The Salt Lake Group in Cache Valley, Utah and Idaho

Fluvial and lacustrine sediments of great thickness accumulated in the intermountain basins of the western United States during Tertiary time. The Salt Lake group in northern Utah and parts of surrounding states is a conspicuous stratigraphic unit of these basins. The beds of light color in Morgan Valley in the Wasatch Mountains of northern Utah were named the Salt Lake group by Hayden (1869) because of similar occurrences in Salt Lake Valley and because he reasoned that the succession could be divided into formations. Similar rocks crop out in Ogden Valley, north of Morgan Valley, and in Cache Valley, Utah and Idaho. Cache Valley is bounded by the Wasatch and Malad Ranges to the west and the Bear River Range to the east (Fig. 1). It extends from the divide between Ogden and Cache valleys about 18 miles south of Los an. Utah. to Red Rock Pass. about 19 miles northwest of Preston. Idaho. The Bear River enters Cache Valley northeast of Preston. Idaho. and leaves through the Bear River Narrows west of Logan. Utah. at a point between the northern end of the Wasatch Range and the Malad Range. Red Rock Pass, northwest of Preston, Idaho, was the outlet of Lake Bonneville

Analysis of multiply spliced transcripts in lymphoid tissue reservoirs of rhesus macaques infected with RT-SHIV during HAART.

Highly active antiretroviral therapy (HAART) can reduce levels of human immunodeficiency virus type 1 (HIV-1) to undetectable levels in infected individuals, but the virus is not eradicated. The mechanisms of viral persistence during HAART are poorly defined, but some reservoirs have been identified, such as latently infected resting memory CD4⁺ T cells. During latency, in addition to blocks at the initiation and elongation steps of viral transcription, there is a block in the export of viral RNA (vRNA), leading to the accumulation of multiply-spliced transcripts in the nucleus. Two of the genes encoded by the multiply-spliced transcripts are Tat and Rev, which are essential early in the viral replication cycle and might indicate the state of infection in a given population of cells. Here, the levels of multiply-spliced transcripts were compared to the levels of gag-containing RNA in tissue samples from RT-SHIV-infected rhesus macaques treated with HAART. Splice site sequence variation was identified during development of a TaqMan PCR assay. Multiply-spliced transcripts were detected in gastrointestinal and lymphatic tissues, but not the thymus. Levels of multiply-spliced transcripts were lower than levels of gag RNA, and both correlated with plasma virus loads. The ratio of multiply-spliced to gag RNA was greatest in the gastrointestinal samples from macaques with plasma virus loads <50 vRNA copies per mL at necropsy. Levels of gag RNA and multiply-spliced mRNA in tissues from RT-SHIV-infected macaques correlate with plasma virus load

60 million years of glaciation in the Transantarctic Mountains

The Antarctic continent reached its current polar location ~83 Ma and became shrouded by ice sheets ~34 Ma, coincident with dramatic global cooling at the Eocene-Oligocene boundary. However, it is not known whether the first Antarctic glaciers formed immediately prior to this or were present significantly earlier. Here we show that mountain glaciers were likely present in the Transantarctic Mountains during the Late Palaeocene (~60–56 Ma) and middle Eocene (~48–40 Ma). Temperate (warm-based) glaciers were prevalent during the Late Eocene (~40–34 Ma) and, in reduced numbers, during the Oligocene (~34–23 Ma), before larger, likely cold-based, ice masses (including ice sheets) dominated. Some temperate mountain glaciers were present during the Miocene Climatic Optimum (~15 Ma), before a widespread switch to cold-based glaciation. Our findings highlight the longevity of glaciation in Antarctica and suggest that glaciers were present even during the Early-Cenozoic greenhouse world

The potential of trading activity income to fund third sector organisations operating in deprived areas

In the United Kingdom, as in other countries, Third Sector Organisations (TSOs) have been drawn towards income sources associated with trading activities (Teasdale, 2010), but many remain reliant on grant funding to support such activities (Chell, 2007). Using a multivariate analysis approach and data from the National Survey of Charities and Social Enterprises (NSCSE), it is found that trading activities are used relatively commonly in deprived areas. These organisations are also more likely to attempt to access public sector funds. This suggests policy-makers need to consider the impact of funding cuts on TSOs in the most deprived areas as TSOs are unlikely achieve their objectives without continuing support

The effect of volume change and stack pressure on solid‐state battery cathodes

Solid-state lithium batteries may provide increased energy density and improved safety compared with Li-ion technology. However, in a solid-state composite cathode, mechanical degradation due to repeated cathode volume changes during cycling may occur, which may be partially mitigated by applying a significant, but often impractical, uniaxial stack pressure. Herein, we compare the behavior of composite electrodes based on Li4Ti5O12 (LTO) (negligible volume change) and Nb2O5 (+4% expansion) cycled at different stack pressures. The initial LTO capacity and retention are not affected by pressure but for Nb2O5, they are significantly lower when a stack pressure of <2 MPa is applied, due to inter-particle cracking and solid-solid contact loss because of cyclic volume changes. This work confirms the importance of cathode mechanical stability and the stack pressures for long-term cyclability for solid-state batteries. This suggests that low volume-change cathode materials or a proper buffer layer are required for solid-state batteries, especially at low stack pressures

Real and complex random neutrino mass matrices and theta13

Recently it has been shown that one of the basic parameters of the neutrino sector, so called theta13 angle is very small, but quite probably non-zero. We argue that the small value of theta13 can still be reproduced easily by a wide spectrum of randomly generated models of neutrino masses. For that we consider real and complex neutrino mass matrices, also including sterile neutrinos. A qualitative difference between results for real and complex mass matrices in the region of small theta13 values is observed. We show that statistically the present experimental data prefers random models of neutrino masses with sterile neutrinos.Comment: v3: Discussion about 3+1 scenario extended, fig 5,6 adde

Best practice recommendations for medically assisted reproduction in patients with known cardiovascular disease or at high risk of cardiovascular disease : A consensus statement supported by the UK Maternal Cardiology Society (UKMCS), British Fertility Society, MacDonald Obstetric Medicine Society (MOMS), British Cardiovascular Society (BCS), British Cardiovascular Intervention Society (BCIS), British Society for Heart Failure (BSH), Scottish Obstetric Cardiac Network (SOCN), Royal College of Obstetricians and Gynaecologists (RCOG), Association of Anaesthetists, Fertility UK, Primary Care Cardiovascular Society (PCCS), Obstetric Anaesthetists Association (OAA), Association of Inherited Cardiac Conditions (AICC)

\ua9 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.Increasing numbers of people are seeking assisted conception. In people with known cardiac disease or risk factors for cardiac disease, assisted conception may carry increased risks during treatment and any subsequent pregnancy. These risks should be assessed, considered and minimized prior to treatment

Limits on Active to Sterile Neutrino Oscillations from Disappearance Searches in the MINOS, Daya Bay, and Bugey-3 Experiments

Searches for a light sterile neutrino have been performed independently by the MINOS and the Daya Bay experiments using the muon (anti) neutrino and electron antineutrino disappearance channels, respectively. In this Letter, results from both experiments are combined with those from the Bugey-3 reactor neutrino experiment to constrain oscillations into light sterile neutrinos. The three experiments are sensitive to complementary regions of parameter space, enabling the combined analysis to probe regions allowed by the Liquid Scintillator Neutrino Detector (LSND) and MiniBooNE experiments in a minimally extended four-neutrino flavor framework. Stringent limits on sin(2) 2 theta(mu e) are set over 6 orders of magnitude in the sterile mass-squared splitting Delta m(41)(2). The sterile-neutrino mixing phase space allowed by the LSND and MiniBooNE experiments is excluded for Delta m(41)(2) \u3c 0.8 eV(2) at 95% CLs

Lower Rates of Heart Failure and All-Cause Hospitalizations During Pulmonary Artery Pressure-Guided Therapy for Ambulatory Heart Failure: One-Year Outcomes From the CardioMEMS Post-Approval Study.

BACKGROUND: Ambulatory hemodynamic monitoring with an implantable pulmonary artery (PA) sensor is approved for patients with New York Heart Association Class III heart failure (HF) and a prior HF hospitalization (HFH) within 12 months. The objective of this study was to assess the efficacy and safety of PA pressure-guided therapy in routine clinical practice with special focus on subgroups defined by sex, race, and ejection fraction. METHODS: This multi-center, prospective, open-label, observational, single-arm trial of 1200 patients across 104 centers within the United States with New York Heart Association class III HF and a prior HFH within 12 months evaluated patients undergoing PA pressure sensor implantation between September 1, 2014, and October 11, 2017. The primary efficacy outcome was the difference between rates of adjudicated HFH 1 year after compared with the 1 year before sensor implantation. Safety end points were freedom from device- or system-related complications at 2 years and freedom from pressure sensor failure at 2 years. RESULTS: Mean age for the population was 69 years, 37.7% were women, 17.2% were non-White, and 46.8% had preserved ejection fraction. During the year after sensor implantation, the mean rate of daily pressure transmission was 76±24% and PA pressures declined significantly. The rate of HFH was significantly lower at 1 year compared with the year before implantation (0.54 versus 1.25 events/patient-years, hazard ratio 0.43 [95% CI, 0.39-0.47], CONCLUSIONS: In routine clinical practice as in clinical trials, PA pressure-guided therapy for HF was associated with lower PA pressures, lower rates of HFH and all-cause hospitalization, and low rates of adverse events across a broad range of patients with symptomatic HF and prior HFH. Registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT02279888

Cardiac mitochondrial function depends on BUD23 mediated ribosome programming.

Efficient mitochondrial function is required in tissues with high energy demand such as the heart, and mitochondrial dysfunction is associated with cardiovascular disease. Expression of mitochondrial proteins is tightly regulated in response to internal and external stimuli. Here we identify a novel mechanism regulating mitochondrial content and function, through BUD23-dependent ribosome generation. BUD23 was required for ribosome maturation, normal 18S/28S stoichiometry and modulated the translation of mitochondrial transcripts in human A549 cells. Deletion of Bud23 in murine cardiomyocytes reduced mitochondrial content and function, leading to severe cardiomyopathy and death. We discovered that BUD23 selectively promotes ribosomal interaction with low GC-content 5'UTRs. Taken together we identify a critical role for BUD23 in bioenergetics gene expression, by promoting efficient translation of mRNA transcripts with low 5'UTR GC content. BUD23 emerges as essential to mouse development, and to postnatal cardiac function