Enrutamiento de almacenes cruzados considerando ventanas de tiempo y precios de ruta (estudio de caso: transporte de contenedores del puerto de Chabahar)

In this study, we develop a model for routing cross-docking centers considering time windows and pricing routs. In this model picking and delivery in several times is permitted and each knot can be serviced by more than one vehicle. Every truck can transport one or more product, in other words, we consider compatibility between product and vehicle. This model includes two goals: reducing the total cost and reducing the cost of carrying goods (freight fare). The total cost includes the cost required to traverse between the points, the cost of traversing the routes between the central cross-docking center and the first points after moving, and the cost to traverse the routes between the last points in each route and the depots that must be minimized. In general, the purpose of the model is to obtain the number of cross-docking center, the number of vehicles and the best route in the distribution network. We present a nonlinear programming model for this problem. We have solved the proposed model by GAMS. As the dimensions of the problem increase, the implementation time of the program increases progressively. So, in order to solve the model in medium and large scales, we proposed a genetic meta-heuristic algorithm. The results of examining different issues by the meta-heuristic approach show the very high efficiency of the developed algorithms in terms of the solution time and the answer of the problem.En esta investigación, se presenta un modelo para el enrutamiento entre almacenes con ventanas de tiempo y precios de ruta. En este modelo, se permite la recogida y entrega en varias ocasiones y cada nodo puede recibir servicio con más de un vehículo. Cada camión puede transportar uno o más tipos de mercancías, es decir, se considera la compatibilidad entre la mercancía y el vehículo. En este modelo, hay dos objetivos, que incluyen reducir el costo total y reducir el precio de envío de mercancías (flete). El costo total incluye el costo de recorrer los senderos entre los puntos, el costo de recorrer los senderos entre el almacén de la intersección central y los primeros puntos después de la salida, y el costo de recorrer los senderos entre los últimos puntos de cada sendero y los almacenes que deben minimizarse. En general, el propósito del modelo es obtener el número de almacenes, el número de vehículos y la mejor ruta en la red de distribución. Y presentamos un modelo de programación no lineal para este problema. Hemos resuelto el modelo propuesto con GAMS. A medida que aumenta el tamaño del problema, el tiempo de ejecución del programa aumenta considerablemente. Por tanto, para resolver el modelo en medianas y grandes dimensiones, presentamos el algoritmo genético metaheurístico. Los resultados de examinar varios problemas con metaheurísticas muestran la altísima eficiencia de los algoritmos propuestos en términos de tiempo de resolución de problemas

Enrutamiento de almacenes cruzados considerando ventanas de tiempo y precios de ruta (estudio de caso: transporte de contenedores del puerto de Chabahar)

In this study, we develop a model for routing cross-docking centers considering time windows and pricing routs. In this model picking and delivery in several times is permitted and each knot can be serviced by more than one vehicle. Every truck can transport one or more product, in other words, we consider compatibility between product and vehicle. This model includes two goals: reducing the total cost and reducing the cost of carrying goods (freight fare). The total cost includes the cost required to traverse between the points, the cost of traversing the routes between the central cross-docking center and the first points after moving, and the cost to traverse the routes between the last points in each route and the depots that must be minimized. In general, the purpose of the model is to obtain the number of cross-docking center, the number of vehicles and the best route in the distribution network. We present a nonlinear programming model for this problem. We have solved the proposed model by GAMS. As the dimensions of the problem increase, the implementation time of the program increases progressively. So, in order to solve the model in medium and large scales, we proposed a genetic meta-heuristic algorithm. The results of examining different issues by the meta-heuristic approach show the very high efficiency of the developed algorithms in terms of the solution time and the answer of the problem.En esta investigación, se presenta un modelo para el enrutamiento entre almacenes con ventanas de tiempo y precios de ruta. En este modelo, se permite la recogida y entrega en varias ocasiones y cada nodo puede recibir servicio con más de un vehículo. Cada camión puede transportar uno o más tipos de mercancías, es decir, se considera la compatibilidad entre la mercancía y el vehículo. En este modelo, hay dos objetivos, que incluyen reducir el costo total y reducir el precio de envío de mercancías (flete). El costo total incluye el costo de recorrer los senderos entre los puntos, el costo de recorrer los senderos entre el almacén de la intersección central y los primeros puntos después de la salida, y el costo de recorrer los senderos entre los últimos puntos de cada sendero y los almacenes que deben minimizarse. En general, el propósito del modelo es obtener el número de almacenes, el número de vehículos y la mejor ruta en la red de distribución. Y presentamos un modelo de programación no lineal para este problema. Hemos resuelto el modelo propuesto con GAMS. A medida que aumenta el tamaño del problema, el tiempo de ejecución del programa aumenta considerablemente. Por tanto, para resolver el modelo en medianas y grandes dimensiones, presentamos el algoritmo genético metaheurístico. Los resultados de examinar varios problemas con metaheurísticas muestran la altísima eficiencia de los algoritmos propuestos en términos de tiempo de resolución de problemas

Rolle von aseptischen Entzündungsprozessen im Liquor cerebrospinalis für den Schmerz und den Schweregrad der Polyneuropathie

Die vorliegende Arbeit ging folgenden Fragestellungen nach: 1. Liegen bei den Patienten mit einer schmerzhaften PNP im Vergleich zu Patienten mit einer nicht schmerzhaften PNP signifikante Unterschiede im Liquorprofil im Rahmen einer retrospektiven Untersuchung vor, die die Hypothese unterstützen würden, dass ein aseptischer Entzündungsprozess bei der Entstehung und Aufrechterhaltung von neuropathischen Schmerzen im Zusammengang mit einer PNP eine Rolle spielt? 2. Liegen bei den Patienten mit einer schweren PNP im Vergleich zu Patienten mit einer nicht schweren PNP signifikante Unterschiede im Liquorprofil im Rahmen einer ret- rospektiven Untersuchung vor, die die Hypothese unterstützen würden, dass ein aseptischer Entzündungsprozess bei der Entstehung und Aufrechterhaltung vom Schweregrad einer PNP eine Rolle spielt? Hierzu wurden Daten von 1243 Patienten mit der Diagnose Polyneuropathie untersucht, nach Anwendung der definierten Ein- und Ausschlusskriterien wurden 60 Patienten für die Untersuchung selektiert. Die erhobenen Daten im Liquor wurden nach einer statistischen Signifikanz mittels eines U-Tests definiert und nach einem P-Wert < 0,05 untersucht. Aseptische Entzündungsvorgänge im Sinne einer gesteigerten Zytokinproduktion und Akti- vierung des Immunsystems und Mikroglia im zentralen Nervensystem scheinen bei der In- duktion und Unterhaltung neuropathischer Schmerzen im Rahmen peripherer Nervenläsio- nen neben anderen pathophysiologischen Mechanismen eine Rolle zu spielen. Diese These wird durch das Vorliegen von statistisch signifikanten Unterschieden bei den ermittelten Werten im Sinne von erhöhten Werten im Liquor in der Gruppe der schmerzhaften PNP für Gesamtprotein (P-Wert 0,040*), IgA (P-Wert 0,016*) und IgG (P-Wert 0,048*) unterstützt. Diesbezüglich sind jedoch weitere Forschungen zur spezifischen Untersuchung und Klärung dieser Hypothese erforderlich

Developing and ranking strategies for machinery companies via QSPM and SWOT matrix: A case study in Toolid Atash machinery company

This paper aims to develop financial strategies for Toolid Atash Company in order to achieve product development and product improvement. For this task, we worked in a team consisting of four groups-mates and two company staff. The team helped us to explicate and clarify the mission and vision of the company. Using internal factor evaluation matrix and external factor evaluation matrix; the strengths, weaknesses, opportunities and threats of the company were detected. Then, SWOT matrix was completed. In addition, the competitive position of the company was identified via a competitive evaluation matrix. Regarding SWOT matrix and competitors some proper strategy for these sorts of companies was developed and ranked based on QSPM matrix

Ground state of the staggered Heisenberg-Γ\Gamma honeycomb model in a magnetic field

We study the ground state properties of the $S=\frac{1}{2}$ staggered Heisenberg-$\Gamma$ honeycomb model under a magnetic field based on analytical and numerical methods. Our calculations show that the conventional zigzag and stripy phases are favored because of the staggered Heisenberg interaction away from the pure $\Gamma$ limit. In our classical analysis, we find that the field induces a series of competing magnetic phases with relatively large unit cells in the region sandwiched between the two magnetic phases with long-range ordering. In the quantum treatment, these large magnetic unit cells are destabilized by strong quantum fluctuations that result in the stabilization of a gapless quantum spin liquid behavior. In a honeycomb $\Gamma$ magnet, we disclose an intermediate-field gapless quantum spin liquid phase driven by a tilted field away from the out-of-plane direction only for a narrow region between the low-field zigzag and high-field fully polarized phases.Comment: 12 pages, 12 figure

Developing and ranking strategies for machinery companies via QSPM and SWOT matrix: A case study in Toolid Atash machinery company

This paper aims to develop financial strategies for Toolid Atash Company in order to achieve product development and product improvement. For this task, we worked in a team consisting of four groups-mates and two company staff. The team helped us to explicate and clarify the mission and vision of the company. Using internal factor evaluation matrix and external factor evaluation matrix; the strengths, weaknesses, opportunities and threats of the company were detected. Then, SWOT matrix was completed. In addition, the competitive position of the company was identified via a competitive evaluation matrix. Regarding SWOT matrix and competitors some proper strategy for these sorts of companies was developed and ranked based on QSPM matrix

Developing and ranking strategies for machinery companies via QSPM and SWOT matrix: A case study in Toolid Atash machinery company

This paper aims to develop financial strategies for Toolid Atash Company in order to achieve product development and product improvement. For this task, we worked in a team consisting of four groups-mates and two company staff. The team helped us to explicate and clarify the mission and vision of the company. Using internal factor evaluation matrix and external factor evaluation matrix; the strengths, weaknesses, opportunities and threats of the company were detected. Then, SWOT matrix was completed. In addition, the competitive position of the company was identified via a competitive evaluation matrix. Regarding SWOT matrix and competitors some proper strategy for these sorts of companies was developed and ranked based on QSPM matrix

The Effect of Exchange Rate and Exchange Rate Uncertainty on Domestic Consumption in SAARC Member Countries from 2005 to 2020

The exchange rate and its uncertainty are the key economic variables that influence other macroeconomic variables through various channels. Domestic consumption will be influenced by the exchange rate and its uncertainty. This research investigates the impact of the exchange rate and its uncertainty on the private sector consumption of the member countries of the South Asian Association for Regional Cooperation (SAARC) from 2005 to 2020. The data has been extracted from the World Bank websites, the Asian Development Bank, and the Ministry of Finance of Afghanistan. The uncertainty of the exchange rate data has been extracted using the ARCH method, and the research model has been estimated using the GLS method. The research results indicate that the exchange rate and its uncertainty have a significant and positive effect on private-sector consumption. The positive relationship between the exchange rate and its uncertainty with consumption is consistent with the theory of currency pass-through. Additionally, the impact of income on domestic consumption is positive and statistically significant, while the impact of government consumption expenditure on private-sector consumption is negative and significant