Karl Tomm’s Internalized Other Interviewing: From Theory to Practice

Over the last 40 years, the Canadian psychiatrist and family therapist Karl Tomm has been a key contributor to postmodern developments in family therapy (Collins & Tomm, 2009; Strong et al., 2008; Tomm, Hoyt, & Madigan, 2001). This dissertation traces the people, ideas, and practices that have influenced Tomm\u27s approach, providing an in- depth examination of the method he developed for putting his ideas into practice: Internalized Other Interviewing (IOI). A systemic, relational approach to the practice of postmodern family therapy uses language as a means to create change. Family therapists routinely use different types of questions to ask clients about other people in their lives. Direct, information-seeking questions privilege objectivity, whereas interpersonal perception questions privilege subjective assumptions and allow for new possibilities to arise. The IOI approach offers a third way to ask questions that privilege subject-dependent assumptions and embodied knowledge (K. Tomm, personal communication, August 15, 2019). By inviting clients to speak from their experience of the other, therapists gain entry to a broader base of knowledge.Grounded in social constructionism and bringforthism (Strong et al., 2008; Tomm, 1999, 2002, 2014b), IOI has remained relatively unrecognized and underutilized in clinical work. To date, the theoretical underpinnings and historical development of IOI have not been thoroughly delineated. This dissertation provides the necessary background information and detailed examples for therapists to put the practice in context.Archival information about case examples collected during and following the author\u27s externship at the Calgary Family Therapy Centre in August 2019 have been interwoven throughout the manuscript. These case descriptions, along with Karl Tomm\u27s reflective thoughts, are used to illustrate and illuminate the theory and practice of IOI, bringing to life Tomm\u27s inimitable way of working systemically with individuals, couples, and families

Identifying gene-environment interactions in schizophrenia:contemporary challenges for integrated, large-scale investigations

Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G x E), however, so far, thorough replication of findings is rare and G x E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G x E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G x E in schizophrenia. While such investigations are now well underway, new challenges emerge for G x E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotype

How Many Replicators Does It Take to Achieve Reliability? Investigating Researcher Variability in a Crowdsourced Replication

The paper reports findings from a crowdsourced replication. Eighty-four replicator teams attempted to verify results reported in an original study by running the same models with the same data. The replication involved an experimental condition. A “transparent” group received the original study and code, and an “opaque” group received the same underlying study but with only a methods section and description of the regression coefficients without size or significance, and no code. The transparent group mostly verified the original study (95.5%), while the opaque group had less success (89.4%). Qualitative investigation of the replicators’ workflows reveals many causes of non-verification. Two categories of these causes are hypothesized, routine and non-routine. After correcting non-routine errors in the research process to ensure that the results reflect a level of quality that should be present in ‘real-world’ research, the rate of verification was 96.1 in the transparent group and 92.4 in the opaque group. Two conclusions follow: (1) Although high, the verification rate suggests that it would take a minimum of three replicators per study to achieve replication reliability of at least 95 confidence assuming ecological validity in this controlled setting, and (2) like any type of scientific research, replication is prone to errors that derive from routine and undeliberate actions in the research process. The latter suggests that idiosyncratic researcher variability might provide a key to understanding part of the “reliability crisis” in social and behavioral science and is a reminder of the importance of transparent and well documented workflows

Efficient Implementation of Application-Aware Spinlock Control in MPSoCs

Recent years have seen considerable progress in epidemiological and molecular genetic research into environmental and genetic factors in schizophrenia, but methodological uncertainties remain with regard to validating environmental exposures, and the population risk conferred by individual molecular genetic variants is small. There are now also a limited number of studies that have investigated molecular genetic candidate gene-environment interactions (G × E), however, so far, thorough replication of findings is rare and G × E research still faces several conceptual and methodological challenges. In this article, we aim to review these recent developments and illustrate how integrated, large-scale investigations may overcome contemporary challenges in G × E research, drawing on the example of a large, international, multi-center study into the identification and translational application of G × E in schizophrenia. While such investigations are now well underway, new challenges emerge for G × E research from late-breaking evidence that genetic variation and environmental exposures are, to a significant degree, shared across a range of psychiatric disorders, with potential overlap in phenotyp

Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients

BACKGROUN