65 research outputs found
Nulling interferometry: performance comparison between Antarctica and other ground-based sites
Detecting the presence of circumstellar dust around nearby solar-type main
sequence stars is an important pre-requisite for the design of future
life-finding space missions such as ESA's Darwin or NASA's Terrestrial Planet
Finder (TPF). The high Antarctic plateau may provide appropriate conditions to
perform such a survey from the ground. We investigate the performance of a
nulling interferometer optimised for the detection of exozodiacal discs at Dome
C, on the high Antarctic plateau, and compare it to the expected performance of
similar instruments at temperate sites. Based on the currently available
measurements of the turbulence characteristics at Dome C, we adapt the GENIEsim
software (Absil et al. 2006, A&A 448) to simulate the performance of a nulling
interferometer on the high Antarctic plateau. To feed a realistic instrumental
configuration into the simulator, we propose a conceptual design for ALADDIN,
the Antarctic L-band Astrophysics Discovery Demonstrator for Interferometric
Nulling. We assume that this instrument can be placed above the 30-m high
boundary layer, where most of the atmospheric turbulence originates. We show
that an optimised nulling interferometer operating on a pair of 1-m class
telescopes located 30 m above the ground could achieve a better sensitivity
than a similar instrument working with two 8-m class telescopes at a temperate
site such as Cerro Paranal. The detection of circumstellar discs about 20 times
as dense as our local zodiacal cloud seems within reach for typical Darwin/TPF
targets in a integration time of a few hours. Moreover, the exceptional
turbulence conditions significantly relax the requirements on real-time control
loops, which has favourable consequences on the feasibility of the nulling
instrument.Comment: 10 pages, accepted for publication in A&
Predictors and outcomes of COVID-19 patients with hypoxemia in Lagos, Nigeria
Objectives: The coronavirus disease 2019 (COVID-19) pandemic is the current public health concern. Hypoxemia has been identified as an independent risk factor for mortality in COVID-19 patients regardless of age or sex. This study therefore aimed to assess the profile of COVID-19 patients with hypoxemia in Lagos, Nigeria and identify their associated socio-demographic and clinical risk factors, predictors, and outcomes.Materials and Methods: This was a retrospective cohort study in which data were extracted from medical records of real-time polymerase chain reaction confirmed COVID-19 positive patients admitted between April and October 2020. Data extracted included age, sex, comorbidities, disease category/classification, symptoms, lowest oxygen saturation (SPO2), and outcomes. Bivariate analysis was done to test associations between hypoxemia and other variables. Multivariate analysis was done to determine significant predictors of hypoxemia.Results: A total of 266 patients were included in the study; mean (SD) 49.80 (± 16.68) years. Hypoxemia (lowest SPO2 ≤ 90 in adults and < 92% in children) was found in 102 (38.3 %) of the cases. SPO2 of hypoxemic patients ranged from 33% to 90%, Mean ±SD of 77±13%. About half of the hypoxemic cases, 53 (52%) were ≥ 60 years and mostly male 70 (68.6%). Difficulty breathing was present in 56 (55%), while the common comorbidities were hypertension 86 (32.3%) and diabetes mellitus 47 (17.7%). Age ≥ 60, difficulty breathing, and fever were independent predictors of hypoxemia. Hypoxemia was significantly associated with death (X2-42.13; P < 0.001); odds ratio 14.5 (95% CI: 5.4–38.8).Conclusion: Hypoxemia occurred in 1 out of every 3 COVID-19 patients with poor prognosis. SPO2 monitoring and early presentation in hospital for those 60 years and above or with dyspnea may be essential for early identification and treatment of hypoxemia to reduce mortality
Transforming Parkinson\u27s Care in Africa (TraPCAf): Protocol for a multimethodology National Institute for Health and Care Research Global Health Research Group project
Direct constraint on the distance of y2 Velorum from AMBER/VLTI observations
In this work, we present the first AMBER observations, of the Wolf-Rayet and
O (WR+O) star binary system y2 Velorum. The AMBER instrument was used with the
telescopes UT2, UT3, and UT4 on baselines ranging from 46m to 85m. It delivered
spectrally dispersed visibilities, as well as differential and closure phases,
with a resolution R = 1500 in the spectral band 1.95-2.17 micron. We interpret
these data in the context of a binary system with unresolved components,
neglecting in a first approximation the wind-wind collision zone flux
contribution. We show that the AMBER observables result primarily from the
contribution of the individual components of the WR+O binary system. We discuss
several interpretations of the residuals, and speculate on the detection of an
additional continuum component, originating from the free-free emission
associated with the wind-wind collision zone (WWCZ), and contributing at most
to the observed K-band flux at the 5% level. The expected absolute separation
and position angle at the time of observations were 5.1±0.9mas and
66±15° respectively. However, we infer a separation of
3.62+0.11-0.30 mas and a position angle of 73+9-11°. Our analysis thus
implies that the binary system lies at a distance of 368+38-13 pc, in agreement
with recent spectrophotometric estimates, but significantly larger than the
Hipparcos value of 258+41-31 pc
APOE E4 is associated with impaired self-declared cognition but not disease risk or age of onset in Nigerians with Parkinson's disease
The relationship between APOE polymorphisms and Parkinson's disease (PD) in black Africans has not been previously investigated. We evaluated the association between APOE polymorphic variability and self-declared cognition in 1100 Nigerians with PD and 1097 age-matched healthy controls. Cognition in PD was assessed using the single item cognition question (item 1.1) of the MDS-UPDRS. APOE genotype and allele frequencies did not differ between PD and controls (p > 0.05). No allelic or genotypic association was observed between APOE and age at onset of PD. In PD, APOE ε4/ε4 conferred a two-fold risk of cognitive impairment compared to one or no ε4 (HR: 2.09 (95% CI: 1.13-3.89; p = 0.02)), while APOE ε2 was associated with modest protection against cognitive impairment (HR: 0.41 (95% CI 0.19-0.99, p = 0.02)). Of 773 PD with motor phenotype and APOE characterized, tremor-dominant (TD) phenotype predominated significantly in ε2 carriers (87/135, 64.4%) compared to 22.2% in persons with postural instability/gait difficulty (PIGD) (30/135) and 13.3% in indeterminate (ID) (18/135, 13.3%) (p = 0.037). Although the frequency of the TD phenotype was highest in homozygous ε2 carriers (85.7%), the distribution of motor phenotypes across the six genotypes did not differ significantly (p = 0.18). Altogether, our findings support previous studies in other ethnicities, implying a role for APOE ε4 and ε2 as risk and protective factors, respectively, for cognitive impairment in PD
Near-Infrared interferometry of Eta Carinae with high spatial and spectral resolution using the VLTI and the AMBER instrument
We present the first NIR spectro-interferometry of the LBV Eta Carinae. The K
band observations were performed with the AMBER instrument of the ESO Very
Large Telescope Interferometer using three 8.2m Unit Telescopes with baselines
from 42 to 89m. The aim of this work is to study the wavelength dependence of
Eta Car's optically thick wind region with a high spatial resolution of 5 mas
(11 AU) and high spectral resolution. The medium spectral resolution
observations (R=1,500) were performed in the wavelength range around both the
HeI 2.059 micron and the Br gamma 2.166 micron emission lines, the high
spectral resolution observations (R=12,000) only in the Br gamma line region.
In the K-band continuum, a diameter of 4.0 +/-0.2 mas (Gaussian FWHM, fit range
28-89m) was measured for Eta Car's optically thick wind region. If we fit
Hillier et al. (2001) model visibilities to the observed AMBER visibilities, we
obtain 50 % encircled-energy diameters of 4.2, 6.5 and 9.6mas in the 2.17
micron continuum, the HeI, and the Br gamma emission lines, respectively. In
the continuum near the Br gamma line, an elongation along a position angle of
120+/-15 degrees was found, consistent with previous VLTI/VINCI measurements by
van Boekel et al. (2003). We compare the measured visibilities with predictions
of the radiative transfer model of Hillier et al. (2001), finding good
agreement. Furthermore, we discuss the detectability of the hypothetical hot
binary companion. For the interpretation of the non-zero differential and
closure phases measured within the Br gamma line, we present a simple geometric
model of an inclined, latitude-dependent wind zone. Our observations support
theoretical models of anisotropic winds from fast-rotating, luminous hot stars
with enhanced high-velocity mass loss near the polar regions.Comment: 22 pages, 14 figures, 2 tables; A&A in pres
Constraining the wind launching region in Herbig Ae stars: AMBER/VLTI spectroscopy of HD 104237
This is the author accepted manuscript. The final version is available from EDP Sciences via the DOI in this record.Aims. We investigate the origin of the BrÎł emission of the Herbig Ae star HD 104237 on Astronomical Unit (AU) scales.
Methods. Using AMBER/VLTI at a spectral resolution R = 1500 we spatially resolve the emission in both the BrÎł line and the adjacent continuum.
Results. The visibility does not vary between the continuum and the BrÎł line, even though the line is strongly detected in the spectrum, with a peak
intensity 35% above the continuum. This demonstrates that the line and continuum emission have similar size scales. We assume that the K-band
continuum excess originates in a “puffed-up” inner rim of the circumstellar disk, and discuss the likely origin of Brγ.
Conclusions. We conclude that this emission most likely arises from a compact disk wind, launched from a region 0.2–0.5 AU from the star, with
a spatial extent similar to that of the near infrared continuum emission region, i.e., very close to the inner rim location.This work has been partly supported by the
MIUR COFIN grant 2003/027003-001 and 025227/2004 to the INAFOsservatorio
Astrofisico di Arcetri. This project has benefited from
funding from the French Centre National de la Recherche Scientifique
(CNRS) through the Institut National des Sciences de l’Univers
(INSU) and its Programmes Nationaux (ASHRA, PNPS). The authors
from the French laboratories would like to thank the successive
directors of the INSU/CNRS directors. C. Gil work was supported
in part by the Fundac¸˜ao para a Ciˆencia e a Tecnologia through
project POCTI/CTE-AST/55691/2004 from POCTI,with funds from
the European program FEDER
Interferometric data reduction with AMBER/VLTI. Principle, estimators, and illustration
This is the author accepted manuscript. The final version is available from EDP Sciences via the DOI in this record.Aims. In this paper, we present an innovative data reduction method for single-mode interferometry. It has been specifically developed for the
AMBER instrument, the three-beam combiner of the Very Large Telescope Interferometer, but it can be derived for any single-mode interferometer.
Methods. The algorithm is based on a direct modelling of the fringes in the detector plane. As such, it requires a preliminary calibration of the
instrument in order to obtain the calibration matrix that builds the linear relationship between the interferogram and the interferometric observable,
which is the complex visibility. Once the calibration procedure has been performed, the signal processing appears to be a classical least-square
determination of a linear inverse problem. From the estimated complex visibility, we derive the squared visibility, the closure phase, and the
spectral differential phase.
Results. The data reduction procedures have been gathered into the so-called amdlib software, now available for the community, and are presented
in this paper. Furthermore, each step in this original algorithm is illustrated and discussed from various on-sky observations conducted with the
VLTI, with a focus on the control of the data quality and the effective execution of the data reduction procedures. We point out the present limited
performances of the instrument due to VLTI instrumental vibrations which are difficult to calibrate.The AMBER project4 was founded by the French Centre
National de la Recherche Scientifique (CNRS), the Max Planck Institute fĂĽr
Radioastronomie (MPIfR) in Bonn, the Osservatorio Astrofisico di Arcetri
(OAA) in Firenze, the French Region “Provence Alpes Côte D’Azur” and
the European Southern Observatory (ESO). The CNRS funding has been
made through the Institut National des Sciences de l’Univers (INSU) and its
Programmes Nationaux (ASHRA, PNPS, PNP).
The OAA co-authors acknowledge partial support from MIUR grants to the
Arcetri Observatory: A LBT interferometric arm, and analysis of VLTI interferometric
data and From Stars to Planets: accretion, disk evolution and
planet formation and from INAF grants to the Arcetri Observatory Stellar and
Extragalactic Astrophysics with Optical Interferometry. C. Gil work was supported
in part by the Fundação para a Ciência e a Tecnologia through project
POCTI/CTE-AST/55691/2004 from POCTI, with funds from the European program
FEDER
Constraining the wind launching region in Herbig Ae stars: AMBER/VLTI spectroscopy of HD 104237
Astronomy and Astrophysics, 464, pp. 55-58, http://dx.doi.org./10.1051/0004-6361:20065719International audienc
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