1,954 research outputs found
Effects of cell cycle noise on excitable gene circuits
We assess the impact of cell cycle noise on gene circuit dynamics. For
bistable genetic switches and excitable circuits, we find that transitions
between metastable states most likely occur just after cell division and that
this concentration effect intensifies in the presence of transcriptional delay.
We explain this concentration effect with a 3-states stochastic model. For
genetic oscillators, we quantify the temporal correlations between daughter
cells induced by cell division. Temporal correlations must be captured properly
in order to accurately quantify noise sources within gene networks.Comment: 15 pages, 8 figure
Recommended from our members
Generalized Kasha's Model: T-Dependent Spectroscopy Reveals Short-Range Structures of 2D Excitonic Systems
Judging the impact of leadership-development activities on school practice
The nature and effectiveness of professional-development activities should be judged in a way that takes account of
both the achievement of intended outcomes and the unintended consequences that may result. Our research project set out to create a robust approach that school staff members could use to assess the impact of
professional-development programs on leadership and management practice without being constrained in this judgment by the stated aims of the program. In the process,
we identified a number of factors and requirements relevant to a wider audience than that concerned with the development of leadership and management in England.
Such an assessment has to rest upon a clear understanding of educational leadership,a clearly articulated model of practice, and a clear model of potential forms of impact.
Such foundations, suitably adapted to the subject being addressed, are appropriate for assessing all teacher professional development
Effects of Cell Cycle Noise on Excitable Gene Circuits
We assess the impact of cell cycle noise on gene circuit dynamics. For bistable genetic switches and excitable circuits, we find that transitions between metastable states most likely occur just after cell division and that this concentration effect intensifies in the presence of transcriptional delay. We explain this concentration effect with a three-states stochastic model. For genetic oscillators, we quantify the temporal correlations between daughter cells induced by cell division. Temporal correlations must be captured properly in order to accurately quantify noise sources within gene networks
In-vivo force, frequency, and velocity of dog gastrointestinal contractile activity
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/44364/1/10620_2005_Article_BF02233438.pd
Spectrum of Sizes for Perfect Deletion-Correcting Codes
One peculiarity with deletion-correcting codes is that perfect
-deletion-correcting codes of the same length over the same alphabet can
have different numbers of codewords, because the balls of radius with
respect to the Levenshte\u{\i}n distance may be of different sizes. There is
interest, therefore, in determining all possible sizes of a perfect
-deletion-correcting code, given the length and the alphabet size~.
In this paper, we determine completely the spectrum of possible sizes for
perfect -ary 1-deletion-correcting codes of length three for all , and
perfect -ary 2-deletion-correcting codes of length four for almost all ,
leaving only a small finite number of cases in doubt.Comment: 23 page
The Primordial Inflation Polarization Explorer (PIPER)
The Primordial Inflation Polarization Explorer (PIPER) is a balloon-borne
cosmic microwave background (CMB) polarimeter designed to search for evidence
of inflation by measuring the large-angular scale CMB polarization signal.
BICEP2 recently reported a detection of B-mode power corresponding to the
tensor-to-scalar ratio r = 0.2 on ~2 degree scales. If the BICEP2 signal is
caused by inflationary gravitational waves (IGWs), then there should be a
corresponding increase in B-mode power on angular scales larger than 18
degrees. PIPER is currently the only suborbital instrument capable of fully
testing and extending the BICEP2 results by measuring the B-mode power spectrum
on angular scales = ~0.6 deg to 90 deg, covering both the reionization
bump and recombination peak, with sensitivity to measure the tensor-to-scalar
ratio down to r = 0.007, and four frequency bands to distinguish foregrounds.
PIPER will accomplish this by mapping 85% of the sky in four frequency bands
(200, 270, 350, 600 GHz) over a series of 8 conventional balloon flights from
the northern and southern hemispheres. The instrument has background-limited
sensitivity provided by fully cryogenic (1.5 K) optics focusing the sky signal
onto four 32x40-pixel arrays of time-domain multiplexed Transition-Edge Sensor
(TES) bolometers held at 140 mK. Polarization sensitivity and systematic
control are provided by front-end Variable-delay Polarization Modulators
(VPMs), which rapidly modulate only the polarized sky signal at 3 Hz and allow
PIPER to instantaneously measure the full Stokes vector (I, Q, U, V) for each
pointing. We describe the PIPER instrument and progress towards its first
flight.Comment: 11 pages, 7 figures. To be published in Proceedings of SPIE Volume
9153. Presented at SPIE Astronomical Telescopes + Instrumentation 2014,
conference 915
Sea ice extent and seasonality for the Early Pliocene northern Weddell Sea
Growth increment analysis coupled with stable isotopic data (δ18O/δ13C) from Early Pliocene (ca 4.7 Ma)
Austrochlamys anderssoni from shallow marine sediments of the Cockburn Island Formation, northern
Antarctic Peninsula, suggest these bivalves grew through much of the year, even during the coldest parts of
winter recorded in the shells. The high frequency fluctuation in growth increment width of A. anderssoni
appears to reflect periodic, but year-round, agitation of the water column enhancing benthic food supply
from organic detritus. This suggests that Austrochlamys favoured waters that were largely sea ice free. Our
data support interpretation of the Cockburn Island Formation as an interglacial marine deposit and the
previous hypothesis that Austrochlamys retreated from the Antarctic as sea ice extent expanded, this
transition occurring during climate cooling in the Late Pliocene
Regulation of Translesion Synthesis DNA Polymerase η by Monoubiquitination
DNA polymerase eta is a Y family polymerase involved in translesion synthesis (TLS). Its action is initiated by simultaneous interaction between the PIP box in pol eta and PCNA and between the UBZ in pol eta and monoubiquitin attached to PCNA. Whereas monoubiquitination of PCNA is required for its interaction with pol eta during TLS, we now show that monoubiquitination of pol eta inhibits this interaction, preventing its functions in undamaged cells. Identification of monoubiquitination sites within pol eta nuclear localization signal (NLS) led to the discovery that pol eta NLS directly contacts PCNA, forming an extended pol eta-PCNA interaction surface. We name this the PCNA-interacting region (PIR) and show that its monoubiquitination is downregulated by various DNA-damaging agents. We propose that this mechanism ensures optimal availability of nonubiquitinated, TLS-competent pol eta after DNA damage. Our work shows how monoubiquitination can either positively or negatively regulate the assembly of a protein complex, depending on which substrates are targeted by ubiquitin
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