Desarrollo de un modelo de negocios con aplicación de ingeniería industrial para la creación de la empresa avc químicos SAS

Ingeniería IndustrialEl proyecto titulado DESARROLLO DE UN MODELO DE NEGOCIOS CON APLICACIÓN DE INGENIERIA INDUSTRIAL: PARA CREACION DE EMPRESA AVC QUMICOS SAS realizado por ADRIAN ALFONSO VALLEJO CARRILLO, identificado con C.C. No. 1047341210, para optar título de INGENIERO INDUSTRIAL, con director HAROL PEREZ OLIVERA, por medio de la facultad de INGENIERÍA INDUSTRIAL de la UNIVERDIDAD DE LA COSTA en la ciudad de BARRANQUILLA del año 2013, el objetivo primal esta enfocado en la demostración de la factibilidad de una empresa, que se dedique a la fabricación y comercialización de químicos de limpieza, en gama industrial en la ciudad de barranquilla a través de un estudio detallado de un plan de negocios con aplicación de ingeniería industrial. Este trabajo, conserva la esencia de una investigación cualitativa se recoge toda la información del mercado con respecto al sector de los químicos de aseo, esta se filtra y se ordena, cada paso de este proyecto lleva consigo la aplicación de conceptos de ingeniería, buscando la integración de todos estos, para el desarrollo del modelo productivo. En el proyecto se analiza cada uno de los factores necesarios en el estudio del negocio: estudio de mercado, estudio técnico, estudio financiero, estudio organizacional y el estudio de impacto, dando como conclusiones: el mercado a atacar, la reantabilidad de este mismos, los productos necesarios a crear, fechas de retorno y utilidades en el plan, entre otrasThe project entitled DEVELOPING A BUSINESS MODEL WITH APPLICATION TO ENGINEERING INDUSTRAIL CREATION ENTERPRISE AVC QUMICOS SAS made by ADRIAN ALFONSO VALLEJO CARRILLO, identified with CC No. 1047341210, for title of INDUSTRIAL ENGINEER for the faculty of INDUSTRIAL ENGINEER; whit director HAROL PEREZ OLIVERA, for the UNIVERDIDAD OF THE COAST in BARRANQUILLA's city in the year 2013, ride like objective yearling the demonstration of the feasibility of a company that one dedicates to the manufacture and chemists' commercialization of cleanliness in industrial range in the city of barranquilla across a detailed study of a business plan with the application of industrial engineering. This work preserves the essence of a qualitative and applied investigation, due to the fact that all the information of the market is gathered with regard to the sector of the chemists of bathroom, this one filters and is ordained, and every step of this project goes I obtain the application of concepts of engineering looked the integration of all the these ones for the development of the productive model. In the project it is analyzed each of the necessary factors in the study of the business: market research, technical study, financial study, I study organizacional and the study of impact, giving as conclusions: the market to attacking, the profitability of this one same, the necessary products to creating, you date of return and usefulness in the plan, between other

Diseño e implementación de un sistema SCADA, para el control automático de las compuertas de guillotina y monitoreo del sistema de pesaje de balanceados, en la Avícola la Morenita.

Se realizó el diseño e implementación de un sistema SCADA, para el control automático de las compuertas de guillotina y monitoreo del sistema de pesaje de balanceados, en la Avícola la Morenita. En este trabajo se investigó acerca de la comunicación a aplicar; topología y configuración para el envío y recepción de datos entre el PLC con el indicador de peso con el módulo de comunicación CM 1241 RS-232, sobre sistemas SCADA; utilizando una HMI KTP700 DP y el software LabVIEW. Creada la subred con los dispositivos, se procede a programar cada uno de los dispositivos que conforman el proceso de pesaje y control de las compuertas de guillotina con pulsadores, leds, sensores, cilindros y el indicador de peso LEXUS con el software TIA PORTAL V13. Realizada la configuración y programación en el PLC se diseñó los procesos con sus respectivos controles e indicadores para visualizar en la HMI, otorgando una interfaz sencilla con él usuario. Además, se realizó el enlace a LabVIEW mediante un servidor, realizando en este software el diseño del sistema. Al terminar la implementación del SCADA, se realizaron las pruebas de funcionamiento tanto de la transferencia de datos, como del control de las compuertas del proceso, consiguiendo un control correcto y adquisición de datos del sistema en tiempo real, tanto en la pantalla del HMI y en LabVIEW. Para el adecuado manejo y óptimo desempeño de los procesos y dispositivos, se establece un manual de operación y mantenimiento con reglas de seguridad, para mantener un buen funcionamiento de los equipos y evitar mal manejo. Los operarios deben tener conocimientos en el manejo de la HMI y LabVIEW, o recibir una capacitación por el dueño o encargado del proceso de producción, para el correcto manejo de puesta en marcha y paro de los equipos de la planta.The design and implementation of a SCADA system were conducted, for the automatic control of the guillotine gates and monitoring of the weighing system of balanced animal feed in the poultry farm La Morenita. In this work was investigated about the communication to be applied; topology and configuration for sending and receiving data between the PLC with the weight indicator with the communication module CM 1241 RS-232, on SCADA systems; by using a KTP700 DP HMI and the LabVIEW software. Once the subnet has been created with the devices, it is proceed to program each on of the devices that make up the weighing and control process of the guillotine doors with push buttons, LEDs, sensors, cylinders and the LEXUS weight indicator with the TIA PORTAL V13 software. After the configuration and programming in the PLC, the processes were designed with its respective controls and indicators to visualize in the HMI, granting a simple interface to the user. Furthermore, the link to LabVIEW was carried out through a server, making the design of the system in this software. At the end of the implementation of the SCADA, the operation tests of both the data transfer and the control of the process gates were performed, obtaining a correct control and acquisition of system data in real time, both in the HMI screen and in the LabVIEW. For the proper handling and optimal performance of the processes and devices, an operation and maintenance manual with safety rules is established, in order to maintain a good operation of the equipment and to avoid mishandling. Operators must have knowledge in the management of HMI and LabVIEW, or to receive training by the owner or person in charge of the production process, for the correct management of start-up and stoppage of the plant equipment

Design of a 7m Davies-Cotton Cherenkov telescope mount for the high energy section of the Cherenkov Telescope Array

The Cherenkov Telescope Array is the next generation ground-based observatory for the study of very-high-energy gamma-rays. It will provide an order of magnitude more sensitivity and greater angular resolution than present systems as well as an increased energy range (20 GeV to 300 TeV). For the high energy portion of this range, a relatively large area has to be covered by the array. For this, the construction of ~7 m diameter Cherenkov telescopes is an option under study. We have proposed an innovative design of a Davies-Cotton mount for such a telescope, within Cherenkov Telescope Array specifications, and evaluated its mechanical and optical performance. The mount is a reticulated-type structure with steel tubes and tensioned wires, designed in three main parts to be assembled on site. In this work we show the structural characteristics of the mount and the optical aberrations at the focal plane for three options of mirror facet size caused by mount deformations due to wind and gravity.Facultad de Ingenierí

A surrogate-assisted measurement correction method for accurate and low-cost monitoring of particulate matter pollutants

Air pollution involves multiple health and economic challenges. Its accurate and low-cost monitoring is important for developing services dedicated to reduce the exposure of living beings to the pollution. Particulate matter (PM) measurement sensors belong to the key components that support operation of these systems. In this work, a modular, mobile Internet of Things sensor for PM measurements has been proposed. Due to a limited accuracy of the PM detector, the measurement data are refined using a two-stage procedure that involves elimination of the non-physical signal spikes followed by a non-linear correction of the responses using a multiplicative surrogate model. The correction layer is derived from the sparse and non-uniform calibration data, i.e., a combination of the measurements from the PM monitoring station and the sensor obtained in the same location over a specified (relatively short) interval. The device and the method have been both demonstrated based on the data obtained during three measurement campaigns. The proposed correction scheme improves the fidelity of PM measurements by around two orders of magnitude w.r.t. the responses for which the post-processing has not been considered. Performance of the proposed surrogate-assisted technique has been favorably compared against the benchmark approaches from the literature

In Vitro Antioxidant and Antihypertensive Activity of Edible Insects Flours (Mealworm and Grasshopper) Fermented with Lactococcus lactis Strains

The objective of the present study was to evaluate the potential antioxidant and angiotensin converting enzyme inhibition (ACEI) activity of edible insect flours fermented with Lactococcus lactis strains. For the fermentation, mealworm and grasshoppers flours were dissolved (0.5% w/v) in buffer solution (pH 7.0) and individually inoculated (3%) with Lactococcus lactis strains (NRRL B-50571, NRRL B-50572). The samples were incubated for 72 h at 30 ◦C, and the pH was recorded. The degree of hydrolysis (DH) and protein content were determined. The total polyphenol compounds, antioxidant activity (ABTS, DPPH, ORAC, and FRAP), and ACEI of the \u3c3 kDa fractions were ana- lyzed. The pH of the fermented samples decreased to 3.5–3.9 (p \u3c 0.05). The fermented grasshopper flour showed an increased DH (0.42%) and overall higher total polyphenol content (8.23 mg Gallic Acid Equivalent/mL). In general, the highest antioxidant activity was for the grasshopper fractions fermented for 24 h by Lactococcus lactis NRRL B-50572, which also showed 23.47% ACEI inhibition with an IC50 of 0.97 mg/mL. The peptide profile obtained increased after fermentation, being higher for the mealworm flour fermented sample. This study presents, for the first time, the use of specific strains of Lactococus lactis for fermenting edible insect-derived products in the production of bioactive compounds with potential antioxidant and antihypertensive activity

An integrative approach unveils FOSL1 as an oncogene vulnerability in KRAS-driven lung and pancreatic cancer

KRAS mutated tumours represent a large fraction of human cancers, but the vast majority remains refractory to current clinical therapies. Thus, a deeper understanding of the molecular mechanisms triggered by KRAS oncogene may yield alternative therapeutic strategies. Here we report the identification of a common transcriptional signature across mutant KRAS cancers of distinct tissue origin that includes the transcription factor FOSL1. High FOSL1 expression identifies mutant KRAS lung and pancreatic cancer patients with the worst survival outcome. Furthermore, FOSL1 genetic inhibition is detrimental to both KRAS-driven tumour types. Mechanistically, FOSL1 links the KRAS oncogene to components of the mitotic machinery, a pathway previously postulated to function orthogonally to oncogenic KRAS. FOSL1 targets include AURKA, whose inhibition impairs viability of mutant KRAS cells. Lastly, combination of AURKA and MEK inhibitors induces a deleterious effect on mutant KRAS cells. Our findings unveil KRAS downstream effectors that provide opportunities to treat KRAS-driven cancers

Influence of cellulase or xylanase on the in vitro rumen gas production and fermentation of corn stover

In vitro gas production (GP) technique was used to investigate effect of exogenous enzymes cellulase (CEL) or xylanase (XYL) at different doses on in vitro fermentation characteristics of corn stover. Enzymes were supplemented at 0 (control), 10, 20, 40 and 80 μg/g DM. Gas production was determined at 2, 4, 6, 8, 10, 12, 24, 36, 48 and 72 h of incubation. After 72 h, the incubation was stopped and supernatant pH was determined, and filtered to determine dry matter (DMD), neutral detergent fiber (NDFD) and acid detergent fiber (ADFD) degradabilities. Interaction effects occurred for enzyme type and dose for all measured gas parameters with exception of the lag time, DMD, organic matter degradability (OMD), NDFD, metabolizable energy (ME), short chain fatty acids (SCFA) and microbial crude protein (MCP) production. Cellulase and XYL increased GP (P<0.05) at different incubation hours with better results at the dose of 40 μg/g DM. The dose 80 μg XYL/g DM had the lowest GP compared to other doses. In addition, CEL and XYL decreased pH with increasing OMD, ME, SCFA and MCP production at 40 μg/ g DM of corn stover. The present results suggested that the level of CEL and XYL at 40 μg/g DM have higher GP than other levels of enzymes, imply this level can be more effectively to improve rumen fermentation; however, the difference of XYL between treatments and control was less than that of CEL

Los Inconscientes: una revisión bibliográfica y comparativa de diferentes miradas sobre el concepto

Currently, in the academic field, the different currents in psychology are often opposed without deepening their points of agreement. As a result of this, the present investigation makes a comparison of the unconscious concept according to: Sigmund Freud father of Psychoanalysis; Milton Erickson influencing the Systemic model; And Manuel Froufe compiler and impeller of the unconscious within the Cognitive model. The methodology was documentary, for which we used texts extracted from specific search engines such as: Google Academic, Redalyc, Scielo, Proquest, and books of authors relevant to the topic. It was concluded that there is a difference in the area in which the term was developed, being clinical in Erickson and Freud and academic-experimental in Froufe. It is also important to note that the popularity of the unconscious is remarkable in Freud, in Erickson's case it is comparatively minor, but not so with the cognitive unconscious, because its formulation is of recent appearance and does not yet have clinical developments.Actualmente en el ámbito académico se suelen oponer las distintas corrientes en psicología sin profundizar en sus puntos de coincidencia. A raíz de esto, la presente investigación realiza una comparación del concepto inconsciente según: Sigmund Freud padre del Psicoanálisis; Milton Erickson influenciador del modelo Sistémico; y Manuel Froufe compilador e impulsor del inconsciente dentro del modelo Cognitivo.La metodología fue de tipo documental, para lo cual se utilizaron textos extraídos de motores de búsqueda específicos de investigación tales como: Google Académico, Redalyc, Scielo, Proquest, y libros de divulgación de autores pertinentes a la temática.Se pudo concluir que existe una diferencia en lo que respecta al ámbito en la cual se desarrolló el término, siendo clínico en Erickson y Freud y académico-experimental en Froufe. También es importante destacar que la popularidad del inconsciente es notable en Freud, en el caso de Erickson es menor comparativamente hablando, pero no ocurre lo mismo con el inconsciente cognitivo, debido a que su formulación es de reciente aparición y aún no cuenta con desarrollos clínicos, sino más bien experimentales.

Endothelial C-type natriuretic peptide maintains vascular homeostasis

PMCID: PMC4151218Wellcome Trust (084449/Z/07/Z and 078496/Z/05/Z