Requirement management in software projects in the healthcare area: state of the art.

Este artículo presenta un análisis general del estado de la gestión de requisitos en proyectos informáticos que involucren tecnología y salud. El objetivo es definir el estado actual de los requisitos de proyectos informáticos que integran las TIC y la salud. En la metodología se efectuó una revisión documental acerca de la gestión de requisitos, proyectos informáticos, salud, y TIC. Se proponen ideas y se cuestionan los enfoques de los escritos académicos relacionados con el tema consultado. El resultado permite ver que no existe una integración clara en los conceptos de salud, informática y gestión de proyectos para involucrar las TIC. Se concluye que es necesario tener en cuenta muchas premisas, variables y factores que son importantes al momento de iniciar un proyecto de salud. Las TIC, hacen parte fundamental de este proceso, contar con ellas es primordial y necesario.This article presents a general analysis of the condition of the management of requirements in IT projects that involve technology and health. The aim is to define the current condition of the requirements of IT projects that integrate the TIC and the health. In the methodology a documentary review was effected it brings over of the management of requirements, IT projects, health, and TIC. They propose ideas and there question the approaches of the written academicians related to the consulted topic. The result allows seeing that a clear integration does not exist in the concepts of health, computer science and project management to involve the TIC. One concludes that it is necessary bear in mind many premises, variables and factors that are important to the moment to initiate a project of health. The TIC, they make fundamental part of this process, rely on them it is basic and necessary.Este artigo apresenta uma análise geral do estado de gerenciamento de requisitos em projetos de software que envolve tecnologia e saúde. O objetivo é definir o estado atual dos requisitos de projetos de software que integram as TIC e a saúde. A metodologia foi uma análise documental sobre a gestão de requisitos, projetos de software, saúde e TIC. Proposta de ideias e abordagens dos escritos acadêmicos relacionados ao assunto consultado é pergunta. O resultado permite que você veja que clara sobre os conceitos de saúde, integração e projeto gerenciamento do computador lá é para não envolvendo as TIC. Conclui-se que é necessário ter em conta muitas instalações, variáveis e fatores que são importantes ao iniciar um projeto de saúde. As TIC, são uma parte essencial deste processo, tê-los é essencial e necessário

Assessing the impact of COVID-19 on liver cancer management (CERO-19)

Background & Aims: The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to healthcare systems and it may have heavily impacted patients with liver cancer (LC). Herein, we evaluated whether the schedule of LC screening or procedures has been interrupted or delayed because of the COVID-19 pandemic. Methods: An international survey evaluated the impact of the COVID-19 pandemic on clinical practice and clinical trials from March 2020 to June 2020, as the first phase of a multicentre, international, and observational project. The focus was on patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma, cared for around the world during the first COVID-19 pandemic wave. Results: Ninety-one centres expressed interest to participate and 76 were included in the analysis, from Europe, South America, North America, Asia, and Africa (73.7%,17.1%, 5.3%, 2.6%, and 1.3% per continent, respectively). Eighty-seven percent of the centres modified their clinical practice: 40.8% the diagnostic procedures, 80.9% the screening programme, 50% cancelled curative and/or palliative treatments for LC, and 41.7% modified the liver transplantation programme. Forty-five out of 69 (65.2%) centres in which clinical trials were running modified their treatments in that setting, but 58.1% were able to recruit new patients. The phone call service was modified in 51.4% of centres which had this service before the COVID-19 pandemic (n = 19/37). Conclusions: The first wave of the COVID-19 pandemic had a tremendous impact on the routine care of patients with liver cancer. Modifications in screening, diagnostic, and treatment algorithms may have significantly impaired the outcome of patients. Ongoing data collection and future analyses will report the benefits and disadvantages of the strategies implemented, aiding future decision-making. Lay summary: The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to healthcare systems globally. Herein, we assessed the impact of the first wave pandemic on patients with liver cancer and found that routine care for these patients has been majorly disrupted, which could have a significant impact on outcomes. (C) 2021 The Authors. Published by Elsevier B.V. on behalf of European Association for the Study of the Liver (EASL)

Assessing the impact of COVID-19 on liver cancer management (CERO-19).

BACKGROUND & AIMS: The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to healthcare systems and it may have heavily impacted patients with liver cancer (LC). Herein, we evaluated whether the schedule of LC screening or procedures has been interrupted or delayed because of the COVID-19 pandemic. METHODS: An international survey evaluated the impact of the COVID-19 pandemic on clinical practice and clinical trials from March 2020 to June 2020, as the first phase of a multicentre, international, and observational project. The focus was on patients with hepatocellular carcinoma or intrahepatic cholangiocarcinoma, cared for around the world during the first COVID-19 pandemic wave. RESULTS: Ninety-one centres expressed interest to participate and 76 were included in the analysis, from Europe, South America, North America, Asia, and Africa (73.7%, 17.1%, 5.3%, 2.6%, and 1.3% per continent, respectively). Eighty-seven percent of the centres modified their clinical practice: 40.8% the diagnostic procedures, 80.9% the screening programme, 50% cancelled curative and/or palliative treatments for LC, and 41.7% modified the liver transplantation programme. Forty-five out of 69 (65.2%) centres in which clinical trials were running modified their treatments in that setting, but 58.1% were able to recruit new patients. The phone call service was modified in 51.4% of centres which had this service before the COVID-19 pandemic (n = 19/37). CONCLUSIONS: The first wave of the COVID-19 pandemic had a tremendous impact on the routine care of patients with liver cancer. Modifications in screening, diagnostic, and treatment algorithms may have significantly impaired the outcome of patients. Ongoing data collection and future analyses will report the benefits and disadvantages of the strategies implemented, aiding future decision-making. LAY SUMMARY: The coronavirus disease 2019 (COVID-19) pandemic has posed unprecedented challenges to healthcare systems globally. Herein, we assessed the impact of the first wave pandemic on patients with liver cancer and found that routine care for these patients has been majorly disrupted, which could have a significant impact on outcomes

Identification and characterization of environmental conflicts in the Town of Fontibón, Bogotá D.C

En Colombia el número de problemas ambientales ha ido en aumento debido a sus procesos de desarrollo económico, lo que a su vez ha generado un aumento significativo de inconformidad por parte de distintos actores de la sociedad que se manifiestan de diversas maneras con la intención de atenuar , cambiar o eliminar el problema que los afecta. Para Bogotá, la situación frente a los conflictos ambientales no es diferente. El distrito se encuentra en un crecimiento constante que a menudo genera divergencia y contrapone los intereses de los distintos actores que intervienen en la cotidianidad y el desarrollo de la ciudad. Por esta razón, para el caso específico de la localidad de Fontibón es relevante contar con una identificación y caracterización de conflictos ambientales que permitan detallar los problemas ambientales, las respuestas y el accionar de los actores y la evolución de los mismos, con la finalidad de Brinde un insumo a investigadores y tomadores de decisiones que eventualmente puedan aportar para la solución de dichos conflictos ambientales. Para este propósito, se recurre a herramientas metodológicas tales como la revisión de literatura, búsqueda de información secundaria, entrevistas, cartografía social y análisis de datos, que a su vez ayuden a establecer una entrada de información para el Observatorio Distrital de Conflictos Ambientales - ODCA referente a los conflictos ambientales presentes en la localidad de Fontibón.In Colombia, the number of environmental problems has been increasing due to its economic development processes, which in turn has generated a significant increase in nonconformity on the part of different actors in society who manifest themselves in various ways with the intention of attenuating , change or eliminate the problem that affects them. For Bogotá, the situation regarding environmental conflicts is no different. The district is in constant growth that often generates divergence and opposes the interests of the different actors that intervene in the daily life and development of the city. For this reason, for the specific case of the town of Fontibón, it is relevant to have an identification and characterization of environmental conflicts that allow detailing the environmental problems, the responses and the actions of the actors and their evolution, with the purpose of Provide an input to researchers and decision makers who can eventually contribute to the solution of these environmental conflicts. For this purpose, methodological tools such as literature review, search for secondary information, interviews, social cartography and data analysis are used, which in turn help to establish an input for the District Observatory of Environmental Conflicts - ODCA. referring to the environmental conflicts present in the town of Fontibón

Propuesta de implementación de manuales de procesos y procedimientos operativos para la empresa Clínica Nueva Sonrisa Ltda. de la ciudad de Cali

El siguiente proyecto de investigación, Propuesta de Implementación de Manuales de Procesos y Procedimientos Operativos para La Empresa Clínica Nueva Sonrisa Ltda., de la ciudad de Cali. En sus áreas administrativas y operativas contribuye al estudio de planeación estratégica de una Clínica de prestación de servicios odontológicos de la ciudad de Cali, implementando una metodología de cambio con base en todos los estándares que han sido objeto del presente estudio. Los Manuales de Procesos y Procedimientos que se presentan de carácter práctico y ante todo, autoinstruccional. Es decir, aporta los elementos teóricos y prácticos necesarios para realizar el trabajo para el cual fue desarrollado. Los Manuales están organizados de manera que el diseño e implementación de Procesos y procedimientos parezcan lo más claro posible. La idea es ir recorriendo los pasos desde el principio, pero también poder volver sobre un punto y aclarar dudas a medida que se desarrolla el proyecto, consultando e indagando para encontrar las debilidades en las áreas de trabajo. Lo primero que encontraremos será la descripción de la empresa y su situación actual, para así dar los primeros pasos en la formulación del proyecto. A continuación, encontraremos todo lo relacionado con la identificación del problema sobre el cual se trabajará y la priorización de alternativas para su solución y así, estar en condiciones de empezar a afinar la propuesta, analizando el entorno y así definir objetivos específicos. 5 El objetivo de los manuales es entregar las herramientas para formular soluciones a problemas que hayan identificado en su entorno. Proponiendo que el proyecto represente una inquietud emanada del quehacer cotidiano; tal vez un problema que hace mucho tiempo necesita solución y que hasta ahora no sabían por dónde comenzar a abordar. Para resolverlo, se requiere de la colaboración de los funcionarios involucrados en el proceso que quieren mejorar su entorno. Se pretende que los Manuales sirvan para generar cambios más sustantivos en el ámbito de toma de decisión, aumento de la efectividad de los funcionarios, incrementar su nivel de competitividad en el mercado y cumplir con todos los estándares requeridos por los entes de vigilancia y control para las empresas prestadoras de servicios de salud. Se espera que la siguiente presentación sea de gran utilidad para sus lectores y sea utilizada como herramienta para el logro de los objetivos de estudio.1. Problema .................................................................................. 6 2. Objetivos .................................................................................. 12 3. Justificación ............................................................................... 13 4. Marco de referencia .................................................................. 20 5. Diseño metodológico ................................................................ 25 6. Fuentes y técnicas de recolección de información .................... 28 7. Presupuesto ............................................................................... 34 Desarrollo del proyecto 1. Descripción de la empresa ......................................................... 36 2. identificación de la necesidad, oportunidad o problemática ....... 39 3. Nivel institucional ........................................................................ 41 4. Diagnóstico empresarial ............................................................. 42 5. Análisis dofa ............................................................................... 48 6. Estructural organizacional ......................................................... 49 7. Recursos .................................................................................... 52 8. Grupos de interés de la empresa ............................................... 53 9. Estratégicas diseñadas para lograr la misión y la visión ............ 54 10. Situación financiera .................................................................. 57 11. Situación del mercado .............................................................. 67 12. Situación técnica ...................................................................... 70PregradoAdministrador de Negocio

Análisis descriptivo de los factores de impacto en las pruebas Saber Pro de estudiantes de Ingeniería Electrónica

En este documento se presentan y analizan los resultados obtenidos al aplicar un instrumento de recolección de información a estudiantes de ingeniería electrónica de la Universidad Francisco de Paula Santander, con el fin de determinar los factores de impacto en las pruebasSaber Pro. En su mayoría, las opciones de respuesta se encontraron en escala de Likert y se indagó respecto al nivel aptitudinal de los estudiantes, su preparación para las pruebas y el nivel en el que debe mejorarse la preparación de los módulos que se evalúan en la prueba de estado. Se obtuvo información de relevancia para contribuir en la toma de decisiones y el mejoramiento continuo tanto en los procesos de aprendizaje, como en el desempeño de los estudiantes en las pruebas Saber Pro. Con esto, se fortalecen los procesos implementados por el programa académico en pro de la reacreditación del programa académico en alta calidad.This document presents and analyzes the results obtained when applying a data collection instrument to electronic engineering students of the Universidad Francisco de Paula Santander, to determine the impact factors in the Saber Pro tests. Most of the answer options were found in Likert scale and it was investigated the students' aptitude level, their preparation for the tests and the level in which the preparation of the modules that are evaluated in the state test should be improved. Relevant information was obtained to contribute to decision making for continuous improvement in both the learning processes and the students' performance in the Saber Pro tests. With this, the processes implemented by the academic program are strengthened for the re-accreditation of the academic program in high quality

<i>NTH2</i> 1271_1272delTA Gene Disruption Results in Salt Tolerance in <i>Saccharomyces cerevisiae</i>

Trehalose is a common energy reservoir, and its accumulation results in osmotic protection. This sugar can accumulate through its synthesis or slow degradation of the reservoir by trehalase enzymes. Saccharomyces cerevisiae contains two neutral trehalases, NTH1 and NTH2, responsible for 75% and 25% of the enzymatic metabolism. We were interested in the loss-of-function of both enzymes with CRISPR/Cas9. The later NTH2 was of great importance since it is responsible for minor metabolic degradation of this sugar. It was believed that losing its functionality results in limited osmotic protection. We constructed an osmotolerant superior yeast capable of growing in 0.85 M NaCl after independent nth21271_1272delTA mutation by CRISPR/Cas9 technology, compared with nth1 893_894insT and wild type. We suggest that this yeast model could give clues to breeding commercial yeast resulting in non-GMO salinity-tolerant strains

NTH2 1271_1272delTA Gene Disruption Results in Salt Tolerance in Saccharomyces cerevisiae

Trehalose is a common energy reservoir, and its accumulation results in osmotic protection. This sugar can accumulate through its synthesis or slow degradation of the reservoir by trehalase enzymes. Saccharomyces cerevisiae contains two neutral trehalases, NTH1 and NTH2, responsible for 75% and 25% of the enzymatic metabolism. We were interested in the loss-of-function of both enzymes with CRISPR/Cas9. The later NTH2 was of great importance since it is responsible for minor metabolic degradation of this sugar. It was believed that losing its functionality results in limited osmotic protection. We constructed an osmotolerant superior yeast capable of growing in 0.85 M NaCl after independent nth21271_1272delTA mutation by CRISPR/Cas9 technology, compared with nth1&nbsp;893_894insT and wild type. We suggest that this yeast model could give clues to breeding commercial yeast resulting in non-GMO salinity-tolerant strains

Resúmenes proyectos de investigación en psicología financiamiento fondo nacional de desarrollo cientifico y tecnologico - FONDECYT aprobados año 2014

Durante el año 2014 se resolvieron los concursos FONDECYT regular 2014 y de Iniciación a la investigación 2013. En el concurso de Iniciación a la Investigación, se presentaron 703 proyectos, de los cuales fueron aprobaron 308. De estos, 6 corresponden a Psicología (de un total de 20 proyectos postulados), por un valor de 358.897 millones de pesos, lo que constituye el 1,5% del total del financiamiento otorgado en esta categoría. En el concurso regular, de 1286 proyectos postulados, se aprobaron para financiamiento 581. De estos, 21 proyectos corresponden a Psicología (de un total de 45 presentados), por un valor de 2.097.829 millones, lo que equivale al 3,0% del monto total asignado a este concurso. Se presentan en este artículo especial, resúmenes de20 proyectos aprobados para el área, los cuales comenzaron a ejecutarse en noviembre del 2013 (iniciación) y que estarán ejecutándose hasta el periodo 2016-2017. During 2012 the Grants from FONDECYT for Regular Competitions 2014 and for Introduction to Research 2013 were resolved. For Introduction to Research, 703 projects was submitted and 308 projects were approved. Of these, 6 corresponded to Psychology (from a total of 20 projects nominated), with an amount of 358.897 million pesos, representing 1,5 % of total awarded  funding in this category. In Regular Competition, from 1286 projects submitted for funding and 581 were approved. Of these, 21 projects are from Psychology (out of 45 submitted), valued at 2.097.829 million, equivalent to 3,0% of the total amount allocated for this competition. In this special report, summaries from 20 projects approved in the area are presented. They began to run in November 2013 (Introduction) and will run until the period 2016-201

Drug Development in Conformational Diseases: A Novel Family of Chemical Chaperones that Bind and Stabilise Several Polymorphic Amyloid Structures

<div><p>The increasing prevalence of conformational diseases, including Alzheimer's disease, type 2 Diabetes Mellitus and Cancer, poses a global challenge at many different levels. It has devastating effects on the sufferers as well as a tremendous economic impact on families and the health system. In this work, we apply a cross-functional approach that combines ideas, concepts and technologies from several disciplines in order to study, <i>in silico</i> and <i>in vitro</i>, the role of a novel chemical chaperones family (NCHCHF) in processes of protein aggregation in conformational diseases. Given that Serum Albumin (SA) is the most abundant protein in the blood of mammals, and Bovine Serum Albumin (BSA) is an off-the-shelf protein available in most labs around the world, we compared the ligandability of BSA:NCHCHF with the interaction sites in the Human Islet Amyloid Polypeptide (hIAPP):NCHCHF, and in the amyloid pharmacophore fragments (Aβ17–42 and Aβ16–21):NCHCHF. We posit that the merging of this interaction sites is a meta-structure of pharmacophore which allows the development of chaperones that can prevent protein aggregation at various states from: stabilizing the native state to destabilizing oligomeric state and protofilament. Furthermore to stabilize fibrillar structures, thus decreasing the amount of toxic oligomers in solution, as is the case with the NCHCHF. The paper demonstrates how a set of NCHCHF can be used for studying and potentially treating the various physiopathological stages of a conformational disease. For instance, when dealing with an acute phase of cytotoxicity, what is needed is the recruitment of cytotoxic oligomers, thus chaperone F, which accelerates fiber formation, would be very useful; whereas in a chronic stage it is better to have chaperones <b>A</b>, <b>B</b>, <b>C</b>, and <b>D</b>, which stabilize the native and fibril structures halting self-catalysis and the creation of cytotoxic oligomers as a consequence of fiber formation. Furthermore, all the chaperones are able to protect and recondition the cerebellar granule cells (CGC) from the cytotoxicity produced by the hIAPP_20–29 fragment or by a low potassium medium, regardless of their capacity for accelerating or inhibiting <i>in vitro</i> formation of fibers. <i>In vivo</i> animal experiments are required to study the impact of chemical chaperones in cognitive and metabolic syndromes.</p></div