581 research outputs found
Consistent treatment of incompletely converged iterative linear solvers in reverse-mode algorithmic differentiation
Geometric continuity constraints of automatically derived parametrisations in CAD-based shape optimisation
A combined theoretical and experimental study of the low temperature properties of BaZrO3
Low temperature properties of BaZrO3 are revealed by combining experimental
techniques (X-ray diffraction, neutron scattering and dielectric measurements)
with theoretical first-principles-based methods (total energy and linear
response calculations within density functional theory, and effective
Hamiltonian approaches incorporating/neglecting zero-point phonon vibrations).
Unlike most of the perovskite systems, BaZrO3 does not undergo any
(long-range-order) structural phase transition and thus remains cubic and
paraelectric down to 2 K, even when neglecting zero-point phonon vibrations. On
the other hand, these latter pure quantum effects lead to a negligible thermal
dependency of the cubic lattice parameter below ~ 40 K. They also affect the
dielectricity of BaZrO3 by inducing an overall saturation of the real part of
the dielectric response, for temperatures below ~ 40 K. Two fine structures in
the real part, as well as in the imaginary part, of dielectric response are
further observed around 50-65 K and 15 K, respectively. Microscopic origins
(e.g., unavoidable defects and oxygen octahedra rotation occurring at a local
scale) of such anomalies are suggested. Finally, possible reasons for the facts
that some of these dielectric anomalies have not been previously reported in
the better studied KTaO3 and SrTiO3 incipient ferroelectrics are also
discussed.Comment: 8 pages, 5 figures, submitted to Physical Review
Low-rank and sparse recovery of human gait data
Due to occlusion or detached markers, information can often be lost while capturing human motion with optical tracking systems. Based on three natural properties of human gait movement, this study presents two different approaches to recover corrupted motion data. These properties are used to define a reconstruction model combining low-rank matrix completion of the measured data with a group-sparsity prior on the marker trajectories mapped in the frequency domain. Unlike most existing approaches, the proposed methodology is fully unsupervised and does not need training data or kinematic information of the user. We evaluated our methods on four different gait datasets with various gap lengths and compared their performance with a state-of-the-art approach using principal component analysis (PCA). Our results showed recovering missing data more precisely, with a reduction of at least 2 mm in mean reconstruction error compared to the literature method. When a small number of marker trajectories is available, our findings showed a reduction of more than 14 mm for the mean reconstruction error compared to the literature approach
Total energy calculation of high pressure selenium: The origin of incommensurate modulations in Se-IV and the instability of proposed Se-II
We present calculation of the high pressure crystal structures in selenium,
including rational approximants to the recently reported incommensurate phases.
We show how the incommensurate phases can be intuitively explained in terms of
imaginary phonon frequencies arising from Kohn anomalies in the putative
undistorted phase. We also find inconsistencies between the calculated and
experimental Se-II phase - the calculations show it to be a metastable metal
while the experiment finds a stable semiconductor. We propose that the
experimentally reported structure is probably in error.Comment: 4 pages 4 figure
Muslim active citizenship in Australia: Socioeconomic challenges and the emergence of a Muslim elite
The most recent national Census demonstrated that Australian Muslims continue to occupy a socioeconomically disadvantaged position. On key indicators of unemployment rate, income, type of occupation and home ownership, Muslims consistently under-perform the national average. This pattern is evident in the last three Census data (2001, 2006 and 2011). Limited access to resources and a sense of marginalisation challenge full engagement with society and the natural growth of emotional affiliation with Australia. Muslim active citizenship is hampered by socioeconomic barriers. At the same time, an increasingly proactive class of educated Muslim elite has emerged to claim a voice for Muslims in Australia and promote citizenship rights and responsibilities. <br /
NPEPPS Is a Druggable Driver of Platinum Resistance
There is an unmet need to improve the efficacy of platinum-based cancer chemotherapy, which is used in primary and metastatic settings in many cancer types. In bladder cancer, platinum-based chemotherapy leads to better outcomes in a subset of patients when used in the neoadjuvant setting or in combination with immunotherapy for advanced disease. Despite such promising results, extending the benefits of platinum drugs to a greater number of patients is highly desirable. Using the multiomic assessment of cisplatin-responsive and -resistant human bladder cancer cell lines and whole-genome CRISPR screens, we identified puromycin-sensitive aminopeptidase (NPEPPS) as a driver of cisplatin resistance. NPEPPS depletion sensitized resistant bladder cancer cells to cisplatin in vitro and in vivo. Conversely, overexpression of NPEPPS in sensitive cells increased cisplatin resistance. NPEPPS affected treatment response by regulating intracellular cisplatin concentrations. Patient-derived organoids (PDO) generated from bladder cancer samples before and after cisplatin-based treatment, and from patients who did not receive cisplatin, were evaluated for sensitivity to cisplatin, which was concordant with clinical response. In the PDOs, depletion or pharmacologic inhibition of NPEPPS increased cisplatin sensitivity, while NPEPPS overexpression conferred resistance. Our data present NPEPPS as a druggable driver of cisplatin resistance by regulating intracellular cisplatin concentrations.</p
Advanced material against human (Including Covidâ19) and plant viruses: nanoparticles as a feasible strategy
The SARSâCoVâ2 virus outbreak revealed that these nanoâpathogens have the ability to rapidly change lives. Undoubtedly, SARSâCoVâ2 as well as other viruses can cause important global impacts, affecting public health, as well as, socioeconomic development. But viruses are not only a public health concern, they are also a problem in agriculture. The current treatments are often ineffective, are prone to develop resistance, or cause considerable adverse side effects. The use of nanotechnology has played an important role to combat viral diseases. In this review three main aspects are in focus: first, the potential use of nanoparticles as carriers for drug delivery. Second, its use for treatments of some human viral diseases, and third, its application as antivirals in plants. With these three themes, the aim is to give to readers an overview of the progress in this promising area of biotechnology during the 2017â2020 period, and to provide a glance at how tangible is the effectiveness of nanotechnology against viruses. Future prospects are also discussed. It is hoped that this review can be a contribution to general knowledge for both specialized and nonâspecialized readers, allowing a better knowledge of this interesting topic.REDESâANID. Grant Number: 180003
Universidad de La Frontera. Grant Number: DI20â1003
FAPESP. Grant Numbers: 2018/08194â2, 2018/02832â7
CNPq. Grant Numbers: 404815/2018â9, 313117/2019â5
CONICYT/FAPESP. Grant Number: 2018/08194â2
Coordenação de Aperfeiçoamento de Pessoal de NĂvel Superior. Grant Numbers: 001, ANID/FONDAP/15130015
FCT. Grant Number: PTDC/CTMâTEX/28295/2017
FEDER
POCI
Portugal 2020 program
COMPETE. Grant Number: UID/CTM/00264/2019
FCT/MCTE
Sastav eteriÄnog ulja biljke Teucrium scordium L.
Composition of the essential oil obtained from dried flowering aerial parts of Teucrium scordium L. (Labiatae) was analyzed by GC and GC/MS. Fifty-six components were identified in the essential oil of T. scordium. The major constituents of the oil were betha-caryophyllene (22.8%), (E)-betha-farnesene (10.4%), caryophyllene oxide (8.6%), 1,8-cineole (6.1%) and betha-eudesmol (5.1%).Sastav eteriÄnog ulja iz osuĆĄenih nadzemnih dijelova biljke Teucrium scordium L. (Labiatae) u cvatu analiziran je pomoÄu GC i GC/MS. Identificirano je pedeset ĆĄest komponenata, a najvaĆŸniji sastojci ulja su beta-kariofilen (22,8%), (E)-beta-farnesen (10,4%), oksid kariofilen (8,6%), 1,8-cineol (6,1%) i beta-eudezmol (5,1%)
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