strategies, intolerance to uncertainty) and that allow determining the frequency, intensity and severity of cases identified by type of emotional problem. • Measure the fidelity of the use of the intervention manual in each treatment condition. • Evaluate the degree of satisfaction, acceptance, complexity and modality of the transdiagnostic intervention. • To know the degree of suitability of the transdiagnostic intervention from the point of view of therapists and supervisors in relation to the problems of the studied sample and the recommendations for its improvement. • To compare the clinical utility of the transdiagnostic intervention via the internet for the treatment of emotional disorders and those derived from stress and trauma against the efficacy of the CBT intervention and the waiting list group

Chronic exercise increases plasma brain-derived neurotrophic factor levels, pancreatic islet size, and insulin tolerance in a TrkB-dependent manner.

BACKGROUND: Physical exercise improves glucose metabolism and insulin sensitivity. Brain-derived neurotrophic factor (BDNF) enhances insulin activity in diabetic rodents. Because physical exercise modifies BDNF production, this study aimed to investigate the effects of chronic exercise on plasma BDNF levels and the possible effects on insulin tolerance modification in healthy rats. METHODS: Wistar rats were divided into five groups: control (sedentary, C); moderate- intensity training (MIT); MIT plus K252A TrkB blocker (MITK); high-intensity training (HIT); and HIT plus K252a (HITK). Training comprised 8 weeks of treadmill running. Plasma BDNF levels (ELISA assay), glucose tolerance, insulin tolerance, and immunohistochemistry for insulin and the pancreatic islet area were evaluated in all groups. In addition, Bdnf mRNA expression in the skeletal muscle was measured. PRINCIPAL FINDINGS: Chronic treadmill exercise significantly increased plasma BDNF levels and insulin tolerance, and both effects were attenuated by TrkB blocking. In the MIT and HIT groups, a significant TrkB-dependent pancreatic islet enlargement was observed. MIT rats exhibited increased liver glycogen levels following insulin administration in a TrkB-independent manner. CONCLUSIONS/SIGNIFICANCE: Chronic physical exercise exerted remarkable effects on insulin regulation by inducing significant increases in the pancreatic islet size and insulin sensitivity in a TrkB-dependent manner. A threshold for the induction of BNDF in response to physical exercise exists in certain muscle groups. To the best of our knowledge, these are the first results to reveal a role for TrkB in the chronic exercise-mediated insulin regulation in healthy rats

Capsaicin Causes Vasorelaxation of Rat Aorta through Blocking of L-type Ca2+ Channels and Activation of CB1 Receptors

The aim of this work was to determine whether Capsaicin may exert a vascular regulation through the activation of CB1 and/or CB2 receptors causing vasorelaxation in the rat aorta. Our results show the location of TRPV1 mainly in the endothelial and smooth muscle cells membrane. Nevertheless, Capsaicin caused vasorelaxation of this artery through a mechanism independent of TRPV1, since the specific antagonists Capsazepine and SB-366791 did not block the effect of Capsaicin. Because the significant expression of CB1 and CB2 receptors has been previously reported in the rat aorta, we used antagonists for these two receptors prior to the addition of Capsaicin. In these experiments, we found that the inhibition of CB1 using AM281, decreases the vasorelaxant effect caused by Capsaicin. On the other hand, the vasorelaxant effect is not altered in the presence of the CB2 receptor antagonist AM630. Furthermore, a partial decrease of the effect of Capsaicin was also seen when L-type calcium channels are blocked. A complete block of Capsaicin-induced vasorelaxation was achieved using a combination of Verapamil and AM281. In accordance to our results, Capsaicin-induced vasorelaxation of the rat aorta is neither dependent of TRPV1 or CB2 receptors, but rather it is strongly suggested that a tandem mechanism between inactivation of L-type calcium channels and the direct activation of CB1 receptors is involved. These findings are supported by CB1 docking simulation which predicted a binding site on CB1 receptors for Capsaicin

Fototeca de la Coordinación Nacional de Monumentos Históricos. Num. 18 Año 6 (2003) mayo-agosto. Alquimia. Sistema Nacional de Fototecas

- Conocer un acervo - La emotividad del documento, por Georgina Rodríguez Hernández - Variaciones sobre el Edén, por Hugo Arciniega - La ciudad en el paisaje y el monumento en la fotografía: apuntes sobre una compleja relación, por Irving Domínguez - Fotografía y habitación vernácula, por Deborah Dorotinsky Alperstein - La génesis de un proyecto de conservación de monumentos, por Martha R. Miranda Santos - Luis Lladó: el desacato al neoclásico, por Georgina Rodríguez Hernández - La catalogación en la FCNMH, por Georgina Rodríguez Hernández - En la región de las nubes, por Alejandrina Escudero - La linterna mágica en México, por Adriana Konzevik - Barranca de Metztitlán. Reserva de la biosfera, por Ernesto Peñaloza Méndez