8 research outputs found
Ultrastructural pathology of nephropathies with organized deposits: a case series
Renal organized or structured deposits are much less frequent than those with usual type immunocomplex deposits and are encountered in a wide variety of primary and systemic disorders. It has been suggested that immunoglobulins (Igs) are responsible for organized deposits. We report 5 cases who have been diagnosed and treated in our hospital. Patients were aged 52 to 72 years, three of them were males and had variable degree of renal function, from normal serum creatinine to uraemia. Proteinuria was detected in all patients while monoclonal component was present only in the serum of one subject. Ultrastructural analysis of renal specimens revealed organized deposits. Diagnoses that were made are the following: membranoproliferative glomerulonephritis with finger print, immunotactoid glomerulopathy, membranoproliferative glomerulonephritis with arched deposits, primary amyloidosis and light chain deposition disease. In systemic disorders ultrastructural pathology could be particularly valuable for correct deposits classification, precise localization and pattern of deposition of Igs
Light chain deposition disease presenting as paroxysmal atrial fibrillation: a case report
<p>Abstract</p> <p>Introduction</p> <p>Light chain deposition disease (LCDD) can involve the heart and cause severe heart failure. Cardiac involvement is usually described in the advanced stages of the disease. We report the case of a woman in whom restrictive cardiomyopathy due to LCDD presented with paroxysmal atrial fibrillation.</p> <p>Case presentation</p> <p>A 55-year-old woman was admitted to our emergency department because of palpitations. In a recent blood test, serum creatinine was 1.4 mg/dl. She was found to have high blood pressure, left ventricular hypertrophy and paroxysmal atrial fibrillation. An ACE-inhibitor was prescribed but her renal function rapidly worsened and she was admitted to our nephrology unit. On admission serum creatinine was 9.4 mg/dl, potassium 6.8 mmol/l, haemoglobin 7.7 g/dl, N-terminal pro-brain natriuretic peptide 29894 pg/ml. A central venous catheter was inserted and haemodialysis was started. She underwent a renal biopsy which showed kappa LCDD. Bone marrow aspiration and bone biopsy demonstrated kappa light chain multiple myeloma. Echocardiographic findings were consistent with restrictive cardiomyopathy. Thalidomide and dexamethasone were prescribed, and a peritoneal catheter was inserted. Peritoneal dialysis has now been performed for 15 months without complications.</p> <p>Discussion</p> <p>Despite the predominant tubular deposition of kappa light chain, in our patient the first clinical manifestation of LCDD was cardiac disease manifesting as atrial fibrillation and the correct diagnosis was delayed. The clinical management initially addressed the cardiovascular symptoms without paying sufficient attention to the pre-existing slight increase in our patient's serum creatinine. However cardiac involvement is a quite uncommon presentation of LCDD, and this unusual case suggests that the onset of acute arrhythmias associated with restrictive cardiomyopathy and impaired renal function might be related to LCDD.</p
The second grade fluid and averaged Euler equations with Navier-slip boundary conditions
Interazioni tra dinamiche implicite ed esplicite nell'insoddisfazione corporea in preadolescenti ed adolescenti non clinici.
Gastrointestinal Involvement in Anderson-Fabry Disease: A Narrative Review
Anderson-Fabry disease (FD) is an X-linked lysosomal storage disorder leading to a wide array of clinical manifestations. Among these, gastrointestinal (GI) symptoms such as abdominal pain, bloating, and diarrhea affect about half of the FD adults and more than half of FD children. GI symptoms could be the first manifestation of FD; however, being non-specific, they overlap with the clinical picture of other conditions, such as irritable bowel syndrome and inflammatory bowel disease. This common overlap is the main reason why FD patients are often unrecognized and diagnosis is delayed for many years. The present narrative review is aimed to promote awareness of the GI manifestations of FD amongst general practitioners and specialists and highlight the latest findings of this rare condition including diagnostic tools and therapies. Finally, we will discuss some preliminary data on a patient presenting with GI symptoms who turned to be affected by a variant of uncertain significance of alpha-galactosidase (GLA) gene
Ătudes de linguistique latine I
Les articles rĂ©unis dans les numĂ©ros 102 et 103 de Pallas (Ă paraĂźtre en mars 2017) sont issus du 18e Colloque international de linguistique latine qui sâest tenu du 8 au 13 juin 2015 Ă Toulouse, dans le cadre de PLH-CRATA. Ils reprĂ©sentent des contributions Ă tous les domaines de linguistique latine. Le numĂ©ro 102 de Pallas contient des Ă©tudes consacrĂ©es Ă la syntaxe (syntagme nominal et constructions verbales), Ă lâanaphore et Ă la deixis ainsi quâĂ la pragmatique (connecteurs, constructions clivĂ©es, actes de parole...). Certaines contributions explorent de nouveaux concepts (focus dâempathie, solidaritĂ©...) ou de nouvelles mĂ©thodes, dâautres offrent des dĂ©veloppements en diachronie du latin, dâautres proposent des perspectives dâordre typologique. Ces Ă©tudes explorant des domaines variĂ©s permettent non seulement dâenrichir notre connaissance du latin mais aussi de faire le point sur telle ou telle question et dâoffrir des perspectives pour les recherches ultĂ©rieures. NumĂ©ro coordonnĂ© par Olga Spevak, maĂźtre de confĂ©rences HDR Ă lâuniversitĂ© Toulouse - Jean JaurĂšs, oĂč elle enseigne la philologie latine et grecque