405 research outputs found
Reconstructing the Inflaton Potential
A review is presented of recent work by the authors concerning the use of
large scale structure and microwave background anisotropy data to determine the
potential of the inflaton field. The importance of a detection of the
stochastic gravitational wave background is emphasised, and some preliminary
new results of tests of the method on simulated data sets with uncertainties
are described. (Proceedings of ``Unified Symmetry in the Small and in the
Large'', Coral Gables, 1994)Comment: 13 pages, uuencoded postscript file with figures included (LaTeX file
available from ARL), FERMILAB-Conf 94/189
Homozygosity by descent mapping of blood pressure in the Old Order Amish: evidence for sex specific genetic architecture
<p>Abstract</p> <p>Background</p> <p>High blood pressure is a well established risk factor for morbidity and mortality acting through heart disease, stroke and cardiovascular disease. Genome wide scans have linked regions of nearly every human chromosome to blood pressure related traits. We have capitalized on beneficial qualities of the Old Order Amish of Lancaster, PA, a closed founder population with a relatively small number of founders, to perform a genome wide homozygosity by descent mapping scan. Each individual in the study has a non zero probability of consanguinity. Systolic and diastolic blood pressures are shown to have appreciable dominance variance components.</p> <p>Results</p> <p>Areas of two chromosomes were identified as suggestive of linkage to SBP and 5 areas to DBP in either the overall or sex specific analyses. The strongest evidence for linkage in the overall sample was to Chromosome 18q12 (LOD = 2.6 DBP). Sex specific analyses identified a linkage on Chromosome 4p12-14 (LOD in men only = 3.4 SBP). At Chromosome 2q32-33, an area where we previously reported significant evidence for linkage to DBP using a conventional identity by descent approach, the LOD was 1.4; however an appreciable sex effect was observed with men accounting for most of the linkage (LOD in men only = 2.6).</p> <p>Conclusion</p> <p>These results add evidence to a sex specific genetic architecture to blood pressure related traits, particularly in regions of linkage on chromosome 2, 4 and 18.</p
Ionic Liquids Enabling Revolutionary Closed-Loop Life Support
Minimizing resupply from Earth is essential for future long duration manned missions. The current oxygen recovery system aboard the International Space Station is capable of recovering approximately 50% of the oxygen from metabolic carbon dioxide. For long duration manned missions, a minimum of 75% oxygen recovery is targeted with a goal of greater than 90%. Theoretically, the Bosch process can recover 100% of oxygen, making it a promising technology for oxygen recovery for long duration missions. However, the Bosch process produces elemental carbon which ultimately fouls the catalyst. Once the catalyst performance is compromised, it must be replaced resulting in undesired resupply mass. Based on the performance of a Bosch system designed by NASA in the 1990's, a three year Martian mission would require approximately 1315 kg (2850 lbs) of catalyst resupply. It may be possible to eliminate catalyst resupply with a fully regenerable system using an Ionic Liquid (IL)-based Bosch system. In 2016, we reported the feasibility of using ILs to produce an iron catalyst on a copper substrate and to regenerate the iron catalyst by extracting the iron from the copper substrate and product carbon. Additionally, we described a basic system concept for an IL-based Bosch. Here we report the results of efforts to scale catalyst preparation, catalyst regeneration, and to scale the carbon formation processing rate of a single reactor
Bubble Growth as a Detonation
Bubble growth as a detonation is studied in the context of cosmological phase
transitions. It is proved that the so called Chapman-Jouguet hypothesis, which
restricts the types of detonations that can occur in spherically symmetric
chemical burning, does not hold in the case of phase transitions. Therefore a
much larger class of detonation solutions exists in phase transitions than in
chemical burning.Comment: 15 LaTeX-pages with 5 ps-figures appended at the end, preprint
HU-TFT-93-4
Reconstructing Single Field Inflationary Actions From CMBR Data
This paper describes a general program for deriving the action of single
field inflation models with nonstandard kinetic energy terms using CMBR power
spectrum data. This method assumes that an action depends on a set of
undetermined functions, each of which is a function of either the inflaton wave
function or its time derivative. The scalar, tensor and non-gaussianity of the
curvature perturbation spectrum are used to derive a set of reconstruction
equations whose solution set can specify up to three of the undetermined
functions. The method is then used to find the undetermined functions in
various types of actions assuming power law type scalar and tensor spectra. In
actions that contain only two unknown functions, the third reconstruction
equation implies a consistency relation between the non-gaussianty, sound speed
and slow roll parameters. In particular we focus on reconstructing a
generalized DBI action with an unknown potential and warp factor. We find that
for realistic scalar and tensor spectra, the reconstructed warp factor and
potential are very similar to the theoretically derived result. Furthermore,
physical consistency of the reconstructed warp factor and potential imposes
strict constraints on the scalar and tensor spectral indices.Comment: 33 pages, 3 figures: v3 - References adde
Alterations to nuclear architecture and genome behavior in senescent cells.
The organization of the genome within interphase nuclei, and how it interacts with nuclear structures is important for the regulation of nuclear functions. Many of the studies researching the importance of genome organization and nuclear structure are performed in young, proliferating, and often transformed cells. These studies do not reveal anything about the nucleus or genome in nonproliferating cells, which may be relevant for the regulation of both proliferation and replicative senescence. Here, we provide an overview of what is known about the genome and nuclear structure in senescent cells. We review the evidence that nuclear structures, such as the nuclear lamina, nucleoli, the nuclear matrix, nuclear bodies (such as promyelocytic leukemia bodies), and nuclear morphology all become altered within growth-arrested or senescent cells. Specific alterations to the genome in senescent cells, as compared to young proliferating cells, are described, including aneuploidy, chromatin modifications, chromosome positioning, relocation of heterochromatin, and changes to telomeres
Utilizing Ionic Liquids to Enable the Future of Closed-Loop Life Support Technology
Current oxygen recovery technology onboard the International Space Station only recovers approximately 50% of the oxygen from metabolic carbon dioxide, thus requiring resupply mass in order to sustain life onboard. Future long duration manned missions will require maximum oxygen recovery in order to reduce resupply mass. Complete recovery of oxygen can be achieved through Bosch technology. The challenge with this technology is that the solid carbon produced during the process results in undesired catalyst resupply mass. Although there have been several approaches to solve this challenge, in order to totally eliminate the need for resupply only one potential process has been identified. This process is a fully-regenerable Ionic Liquid (IL)-based Bosch system that employs in situ resources. In 2016, efforts were made that proved the feasibility of an IL-based Bosch system. ILs were used to electroplate iron onto a copper substrate and to regenerate the iron by extracting the iron from the copper substrate and product carbon. In 2017, efforts were initiated to scale the proposed technology. Here we report the results of those efforts as well as an IL-based Bosch system concept and basic reactor design
The Relevance of Pyrogenic Carbon for Carbon Budgets From Fires: Insights From the FIREX Experiment
Vegetation fires play an important role in global and regional carbon cycles. Due to climate warming and land use shifts, fire patterns are changing and fire impacts increasing in many of the world's regions. Reducing uncertainties in carbon budgeting calculations from fires is therefore fundamental to advance our current understanding and forecasting capabilities. Here we study 20 chamber burns from the FIREX FireLab experiment, which burnt a representative set of North American wildland fuels, to assess the following: (i) differences in carbon emission estimations between the commonly used âconsumed biomassâ approach and the âburnt carbonâ approach; (ii) pyrogenic carbon (PyC) production rates; and (iii) thermal and chemical recalcitrance of the PyC produced, as proxies of its biogeochemical stability. We find that the âconsumed biomassâ approach leads to overestimation of carbon emissions by 2â27% (most values between 2% and 10%). This accounting error arises largely from not considering PyC production and, even if relatively small, can therefore have important implications for mediumâ and longâterm carbon budgeting. A large fraction (34â100%) of this PyC was contained in the charred fine residue, a postfire material frequently overlooked in fire carbon research. However, the most recalcitrant PyC was in the form of woody charcoal, with estimated halfâlives for most samples exceeding 1,000 years. Combustion efficiency was relatively high in these laboratory burns compared to actual wildland fire conditions, likely leading to lower PyC production rates. We therefore argue that the PyC production values obtained here, and associated overestimation of carbon emissions, should be taken as lowâend estimates for wildland fire conditions
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