CONTROVERSIAL INNOCENT PASSAGES IN THE BLACK SEA, 1982 - 2021

How and why has Russia disputed innocent passages by Western warships in the Black Sea since the implementation of the United Nations Convention on the Law of the Sea (UNCLOS III) in 1982, and how has the West justified conducting these passages? This thesis focuses on the historical, geopolitical, and legal context surrounding four instances of innocent passage conducted by USS Yorktown and USS Caron (1986 and 1988), HMS Dragon (2020), and HMS Defender (2021) within 12 nautical miles of Crimea, in order to explain the broader implications that these innocent passages have for operations in the disputed waters of the Black Sea and the South China Sea. Whereas the 1986 innocent passage was met with Soviet naval interference and diplomatic protests, the 1988 innocent passage escalated to an infamous shouldering or “bumping incident.” A similar pattern of escalation took place after Russia’s 2014 annexation of Crimea. In my thesis, I provide a historical context for the innocent passages, and I explore U.S. and UK reasoning for conducting the innocent passages as well as Russia’s objections to the passages. Finally, I assess what the disputes suggest for similar maritime disputes with China in the South China Sea and propose a template for Navy-Wide Freedom of Navigation Operations (FONOP) guidance.Outstanding ThesisLieutenant, United States NavyApproved for public release. Distribution is unlimited

Round-Table Group Therapy with Psychotic Patients

Although the use of group procedures for dealing with emotionally disturbed individuals goes back centuries, it is only within comparatively recent years that it has been used extensively and intensively in our mental hospitals with an awareness of group mechanisms and the forces that make up for restoring the desirable state of psychic equilibrium. As applied today group psychotherapy is initially a concession to the fact that there are too few therapists for the many patients in our mental hospitals and that, in order to reach as many patients as possible, group techniques must be applied

Marjolin\u27s Tumor Complicating Chronic Periprosthetic Infection of a Total Knee Arthroplasty

Marjolin\u27s tumor is a term used to describe a malignancy developing in the setting of a chronic wound, infection, or other tissue subject to chronic inflammatory changes. These malignancies usually present after many years of chronicity, and can range from lower grade basal cell carcinomas to high-grade sarcomas. We present the case of a squamous cell carcinoma that developed within a chronic periprosthetic infection of a total knee arthroplasty of 7 years duration. The intra-articular location, association with an orthopaedic implant, and brief latency period are all unique features of this case

Modelling the impact of local reactive school closures on critical care provision during an influenza pandemic

Despite the fact that the 2009 H1N1 pandemic influenza strain was less severe than had been feared, both seasonal epidemics of influenza-like-illness and future influenza pandemics have the potential to place a serious burden on health services. The closure of schools has been postulated as a means of reducing transmission between children and hence reducing the number of cases at the peak of an epidemic; this is supported by the marked reduction in cases during school holidays observed across the world during the 2009 pandemic. However, a national policy of long-duration school closures could have severe economic costs. Reactive short-duration closure of schools in regions where health services are close to capacity offers a potential compromise, but it is unclear over what spatial scale and time frame closures would need to be made to be effective. Here, using detailed geographical information for England, we assess how localized school closures could alleviate the burden on hospital intensive care units (ICUs) that are reaching capacity. We show that, for a range of epidemiologically plausible assumptions, considerable local coordination of school closures is needed to achieve a substantial reduction in the number of hospitals where capacity is exceeded at the peak of the epidemic. The heterogeneity in demand per hospital ICU bed means that even widespread school closures are unlikely to have an impact on whether demand will exceed capacity for many hospitals. These results support the UK decision not to use localized school closures as a control mechanism, but have far wider international public-health implications. The spatial heterogeneities in both population density and hospital capacity that give rise to our results exist in many developed countries, while our model assumptions are sufficiently general to cover a wide range of pathogens. This leads us to believe that when a pandemic has severe implications for ICU capacity, only widespread school closures (with their associated costs and organizational challenges) are sufficient to mitigate the burden on the worst-affected hospitals

Laser interstitial thermal therapy in grade 2/3 IDH1/2 mutant gliomas: A preliminary report and literature review

Laser interstitial thermal therapy (LITT) has become an increasingly utilized alternative to surgical resection for the treatment of glioma in patients. However, treatment outcomes in isocitrate dehydrogenase 1 and 2

Dissecting T Cell Contraction In Vivo Using a Genetically Encoded Reporter of Apoptosis

SummaryContraction is a critical phase of immunity whereby the vast majority of effector T cells die by apoptosis, sparing a population of long-lived memory cells. Where, when, and why contraction occurs has been difficult to address directly due in large part to the rapid clearance of apoptotic T cells in vivo. To circumvent this issue, we introduced a genetically encoded reporter for caspase-3 activity into naive T cells to identify cells entering the contraction phase. Using two-photon imaging, we found that caspase-3 activity in T cells was maximal at the peak of the response and was associated with loss of motility followed minutes later by cell death. We demonstrated that contraction is a widespread process occurring uniformly in all organs tested and targeting phenotypically diverse T cells. Importantly, we identified a critical window of time during which antigen encounters act to antagonize T cell apoptosis, supporting a causal link between antigen clearance and T cell contraction. Our results offer insight into a poorly explored phase of immunity and provide a versatile methodology to study apoptosis during the development or function of a variety of immune cells in vivo

MDN brain descending neurons coordinately activate backward and inhibit forward locomotion.

Command-like descending neurons can induce many behaviors, such as backward locomotion, escape, feeding, courtship, egg-laying, or grooming (we define 'command-like neuron' as a neuron whose activation elicits or 'commands' a specific behavior). In most animals, it remains unknown how neural circuits switch between antagonistic behaviors: via top-down activation/inhibition of antagonistic circuits or via reciprocal inhibition between antagonistic circuits. Here, we use genetic screens, intersectional genetics, circuit reconstruction by electron microscopy, and functional optogenetics to identify a bilateral pair of Drosophila larval 'mooncrawler descending neurons' (MDNs) with command-like ability to coordinately induce backward locomotion and block forward locomotion; the former by stimulating a backward-active premotor neuron, and the latter by disynaptic inhibition of a forward-specific premotor neuron. In contrast, direct monosynaptic reciprocal inhibition between forward and backward circuits was not observed. Thus, MDNs coordinate a transition between antagonistic larval locomotor behaviors. Interestingly, larval MDNs persist into adulthood, where they can trigger backward walking. Thus, MDNs induce backward locomotion in both limbless and limbed animals

Exploring the Factors Associated with Undergraduate Students’ Online Learning Anxiety: Development of the Online Learner Anxiety Scale

The purpose of this research was to explore the factors associated with online learning anxiety by carefully designing, developing, and providing preliminary validity and reliability evidence of a scale to measure undergraduate students’ online learning anxiety. We created a conceptual framework to organize the literature surrounding online learning anxiety and used this framework to develop an initial item pool of 30 items. The researchers recruited N = 297 undergraduate student participants from four public universities in the southeastern United States from whom we collected and analyzed data for descriptive statistics, internal consistency reliability, exploratory factor analysis, and correlational analysis. Following systematic analytic procedures, we arrived at a three-factor model explaining approximately 65% of the variability in these data and retained 24 items in the final model with minimal cross-loadings in the pattern matrix. We labeled the identified factors as (1) online learner feelings of negativity and inadequacy, (2) online learner apprehension towards personal communication, and (3) online learner discomfort with instructor capacity and communication. The final instrument was named the Online Learner Anxiety Scale (OLAS). Scores on the OLAS were correlated with five other measures hypothesized to relate to online learning anxiety thereby providing stronger construct validity evidence. The OLAS was found to produce reliable scores that can be validly inferred as measures of online learning anxiety among undergraduate students in institutions of higher education. These findings are discussed and framed in light of current literature on online learning and possible future research directions.

CdTe Focal Plane Detector for Hard X-Ray Focusing Optics

The demand for higher resolution x-ray optics (a few arcseconds or better) in the areas of astrophysics and solar science has, in turn, driven the development of complementary detectors. These detectors should have fine pixels, necessary to appropriately oversample the optics at a given focal length, and an energy response also matched to that of the optics. Rutherford Appleton Laboratory have developed a 3-side buttable, 20 millimeter x 20 millimeter CdTe-based detector with 250 micrometer square pixels (80 x 80 pixels) which achieves 1 kiloelectronvolt FWHM (Full-Width Half-Maximum) @ 60 kiloelectronvolts and gives full spectroscopy between 5 kiloelectronvolts and 200 kiloelectronvolts. An added advantage of these detectors is that they have a full-frame readout rate of 10 kilohertz. Working with NASA Goddard Space Flight Center and Marshall Space Flight Center, 4 of these 1 millimeter-thick CdTe detectors are tiled into a 2 x 2 array for use at the focal plane of a balloon-borne hard-x-ray telescope, and a similar configuration could be suitable for astrophysics and solar space-based missions. This effort encompasses the fabrication and testing of flight-suitable front-end electronics and calibration of the assembled detector arrays. We explain the operation of the pixelated ASIC readout and measurements, front-end electronics development, preliminary X-ray imaging and spectral performance, and plans for full calibration of the detector assemblies. Work done in conjunction with the NASA Centers is funded through the NASA Science Mission Directorate Astrophysics Research and Analysis Program