Rola terapii biologicznej w podtrzymaniu remisji u dzieci z chorobą Leśniowskiego i Crohna

AbstractIn recent years there has been an increase in the incidence of inflammatory bowel disease including Crohn's disease in children. The aim of treatment of Crohn's disease is the induction and maintenance of remission. Currently, it is believed that to achieve healing of the intestinal mucosa may be synonymous with getting complete remission and inhibition of disease progression. Biologics and immunomodulators have a definite place in the treatment of Crohn disease. However, there are no clear guidelines on the efficacy and safety of these two classes of drugs for the children treatment. In addition, questions about the safety of long-term use of biological drugs as well as the best moment of their inclusion needs further reaserch

Variability in transport of terrigenous material on the shelves and the deep Arctic Ocean during the Holocene

Arctic coastal zones serve as a sensitive filter for terrigenous matter input onto the shelves via river discharge and coastal erosion. This material is further distributed across the Arctic by ocean currents and sea ice. The coastal regions are particularly vulnerable to changes related to recent climate change. We compiled a pan-Arctic review that looks into the changing Holocene sources, transport processes and sinks of terrigenous sediment in the Arctic Ocean. Existing palaeoceanographic studies demonstrate how climate warming and the disappearance of ice sheets during the early Holocene initiated eustatic sea-level rise that greatly modified the physiography of the Arctic Ocean. Sedimentation rates over the shelves and slopes were much greater during periods of rapid sea-level rise in the early and middle Holocene, as a result of the relative distance to the terrestrial sediment sources. However, estimates of suspended sediment delivery through major Arctic rivers do not indicate enhanced delivery during this time, which suggests enhanced rates of coastal erosion. The increased supply of terrigenous material to the outer shelves and deep Arctic Ocean in the early and middle Holocene might serve as analogous to forecast changes in the future Arctic.Peer reviewe

Variability in transport of terrigenous material on the shelves and the deep Arctic Ocean during the Holocene

Arctic coastal zones serve as a sensitive filter for terrigenous matter input onto the shelves via river discharge and coastal erosion. This material is further distributed across the Arctic by ocean currents and sea ice. The coastal regions are particularly vulnerable to changes related to recent climate change. We compiled a pan-Arctic review that looks into the changing Holocene sources, transport processes and sinks of terrigenous sediment in the Arctic Ocean. Existing palaeoceanographic studies demonstrate how climate warming and the disappearance of ice sheets during the early Holocene initiated eustatic sea-level rise that greatly modified the physiography of the Arctic Ocean. Sedimentation rates over the shelves and slopes were much greater during periods of rapid sea-level rise in the early and middle Holocene, as a result of the relative distance to the terrestrial sediment sources. However, estimates of suspended sediment delivery through major Arctic rivers do not indicate enhanced delivery during this time, which suggests enhanced rates of coastal erosion. The increased supply of terrigenous material to the outer shelves and deep Arctic Ocean in the early and middle Holocene might serve as analogous to forecast changes in the future Arctic.Peer reviewe

Electrochemically synthesized polymers in molecular imprinting for chemical sensing

This critical review describes a class of polymers prepared by electrochemical polymerization that employs the concept of molecular imprinting for chemical sensing. The principal focus is on both conducting and nonconducting polymers prepared by electropolymerization of electroactive functional monomers, such as pristine and derivatized pyrrole, aminophenylboronic acid, thiophene, porphyrin, aniline, phenylenediamine, phenol, and thiophenol. A critical evaluation of the literature on electrosynthesized molecularly imprinted polymers (MIPs) applied as recognition elements of chemical sensors is presented. The aim of this review is to highlight recent achievements in analytical applications of these MIPs, including present strategies of determination of different analytes as well as identification and solutions for problems encountered

Management of perioperative stress in children and parents. Part I — The preoperative period

 Hospitalisation and surgery are undoubtedly one of the most difficult experiences the children and their parents have to face. The lack of appropriately provided information about treatment and other hospitalization-related aspects increases anxiety and uncertainty. Besides showing sincere empathy, physicians working with paediatric patients should know the strategies to reduce perioperative stress in children and their families. The first part of our paper describes various well-tried methods of preoperative management, some of which can be applied before hospitalization. The crucial elements of such a strategy are to dissipate the emerging doubts by providing children and parents with relevant and understandable information and to familiarise them with the hospital setting.  Hospitalisation and surgery are undoubtedly one of the most difficult experiences the children and their parents have to face. The lack of appropriately provided information about treatment and other hospitalization-related aspects increases anxiety and uncertainty. Besides showing sincere empathy, physicians working with paediatric patients should know the strategies to reduce perioperative stress in children and their families. The first part of our paper describes various well-tried methods of preoperative management, some of which can be applied before hospitalization. The crucial elements of such a strategy are to dissipate the emerging doubts by providing children and parents with relevant and understandable information and to familiarise them with the hospital setting.

Management of perioperative stress in children and parents. Part II — anaesthesia and postoperative period

The majority of children, even those well prepared and with positive attitudes, experiences stress in the operating theatre and during the postoperative period. In some cases, the stress is even stronger for their parents. The role of anaesthetists is to minimize the unpleasant sensations by providing painless vein cannulation, uneventful induction of anaesthesia, suitably planned and timed analgesia, and prevention of postoperative vomiting. The effectiveness of combined analgesics, early administration of saturating doses and analgesia supplemented or based on methods of block anaesthesia – particularly on peripheral and local blocks, less appreciated in children, have been highlighted. Such a stress-reducing strategy should be initiated before hospitalisation and consistently continued to its completion or even longer, the example of which are one-day surgery patients who should receive prescriptions for or suitable drugs (mainly analgesics) on discharge for use in the home setting. Preparation of local programmes for management reducing surgery-associated stress in children is worth recommending. The majority of children, even those well prepared and with positive attitudes, experiences stress in the operating theatre and during the postoperative period. In some cases, the stress is even stronger for their parents. The role of anaesthetists is to minimize the unpleasant sensations by providing painless vein cannulation, uneventful induction of anaesthesia, suitably planned and timed analgesia, and prevention of postoperative vomiting. The effectiveness of combined analgesics, early administration of saturating doses and analgesia supplemented or based on methods of block anaesthesia – particularly on peripheral and local blocks, less appreciated in children, have been highlighted. Such a stress-reducing strategy should be initiated before hospitalisation and consistently continued to its completion or even longer, the example of which are one-day surgery patients who should receive prescriptions for or suitable drugs (mainly analgesics) on discharge for use in the home setting. Preparation of local programmes for management reducing surgery-associated stress in children is worth recommending.

GRAINet: mapping grain size distributions in river beds from UAV images with convolutional neural networks

Grain size analysis is the key to understand the sediment dynamics of river systems. We propose GRAINet, a data-driven approach to analyze grain size distributions of entire gravel bars based on georeferenced UAV images. A convolutional neural network is trained to regress grain size distributions as well as the characteristic mean diameter from raw images. GRAINet allows for the holistic analysis of entire gravel bars, resulting in (i) high-resolution estimates and maps of the spatial grain size distribution at large scale and (ii) robust grading curves for entire gravel bars. To collect an extensive training dataset of 1491 samples, we introduce digital line sampling as a new annotation strategy. Our evaluation on 25 gravel bars along six different rivers in Switzerland yields high accuracy: the resulting maps of mean diameters have a mean absolute error (MAE) of 1.1 cm, with no bias. Robust grading curves for entire gravel bars can be extracted if representative training data are available. At the gravel bar level the MAE of the predicted mean diameter is even reduced to 0.3 cm, for bars with mean diameters ranging from 1.3 to 29.3 cm. Extensive experiments were carried out to study the quality of the digital line samples, the generalization capability of GRAINet to new locations, the model performance with respect to human labeling noise, the limitations of the current model, and the potential of GRAINet to analyze images with low resolutions

Types of colourants used in tattoo and permanent make‐up techniques, legal regulations, health, and psychological aspects of tattooing

Abstract Background It is estimated that more than 60 million people in Europe, that is, around 12% of the European population, have at least one tattoo. However, there is still little information on the long‐term effects of tattoos. Inks used for tattooing are a mixture of chemicals, with pigments being the main components responsible for the visual effect. The pigments used are not produced specifically as ingredients for tattooing, but mainly/primarily for the needs of industry, where lower purity requirements and quality standards are acceptable. It is therefore necessary to understand the risks associated with tattoos, but also to implement appropriate legal regulations. The aim of this article was to collect and summarise the results of research conducted so far on the type of colourants used in tattoo ink and to analyze the impact of these on human health. In addition, as part of this work, the current legal acts regulating the concentration limits and composition of inks used in tattooing as well as the psychological aspects of tattooing were collected and presented. Methods Scientific reports and articles from renowned journals from 1994 to 2022, relevant review and research publications in PubMed, and Google Scholar were analyzed. To analyze the available research literature, the Web of Science, Scopus, PubMed databases were used. The following keywords were used to search for publications: tattoos, colourants used in tattoos, side effects of tattoos, legal acts, psychological aspects of tattoos. Results The result of the literature analysis indicates a risk to health and side effects associated with tattooing the body. There are still no standardised test methods to analyze tattoo inks and assess their safety. Although the art of tattooing has been known for millennia, European legal authorities have not yet implemented effective regulations. Currently, tattoo products in Europe are covered by the general REACH regulation (Resolution ResAP, 2008; EU regulation 2020/2081, 2020). on product safety. The new amendment in force since January 4, 2022 introduces concentration limits for certain substances used in tattoo and permanent makeup inks. However, these provisions do not sufficiently protect either the consumer or the tattoo industry. Conclusions The results of the research indicate a potentially harmful effect on skin health. A more stringent safety assessment of the colourants used for tattooing is recommended, supported by studies and applicable legislation