Influence of the initial- and final-state configuration interaction on the anisotropy of the resonant Auger decay of Kr 3d⁻¹5p and Xe 4d⁻¹6p states

The anisotropy of resonant Auger decay of photo-excited Kr 3d−13/2,5/25p and Xe 4d−13/2,5/26p states has been studied by multiconfiguration Dirac-Fock method. The calculations account for the configuration interaction both in the initial and in the final states of the Auger decay. For the nonresolved nd−1(n+2)p(J=1) resonances (n=3 for Kr and n=4 for Xe) the average intensities and anisotropies of Auger lines were calculated by weighing each partial rate by the pertinent Dirac-Fock photoexcitation probabilities. Our results show that, in addition to the initial- and final-state correlation, both the relaxation and the exchange interaction have a substantial effect on the anisotropy of these Auger spectra. For most Auger lines there is good agreement between our calculated β parameters and experimental values for the Kr and Xe nd−15/2(n+2)p photoexcitation resonances; there is also satisfactory agreement for the Kr 3d−13/25p and Xe 4d−13/26p resonant Auger spectra. However, the remaining notable discrepancies between theory and experiment indicate that important correlation effects are still omitted in our calculations. Discrepancies between different experimental results stress the need for further improvements on the experimental side

A comprehensive study of the vibrationally resolved S 2p −1 Auger electron spectrum of carbonyl sulfide

High-resolution normal Auger-electron spectra of carbonyl sulfide subsequent to S 2p −1 photoionization at photonenergies of 200, 220, and 240 eV are reported along with corresponding photoelectron spectra. In addition, theoretical results are presented that take the core-hole orientation of the various spin-orbit-split and molecular-field-split S 2p −1 states into account. Auger transitions to eight metastable dicationic final states are observed and assigned on the basis of the theoretical results. From Franck- Condon analysis, assuming Morse potentials along the normal coordinates for seven of the observed quasi-stable dicationic final states, information on the potential-energysurfaces is derived and compared with theoretical results from the literature

Coherence and correlation in the anisotropy of Ne KL-LLL satellite Auger decay

The energies, intensities, and angular anisotropies of the Ne KL-LLL satellite Auger lines have been studied by the multiconfiguration Dirac-Fock method. In addition to the initial- and final-state correlation effects we have studied the influence of the quantum beat effect on this Auger spectrum. Since the energy splitting of the Ne 1s−12p−13P multiplet is much smaller than the lifetime broadening, the coherent excitation of these initial states by the in time and space localized electromagnetic pulse of the projectile has a drastic effect on the angular distribution of Auger electrons. To analyze this coherence effect we have generalized the theory of the angular distribution of Auger electrons to the case of coherent excitation of partially overlapping initial states. The results of our calculations are in good overall agreement with experiment. However, for a quantitative study of the influence of the coherence and the initial spin state on the anisotropy of these Auger lines new measurements with lower error limits are necessary

Competition between decay and dissociation of core-excited OCS studied by X-ray scattering

We show the first evidence of dissociation during resonant inelastic soft X-ray scattering. Carbon and oxygen K-shell and sulfur L-shell resonant and non-resonant X-ray emission spectra were measured using monochromatic synchrotron radiation for excitation and ionization. After sulfur, L2,3 -> {\pi}*, {\sigma}* excitation, atomic lines are observed in the emission spectra as a consequence of competition between de-excitation and dissociation. In contrast the carbon and oxygen spectra show weaker line shape variations and no atomic lines. The spectra are compared to results from ab initio calculations and the discussion of the dissociation paths is based on calculated potential energy surfaces and atomic transition energies.Comment: 12 pages, 6 pictures, 2 tables, http://link.aps.org/doi/10.1103/PhysRevA.59.428

Antitumor effect of oncolytic virus and paclitaxel encapsulated in extracellular vesicles for lung cancer treatment

Standard of care for cancer is commonly a combination of surgery with radiotherapy or chemoradiotherapy. However, in some advanced cancer patients this approach might still remaininefficient and may cause many side effects, including severe complications and even death. Oncolytic viruses exhibit different anti-cancer mechanisms compared with conventional therapies, allowing the possibility for improved effect in cancer therapy. Chemotherapeutics combined with oncolytic viruses exhibit stronger cytotoxic responses and oncolysis. Here, we have investigated the systemic delivery of the oncolytic adenovirus and paclitaxel encapsulated in extracellular vesicles (EV) formulation that, in vitro, significantly increased the transduction ratio and the infectious titer when compared with the virus and paclitaxel alone. We demonstrated that the obtained EV formulation reduced the in vivo tumor growth in animal xenograft model of human lung cancer. Indeed, we found that combined treatment of oncolytic adenovirus and paclitaxel encapsulated in EV has enhanced anticancer effects both in vitro and in vivo in lung cancer models. Transcriptomic comparison carried out on the explanted xenografts from the different treatment groups revealed that only 5.3% of the differentially expressed genes were overlapping indicating that a de novo genetic program is triggered by the presence of the encapsulated paclitaxel: this novel genetic program might be responsible of the observed enhanced antitumor effect. Our work provides a promising approach combining anticancer drugs and viral therapies by intravenous EV delivery as a strategy for the lung cancer treatment.Peer reviewe