Mutação do Hnf1ß (Mody 5) - Estudo de uma família portuguesa

Prémio de Melhor Caso Clínic

Exploring residential satisfaction in shrinking cities: a decision-tree approach

The number of cities experiencing population decline has been increasing worldwide. Despite the existence of theoretical propositions of shrinkage as an opportunity to increase levels of residential satisfaction, the issue has not been addressed empirically. This article contributes to fill this gap by assessing, through survey, the residential satisfaction of inhabitants of four shrinking Portuguese cities. Data were analysed by means of a tree-decision approach: the Chi-squared Automatic Interaction Detection analysis. A sense of safety is the feature that best discriminates inhabitants' level of residential satisfaction. The results show that shrinkage due to deindustrialisation processes is detrimental to residential satisfaction.European Regional Development Fund through the Operational Programme for Competitiveness FactorsFoundation for Science and Technology [EXPL/ATP-EUR/0464/2013]info:eu-repo/semantics/publishedVersio

Reducing the amount of input data in traffic sign classification

Proceeding of: 3th International Conference Modeling Decisions for Artificial Intelligence, MDAI 2006. Tarragona, Catalonia, Spain, april 3-5th, 2006.Several complex problems have to be solved in order to build Intelligent Transport Systems. Among them, it is worth mentioning the detection and classification of tra±c signs which could appear at any position within a captured image. This paper analyzes the influence of the number of attributes in the field of classification of tra±c signs when automatic learning techniques are used. In order to face this task, four different approaches have been considered, three of them symbolic and one sub-symbolic. These techniques have been applied using two different input pattern dimensions and their performances have been compared.The research reported here was carried out as a part of the research project CICYT TRA2004-07441-C03-01.No publicad

RETALHOS QUE CONTAM:: ARTICULAÇÕES TEÓRICAS E PRÁTICAS NA FORMAÇÃO DOCENTE DIRECIONADA À INCLUSÃO

O artigo objetiva analisar aprendizagens de acadêmicos de Pedagogia direcionadas à inclusão, com base no projeto Retalhos que contam... Os referenciais teóricos abordam a formação docente e a inclusão, o lócus investigativo foi uma turma do 5° período de Pedagogia de uma Faculdade de Imperatriz/MA. É uma pesquisa-ação, com abordagem qualitativa e exploratória. A análise de conteúdo pautada em Bardin, de livros pedagógicos acessíveis construídos pelos acadêmicos. apontou: a) aprendizagens referentes a inclusão, sobretudo a acessibilidade e as diferenças; b) a produtividade de operar com projetos articulando teoria e prática em prol de uma formação docente consistente voltada à inclusão

A novel predictive architecture for microwave-assisted drying processes based on neural networks

In this contribution, a novel learning architecture based on the interconnection of two different learning-based neural networks has been used to both predict temperature and drying curves and solve inverse modelling equations in microwave-assisted drying processes. In this way, a neural model that combines the accuracy of neural networks based on Radial Basis Functions (RBF) and the algebraic capabilities of the matrix polynomial structures is presented and validated. The architecture has been trained by temperature (Tc(t)) and moisture content (Xt(t)) curves, which have been generated by a previously validated drying model. The results show that the neural model is able to very accurately predict both kind of curves for any combination of the considered input variables (electric field and air temperature) provided that an appropriate training process is performed. The proposed configuration also permits the solution of the inverse problem in the drying process by finding the optimal value for the electric field. This provides Tc(t) or Xt(t) curves that fit to a desired drying condition in a specific time slot.This work was supported in part by the SENECA Fundation (Spain) PCMC75/ 00078/FS/02, and the Spanish Science & Technology Ministry (MCYT) under TIC 2003-08164-C03-03 research project

Segurança Pública no Brasil: O que tem sido Feito em Relação aos Homicídios?

The situation experienced in Brazil can be called "homicide epidemic": in 2014, a rate of 29.1 homicides per 100,000 inhabitants has been reached, an impressively high rate, compared to the world average of 6.9 homicides. The State has shown itself ineffective in face of the deterioration of public security conditions in the country. This paper seeks to verify the evolution of homicide rates in Brazil; analyze the responses given by the State to this increase in crime by verifying the (in)effectiveness of public security policies in reducing homicides; and present public policy strategies in order to reduce violence.A situação vivenciada no Brasil pode ser denominada “epidemia de homicídios”: no ano de 2014 alcançou-se uma taxa de 29,1 homicídios por 100 mil habitantes, taxa impressionantemente alta, se comparada com a média mundial, de 6,9. O Estado tem se mostrado ineficiente diante da degradação das condições de segurança pública no país. O presente trabalho busca verificar a evolução dos índices de homicídios no Brasil; analisar as respostas dadas pelo Estado a esse aumento da criminalidade, verificando a (in)eficácia das políticas de segurança pública no tocante à redução dos homicídios; e apresentar estratégias de políticas públicas visando reduzir a violência

Effects of mitochondrial poisons on glutathione redox potential and carotid body chemoreceptor activity

Producción CientíficaLowoxygen sensing in chemoreceptor cells involves the inhibition of specific plasma membrane K+ channels, suggesting that mitochondria-derived reactive oxygen species (ROS) link hypoxia to K+ channel inhibition, subsequent cell depolarization and activation of neurotransmitter release.We have used several mitochondrial poisons, alone and in combination with the antioxidant N-acetylcysteine (NAC), and quantify their capacity to alter GSH/GSSG levels and glutathione redox potential (EGSH) in rat diaphragm. Selected concentrations of mitochondrial poisons with or without NAC were tested for their capacity to activate neurotransmitter release in chemoreceptor cells and to alter ATP levels in intact rat carotid body (CB).We found that rotenone (1 M), antimycin A (0.2 g/ml) and sodium azide (5mM) decreased EGSH; NAC restored EGSH to control values. At those concentrations mitochondrial poisons activated neurotransmitter release from CB chemoreceptor cells and decreased CB ATP levels, NAC being ineffective to modify these responses. Additional experiments with 3-nitroprionate (5 mM), lower concentrations of rotenone and dinitrophenol revealed variable relationships between EGSH and chemoreceptor cell neurotransmitter release responses and ATP levels. These findings indicate a lack of correlation between mitochondrialgenerated modifications of EGSH and chemoreceptor cells activity. This lack of correlation renders unlikely that alteration of mitochondrial production of ROS is the physiological pathway chemoreceptor cells use to signal hypoxia

Chemoreception in the context of the general biology of ROS

Producción CientíficaSuperoxide anion is the most important reactive oxygen species (ROS) primarily generated in cells. The main cellular constituents with capabilities to generate superoxide anion areNADPHoxidases and mitochondrial respiratory chain. The emphasis of our article is centered in critically examining hypotheses proposing that ROS generated by NADPH oxidase and mitochondria are key elements in O2-sensing and hypoxic responses generation in carotid body chemoreceptor cells. Available data indicate that chemoreceptor cells express a specific isoform of NADPH oxidase that is activated by hypoxia; generated ROS acting as negative modulators of the carotid body (CB) hypoxic responses. Literature is also consistent in supporting that poisoned respiratory chain can produce high amounts of ROS, making mitochondrial ROS potential triggers-modulators of the CB activation elicited by mitochondrial venoms. However, most data favour the notion that levels of hypoxia, capable of strongly activating chemoreceptor cells, would not increase the rate of ROS production in mitochondria, making mitochondrial ROS unlikely triggers of hypoxic responses in the CB. Finally, we review recent literature on heme oxygenases from two perspectives, as potential O2-sensors in chemoreceptor cells and as generators of bilirubin which is considered to be a ROS scavenger of major quantitative importance in mammalian cells

Relación entre el autoconcepto y el rendimiento académico en adolescentes

El estudio presente se centra en las relaciones existentes entre el autoconcepto y el rendimiento académico. Se ha elegido una muestra aleatoria de 67 adolescentes entre 14 y 15 años. Mediante la prueba estandarizada “Autoconcepto resultante del entorno social: Cuestionarios SC1 de Brookover y SC2; SC3 y SC4 de Coopersmith (1982)”, comparada con las notas obtenidas en el anterior trimestre, se ha podido observas cómo se correlaciona la opinión que tiene el adolescente de sí mismo y las notas que finalmente obtienen. Asimismo, apreciamos la influencia que ejerce sobre el autoconcepto de dichos adolescentes la opinión de padres y profesores.Proyecto de Innovación Docente ReiDoCrea. Departamento de Psicología Social. Universidad de Granada