Hepatocyte steatosis is a cytopathic effect of hepatitis C virus genotype 3.

Patients infected with the hepatitis C virus (HCV) often have liver steatosis, suggesting the possibility of a viral cytopathic effect. The aim of this study was to correlate the occurrence and severity of liver steatosis with HCV RNA type, level and sequence of the core-encoding region. We scored the liver steatosis in 101 HCV-infected individuals carefully selected to exclude other risk factors of a fatty liver. Results were compared with HCV RNA genotype and level in serum and liver. In selected patients, we assessed the effect of antiviral therapy on steatosis and the relationship between nucleocapsid sequence heterogeneity and fat infiltration. Steatosis was found in 41 (40.6%) patients, irrespective of sex, age or route of infection. HCV genotype 3 was associated with higher steatosis scores than other genotypes. A significant correlation between steatosis score and titer of intrahepatic HCV RNA was found in patients infected with genotype 3, but not in those infected with genotype 1. In selected patients, response to alpha-interferon was associated with the disappearance of steatosis. Analysis of the nucleocapsid of 14 HCV isolates failed to identify a sequence specifically associated with the development of steatosis. We provide virological and clinical evidence that the steatosis of the liver is the morphological expression of a viral cytopathic effect in patients infected with HCV genotype 3. At variance with published evidence from experimental models, the HCV nucleocapsid protein does not seem to fully explain the lipid accumulation in these patients

South-South Irregular Migration: The Impacts of China’s Informal Gold Rush in Ghana

This article examines irregular South‐South migration from China to Ghana, and the role it played in transforming livelihoods and broader developmental landscapes. It looks at the entry of approximately 50,000 Chinese migrants into the informal small‐scale gold mining sector from 2008‐2013. These migrants mainly hailed from Shanglin County in Guangxi Province. In Ghana, they formed mutually beneficial relationships with local miners, both legal and illegal, introducing machinery that substantially increased gold production. However, the legal status of Chinese miners was particularly problematic as, by law, small‐scale mining is restricted to Ghanaian citizens. In mid‐2013, President Mahama established a military task force against illegal mining, resulting in the deportation of many Chinese miners. The article examines the experiences of both Chinese migrants and Ghanaian miners. Findings are that irregular migration into an informal sector had long‐lasting impacts and played a significant role in the transformation of economic, political, and physical landscapes in Ghana

Water balance of the olive tree-annual crop association: A modeling approach

Water transfers within mixed crops systems are complicated to understand due to the large number of complex interactions between the various components. Standard techniques fail to provide the proper assessment of the components of the water balance. Experiments and modeling developments are used to understand the dynamics of water transfers within the association of olive trees with annual crops under irrigation in Central Tunisia. The whole system is represented by a unit area made up of three components: a plot with the annual crop, a plot with the olive tree and a plot of bare soil. The modeling approach is based on the concept of reservoir. The model works on a daily time step and accounts for the lateral transfers of water occurring between the components of the system: (i) the water uptake by the roots of olive trees; (ii) the physical flow of water between the irrigated plot and the non-irrigated ones. A field experiment was carried out during 2 years (2002, 2003) and three crop cycles (spring potato, spring pea and autumn potato) in order to calibrate the model and test its validity. Olive tree transpiration was estimated from sap flow measurements and soil moisture in the different compartments was measured by neutron probe technique. The experimental data compare fairly well with the model outputs. The first purpose of the model is to understand the functioning of the olive tree-annual crop association from a water standpoint, but it can be easily extended to other intercropping systems mixing perennial vegetation with annual crops or used as a management tool. The estimates of the water extracted by the olive trees in each reservoir appear to be much more significant than those of the water physically transferred between reservoirs.

2019 ESC/EAS guidelines for the management of dyslipidaemias: Lipid modification to reduce cardiovascular risk

Cardiolog