Future without delirium: not quite there yet but we can start by prescribing touch

© The Author(s) 2022. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.The recently published article by Kotfs et al. “The future of intensive care: delirium should no longer be an issue”, brought us great interest and although we agree with the authors’ perspective this is still far from being reality. Despite delirium increase report as an adverse event, it is often faced on daily practice as a patient’s “weakness” or an inevitability due to acute illness that we fail to avoid. Tis perspective precludes multidisciplinary team effort from targeting the modifiable components of delirium mentioned in the paper.info:eu-repo/semantics/publishedVersio

Nematodes vs Macrofauna assemblages along an estuarine gradient (Mondego estuary, Portugal)

The spatial distribution of the nematodes and macrofauna communities in the subtidal sediments along estuarine gradient in the Mondego estuary was studied. The main aim is to compare the response of the nematodes and macrofauna communities structure adjusted for each estuarine stretch. Spatial distribution of nematode assemblages followed the estuarine gradients, allowing to distinguish: The freshwater and oligohaline sections, characterised by the presence of freshwater nematodes, low densities and diversity; Mesohaline section, the densities and diversity were also low; Polyhaline and Euhaline sections, attained highest densities and diversity. Significant differences of diversity were obtained between estuarine sections by Shannon-Wiener index. Significant differences in macrofauna densities were also obtained, the highest values were obtained in euhaline and mesohaline areas. The euhaline stations presented higher species richness, while the freshwater section registered lower values. Significant differences of diversity were also obtained between estuarine sections by Shannon-Wiener index. From the management point of view both communities are very useful in assessing ecological quality in transitional waters, however the rapid response of nematodes to environmental changes became an important tool

Examination of change factor methodologies for climate change impact assessment

Citation: Anandhi, A., Frei, A., Pierson, D. C., Schneiderman, E. M., Zion, M. S., Lounsbury, D., and Matonse, A. H. ( 2011), Examination of change factor methodologies for climate change impact assessment, Water Resour. Res., 47, W03501, doi:10.1029/2010WR009104.A variety of methods are available to estimate values of meteorological variables at future times and at spatial scales that are appropriate for local climate change impact assessment. One commonly used method is Change Factor Methodology (CFM), sometimes referred to as delta change factor methodology. Although more sophisticated methods exist, CFM is still widely applicable and used in impact analysis studies. While there are a number of different ways by which change factors (CFs) can be calculated and used to estimate future climate scenarios, there are no clear guidelines available in the literature to decide which methodologies are most suitable for different applications. In this study several categories of CFM (additive versus multiplicative and single versus multiple) for a number of climate variables are compared and contrasted. The study employs several theoretical case studies, as well as a real example from Cannonsville watershed, which supplies water to New York City, USA. Results show that in cases when the frequency distribution of Global Climate Model (GCM) baseline climate is close to the frequency distribution of observed climate, or when the frequency distribution of GCM future climate is close to the frequency distribution of GCM baseline climate, additive and multiplicative single CFMs provide comparable results. Two options to guide the choice of CFM are suggested. The first option is a detailed methodological analysis for choosing the most appropriate CFM. The second option is a default method for use under circumstances in which a detailed methodological analysis is too cumbersome

Membrane structure and interactions of a short Lycotoxin I anaiogue

Lycotoxin I and Lycotoxin II are natural anti-microbial peptides, that were identified in the venom of the Wolf Spider Lycosa carolinensis. These peptides were found to be potent growth inhibitors for bacteria (Escherichia coli) and yeast (Candida glabrata) at micromolar concentrations. Recently, shortened analogues of Lycol and LycoII have been reported to have decreased haemolytic effects. A shorter Lyco-I analogue studied, Lycol 1-15 (H-IWLTALKFLGKHAAK-NH2), was active only above 10 pm, but was also the least haemolytic. On the basis of these findings, we became interested in obtaining a deeper insight into the membrane activity of LycoI 1-15, as this peptide may represent the first major step for the future development of selective, i.e. non-haemolytic, Lycotoxin-based antibiotics. The interaction of this peptide with liposomes of different composition was studied by microcalorimetry [differential scanning calorimetry (DSC) and isothermal titration calorimetry (ITC)l and CD. The results obtained from the calorimetric and spectroscopic techniques were jointly discussed in an attempt to further understand the interaction of this peptide with model membranes. Copyright (c) 2007 European Peptide Society and John Wiley & Sons, Ltd

AnBx - Security Protocols Design and Verification

Designing distributed protocols is challenging, as it requires actions at very different levels: from the choice of network-level mechanisms to protect the exchange of sensitive data, to the definition of structured interaction patterns to convey application-specific guarantees. Current security infrastructures provide very limited support for the specification of such guarantees. As a consequence, the high-level security properties of a protocol typically must often be hard-coded explicitly, in terms of low-level cryptographic notions and devices which clutter the design and undermine its scalability and robustness. To counter these problems, we propose an extended Alice & Bob notation for protocol narrations (AnBx) to be employed for a purely declarative modelling of distributed protocols. These abstractions provide a compact specification of the high-level security guarantees they convey, and help shield the design from the details of the underlying cryptographic infrastructure. We discuss an implementation of the abstractions based on a translation from the AnBx notation to the AnB language supported by the OFMC [1,2] verification tool. We show the practical effectiveness of our approach by revisiting the iKP e-payment protocols, and showing that the security goals achieved by our declarative specification outperform those offered by the original protocols

SARS‐CoV2 pneumonia recovery is linked to expansion of innate lymphoid cells type 2 expressing CCR10

© 2021 The Authors. European Journal of Immunology published by Wiley-VCH GmbH. This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.Accelerate lung repair in SARS-CoV-2 pneumonia is essential for pandemic handling. Innate lymphoid cells (ILCs) are likely players, given their role in mucosal protection and tissue homeostasis. We studied ILC subpopulations at two time points in a cohort of patients admitted in the hospital due to SARS-CoV-2 infection. COVID-19 patients with moderate/severe respiratory failure featured profound depletion of circulating ILCs at hospital admission, in agreement with overall lymphocyte depletion. However, ILCs recovered in direct correlation with lung function improvement as measured by oxygenation index and in negative association with inflammatory and lung/endothelial damage markers like RAGE. While both ILC1 and ILC2 expanded, ILC2 showed the most striking phenotype changes, with CCR10 upregulation in strong correlation with these parameters. Overall, CCR10+ ILC2 emerge as relevant contributors to SARS-CoV-2 pneumonia recovery.This work was funded by the following grants from Fundação para a Ciência e a Tecnologia (FCT), Portugal, through “APOIO ESPECIAL RESEARCH4COVID-19,” project numbers 125 to SMF and 803 to ACT. AMCG and GBF received fellowships funded by FCT (DOCTORATES4COVID-19, 2020.10202.BD) and JANSSEN- CILAG FARMACÊUTICA, respectively.info:eu-repo/semantics/publishedVersio

Conserving pattern and process in the Southern Ocean: designing a Marine Protected Area for the Prince Edward Islands

South Africa is currently proclaiming a Marine Protected Area (MPA) in the Exclusive Economic Zone (EEZ) of its sub-Antarctic Prince Edward Islands. The objectives of the MPA are to: 1) contribute to a national and global representative system of MPAs, 2) serve as a scientific reference point to inform future management, 3) contribute to the recovery of the Patagonian toothfish (Dissostichus eleginoides), and 4) reduce the bird bycatch of the toothfish fishery, particularly of albatrosses and petrels. This study employs systematic conservation planning methods to delineate a MPA within the EEZ that will conserve biodiversity patterns and processes within sensible management boundaries, while minimizing conflict with the legal toothfish fishery. After collating all available distributional data on species, benthic habitats and ecosystem processes, we used C-Plan software to delineate a MPA with three management zones: four IUCN Category Ia reserves (13% of EEZ); two Conservation Zones (21% of EEZ); and three Category IV reserves (remainder of EEZ). Compromises between conservation target achievement and the area required by the MPA are apparent in the final reserve design. The proposed MPA boundaries are expected to change over time as new data become available and as impacts of climate change become more evident

Modeling Monetary Policy

We develop a macroeconomic framework where money issupplied against only few eligible securities in open marketoperations. The relationship between the policy rate,expected inflation and consumption growth is affected bymoney market conditions, i.e. the varying liquidity value ofeligible assets and the associated risk. This induces a liquiditypremium, which explains the observed systematic wedgebetween the policy rate and consumption Euler interest ratethat standard models equate. It further implies a dampenedresponse of consumption to policy rate shocks that is humpshapedwhen we account for realistic central bank transfersand the dynamics of bond holdings

A prospective survey in European Society of Cardiology member countries of atrial fibrillation management: baseline results of EURO bservational Research Programme Atrial Fibrillation (EORP-AF) Pilot General Registry

Aims: Given the advances in atrial fibrillation (AF) management and the availability of new European Society of Cardiology (ESC) guidelines, there is a need for the systematic collection of contemporary data regarding the management and treatment of AF in ESC member countries. Methods and results: We conducted a registry of consecutive in- and outpatients with AF presenting to cardiologists in nine participating ESC countries. All patients with an ECG-documented diagnosis of AF confirmed in the year prior to enrolment were eligible. We enroled a total of 3119 patients from February 2012 to March 2013, with full data on clinical subtype available for 3049 patients (40.4% female; mean age 68.8 years). Common comorbidities were hypertension, coronary disease, and heart failure. Lone AF was present in only 3.9% (122 patients). Asymptomatic AF was common, particularly among those with permanent AF. Amiodarone was the most common antiarrhythmic agent used (~20%), while beta-blockers and digoxin were the most used rate control drugs. Oral anticoagulants (OACs) were used in 80% overall, most often vitamin K antagonists (71.6%), with novel OACs being used in 8.4%. Other antithrombotics (mostly antiplatelet therapy, especially aspirin) were still used in one-third of the patients, and no antithrombotic treatment in only 4.8%. Oral anticoagulants were used in 56.4% of CHA 2DS2-VASc = 0, with 26.3% having no antithrombotic therapy. A high HAS-BLED score was not used to exclude OAC use, but there was a trend towards more aspirin use in the presence of a high HAS-BLED score. Conclusion: The EURObservational Research Programme Atrial Fibrillation (EORP-AF) Pilot Registry has provided systematic collection of contemporary data regarding the management and treatment of AF by cardiologists in ESC member countries. Oral anticoagulant use has increased, but novel OAC use was still low. Compliance with the treatment guidelines for patients with the lowest and higher stroke risk scores remains suboptimal. © The Author 2013

The thromboxane receptor antagonist NTP42 promotes beneficial adaptation and preserves cardiac function in experimental models of right heart overload

Background: Pulmonary arterial hypertension (PAH) is a progressive disease characterized by increased pulmonary artery pressure leading to right ventricular (RV) failure. While current PAH therapies improve patient outlook, they show limited benefit in attenuating RV dysfunction. Recent investigations demonstrated that the thromboxane (TX) A2 receptor (TP) antagonist NTP42 attenuates experimental PAH across key hemodynamic parameters in the lungs and heart. This study aimed to validate the efficacy of NTP42:KVA4, a novel oral formulation of NTP42 in clinical development, in preclinical models of PAH while also, critically, investigating its direct effects on RV dysfunction. Methods: The effects of NTP42:KVA4 were evaluated in the monocrotaline (MCT) and pulmonary artery banding (PAB) models of PAH and RV dysfunction, respectively, and when compared with leading standard-of-care (SOC) PAH drugs. In addition, the expression of the TP, the target for NTP42, was investigated in cardiac tissue from several other related disease models, and from subjects with PAH and dilated cardiomyopathy (DCM). Results: In the MCT-PAH model, NTP42:KVA4 alleviated disease-induced changes in cardiopulmonary hemodynamics, pulmonary vascular remodeling, inflammation, and fibrosis, to a similar or greater extent than the PAH SOCs tested. In the PAB model, NTP42:KVA4 improved RV geometries and contractility, normalized RV stiffness, and significantly increased RV ejection fraction. In both models, NTP42:KVA4 promoted beneficial RV adaptation, decreasing cellular hypertrophy, and increasing vascularization. Notably, elevated expression of the TP target was observed both in RV tissue from these and related disease models, and in clinical RV specimens of PAH and DCM. Conclusion: This study shows that, through antagonism of TP signaling, NTP42:KVA4 attenuates experimental PAH pathophysiology, not only alleviating pulmonary pathologies but also reducing RV remodeling, promoting beneficial hypertrophy, and improving cardiac function. The findings suggest a direct cardioprotective effect for NTP42:KVA4, and its potential to be a disease-modifying therapy in PAH and other cardiac conditions