The grey partridge in the UK: population status, research, policy and prospects

La perdiz pardilla en el Reino Unido: estado de la población, investigación, gestión y perspectivas Durante los últimos cincuenta años, los efectivos de la perdiz pardilla (Perdix perdix) han descendido catastróficamente en el Reino Unido. Por el contrario, el Programa de Recuento de la Perdiz de la GWCT (Fundación para la Conservación de la Caza y la Fauna Salvaje) presenta un 81% de aumento desde el año 2000 en los lugares del Reino Unido en que interviene. En este estudio exploramos los antecedentes y las razones de estos resultados tan contradictorios. Las investigaciones de la GWCT han tenido como consecuencias recomendaciones científicamente demostradas para la mejora del medio ambiente de la perdiz en el Reino Unido, desde los requerimientos del hábitat hasta la densidad de depredadores. Dichas investigaciones han influido en la política gubernamental del Reino Unido, que ahora incluye uno de los proyectos de Europa más orientadas hacia la conservación y más flexible en cuanto a hábitat y agricultura, lo que permite a los gestores del territorio recuperar gran parte del hábitat costero de la perdiz pardilla. Actualmente, los proyectos sobre agricultura y medio ambiente no abarcan la selección de los depredadores más comunes, de manera que son principalmente los cotos de caza con guardabosques privados los que han aplicado todas las medidas de gestión. El futuro de la perdiz pardilla en el Reino Unido reside en el equilibrio entre la economía de la producción agrícola, las medidas agro–medioambientales, y la caza.La perdiz pardilla en el Reino Unido: estado de la población, investigación, gestión y perspectivas Durante los últimos cincuenta años, los efectivos de la perdiz pardilla (Perdix perdix) han descendido catastróficamente en el Reino Unido. Por el contrario, el Programa de Recuento de la Perdiz de la GWCT (Fundación para la Conservación de la Caza y la Fauna Salvaje) presenta un 81% de aumento desde el año 2000 en los lugares del Reino Unido en que interviene. En este estudio exploramos los antecedentes y las razones de estos resultados tan contradictorios. Las investigaciones de la GWCT han tenido como consecuencias recomendaciones científicamente demostradas para la mejora del medio ambiente de la perdiz en el Reino Unido, desde los requerimientos del hábitat hasta la densidad de depredadores. Dichas investigaciones han influido en la política gubernamental del Reino Unido, que ahora incluye uno de los proyectos de Europa más orientadas hacia la conservación y más flexible en cuanto a hábitat y agricultura, lo que permite a los gestores del territorio recuperar gran parte del hábitat costero de la perdiz pardilla. Actualmente, los proyectos sobre agricultura y medio ambiente no abarcan la selección de los depredadores más comunes, de manera que son principalmente los cotos de caza con guardabosques privados los que han aplicado todas las medidas de gestión. El futuro de la perdiz pardilla en el Reino Unido reside en el equilibrio entre la economía de la producción agrícola, las medidas agro–medioambientales, y la caza.Numbers of grey partridges (Perdix perdix) have declined catastrophically over the last 50 years in the UK. By contrast, the Partridge Count Scheme of the Game & Wildlife Conservation Trust (GWCT) shows an 81% increase on participating UK sites since 2000. We explore the background and reasons for this conflicting picture. GWCT research has led to scientifically proven recommendations for improving the UK partridge environment, ranging from habitat requirements to predator density. The research has influenced UK government policy, which now includes one of the most conservation–oriented and flexible agri–environment schemes in Europe, allowing land managers to recover much of the cost of grey partridge habitat creation. Culling common predators is not covered by agri–environment schemes, so it is primarily shooting estates with private gamekeepers that have implemented the full package of management measures. The future fate of the grey partridge in the UK rests on the balance between the economics of agricultural production, agri–environment measures and shooting

Restoration of a wild grey partridge shoot: a major development in the Sussex study, UK

Restauración de la caza de la perdiz pardilla: un importante progreso en el estudio de Sussex, Reino Unido Desde hace una generación se conoce la base científica de la gestión de la perdiz pardilla. Ésta incluye el control de los depredadores de nidos, la provisión de material para la nidificación, tener suficientes insectos para alimentar a las crías, y un control adecuado de la caza. Más recientemente también se ha considerado importante proveer alimento para las aves adultas y y hábitats para protegerlas de las aves rapaces. El abastecimiento del hábitat puede ser caro, pero en el Reino Unido los costos pueden recuperarse parcialmente mediante proyectos agro-medioambientales. El propietario de la tierra aún tiene que pagar por los servicios de los guardabosques. Desde 2003/2004, una parte del área de estudio de Sussex de la GWCT ha puesto en práctica estos principios de gestión ambiental, con la intención de restaurar la caza de la perdiz pardilla en esta zona del sur de Inglaterra. Los resultados han sido impresionantes, con un aumento de la densidad de parejas en primavera de 0,3/100 ha en 2003 hasta casi 20 parejas/100 ha en el 2010, en un área total de más de 10 km2. Durante los últimos dos años se ha practicado la caza de la perdiz pardilla y los propietarios de las tierras y sus equipos se han ganado el reconocimiento nacional por su labor conservacionista.Restauración de la caza de la perdiz pardilla: un importante progreso en el estudio de Sussex, Reino Unido Desde hace una generación se conoce la base científica de la gestión de la perdiz pardilla. Ésta incluye el control de los depredadores de nidos, la provisión de material para la nidificación, tener suficientes insectos para alimentar a las crías, y un control adecuado de la caza. Más recientemente también se ha considerado importante proveer alimento para las aves adultas y y hábitats para protegerlas de las aves rapaces. El abastecimiento del hábitat puede ser caro, pero en el Reino Unido los costos pueden recuperarse parcialmente mediante proyectos agro-medioambientales. El propietario de la tierra aún tiene que pagar por los servicios de los guardabosques. Desde 2003/2004, una parte del área de estudio de Sussex de la GWCT ha puesto en práctica estos principios de gestión ambiental, con la intención de restaurar la caza de la perdiz pardilla en esta zona del sur de Inglaterra. Los resultados han sido impresionantes, con un aumento de la densidad de parejas en primavera de 0,3/100 ha en 2003 hasta casi 20 parejas/100 ha en el 2010, en un área total de más de 10 km2. Durante los últimos dos años se ha practicado la caza de la perdiz pardilla y los propietarios de las tierras y sus equipos se han ganado el reconocimiento nacional por su labor conservacionista.The scientific basis of wild grey partridge management has been known for a generation. This includes controlling nest predators, providing nesting cover, having sufficient insect food for chicks and appropriate rates of shooting. More recently, measures such as providing food for adult birds and habitats for protection from birds of prey have also been considered important. Habitat provision can be expensive, but in the UK costs can be partially recovered through governmental agri–environment schemes. The landowner still needs to pay for the essential gamekeeper. Since 2003/04, one part of the Game & Wildlife Conservation Trust’s (GWCT) Sussex Study area has put these principles of environmental management into practice with the aim of restoring a wild grey partridge shoot to this part of Southern England. Results have been impressive, with the spring pair density increasing from 0.3 pairs/100 ha in 2003 to nearly 20 pairs/100 ha in 2010 on an area of just over 10 km2. Over the past two years a wild grey partridge shoot has taken place, and the landowner and his team have gained national recognition for their conservation work

Genetic Diversity of the Flavohemoprotein Gene of Giardia lamblia: Evidence for High Allelic Heterozygosity and Copy Number Variation

Purpose: The flavohemoprotein (gFlHb) in Giardia plays an important role in managing nitrosative and oxidative stress, and potentially also in virulence and nitroimidazole drug tolerance. The aim of this study was to analyze the genetic diversity of gFlHb in Giardia assemblages A and B clinical isolates. Methods: gFlHb genes from 20 cultured clinical Giardia isolates were subjected to PCR amplification and cloning, followed by Sanger sequencing. Sequences of all cloned PCR fragments from each isolate were analyzed for single nucleotide variants (SNVs) and compared to genomic Illumina sequence data. Identical clone sequences were sorted into alleles, and diversity was further analyzed. The number of gFlHb gene copies was assessed by mining PacBio de novo assembled genomes in eight isolates. Homology models for assessment of SNV’s potential impact on protein function were created using Phyre2. Results: A variable copy number of the gFlHb gene, between two and six copies, depending on isolate, was found. A total of 37 distinct sequences, representing different alleles of the gFlHb gene, were identified in AII isolates, and 41 were identified in B isolates. In some isolates, up to 12 different alleles were found. The total allelic diversity was high for both assemblages (> 0.9) and was coupled with a nucleotide diversity of < 0.01. The genetic variation (SNVs per CDS length) was 4.8% in sub-assemblage AII and 5.4% in assemblage B. The number of non-synonymous (ns) SNVs was high in gFIHb of both assemblages, 1.6% in A and 3.0% in B, respectively. Some of the identified nsSNV are predicted to alter protein structure and possibly function. Conclusion: In this study, we present evidence that gFlHb, a putative protective enzyme against oxidative and nitrosative stress in Giardia, is a variable copy number gene with high allelic diversity. The genetic variability of gFlHb may contribute metabolic adaptability against metronidazole toxicity.Peer Reviewe

Fermi surface renormalization in Hubbard ladders

We derive the one-loop renormalization equations for the shift in the Fermi-wavevectors for one-dimensional interacting models with four Fermi-points (two left and two right movers) and two Fermi velocities v_1 and v_2. We find the shift to be proportional to (v_1-v_2)U^2, where U is the Hubbard-U. Our results apply to the Hubbard ladder and to the t_1-t_2 Hubbard model. The Fermi-sea with fewer particles tends to empty. The stability of a saddle point due to shifts of the Fermi-energy and the shift of the Fermi-wavevector at the Mott-Hubbard transition are discussed.Comment: 5 pages, 4 Postscript figure

Single Dose Novel Salmonella Vaccine Enhances Resistance against Visceralizing L. major and L. donovani Infection in Susceptible BALB/c Mice

Visceral leishmaniasis is a major neglected tropical disease, with an estimated 500,000 new cases and more than 50,000 deaths attributable to this disease every year. Drug therapy is available but costly and resistance against several drug classes has evolved. Despite all efforts, no commercial, let alone affordable, vaccine is available to date. Thus, the development of cost effective, needle-independent vaccines is a high priority. Here, we have continued efforts to develop live vaccine carriers based on recombinant Salmonella. We used an in silico approach to select novel Leishmania parasite antigens from proteomic data sets, with selection criteria based on protein abundance, conservation across Leishmania species and low homology to host species. Five chosen antigens were differentially expressed on the surface or in the cytosol of Salmonella typhimurium SL3261. A two-step procedure was developed to select optimal Salmonella vaccine strains for each antigen, based on bacterial fitness and antigen expression levels. We show that vaccine strains of Salmonella expressing the novel Leishmania antigens LinJ08.1190 and LinJ23.0410 significantly reduced visceralisation of L. major and enhanced systemic resistance against L. donovani in susceptible BALB/c mice. The results show that Salmonella are valid vaccine carriers for inducing resistance against visceral leishmaniasis but that their use may not be suitable for all antigens

Colossal dielectric constants in transition-metal oxides

Many transition-metal oxides show very large ("colossal") magnitudes of the dielectric constant and thus have immense potential for applications in modern microelectronics and for the development of new capacitance-based energy-storage devices. In the present work, we thoroughly discuss the mechanisms that can lead to colossal values of the dielectric constant, especially emphasising effects generated by external and internal interfaces, including electronic phase separation. In addition, we provide a detailed overview and discussion of the dielectric properties of CaCu3Ti4O12 and related systems, which is today's most investigated material with colossal dielectric constant. Also a variety of further transition-metal oxides with large dielectric constants are treated in detail, among them the system La2-xSrxNiO4 where electronic phase separation may play a role in the generation of a colossal dielectric constant.Comment: 31 pages, 18 figures, submitted to Eur. Phys. J. for publication in the Special Topics volume "Cooperative Phenomena in Solids: Metal-Insulator Transitions and Ordering of Microscopic Degrees of Freedom

Necdin Protects Embryonic Motoneurons from Programmed Cell Death

NECDIN belongs to the type II Melanoma Associated Antigen Gene Expression gene family and is located in the Prader-Willi Syndrome (PWS) critical region. Necdin-deficient mice develop symptoms of PWS, including a sensory and motor deficit. However, the mechanisms underlying the motor deficit remain elusive. Here, we show that the genetic ablation of Necdin, whose expression is restricted to post-mitotic neurons in the spinal cord during development, leads to a loss of 31% of specified motoneurons. The increased neuronal loss occurs during the period of naturally-occurring cell death and is not confined to specific pools of motoneurons. To better understand the role of Necdin during the period of programmed cell death of motoneurons we used embryonic spinal cord explants and primary motoneuron cultures from Necdin-deficient mice. Interestingly, while Necdin-deficient motoneurons present the same survival response to neurotrophic factors, we demonstrate that deletion of Necdin leads to an increased susceptibility of motoneurons to neurotrophic factor deprivation. We show that by neutralizing TNFα this increased susceptibility of Necdin-deficient motoneurons to trophic factor deprivation can be reduced to the normal level. We propose that Necdin is implicated through the TNF-receptor 1 pathway in the developmental death of motoneurons