Evolved model for early fault detection and health tracking in marine diesel engine by means of machine learning techniques

The Coast Guard Command, which has a wide range of duties as saving human lives, protecting natural resources, preventing marine pollution and battle against smuggling, uses diesel main engines in its ships, as in other military and commercial ships. It is critical that the main engines operate smoothly at all times so that they can respond quickly while performing their duties, thus enabling fast and early detection of faults and preventing failures that are costly or take longer to repair. The aim of this study is to create and to develop a model based on current data, to select machine learning algorithms and ensemble methods, to develop and explain the most appropriate model for fast and accurate detection of malfunctions that may occur in 4-stroke high-speed diesel engines. Thus, it is aimed to be an exemplary study for a data-based decision support mechanism

Assessment of structural performance of historical Ishan church

U ovom radu razmatra se povijesna crkva Ishan, smještena u turskom gradu Artvinu, te njena konstrukcijska učinkovitost. Glavni cilj istraživanja je određivanje konstrukcijske učinkovitosti povijesne građevine. Rezultati analiza i podaci iz literature dokazuju da su pukotine nađene u konstrukciji uzrokovane vanjskim utjecajima i prekomjernim opterećenjima. Uz to su kritična naprezanja uočena i na nekoliko mjesta u uporištu glavnih lukova, pa se ta mjesta smatraju rizičnima u smislu konstrukcijske učinkovitosti.This study focuses on the historical Ishan Church in Artvin, Turkey and its structural behaviour. The main purpose of this study is to investigate structural behaviour of the church. Therefore, Ishan Church is modelled numerically, and analyzed by means of static and dynamic analyses. Analysis results and literature review prove that the cracks identified in the structure are caused by external effects and excessive load. Moreover, critical stresses are frequently observed in the skewback of main arches, and these parts are considered to be risky in terms of structural performance

Volume CXIV, Number 4, November 7, 1996

Objective: Turner syndrome (TS) is a chromosomal disorder caused by complete or partial X chromosome monosomy that manifests various clinical features depending on the karyotype and on the genetic background of affected girls. This study aimed to systematically investigate the key clinical features of TS in relationship to karyotype in a large pediatric Turkish patient population.Methods: Our retrospective study included 842 karyotype-proven TS patients aged 0-18 years who were evaluated in 35 different centers in Turkey in the years 2013-2014.Results: The most common karyotype was 45,X (50.7%), followed by 45,X/46,XX (10.8%), 46,X,i(Xq) (10.1%) and 45,X/46,X,i(Xq) (9.5%). Mean age at diagnosis was 10.2±4.4 years. The most common presenting complaints were short stature and delayed puberty. Among patients diagnosed before age one year, the ratio of karyotype 45,X was significantly higher than that of other karyotype groups. Cardiac defects (bicuspid aortic valve, coarctation of the aorta and aortic stenosis) were the most common congenital anomalies, occurring in 25% of the TS cases. This was followed by urinary system anomalies (horseshoe kidney, double collector duct system and renal rotation) detected in 16.3%. Hashimoto's thyroiditis was found in 11.1% of patients, gastrointestinal abnormalities in 8.9%, ear nose and throat problems in 22.6%, dermatologic problems in 21.8% and osteoporosis in 15.3%. Learning difficulties and/or psychosocial problems were encountered in 39.1%. Insulin resistance and impaired fasting glucose were detected in 3.4% and 2.2%, respectively. Dyslipidemia prevalence was 11.4%.Conclusion: This comprehensive study systematically evaluated the largest group of karyotype-proven TS girls to date. The karyotype distribution, congenital anomaly and comorbidity profile closely parallel that from other countries and support the need for close medical surveillance of these complex patients throughout their lifespa

Evaluation of pneumonia incidence and risk factors after rib fracture

Rib fractures are one of the risk factors for pneumonia development. Still, it is often underestimated or neglected. We wanted to determine both the incidence of pneumonia after rib fracture and the risk factors. This study was conducted prospectively and as single-centered. Demographic and clinical data were analyzed to determine the incidence of pneumonia and risk factors in cases applied with isolated chest trauma and diagnosed with rib fractures between January 1, 2022, and January 1, 2023. The mean age of 412 patients in the study was 43.06±17.85 years and 82.3% were male. Rib fractures were present in 18.4% of the patients. Pneumonia incidence was found to be high in patients with a history of Diabetes Mellitus (DM) and Chronic Obstructive Pulmonary Disease (COPD), smokers, multiple rib fractures and those who needed hospitalization. Again, it was observed that the development of pneumonia was not significantly related to the process in patients who developed pneumonia. There was no relationship between other parameters and the incidence of pneumonia. Rib fracture is an important risk factor for the incidence of pneumonia. The incidence of pneumonia increases in smokers, patients with DM and COPD, and those with multiple rib fractures. It is important to be alert for pneumonia in these patients. [Med-Science 2023; 12(3.000): 623-8

The impact of changes in cardiopulmonary resuscitation practices on survival in in-hospital cardiac arrest patients during the COVID-19 pandemic

The Covid-19 pandemic has caused changes in cardiopulmonary resuscitation applications as well as in all practices. In this research, we evaluated the effects of these changes on the management and outcomes of in-hospital cardiac arrest cases. Our study is a single-center, retrospective, observational study. It was conducted with 628 patients with in-hospital arrest who met the study criteria between January 1, 2018, and January 1, 2022. The cases were evaluated in two groups as pre-guideline period and post-guideline period interventions according to the cardiopulmonary resuscitation algorithm published on October 21. Study data were obtained from the hospital automation system, patient files, and clinical data. In the results of the study, the confidence interval was 95% and the statistical significance level was accepted as p [Med-Science 2023; 12(2.000): 352-6

Influence of coronary calcification patterns on hemodynamic outcome of coronary stenoses and remodeling

WOS: 000418480800006PubMed: 28990941Objective: The histological characteristics of plaque may affect the hemodynamic outcome of a given coronary stenosis. In particular, the potential effect of volumetric calcium content and the topographical distribution in the lesion segment on physiological outcome has not yet been investigated. The aim of this study was to identify any potential correlation between patterns of calcification and the fractional flow reserve (FFR) and the coronary remodeling index (RMI). Methods: A total of 26 stable angina pectoris and 34 acute coronary syndrome patients without persistent ST-segment elevation constituted the study population. FFR was used to assess 70 intermediate coronary stenosis lesions. After obtaining hemodynamic measurements, quantitative grayscale and virtual histology-intravascular ultrasound analyses were performed. The depth, length, and circumferential distribution of calcification of the lesions were also recorded. Results: Within the analyzed segment (area of interest, lesion segment), FFR was correlated with maximal thickness of deep calcification (r=-0.285; p=0.021) and calcification angle (r=-0.396; p=0.001). In lesions with a calcification angle >180 degrees, the mean FFR value was significantly lower compared with those <180 degrees (0.64 +/- 0.17 vs. 0.78 +/- 0.08; p=0.024). RMI was correlated with maximal angle of superficial (r=-0.437; p<0.001) and deep (r=0.425; p<0.001) calcification. RMI was correlated with maximal thickness of superficial (r=-0.357; p=0.003) and deep (r=0.417; p<0.001) calcification. RMI was also correlated with FFR (r=-0.477; p<0.001). Conclusion: This study demonstrated that the geometry, location, and amount of calcification of a plaque could affect hemodynamic and anatomical outcome measures in functionally significant stenoses by affecting vessel wall compliance

Prognostic and diagnostic importance of the systemic immune-inflammation index in pediatric head trauma

Head trauma is a leading cause of mortality and morbidity in pediatric patients. The trauma itself leads to the activation of a biomolecular cascade of damage. Purinergic receptors and ATP release play an important role in the activation of astroglia, microglia, monocyte-macrophages, neutrophils, and T cells in this process. The systemic immune inflammation index can be easily calculated, cheap, only requires hemogram parameters, and does not include any subjective findings. Therefore, we believe that it could be a prognostic predictor and a diagnostic marker for pediatric head trauma cases. Our study was designed as a retrospective and single-center study. The study was conducted with pediatric patients who presented to the emergency department with isolated head trauma between June 15, 2022, and December 15, 2022. Demographic data, medical history, white blood count, platelet count, neutrophil count, systemic immune inflammation index (SIII), Glasgow Coma Score, and the presence of pathology on brain computed tomography were recorded on the case report form. The study was conducted with 112 cases. In cases with bleeding, the median value of GCS was significantly lower (p [Med-Science 2023; 12(3.000): 656-60

Epidemiological, Clinical, and Laboratory Features of Children With COVID-19 in Turkey

Objectives: The aim of this study is to identify the epidemiological, clinical, and laboratory features of coronavirus disease 2019 (COVID-19) in children. Methods: A retrospective study was conducted by pediatric infectious disease specialists from 32 different hospitals from all over Turkey by case record forms. Pediatric cases who were diagnosed as COVID-19 between March 16, 2020, and June 15, 2020 were included. Case characteristics including age, sex, dates of disease onset and diagnosis, family, and contact information were recorded. Clinical data, including the duration and severity of symptoms, were also collected. Laboratory parameters like biochemical tests and complete blood count, chest X-ray, and chest computed tomography (CT) were determined. Results: There were 1,156 confirmed pediatric COVID-19 cases. In total, male cases constituted 50.3% (n = 582) and females constituted 49.7% (n = 574). The median age of the confirmed cases was 10.75 years (4.5-14.6). Of the total cases, 90 were younger than 1 year of age (7.8%), 108 were 1-3 years of age (9.3%), 148 were 3-6 years of age (12.8%), 298 were 6-12 years of age (25.8%), 233 were 12-15 years of age (20.2%), and 268 cases were older than 15 years of age (23.2%). The most common symptom of the patients at the first visit was fever (50.4%) (n = 583) for a median of 2 days (IQR: 1-3 days). Fever was median at 38.4 degrees C (38.0-38.7 degrees C). The second most common symptom was cough (n = 543, 46.9%). The other common symptoms were sore throat (n = 143, 12.4%), myalgia (n = 141, 12.2%), dyspnea (n = 118, 10.2%), diarrhea (n = 112, 9.7%), stomachache (n = 71, 6.1%), and nasal discharge (n = 63, 5.4%). When patients were classified according to disease severity, 263 (22.7%) patients were asymptomatic, 668 (57.7%) patients had mild disease, 209 (18.1%) had moderate disease, and 16 (1.5%) cases had severe disease. One hundred and forty-nine (12.9%) cases had underlying diseases among the total cases; 56% of the patients who had severe disease had an underlying condition (p 0.01). The need for hospitalization did not differ between patients who had an underlying condition and those who do not have (p = 0.38), but the need for intensive care was higher in patients who had an underlying condition (p 0.01). Forty-seven (31.5%) of the cases having underlying conditions had asthma or lung disease (38 of them had asthma). Conclusions: To the best of our knowledge, this is one of the largest pediatric data about confirmed COVID-19 cases. Children from all ages appear to be susceptible to COVID-19, and there is a significant difference in symptomatology and laboratory findings by means of age distribution

New coumarin derivatives as carbonic anhydrase inhibitors

WOS: 000336498100006PubMed ID: 23656671In the current study, a series of 4-chloromethyl-7-hydroxy-coumarin derivatives containing imidazolium, benzimidazolium, bisbenzimidazolium and quaternary ammonium salts were synthesized, characterized and the inhibition effects of the derivatives on human carbonic anhydrases (hCA I and hCA II) were investigated as in vitro. Structures of these coumarins were confirmed by FT-IR, (1)H NMR, (13)C NMR and LC-MS analyses. Structure activity relationship study showed that 3d (IC50: 79 mu m M for hCA I and 88 m M for hCA II) performed higher inhibitory activity than others