EFEKTIVITAS MODEL PEMBELAJARAN SENAM MELALUI MEDIA VIDEO PADA SISWA KELAS IX SMPN 2 KOTA BANDUNG

Dalam praktek dilapangan, khususnya pada materi senam lantai siswa terkesan kurang memahami peragaan yang diberikan. Senam lantai yang mengutamakan kelenturan tubuh menuntut peserta didik memahami awalan dalam gerakannya agar tidak menimbulkan cidera ketika memaksakan suatu gerakan. Pemaparan video yang baik dan terperinci dapat dengan mudah menstimuli peserta didik dalam memperagakan setiap gerakan, Metode yang digunakan pada penelitian ini adalah Penelitian Tindakan Kelas (PTK). Penelitian Tindakan Kelas adalah suatu kegiatan ilmiah yang dilakukan oleh guru dalam suatu kelas dengan jalan merancang, melaksanakan,mengamati, dan merefleksi tindakan melalui beberapa siklus secara kolaboratif dan partisipatif dengan tujuan untuk memperbaiki atau meningkatkan kualitas pembelajaran di kelas tersebut Penilaian dari 32 siswa adalah (1) aspek afektif dengan rerata presentase 100% dengan kriteria “Sangat Baik” (2) aspek Kognitif dengan rerata presentase 95% dengan kriteria “Sangat Baik” dan (3) aspek psikomotor dengan rerata presentase 98% dengan kriteria “Sangat Baik”. Penilaian guru menunjukkan bahwa pembelajaran senam lantai menggunakan media video memiliki kualitas yang “Sangat Baik“ dengan rerata presentase keseluruhan 97,6%.Penggunaan video pembelajaran di SMPN 2 Bandung dinilai efektif untuk meningkatkan daya tarik dan perhatian siswa dalam belajar, hal ini bisa diketahui melalui nilai siswa yang berkriteria “Sangat Baik”. Penggunaan video pembelajaran juga dapat meningkatkan perhatian siswa sehingga suasana belajar lebih menyenangkan dan menarik minat siswa dalam belajar sehingga siswa tidak merasa bosan ketika pembelajran berlangsung Keyword : Pembelajaran, media video, senam lantai

SA-18 Retrospective Study of Feline Panleukopenia Virus in Jakarta

Feline Panleukopenia Virus (FPV) is caused by feline parvovirus, a single stranded DNA virus. This virus is a fatal and highly contagious in cats. Control of this disease is complicated by environmental resistance, the shedding of high viral loads and interspecies transmission. Cats all of ages may be affected by FPV but kittens are most susceptible. Signs of disease include diarrhea, lymphopenia, neutropenia, followed by thrombocytopenia and anemia, cerebellar ataxia (in kittens only), abortion and immunosuppression (transient in adult cats) (Truyen et. al 2009). The severity of clinical sign depends on the immune status of the animal and the present of other infections (Rodriguez and Guererro 2017).In Jakarta, the prevalence rate of this viral infection believed still high, but there were only few studies has been reported. The aim of this study were to provide the retrospective data of prevalence rate and survival rate concerning ages and concurrent disease of cats infected by FPV in Veterinary Clinic Drh. Cucu K. Sajuthi and Assosiate, Jakarta, Indonesia

Comparative genetic architectures of schizophrenia in East Asian and European populations

Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk globally. Large-scale schizophrenia genetic studies have reported primarily on European ancestry samples, potentially missing important biological insights. Here, we report the largest study to date of East Asian participants (22,778 schizophrenia cases and 35,362 controls), identifying 21 genome-wide-significant associations in 19 genetic loci. Common genetic variants that confer risk for schizophrenia have highly similar effects between East Asian and European ancestries (genetic correlation = 0.98 ± 0.03), indicating that the genetic basis of schizophrenia and its biology are broadly shared across populations. A fixed-effect meta-analysis including individuals from East Asian and European ancestries identified 208 significant associations in 176 genetic loci (53 novel). Trans-ancestry fine-mapping reduced the sets of candidate causal variants in 44 loci. Polygenic risk scores had reduced performance when transferred across ancestries, highlighting the importance of including sufficient samples of major ancestral groups to ensure their generalizability across populations

Mapping genomic loci implicates genes and synaptic biology in schizophrenia

Schizophrenia has a heritability of 60-80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies

Mapping genomic loci prioritises genes and implicates synaptic biology in schizophrenia

Schizophrenia has a heritability of 60–80%1, much of which is attributable to common risk alleles. Here, in a two-stage genome-wide association study of up to 76,755 individuals with schizophrenia and 243,649 control individuals, we report common variant associations at 287 distinct genomic loci. Associations were concentrated in genes that are expressed in excitatory and inhibitory neurons of the central nervous system, but not in other tissues or cell types. Using fine-mapping and functional genomic data, we identify 120 genes (106 protein-coding) that are likely to underpin associations at some of these loci, including 16 genes with credible causal non-synonymous or untranslated region variation. We also implicate fundamental processes related to neuronal function, including synaptic organization, differentiation and transmission. Fine-mapped candidates were enriched for genes associated with rare disruptive coding variants in people with schizophrenia, including the glutamate receptor subunit GRIN2A and transcription factor SP4, and were also enriched for genes implicated by such variants in neurodevelopmental disorders. We identify biological processes relevant to schizophrenia pathophysiology; show convergence of common and rare variant associations in schizophrenia and neurodevelopmental disorders; and provide a resource of prioritized genes and variants to advance mechanistic studies

Implementation of Scrum Method on MVC-Based Sembakoqu Website

Sembakoqu is a personal online distributor website for selling various kinds of food. With prices and foodstuffs that always go up and people's purchasing power decreases because it is necessary to come to the distributor's place. The purpose of this study is to create an online distributor website to make it easier for the public to find savings in their household and business raw material expenses. In this research, the development of the website system uses the Scrum method which is part of the agile method which can produce good quality software according to user desires. This method has a flexible nature that can be applied to the development of the Sembakoqu system by implementing a computerized payment and reporting system. The testing phase used on this website uses the blackbox method by emphasizing testing on functionality. For application development suggestions that can be carried out in further research, namely the system can be developed into a mobile application, so that consumers can order products on their smartphone devices

Hubungan antara Kadar Seng dalam Serum dengan Fungsi Eksekutif pada Anak dengan Gangguan Pemusatan Perhatian dan Hiperaktivitas (GPPH)

Latar belakang. Belum ada hubungan yang jelas antara kadar seng serum dengan gangguan fungsi eksekutif pada anak dengan GPPH. Tujuan. Mengidentifikasi perbedaan rerata kadar seng dalam serum anak GPPH dengan gangguan dan tanpa gangguan fungsi eksekutif, anak non-GPPH, serta mendapatkan korelasi antara kadar seng dalam serum dengan fungsi eksekutif. Metode. Penelitian potong-lintang yang disertai dengan kelompok kontrol. Dari dua sekolah dasar di Jakarta, secara acak diambil 90 anak sebagai subjek penelitian yang terbagi dalam 3 kelompok, yaitu anak GPPH dengan gangguan (n=30) dan tanpa gangguan (n=30) fungsi eksekutif, serta non-GPPH (n=30). Kadar seng serum diperiksa dengan metode ICP-MS di Laboratorium Prodia Jakarta. Fungsi eksekutif didapatkan melalui kuesioner BRIEF versi Bahasa Indonesia. Analisis data menggunakan SPPS for Windows versi 20. Hasil. Dari seluruh subjek penelitian, 75% mengalami defisiensi seng. Kadar seng tidak normal terdapat pada 60% anak GPPH dengan gangguan fungsi eksekutif. Rerata serum seng pada kelompok anak GPPH dengan gangguan dan tanpa gangguan fungsi eksekutif, serta non-GPPH berturut-turut 59,40, 55,36, dan 52,93 μg/dL. Tidak dijumpai perbedaan rerata seng di antara tiga kelompok tersebut (p=0,119). Koefisien korelasi antara kadar seng serum dengan fungsi eksekutif adalah r=0,128. Kesimpulan. Kadar seng serum diduga tidak berhubungan secara langsung dengan gangguan fungsi eksekutif, tetapi lebih berhubungan dengan gejala klinis GPPH yang menyerupai beberapa gejala gangguan fungsi eksekuti

Tenofovir Disoproxil Fumarate Prenatal as A Complementary Treatment to Prevent Vertical Transmission of Hepatitis B Virus: A Systematic Review

Abstract Vertical transmission is the dominant transmission method in hepatitis B endemic countries. Immunoprophylactic protocols leave 1% to 4% of infants with a higher risk of immunoprophylactic failure. Within the last ten years, publications regarding the use of prenatal Tenofovir disoproxil fumarate (TDF) have been continuously updated. TDF is preferred because of its potency and lower risk of resistance than lamivudine and telbivudine. The studies analyzed in this systematic review consisted of 2 RCT and 7 NRCT studies, involving 3,765 participants. Six studies described a reduction in viral load HBV DNA levels in the intervention group. Furthermore, five studies reported a decrease in the vertical transmission rate higher than the control group, proven with positive HBsAg parameters at newborns in the intervention group. All studies in this systematic review show a reduced risk of immunoprophylactic failure in the intervention group, proven with negative HBsAg and anti-HBs status when infants were 6-12 months old. There were no significant differences between the intervention and control groups in all studies from a safety point of view. Administration of prenatal TDF and the prophylactic protocol can reduce the vertical transmission rate and the risk of immunoprophylactic failure without causing significant adverse effects both during pregnancy and in infants. Given the consideration, the public health sector and physicians should consider TDF prenatal as a complementary treatment to prevent vertical transmission