Evaluation of a New Dental Implant Cervical Design in Comparison with a Conventional Design in an Experimental American Foxhound Model

This is the peer reviewed versión of the following article: "Evaluation of a New Dental Implant Cervical Design in Comparison with a Conventional Design in an Experimental American Foxhound Model ", which has been published in final form at [doi:10.3390/ma11040462],. This article May be used for non-comercial pipotes in accordance with Wiley Terms an Conditions for Use of Self-Archived Versions.Odontologí

Evaluation of the insertion torque, implant stability quotient and drilled hole quality for different drill design: an in vitro Investigation

This is the peer reviewed version of the following article: Gehrke SA, Guirado JLC, Bettach R, Fabbro MD, Martınez CP-A, Shibli JA. Evaluation of the insertion torque, implant stability quotient and drilled hole quality for different drill design: an in vitro Investigation. Clin. Oral Impl. Res. 00, 2016, 1–7], which has been published in final form at 10.1111/clr.12808. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions.Objective: The purpose of the present study was to compare the insertion torque and implant stability quotient between different drill design for implant site preparation. Materials and Methods: Synthetic blocks of bone (type I density) were used for drilling procedures. Three groups were evaluated: Group G1 - drilling with a single bur for a 4.2 mm conical implant; Group G2 and Group G3 - drilling with three consecutive burs for a 4.1 mm cylindrical implant and for a 4.3 mm conical implant respectively. For each group, 15 drilling procedures were performed without irrigation for 10-mm in-depth. The drilled hole quality (HQ) after the osteotomy for implant site preparation was measured in the five-first holes through a fully automated roundness/cylindricity instrument at three levels (top, middle, and bottom of the site). The insertion torque value (ITV) was achieved with a computed torquimeter and the implant stability quotient (ISQ) values were measured using a resonance frequency apparatus. Results: Thesingledrill(group1)achievedasignificantlyhigherITVandISQthanthemultipledrills for osteotomy (groups 2 and 3). Group 1 and 3 displayed significantly better HQ than group 2. Conclusions: Within the limitations of the study, the results suggest that the hole quality, in addition to the insertion torque, may significantly affect implant primary stability.Odontologí

SEM-EDX Study of the Degradation Process of Two Xenograft Materials Used in Sinus Lift Procedures

Some studies have demonstrated that in vivo degradation processes are influenced by the material’s physico-chemical properties. The present study compares two hydroxyapatites manufactured on an industrial scale, deproteinized at low and high temperatures, and how physico-chemical properties can influence the mineral degradation process of material performance in bone biopsies retrieved six months after maxillary sinus augmentation. Residual biomaterial particles were examined by field scanning electron microscopy (SEM) and energy dispersive X-ray spectroscopy (EDX) to determine the composition and degree of degradation of the bone graft substitute material. According to the EDX analysis, the Ca/P ratio significantly lowered in the residual biomaterial (1.08 ± 0.32) compared to the initial composition (2.22 ± 0.08) for the low-temperature sintered group, which also presented high porosity, low crystallinity, low density, a large surface area, poor stability, and a high resorption rate compared to the high-temperature sintered material. This demonstrates that variations in the physico-chemical properties of bone substitute material clearly influence the degradation process. Further studies are needed to determine whether the resorption of deproteinized bone particles proceeds slowly enough to allow sufficient time for bone maturation to occur.Odontologí

Influence of Implant Neck Design on Peri-Implant Tissue Dimensions: A Comparative Study in Dogs

This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Abstract: This in vivo study assessed (hard and soft) peri-implant tissue remodeling around implants with micro-ring and open-thread neck designs placed in a dog model. Twenty histological sections corresponding to four different implant designs that were placed in America Foxhound dogs were obtained from previous studies. All the implants had been placed under identical conditions and were divided into four groups: Group A, micro-rings on implant neck plus 0.5 mm refined surface; Group B, micro-rings on implant neck; Group C, open-thread neck; and, Group D, double-spiral neck. Eight weeks after surgery, the integrated implants were removed and processed for histological examination. Crestal bone loss and bone-to-implant contact was greater for micro-ring necks than open-thread necks. Soft tissues showed significant differences on both buccal and lingual aspects, so that the distance from peri-implant mucosa to the apical portion of the barrier epithelium was smaller in the micro-ring groups. So, in spite of generating greater bone-to-implant contact, implants with micro rings produced more bone loss than open-thread implants. Moreover, the outcomes that were obtained IPX implants smooth neck design produced less bone loss in the cervical area, following by Facility implants when compared with the other open thread and microthreaded implant designs. Implant thread design can influence on bone remodeling in the cervical area, related to bundle bone preservation.Odontologí

Evaluation of surrounding ring of two different extrashort implants design in crestal bone maintanence: A histologic study in dogs.

This is the peer reviewed versión of the following article : " Evaluation of surrounding ring of two different extrashort implants design in crestal bone maintanence: A histologic study in dogs.", which has been published in final form at " FOR PEER REVIEW (DOI)". This article May be used for non-comercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions."Odontologí

The Effect of Germanium‐Loaded Hydroxyapatite Biomaterials on Bone Marrow Mesenchymal Stem Cells Growth

Hydroxyapatite (HA) is a hard mineral component of mineralized tissues, mainly composed of calcium and phosphate. Due to its bioavailability, HA is potentially used for the repair and regeneration of mineralized tissues. For this purpose, the properties of HA are significantly improved by adding natural and synthetic materials. In this sense, the germanium (Ge) mineral was loaded in HA biomaterial by cold isostatic pressure for the first time and characterization and biocompatibility using bone marrow mesenchymal stem cells (BM-MSCs) were investigated. The addition of Ge at 5% improved the solubility (3.32%), stiffness (18.34 MPa), water holding (31.27%) and biodegradation (21.87%) properties of HA, compared to control. Compared to all composite biomaterials, the drug-releasing behavior of HA-3% Ge was higher at pH 1 and 3 and the maximum drug release was obtained at pH 7 and 9 with HA-5% Ge biomaterials. Among the different mediums tested, the DMEM-medium showed a higher drug release rate, especially at 60 min. HA-Ge biomaterials showed better protein adhesion and apatite layer formation, which ultimately proves the compatibility in BM-MSCs culture. Except for higher concentrations of HA (5 and 10 mg/mL), the different concentrations of Ge and HA and wells coated with 1% of HA-1% Ge had higher BM-MSCs growth than control. All these findings concluded that the fabricated HA biomaterials loaded with Ge could be the potential biomaterial for culturing mammalian cells towards mineralized tissue repair and regeneration.This research was funded by MCIN/AEI/10.13039/501100011033 Grant numbers PID2020-116693RB-C21 and PID2020-116693RB-C22Generalitat Valenciana Grant number CIAICO/2021/157and Internal Research Fund from Universidad Católica San Antonio de Murcia (UCAM), Grant number PMAFI-27/21, Murcia, Spain

ECMO for COVID-19 patients in Europe and Israel

Since March 15th, 2020, 177 centres from Europe and Israel have joined the study, routinely reporting on the ECMO support they provide to COVID-19 patients. The mean annual number of cases treated with ECMO in the participating centres before the pandemic (2019) was 55. The number of COVID-19 patients has increased rapidly each week reaching 1531 treated patients as of September 14th. The greatest number of cases has been reported from France (n = 385), UK (n = 193), Germany (n = 176), Spain (n = 166), and Italy (n = 136) .The mean age of treated patients was 52.6 years (range 16–80), 79% were male. The ECMO configuration used was VV in 91% of cases, VA in 5% and other in 4%. The mean PaO2 before ECMO implantation was 65 mmHg. The mean duration of ECMO support thus far has been 18 days and the mean ICU length of stay of these patients was 33 days. As of the 14th September, overall 841 patients have been weaned from ECMO support, 601 died during ECMO support, 71 died after withdrawal of ECMO, 79 are still receiving ECMO support and for 10 patients status n.a. . Our preliminary data suggest that patients placed on ECMO with severe refractory respiratory or cardiac failure secondary to COVID-19 have a reasonable (55%) chance of survival. Further extensive data analysis is expected to provide invaluable information on the demographics, severity of illness, indications and different ECMO management strategies in these patients

Submerged flapless technique vs. conventional flap approach for implant placement: experimental domestic pig study with 12-month follow-up

ObjectivesThe aim of our study was to compare osseointegration and peri-implant crestal bone resorption in submerged flapless and conventional flap surgery over a 12-month follow-up. Materials and methodsThe study used five domestic pigs. Implants were inserted 9weeks after tooth extraction. Each animal received six implants in the mandible, following a split-mouth design: one side was treated using a flapless technique using mini-incisions, while a flap was raised on the other. The animals were sacrificed at 2weeks, 1, 3, 6 and 12months after implant placement. Radiographic images were taken to analyze crestal bone loss, and samples were extracted for histopathological and bone-to-implant contact (BIC) analyses. ResultsSignificantly, greater crestal bone loss (P=0.005) was obtained in the flap group compared with the flapless group. The flapless group presented significantly higher percentages of BIC (P lt 0.05) at 3, 6 and 12months compared with the conventional flap group. ConclusionsWithin the limitations of this experimental animal study, it may be concluded that the type of surgery (flap or flapless) affects peri-implant bone preservation and osseointegration of regular platform implants. Flapless surgery is associated with peri-implant crestal bone preservation. Flapless surgery in combination with submerged implants allows higher osseointegration values

Evaluation of a New Dental Implant Cervical Design in Comparison with a Conventional Design in an Experimental American Foxhound Model

The aim of this study was to evaluate osseointegration and crestal bone height in implants with a triangular cervical design in comparison with a standard rounded cervical design. The control group consisted of 24 implants with a standard cervical design, and the test group of 24 implants with a triangular cervical design. The implants were inserted in healed bone in six American Foxhounds. Crestal bone height and tissue thickness in the cervical portion were measured after 12 weeks healing. Data analysis found mean crestal bone loss of: 0.31 ± 0.24 mm on the buccal side, 0.35 ± 0.14 mm on the lingual in the test group, and 0.71 ± 0.28 mm buccal loss, and 0.42 ± 0.30 mm lingual in the control group; with statistically significant differences on the buccal aspect (p = 0.0019). Mean tissue thickness in the test group was 1.98 ± 0.17 mm on the buccal aspect, and 2.43 ± 0.93 mm in the lingual; in the control group it was 2.48 ± 0.61 mm buccal thickness, and 2.88 ± 0.14 mm lingual, with significant differences on both aspects (p = 0.0043; p = 0.0029). The results suggest that greater thickness of peri-implant tissue can be expected when the triangular cervical implant design is used rather than the standard cervical design