Automated condition monitoring of mill ball size distribution and grate open area

Grinding media in coarse grinding tumbling mills constitute the biggest consumable cost to a comminution processing plant, therefore it is critically important to minimize associated wear. Secondly, efficient grinding is dependent on tight control of the desired ball size distribution, or else optimum impact breakage cannot be assured. Despite the significance of minitoring ball size distribution for mill operation, no practically deployable systems are currently in industry use to measure it. This paper describes a new method for highly accurate, comprehensive, and rapid determination of ball size distribution.Accurate SAG and AG mill product size control is dependent on appropriate Grate Open Area dimensions. Wear of the grate hole edges or in the plate thickness results in an increase of the open area due to the tapered hole cross section, which can result in oversize product exiting the mill. Conversely, some grate castings feature peening of the edges during mill operation, thereby decreasing open area, and therefore preventing the desireed top size product from exiting the mill.SAG mill throughput requires grate holes to remain open or else throughput is restricted. Many grates in operation are pegged by grinding media to varying degrees of severity. This paper introduces a comprehensive, accurate and rapid method to measure and track the size and pegging status of each and all grate holes in situ, and therefore provides tracking information on the Open Area of a SAG mill. This enables operators to control the primary mill product size and therefore the opportunity to stabilize downstream processes

The Kr2Det project: Search for mass-3 state contribution |U_{e3}|^2 to the electron neutrino using a one reactor - two detector oscillation experiment at Krasnoyarsk underground site

The main physical goal of the project is to search with reactor antineutrinos for small mixing angle oscillations in the atmospheric mass parameter region around {\Delta}m^{2}_{atm} ~ 2.5 10^{-3} eV^2 in order to find the element U_{e3} of the neutrino mixing matrix or to set a new more stringent constraint (U_{e3} is the contribution of mass-3 state to the electron neutrino flavor state). To achieve this we propose a "one reactor - two detector" experiment: two identical antineutrino spectrometers with $\sim$50 ton liquid scintillator targets located at ~100 m and ~1000 m from the Krasnoyarsk underground reactor (~600 mwe). In no-oscillation case ratio of measured positron spectra of the \bar{{\nu}_e} + p \to e^{+} + n reaction is energy independent. Deviation from a constant value of this ratio is the oscillation signature. In this scheme results do not depend on the exact knowledge of the reactor power, nu_e spectra, burn up effects, target volumes and, which is important, the backgrounds can periodically be measured during reactor OFF periods. In this letter we present the Krasnoyarsk reactor site, give a schematic description of the detectors, calculate the neutrino detection rates and estimate the backgrounds. We also outline the detector monitoring and calibration procedures, which are of a key importance. We hope that systematic uncertainties will not accede 0.5% and the sensitivity U^{2}_{e3} ~4 10^{-3} (at {\Delta}m^{2} = 2.5 10^{-3} eV^2) can be achieved.Comment: Latex 2e, 9 pages and 5 ps figure

Low Energy Neutrino Physics after SNO and KamLAND

In the recent years important discoveries in the field of low energy neutrino physics (E$_\nu$ in the $\approx$ MeV range) have been achieved. Results of the solar neutrino experiment SNO show clearly flavor transitions from $\nu_e$ to $\nu_{\mu,\tau}$. In addition, the long standing solar neutrino problem is basically solved. With KamLAND, an experiment measuring neutrinos emitted from nuclear reactors at large distances, evidence for neutrino oscillations has been found. The values for the oscillation parameters, amplitude and phase, have been restricted. In this paper the potential of future projects in low energy neutrino physics is discussed. This encompasses future solar and reactor experiments as well as the direct search for neutrino masses. Finally the potential of a large liquid scintillator detector in an underground laboratory for supernova neutrino detection, solar neutrino detection, and the search for proton decay $p \to K^+ \nu$ is discussed.Comment: Invited brief review, World Scientific Publishing Compan

Cisplatin based therapy: The role of the mitogen activated protein kinase signaling pathway

Cisplatin is a widely used chemotherapeutic agent for treatment of various cancers. However, treatment with cisplatin is associated with drug resistance and several adverse side effects such as nephrotoxicity, reduced immunity towards infections and hearing loss. A Combination of cisplatin with other drugs is an approach to overcome drug resistance and reduce toxicity. The combination therapy also results in increased sensitivity of cisplatin towards cancer cells. The mitogen activated protein kinase (MAPK) pathway in the cell, consisting of extracellular signal regulated kinase, c-Jun N-terminal kinase, p38 kinases, and downstream mediator p90 ribosomal s6 kinase (RSK); is responsible for the regulation of various cellular events including cell survival, cell proliferation, cell cycle progression, cell migration and protein translation. This review article demonstrates the role of MAPK pathway in cisplatin based therapy, illustrates different combination therapy involving cisplatin and also shows the importance of targeting MAPK family, particularly RSK, to achieve increased anticancer effect and overcome drug resistance when combined with cisplatin. - 2018 The Author(s).Scopu

Uromodulin (Tamm–Horsfall protein): guardian of urinary and systemic homeostasis

Biology has taught us that a protein as abundantly made and conserved among species as Tamm–Horsfall protein (THP or uromodulin) cannot just be a waste product serving no particular purpose. However, for many researchers, THP is merely a nuisance during urine proteome profiling or exosome purification and for clinicians an enigmatic entity without clear disease implications. Thanks to recent human genetic and correlative studies and animal modeling, we now have a renewed appreciation of this highly prevalent protein in not only guarding urinary homeostasis, but also serving as a critical mediator in systemic inter-organ signaling. Beyond a mere barrier that lines the tubules, or a surrogate for nephron mass, mounting evidence suggests that THP is a multifunctional protein critical for modulating renal ion channel activity, salt/water balance, renal and systemic inflammatory response, intertubular communication, mineral crystallization and bacterial adhesion. Indeed, mutations in THP cause a group of inherited kidney diseases, and altered THP expression is associated with increased risks of urinary tract infection, kidney stone, hypertension, hyperuricemia and acute and chronic kidney diseases. Despite the recent surge of information surrounding THP’s physiological functions and disease involvement, our knowledge remains incomplete regarding how THP is normally regulated by external and intrinsic factors, how precisely THP deficiency leads to urinary and systemic pathophysiology and in what clinical settings THP can be used as a theranostic biomarker and a target for modulation to improve patient outcomes

A new ordering principle for the classical statistical analysis of Poisson processes with background

Inspired by the recent proposal by Feldman and Cousins of a ``unified approach to the classical statistical analysis of small signals'' based on a choice of ordering in Neyman's construction of classical confidence intervals, I propose a new ordering principle for the classical statistical analysis of Poisson processes with background which minimizes the effect on the resulting confidence intervals of the observation of less background events than expected. The new ordering principle is applied to the calculation of the confidence region implied by the recent null result of the KARMEN neutrino oscillation experiment.Comment: 16 pages including 5 figures, RevTeX. Final version published in Phys. Rev. D 59 (1999) 05300

Neutrino mixing and CP-violation

The prospects of measuring the leptonic angles and CP-odd phases at a neutrino factory are discussed in two scenarios: 1) three active neutrinos as indicated by the present ensemble of atmospheric plus solar data; 2) three active plus one sterile neutrino when the LSND signal is also taken into account. For the latter we develop one and two mass dominance approximations. The appearance of wrong sign muons in long baseline experiments and tau leptons in short baseline ones provides the best tests of CP-violation in scenarios 1) and 2), respectively.Comment: 22 pages, LaTeX2e, 17 eps files, use package epsfi

Plasma host protein biomarkers correlating with increasing Mycobacterium tuberculosis infection activity prior to tuberculosis diagnosis in people living with HIV

BACKGROUND: Biomarkers correlating with Mycobacterium tuberculosis infection activity/burden in asymptomatic individuals are urgently needed to identify and treat those at highest risk for developing active tuberculosis (TB). Our main objective was to identify plasma host protein biomarkers that change over time prior to developing TB in people living with HIV (PLHIV). METHODS: Using multiplex MRM-MS, we investigated host protein expressions from 2 years before until time of TB diagnosis in longitudinally collected (every 3-6 months) and stored plasma from PLHIV with incident TB, identified within a South African (SA) and US cohort. We performed temporal trend and discriminant analyses for proteins, and, to assure clinical relevance, we further compared protein levels at TB diagnosis to interferon-gamma release assay (IGRA; SA) or tuberculin-skin test (TST; US) positive and negative cohort subjects without TB. SA and US exploratory data were analyzed separately. FINDINGS: We identified 15 proteins in the SA (n=30) and 10 in the US (n=24) incident TB subjects which both changed from 2 years prior until time of TB diagnosis after controlling for 10% false discovery rate, and were significantly different at time of TB diagnosis compared to non-TB subjects (p<0.01). Five proteins, CD14, A2GL, NID1, SCTM1, and A1AG1, overlapped between both cohorts. Furthermore, after cross-validation, panels of 5 – 12 proteins were able to predict TB up to two years before diagnosis. INTERPRETATION: Host proteins can be biomarkers for increasing Mycobacterium tuberculosis infection activity/burden, incipient TB, and predict TB development in PLHIV. FUNDING: NIH/NIAID AI117927, AI146329, and AI127173 to JMA

Is CP Violation Observable in Long Baseline Neutrino Oscillation Experiments ?

We have studied CP violation originated by the phase of the neutrino mixing matrix in the long baseline neutrino oscillation experiments. The direct measurements of CP violation is the difference of the transition probabilities between CP-conjugate channels. In those experiments, the CP violating effect is not suppressed if the highest neutrino mass scale is taken to be 1\sim 5 \eV, which is appropriate for the cosmological hot dark matter. Assuming the hierarchy for the neutrino masses, the upper bounds of CP violation have been caluculated for three cases, in which mixings are constrained by the recent short baseline ones. The calculated upper bounds are larger than $10^{-2}$, which will be observable in the long baseline accelerator experiments. The matter effect, which is not CP invariant, has been also estimated in those experiments.Comment: 28 pages, LaTex file, 6 figures included using epsfig Matter effect is estimated(Figs.3(a) (b)). Physical parameters are change

Quantum Dissipative Effects and Neutrinos : current constraints and future perspectives

We establish the most stringent experimental constraints coming from recent terrestrial neutrino experiments on quantum mechanical decoherence effects in neutrino systems. Taking a completely phenomenological approach, we probe vacuum oscillations plus quantum decoherence between two neutrino species in the channels $\nu_\mu \to \nu_\tau$, $\nu_\mu \to \nu_e$ and $\nu_e \to \nu_\tau$, admitting that the quantum decoherence parameter $\gamma$ is related to the neutrino energy $E_\nu$ as : $\gamma=\gamma_0 (E_\nu/\text{GeV})^{n}$, with $n=-1,0,1$ and 2. Our bounds are valid for a neutrino mass squared difference compatible with the atmospheric, the solar and, in many cases, the LSND scale. We also qualitatively discuss the perspectives of the future long baseline neutrino experiments to further probe quantum dissipation.Comment: 26 pages, 8 encapsulated postscript figure