Single high-dose buprenorphine for opioid craving during withdrawal.

BackgroundOpioid use disorder is one of the most prevalent addiction problems worldwide. Buprenorphine is used as a medication to treat this disorder, but in countries where buprenorphine is unavailable in combination with naloxone, diversion can be a problem if the medication is given outside a hospital setting.ObjectiveThe objective of this research is to evaluate the effect of a single, high dose of buprenorphine on craving in opioid-dependent patients over 5 days of abstinence from use of other opioids. The primary goal was to determine the safety and efficacy of buprenorphine during withdrawal in a hospital setting.MethodsNinety men who used opium, heroin, or prescribed opioids and met DSM-5 criteria for opioid use disorder (severe form) were randomized to three groups (n = 30 per group) to receive a single, sublingual dose of buprenorphine (32, 64, or 96 mg). The study was conducted in an inpatient psychiatric ward, with appropriate precautions and monitoring of respiratory and cardiovascular measures. Buprenorphine was administered when the patients were in moderate opiate withdrawal, as indicated by the presence of four to five symptoms. A structured clinical interview was conducted, and urine toxicology testing was performed at baseline. Self-reports of craving were obtained at baseline and on each of the 5 days after buprenorphine administration.FindingsCraving decreased from baseline in each of the three groups (p < 0.0001), with a significant interaction between group and time (p < 0.038), indicating that groups with higher doses of buprenorphine had greater reduction.ConclusionsA single, high dose of buprenorphine can reduce craving during opioid withdrawal; additional studies with follow-up are warranted to evaluate safety

Effect of Milk thistle plant, Vitis vinifera extract on immune system of rainbow trout (Oncorhynchus mykiss) challenge by diazinon

The pollutants due to effect on the immune system of fish increase fish sensitivity to pathogens. Diazinon is one of the most used organophosphates pesticide in many agricultural areas. This study aimed to evaluate the effect of diazinon on the immune system of rainbow trout (Oncorhynchus mykiss) and application of Milk thistle plant, Vitis vinifera extract to reduce the adverse effects of this pesticide on its immune system. The reduction in the level of plasma peroxides, IgM, total complement and lysozyme were observed in fish exposed to diazinon showing its effect on the fish's immune system. No significant difference between control group and fish fed by Milk thistle plant extract and exposed to diazinon can reflect protective impact of Milk thistle plant extract on the immune system of rainbow trout by eliminating the free radicals and boosting the immune system

Are Nursing Students’ Thesis Topics in Accordance with Burden of Diseases as Disability Adjusted Life Years in Iran?

Introduction: Research is the basis of nursing and should be in accordance with society’s health needs. The purpose of this study was to determine whether the master theses’ subjects in nursing conform to the burden of diseases as Disability Adjusted Life Years (DALYs). Methods: In this comparative study, 373 researches registered in the lists of school libraries or university web sites as master degree theses in nursing during 2000-2005, were investigated. Then, their subjects were compared with the etiology of burden of diseases as Disability Adjusted Life Years in Eastern Mediterranean Region published in World Health Organization Report in 2003. Results: The proportion of theses’ topics and the etiology of burden of diseases, including intentional and unintentional accidents, sensory disorders, congenital anomalies, gastrointestinal and dental diseases, respiratory diseases , nutritional deficiencies and endocrine disorders was less than optimum. In contrast, the proportion of theses’ topics on cardiovascular, genitourinary, dermatology and musculoskeletal diseases, diabetes mellitus, neoplasms and maternal and antenatal problems was more than the related DALYs. In addition it was optimum for neuropsychological disorders. Conclusion: Most theses’ topics were in accordance with this health index. Considering the high number of theses concerning maternal situation, specially ante-natal problems and also, urogenital tract, it is suggested to avoid this over attention and consider other topics such as accidents and their burden more, in doing research and thesis

Post-Traumatic Pulmonary Pseudocyst following Blunt Chest Trauma; a Case Report

Traumatic pulmonary pseudocyst is a rare complication of chest trauma that has been poorly documented and usually resolves without specific treatment. Here, we present a case of pulmonary pseudocyst in a child with chest trauma without obvious symptoms. It is important to consider this diagnosis in patients with chest trauma to avoid unnecessary invasive procedures

A Comparison Between Cyclone Separator Efficiency Enhancement Using Ferrous Powder And Additional Tangential Chamber

Paper presented at 2018 Canadian Society of Mechanical Engineers International Congress, 27-30 May 2018.This paper provides a comparison between the separation efficiency in cyclones separators using two optimization techniques. separation optimizations using ferrous powder, and additional tangential chamber were investigated. The proposed techniques show separation efficiency enhancements compared to the basic cyclone separator design. The separation ratio efficiency, Ԑsp, is evaluated by calculating the outlet to inlet count ratio. Similar to experimental studies in the literature, the inlet and outlet particle counts were evaluated using discretization techniques with the help of a microscope and a membrane collecting the dust at the outlet. It is observed from the two optimization techniques that the addition of ferrous powder while attracting it through magnetic forces provides an additional separation enhancement by 2% for 11 μm particles sizes. This advantage comes with a total of 25% efficiency enhancement for 4 μm particles compared to conventional designs. This study gives an insight on the different approaches proposed

Investigating the Causes of Elderly People Leaving Home during Coronavirus Disease-19 Epidemic

BACKGROUND: Coronavirus disease-19 (COVID-19) disease affects all age groups, especially the elderly, and regarding the high mortality rate among the elderly, preventive measures are needed to reduce mortality in the elderly. AIM: This study was conducted to investigate the causes of in elderly people leaving home in time of COVID-19 epidemic. METHODS: The present study is a descriptive-analytical study performed on 1656 elderly people in Urmia, Iran, by simple random sampling method. The data collection tool in this study was a researcher-made questionnaire that included demographic characteristics, a questionnaire on the causes of the elderly leaving home during the COVID-19 epidemic. Data were analyzed using Chi-square and Fisher tests using SPSS 23 software. RESULTS: The results revealed that the highest concern of the elderly to leave home was to receive health services (45.89%) such as visiting the doctor or the caregiver, receiving medication, and so on. As the second priority, buying daily necessities such as bread, food, clothes … (42.75%) was one of the reasons for the elderly to leave home. Furthermore, education, gender, age, underlying diseases, occupation, and living conditions of the elderly were related to the needs of health services and living necessities and this relationship was statistically significant (p < 0.05). CONCLUSION: Effective interventions should be designed based on the causes of the elderly leaving home, including the use of home distance care and health ambassadors to estimate the needs and causes of leaving home. Therefore, the elderly would be protected from this disease and its mortality

Replacing Sugar by Date Syrup in Gaz and Investigation of Texture Properties

Date Syrup is a natural sweetener that is suitable replacement for sugar in food stuffs formulation. In this Research Amounts of 25-100 percent of sugar in Gaz formulation were replaced with date syrup and to study effect of its use in product formulation, characteristics of texture, color and sensory analyse of treatments were investigated. Statistical analyse of data was also done by SPSS software and Dankan test. The results of this research showed that amount of used date syrup in formulation had a significant effect on color parameters (L*,a*,b*), texture characteristics and sensory analyse of samples. By increase of date syrup in Gaz formulation, samples texture became softer than control sample and yellowness and redness index of samples were increasedDoi: DOI: 10.12777/ijse.6.1.11-15 [How to cite this article: Shafiei, Z., Hojjatoleslami, M., Soha, S., and Shariati, M.A. 2014. The Influence of Malt Extraction Adding to UF Fresh Low Fat Cheese on Its Textural Properties. International Journal of Science and Engineering, 6(1):57-60. Doi: 10.12777/ijse.6.1.11-1

Effects of Plyometric Jump Training in Sand or Rigid Surface on Jump-Related Biomechanical Variables and Physical Fitness in Female Volleyball Players

Background: This study aims to assess the effects of 8 weeks of plyometric jump training (PJT) conducted on sand or a rigid court surface on jump-related biomechanical variables and physical fitness in female indoor volleyball players. Methods: Seventeen participants were randomly divided into a sand surface group (SsG, n = 8) and rigid surface group (RsG, n = 9). Both groups completed equal indoor volleyball training routines. Participants were assessed pre and post the 8-week PJT for jump-related biomechanical variables (countermovement jump (CMJ) RSI; drop jump (DJ) reactive strength index (RSI); spike jump (SJ) height; CMJ height; CMJ rate of force development (RFD); CMJ velocity at take-off; DJ height and CMJ peak force), 20 m linear sprint time, t test for change-of-direction sprint (CODs) time, Wingate test peak power (PP), cardiorespiratory endurance, and leg-press one-repetition maximum (1RM). Results: A two-way mixed analysis of variance (group × time) revealed that there was a significant group × time interaction between DJ height (p = 0.035) and CMJ peak force (p = 0.032) in favour of RsG and SsG, respectively. A significant interaction was also observed for cardiorespiratory endurance (p = 0.01) and 1RM (p = 0.002), both favouring the SsG. No other group × time interaction was observed. Conclusions: The type of surface used during PJT induced specific adaptations in terms of jump-related biomechanical variables and physical fitness in female indoor volleyball players. Based on the individual needs of the athletes, practitioners may prescribe one type of surface preferentially over another to maximize the benefits derived from PJT

Does Endometrial Compaction Predict Clinical Pregnancy Rate after Cleavage Stage Frozen Embryo Transfer?

Objectives: This study aimed to determine the relationships between endometrial compaction and pregnancy outcome in patients receiving artificial endometrial preparation for frozen embryo transfer (FET) cycles. Materials and Methods: This prospective cohort study was performed in a university-affiliated fertility clinic from March 2020 to March 2021. The eligible women undergoing their first or second FET cycle and having the top grading cleavage stage embryos were enrolled. All patients received the same endometrial preparation regime. The alteration in endometrial thickness (EMT) between the day of progesterone initiation and the day of embryo transfer (ET) was measured using consecutive transvaginal sonography. The patients were divided into three groups based on the percentage of endometrial compaction (i.e., the difference of EMT at end of the estrogen-only phase and after three days of progesterone administration (ET day) divided by the EMT on the terminal day of the estrogen-only exposure). Results: Overall, 300 eligible women were evaluated and only 27.3% (82/300) of the studied cycles showed ≥5% compaction, whereas 72.6% (218/300) either expanded or showed minimal compaction. The clinical and ongoing pregnancy rates in group 2 (any expansion) were significantly higher than those in groups 1 and 3 (P=0.002 and P=0.01, respectively). Multivariable logistic regression test indicated that the cycles with any expansion in ET were independently associated with 3.1 times improvement in clinical pregnancy rate in comparison to those with any compaction (P=0.002). Conclusion: Gross endometrial compaction occurred in one-third of FET cycles with no significant positive effect on pregnancy outcomes after cleavage-stage ET