318 research outputs found
Numerical Simulation of Superparamagnetic Nanoparticle Motion in Blood Vessels for Magnetic Drug Delivery
A numerical model is developed for the motion of superparamagnetic
nanoparticles in a non-Newtonian blood flow under the influence of a magnetic
field. The rheological properties of blood are modeled by the Carreau flow and
viscosity, and the stochastic effects of Brownian motion and red blood cell
collisions are considered. The model is validated with existing data and good
agreement with experimental results is shown. The effectiveness of magnetic
drug delivery in various blood vessels is assessed and found to be most
successful in arterioles and capillaries. A range of magnetic field strengths
are modeled using equations for both a bar magnet and a point dipole: it is
shown that the bar magnet is effective at capturing nanoparticles in limited
cases while the point dipole is highly effective across a range of conditions.
A parameter study is conducted to show the effects of changing the dipole
moment, the distance from the magnet to the blood vessel, and the initial
release point of the nanoparticles. The distance from the magnet to the blood
vessel is shown to play a significant role in determining nanoparticle capture
rate. The optimal initial release position is found to be located within the
tumor radius in capillaries and arterioles to prevent rapid diffusion to the
edges of the blood vessel prior to arriving at the tumor, and near the edge of
the magnet when a bar magnet is used.Comment: Fixed the title spacin
Safe drinking water for rural communities using a low-cost household system. Effects of water matrix and field testing
On the Interface Formation Model for Dynamic Triple Lines
This paper revisits the theory of Y. Shikhmurzaev on forming interfaces as a
continuum thermodynamical model for dynamic triple lines. We start with the
derivation of the balances for mass, momentum, energy and entropy in a
three-phase fluid system with full interfacial physics, including a brief
review of the relevant transport theorems on interfaces and triple lines.
Employing the entropy principle in the form given in [Bothe & Dreyer, Acta
Mechanica, doi:10.1007/s00707-014-1275-1] but extended to this more general
case, we arrive at the entropy production and perform a linear closure, except
for a nonlinear closure for the sorption processes. Specialized to the
isothermal case, we obtain a thermodynamically consistent mathematical model
for dynamic triple lines and show that the total available energy is a strict
Lyapunov function for this system
Toward Sustainable Tackling of Biofouling Implications and Improved Performance of TFC FO Membranes Modified by Ag-MOF Nanorods
In this work, nanorods with high antibacterial properties were synthesized with silver acetate as the metal source and 2-aminoterephthalic acid as the organic linker and were then embedded into thin-film composite (TFC) membranes to amend their performance as well as to alleviate biofouling. Silver metal-organic framework (Ag-MOF) nanorods with a length smaller than 40 nm were incorporated within the polyamide thin selective layer of the membranes during interfacial polymerization. The interaction of the synthesized nanorods with the polyamide was favored because of the presence of amine-containing functional groups on the nanorod's surface. The results of X-ray photoelectron spectroscopy, scanning electron microscopy, energy-dispersive X-ray spectroscopy, and atomic force microscopy characterizations proved the presence of Ag-MOF nanorods in the selective layer of thin-film nanocomposite (TFN) membranes. TFN membranes demonstrated improved water permeance, salt selectivity, and superior antibacterial properties. Specifically, the increased hydrophilicity and antibacterial potential of the TFN membranes led to a synergetic effect toward biofouling mitigation. The number of live bacteria attached to the surface of the neat TFC membrane decreased by more than 92% when a low amount of Ag-MOF nanorods (0.2 wt %) was applied. Following contact of the TFN membrane surface with Escherichia coli and Staphylococcus aureus, full inactivation, and degradation of bacteria cells were observed with microscopy, colony-forming unit tests, and disc inhibition zone analyses. This result translated to a negligible amount of the biofilm formed on the active layer. Indeed, the incorporation of Ag-MOF nanorods decreased the metal-ion release rate and therefore provided prolonged antibacterial performance
Characterization and applications of auto-locked vacuum-sealed diode lasers for precision metrology
We demonstrate the performance characteristics of a new class of vacuum-sealed, autolocking diode laser systems and their applications to precision metrology. The laser is based on adaptations of a design that uses optical feedback from an interference filter and it includes a vacuum-sealed cavity, an interchangeable base-plate, and an autolocking digital controller. A change of the base-plate allows operation at desired wavelengths in the visible and near infrared spectral range, whereas the autolocking ability allows the laser to be tuned and frequency stabilized with respect to atomic, molecular, and solid-state resonances without human intervention using a variety of control algorithms programmed into the same controller. We characterize the frequency stability of this laser system based on the Allan deviation (ADEV) of the beat note and of the lock signal. We find that the ADEV floor of 2 × 10−12 and short-term linewidth of ∼200 kHz are strongly influenced by current noise and vacuum sealing. Reducing the current noise and cavity pressure decreases the ADEV floor and increases the averaging time at which the floor occurs, which is a signature of long-term stability. We also show that evacuating the cavity to ∼1 Torr reduces the range of the correction signal of the feedback loop by approximately one order of magnitude, thereby increasing the lock range of the controller. The long-term stability allows the laser to be incorporated into a commercial gravimeter for accurate measurements of gravitational acceleration at the level of a few parts-per-billion, which are comparable to values obtained with an iodine-stabilized He–Ne laser. The autolocking and pattern-matching features of the controller allow the laser to be tuned and stabilized with respect to a temperature tunable transmission spectrum of a fiber-Bragg grating. This capability may be suitable for the development of a differential absorption LIDAR transmitter that can generate data at both on-line and off-line lock points using a single laser
Structural versatility of the quasi-aromatic Möbius type zinc(II)-pseudohalide complexes : experimental and theoretical investigations
In this contribution we report for the first time fabrication, isolation, structural and theoretical characterization of the quasi-aromatic Mobius complexes [Zn(NCS)(2)L-I] (1), [Zn-2(mu(1,1)-N-3)(2)(L-I)(2)][ZnCl3(MeOH)](2)center dot 6MeOH (2) and [Zn(NCS)L-II](2)[Zn(NCS)(4)]center dot MeOH (3), constructed from 1,2-diphenyl-1,2-bis((phenyl(pyridin-2-yl)methylene)hydrazono)ethane (L-I) or benzilbis(acetylpyridin-2-yl)methylidenehydrazone (L-II), respectively, and ZnCl2 mixed with NH4NCS or NaN3. Structures 1-3 are dictated by both the bulkiness of the organic ligand and the nature of the inorganic counter ion. As evidenced from single crystal X-ray diffraction data species 1 has a neutral discrete heteroleptic mononuclear structure, whereas, complexes 2 and 3 exhibit a salt-like structure. Each structure contains a Zn-II atom chelated by one tetradentate twisted ligand L-I creating the unusual Mobius type topology. Theoretical investigations based on the EDDB method allowed us to determine that it constitutes the quasi-aromatic Mobius motif where a metal only induces the pi-delocalization solely within the ligand part: 2.44|e| in 3, 3.14|e| in 2 and 3.44|e| in 1. It is found, that the degree of quasi-aromatic pi-delocalization in the case of zinc species is significantly weaker (by similar to 50%) than the corresponding estimations for cadmium systems - it is associated with the Zn-N bonds being more polar than the related Cd-N connections. The ETS-NOCV showed, that the monomers in 1 are bonded primarily through London dispersion forces, whereas long-range electrostatic stabilization is crucial in 2 and 3. A number of non-covalent interactions are additionally identified in the lattices of 1-3
Bio-nanotechnology application in wastewater treatment
The nanoparticles have received high interest in the field of medicine and water purification, however, the nanomaterials produced by chemical and physical methods are considered hazardous, expensive, and leave behind harmful substances to the environment. This chapter aimed to focus on green-synthesized nanoparticles and their medical applications. Moreover, the chapter highlighted the applicability of the metallic nanoparticles (MNPs) in the inactivation of microbial cells due to their high surface and small particle size. Modifying nanomaterials produced by green-methods is safe, inexpensive, and easy. Therefore, the control and modification of nanoparticles and their properties were also discussed
Lead(II) coordination polymers driven by pyridine-hydrazine donors : from anion-guided self-assembly to structural features
In this work, we report extensive experimental and theoretical investigations on a new series of PbII coordination polymers exhibiting extended supramolecular architectures, namely [Pb2(LI)(NCS)4]n (1), [Pb(HLII)I2]n (2), [Pb(LIII)I]n (3) and [Pb(HLIV)(NO3)2]n·nMeOH (4), which were self-assembled from different PbII salts and various pyridine-hydrazine based linkers, namely 1,2-bis(pyridin-3-ylmethylene)hydrazine (LI), (pyridin-4-ylmethylene)isonicotinohydrazide (HLII), 1-(pyridin-2-yl)ethylidenenicotinohydrazide (HLIII) and phenyl(pyridin-2-yl)methylenenicotinohydrazide (HLIV), respectively. It is recognized that the origin of self-assembling is fundamentally rooted in a dual donor (6s2/6p0 hybridized lone electron pair) and electrophilic behaviour of PbII. This allows production of extended topologies from a 1D polymeric chain in 4 through a 2D layer in 2 to the 3D frameworks in 1 and 3, predominantly due to the cooperative action of both covalent and non-covalent tetrel interactions of the overall type Pb-X (X = O, N, S, I). Counterintuitively, the latter, seemingly weak interactions, have appeared to be even stronger than the typical covalent bonds due to the presence of a bunch of supportive London dispersion dominated contacts: ππ, Lpπ, C-HO, C-HI, C-HH-C as well as more typical mainly electrostatically driven N-HO or N/O-HO hydrogen bonds. It is revealed that the constituting generally strong tetrel type Pb-X (X = O, N, S, I) bonds, though dominated by a classic Coulomb term, are therefore characterized by a very important London dispersion constituent, extremely strong relativistic effects and the two way dative-covalent Pb ↔ X electron charge delocalization contribution as revealed by the Extended Transition State Natural Orbital for Chemical Valence (ETS-NOCV) charge and energy decomposition scheme. It unravels that the pyridine-hydrazine linkers are also excellent London dispersion donors, and that together with the donor-acceptor properties of the heavy (relativistic) PbII atoms and nucleophilic counterions lead to extended self-assembling of 1-4
Lead(ii) Coordination Polymers Driven by Pyridine-Hydrazine Donors: From Anion-Guided Self-Assembly to Structural Features
In this work, we report extensive experimental and theoretical investigations on a new series of PbII coordination polymers exhibiting extended supramolecular architectures, namely [Pb2(LI)(NCS)4]n (1), [Pb(HLII)I2]n (2), [Pb(LIII)I]n (3) and [Pb(HLIV)(NO3)2]n·nMeOH (4), which were self-assembled from different PbII salts and various pyridine-hydrazine based linkers, namely 1,2-bis(pyridin-3-ylmethylene)hydrazine (LI), (pyridin-4-ylmethylene)isonicotinohydrazide (HLII), 1-(pyridin-2-yl)ethylidenenicotinohydrazide (HLIII) and phenyl(pyridin-2-yl)methylenenicotinohydrazide (HLIV), respectively. It is recognized that the origin of self-assembling is fundamentally rooted in a dual donor (6s2/6p0 hybridized lone electron pair) and electrophilic behaviour of PbII. This allows production of extended topologies from a 1D polymeric chain in 4 through a 2D layer in 2 to the 3D frameworks in 1 and 3, predominantly due to the cooperative action of both covalent and non-covalent tetrel interactions of the overall type Pb-X (X = O, N, S, I). Counterintuitively, the latter, seemingly weak interactions, have appeared to be even stronger than the typical covalent bonds due to the presence of a bunch of supportive London dispersion dominated contacts: π⋯π, Lp⋯π, C-H⋯O, C-H⋯I, C-H⋯H-C as well as more typical mainly electrostatically driven N-H⋯O or N/O-H⋯O hydrogen bonds. It is revealed that the constituting generally strong tetrel type Pb-X (X = O, N, S, I) bonds, though dominated by a classic Coulomb term, are therefore characterized by a very important London dispersion constituent, extremely strong relativistic effects and the two way dative-covalent Pb ↔ X electron charge delocalization contribution as revealed by the Extended Transition State Natural Orbital for Chemical Valence (ETS-NOCV) charge and energy decomposition scheme. It unravels that the pyridine-hydrazine linkers are also excellent London dispersion donors, and that together with the donor-acceptor properties of the heavy (relativistic) PbII atoms and nucleophilic counterions lead to extended self-assembling of 1-4. © 2020 The Royal Society of Chemistry.We are grateful to the University of Maragheh for the financial support of this research. The publication has been prepared with the support from the “RUDN University Program 5-100” (recipient F. I. Zubkov, synthesis of the ligands). DFT calculations were partially performed using the PL-Grid Infrastructure and resources provided by the ACC Cyfronet AGH (Cracow, Poland). A. M. Kirillov acknowledges the FCT and Portugal 2020 (LISBOA-01-0145-FEDER-029697 and UIDB/ 00100/2020). ICMAB acknowledges the Severo Ochoa Program (MINECO, SEV-2015-0496). M. P. Mitoraj acknowledges the financial support from the Polish National Science Center within the Sonata Bis Project 2017/26/E/ST4/00104
Lead(ii) Coordination Polymers Driven by Pyridine-Hydrazine Donors: From Anion-Guided Self-Assembly to Structural Features
In this work, we report extensive experimental and theoretical investigations on a new series of PbII coordination polymers exhibiting extended supramolecular architectures, namely [Pb2(LI)(NCS)4]n (1), [Pb(HLII)I2]n (2), [Pb(LIII)I]n (3) and [Pb(HLIV)(NO3)2]n·nMeOH (4), which were self-assembled from different PbII salts and various pyridine-hydrazine based linkers, namely 1,2-bis(pyridin-3-ylmethylene)hydrazine (LI), (pyridin-4-ylmethylene)isonicotinohydrazide (HLII), 1-(pyridin-2-yl)ethylidenenicotinohydrazide (HLIII) and phenyl(pyridin-2-yl)methylenenicotinohydrazide (HLIV), respectively. It is recognized that the origin of self-assembling is fundamentally rooted in a dual donor (6s2/6p0 hybridized lone electron pair) and electrophilic behaviour of PbII. This allows production of extended topologies from a 1D polymeric chain in 4 through a 2D layer in 2 to the 3D frameworks in 1 and 3, predominantly due to the cooperative action of both covalent and non-covalent tetrel interactions of the overall type Pb-X (X = O, N, S, I). Counterintuitively, the latter, seemingly weak interactions, have appeared to be even stronger than the typical covalent bonds due to the presence of a bunch of supportive London dispersion dominated contacts: π⋯π, Lp⋯π, C-H⋯O, C-H⋯I, C-H⋯H-C as well as more typical mainly electrostatically driven N-H⋯O or N/O-H⋯O hydrogen bonds. It is revealed that the constituting generally strong tetrel type Pb-X (X = O, N, S, I) bonds, though dominated by a classic Coulomb term, are therefore characterized by a very important London dispersion constituent, extremely strong relativistic effects and the two way dative-covalent Pb ↔ X electron charge delocalization contribution as revealed by the Extended Transition State Natural Orbital for Chemical Valence (ETS-NOCV) charge and energy decomposition scheme. It unravels that the pyridine-hydrazine linkers are also excellent London dispersion donors, and that together with the donor-acceptor properties of the heavy (relativistic) PbII atoms and nucleophilic counterions lead to extended self-assembling of 1-4. © 2020 The Royal Society of Chemistry.We are grateful to the University of Maragheh for the financial support of this research. The publication has been prepared with the support from the “RUDN University Program 5-100” (recipient F. I. Zubkov, synthesis of the ligands). DFT calculations were partially performed using the PL-Grid Infrastructure and resources provided by the ACC Cyfronet AGH (Cracow, Poland). A. M. Kirillov acknowledges the FCT and Portugal 2020 (LISBOA-01-0145-FEDER-029697 and UIDB/ 00100/2020). ICMAB acknowledges the Severo Ochoa Program (MINECO, SEV-2015-0496). M. P. Mitoraj acknowledges the financial support from the Polish National Science Center within the Sonata Bis Project 2017/26/E/ST4/00104
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