The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study

AIM: The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery. METHODS: This was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin. RESULTS: Overall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P < 0.001). After adjustment, delay was not associated with a lower rate of complete resection (OR 1.18, 95% CI 0.90-1.55, P = 0.224), which was consistent in elective patients only (OR 0.94, 95% CI 0.69-1.27, P = 0.672). Longer delays were not associated with poorer outcomes. CONCLUSION: One in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease

Aprendizagem Ubíqua Sensível ao Contexto: Mapeamento Sistemático da Literatura Sobre Ambientes de Aprendizagem Ubíqua

Ambientes de aprendizagem ubíqua (u-learning) sensíveis ao contexto são sistemas aplicados no domínio da educação, caracterizados pela capacidade de coletar informações do contexto do aluno e modificar seu comportamento, adaptando-se às característica e necessidades de aprendizagem do aluno. Além disso, outra característica importante da u-learning é prover acesso aos recursos computacionais de aprendizagem em qualquer lugar e a qualquer hora, independente de tipo de dispositivo do usuário. Diante deste novo cenário, ainda desconhecido para a maioria da comunidade acadêmica, este artigo se propõe a investigar os ambientes u-learning sensíveis ao contexto propostos na literatura da área e conhecer os serviços educacionais e os tipos de contexto utilizados nesses ambientes, por meio de um mapeamento sistemático da literatura.Context-sensitive ubiquitous learning (u-learning) environments are systems applied in the field of education, characterized by the ability to collect information from the student's context and modify your behavior, adapting to the characteristics and student's learning needs. In addition, another important feature of ulearning is to provide access to computing learning resources anywhere, anytime, regardless of the user's device type. Faced with this new scenario, still unknown to most of the academic community, this paper proposes to investigate the context-sensitive u-learning environments, proposed in the literature of the area, to know the educational services and the types of context used in these environments, through a systematic mapping of the literature.info:eu-repo/semantics/publishedVersio

The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study

The SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery

The impact of surgical delay on resectability of colorectal cancer: An international prospective cohort study

AimThe SARS-CoV-2 pandemic has provided a unique opportunity to explore the impact of surgical delays on cancer resectability. This study aimed to compare resectability for colorectal cancer patients undergoing delayed versus non-delayed surgery.MethodsThis was an international prospective cohort study of consecutive colorectal cancer patients with a decision for curative surgery (January-April 2020). Surgical delay was defined as an operation taking place more than 4 weeks after treatment decision, in a patient who did not receive neoadjuvant therapy. A subgroup analysis explored the effects of delay in elective patients only. The impact of longer delays was explored in a sensitivity analysis. The primary outcome was complete resection, defined as curative resection with an R0 margin.ResultsOverall, 5453 patients from 304 hospitals in 47 countries were included, of whom 6.6% (358/5453) did not receive their planned operation. Of the 4304 operated patients without neoadjuvant therapy, 40.5% (1744/4304) were delayed beyond 4 weeks. Delayed patients were more likely to be older, men, more comorbid, have higher body mass index and have rectal cancer and early stage disease. Delayed patients had higher unadjusted rates of complete resection (93.7% vs. 91.9%, P = 0.032) and lower rates of emergency surgery (4.5% vs. 22.5%, P ConclusionOne in 15 colorectal cancer patients did not receive their planned operation during the first wave of COVID-19. Surgical delay did not appear to compromise resectability, raising the hypothesis that any reduction in long-term survival attributable to delays is likely to be due to micro-metastatic disease

Measurement of the forward-backward asymmetry of electron and muon pair-production in pp collisions at s ? =7

This paper presents measurements from the ATLAS experiment of the forward-backward asymmetry in the reaction pp -> Z/gamma* -> l(+)l(-), with l being electrons or muons, and the extraction of the effective weak mixing angle. The results are based on the full set of data collected in 2011 in pp collisions at the LHC at root s = 7 TeV, corresponding to an integrated luminosity of 4.8 fb(-1). The measured asymmetry values are found to be in agreement with the corresponding Standard Model predictions. The combination of the muon and electron channels yields a value of the effective weak mixing angle of sin(2) theta(lept)(eff) = 0.2308 +/- 0.0005(stat.)+/- 0.0006(syst.)+/- 0.0009(PDF), where the first uncertainty corresponds to data statistics, the second to s ystematic effects and the third to knowledge of the parton density functions. This result agrees with the current world average from the Particle Data Group fit

Measurement of the cross-section for W boson production in association with b-jets in pp collisions at root s=7 TeV with the ATLAS detector

"This paper reports a measurement of the W+b-jets (W+b+X and W+b (b) over bar +X) production cross-section in proton-proton collisions at a centre-of-mass energy of 7 TeV at the LHC. These results are based on data corresponding to an integrated luminosity of 4.6 fb(-1), collected with the ATLAS detector. Cross-sections are presented as a function of jet multiplicity and of the transverse momentum of the leading b-jet for both the muon and electron decay modes of the W boson. The W+b-jets cross-section, corrected for all known detector effects, is quoted in a limited kinematic range. Combining the muon and electron channels, the fiducial cross-section for W+b-jets is measured to be 7.1 +\/- 0.5 (stat) +\/- 1.4 (syst) pb, consistent with the next-to-leading order QCD prediction, corrected for non-perturbative and double-parton interactions (DPI) contributions, of 4.70 +\/- 0.09 (stat) (+0.60)(-0.49) (scale) +\/- 0.06 (PDF) +\/- 0.16 (non-pert) (+0.52)(-0.38) (DPI) pb.