New observations of Tin Mineralization Potential Vis-à-Vis Ore Petrographic, Alteration and Geochemistry in the Southeastern part of Bastar Craton, Central India

The Tin mineralizations occur around the Katekalyan area, hosted in the acid magmatic rocks. The evolution differentiating granitic magma shows residual melt enrichment where end products intruded as pegmatites into the rocks. The different kind of pegmatite occur as simple unzoned, recrystallized (granitic pegmatite), and metasomatic greisenised and albitised pegmatites which emplaced within the pre-existing rocks of metabasic intrusive, granite (KG), granite gneiss (KGG). Sometimes it also found in metasediments as mineralised and non-mineralised characters along the fractures and foliation planes trending N-S, E-W and more frequently are observed NNW-SSE trends. Cassiterite is most important Tin-ore mineral and associated with pegmatites. Some cassiterite samples exhibit colourless to brown shades zoning which indicate multi stage growth. The cassiterite samples contain significant amounts of Sn, Nb, Ta with minor W. The partial melting model shows that the variation 5 to 50% partial melting of bulk continental crust for KG as well as KGG rocks but bulk distribution coefficient for Sr (DSr) shows low i.e. <<10. The upper limit of partial melting of bulk crust estimates ~50 % for KG and KGG rocks are consistent with required rheological, critical melt percentage to leave the source region has decreased granite melt which were capable to mineralised tin ore elements. It is interesting to note that the SnF4 and SnCl4 probably not stable in presence of water under geologically reasonable conditions

Domain of Existence and Uniqueness for Nonlinear Hammerstein Integral Equations

[EN] In this work, we performed an study about the domain of existence and uniqueness for an efficient fifth order iterative method for solving nonlinear problems treated in their infinite dimensional form. The hypotheses for the operator and starting guess are weaker than in the previous studies. We assume omega continuity condition on second order Frechet derivative. This fact it is motivated by showing different problems where the nonlinear operators that define the equation do not verify Lipschitz and Holder condition; however, these operators verify the omega condition established. Then, the semilocal convergence balls are obtained and the R-order of convergence and error bounds can be obtained by following thee main theorem. Finally, we perform a numerical experience by solving a nonlinear Hammerstein integral equations in order to show the applicability of the theoretical results by obtaining the existence and uniqueness balls.This research was partially supported by Ministerio de Economia y Competitividad under grant PGC2018-095896-B-C22.Singh, S.; Martínez Molada, E.; Kumar, A.; Gupta, DK. (2020). Domain of Existence and Uniqueness for Nonlinear Hammerstein Integral Equations. Mathematics. 8(3):1-11. https://doi.org/10.3390/math8030384S11183Hernández, M. A. (2001). Chebyshev’s approximation algorithms and applications. Computers & Mathematics with Applications, 41(3-4), 433-445. doi:10.1016/s0898-1221(00)00286-8Amat, S., Hernández, M. A., & Romero, N. (2008). A modified Chebyshev’s iterative method with at least sixth order of convergence. Applied Mathematics and Computation, 206(1), 164-174. doi:10.1016/j.amc.2008.08.050Argyros, I. K., Ezquerro, J. A., Gutiérrez, J. M., Hernández, M. A., & Hilout, S. (2011). On the semilocal convergence of efficient Chebyshev–Secant-type methods. Journal of Computational and Applied Mathematics, 235(10), 3195-3206. doi:10.1016/j.cam.2011.01.005Hueso, J. L., & Martínez, E. (2013). Semilocal convergence of a family of iterative methods in Banach spaces. Numerical Algorithms, 67(2), 365-384. doi:10.1007/s11075-013-9795-7Zhao, Y., & Wu, Q. (2008). Newton–Kantorovich theorem for a family of modified Halley’s method under Hölder continuity conditions in Banach space. Applied Mathematics and Computation, 202(1), 243-251. doi:10.1016/j.amc.2008.02.004Parida, P. K., & Gupta, D. K. (2007). Recurrence relations for a Newton-like method in Banach spaces. Journal of Computational and Applied Mathematics, 206(2), 873-887. doi:10.1016/j.cam.2006.08.027Parida, P. K., & Gupta, D. K. (2008). Recurrence relations for semilocal convergence of a Newton-like method in Banach spaces. Journal of Mathematical Analysis and Applications, 345(1), 350-361. doi:10.1016/j.jmaa.2008.03.064Cordero, A., Ezquerro, J. A., Hernández-Verón, M. A., & Torregrosa, J. R. (2015). On the local convergence of a fifth-order iterative method in Banach spaces. Applied Mathematics and Computation, 251, 396-403. doi:10.1016/j.amc.2014.11.084Argyros, I. K., & Hilout, S. (2013). On the local convergence of fast two-step Newton-like methods for solving nonlinear equations. Journal of Computational and Applied Mathematics, 245, 1-9. doi:10.1016/j.cam.2012.12.002Argyros, I. K., George, S., & Magreñán, Á. A. (2015). Local convergence for multi-point-parametric Chebyshev–Halley-type methods of high convergence order. Journal of Computational and Applied Mathematics, 282, 215-224. doi:10.1016/j.cam.2014.12.023Wang, X., Kou, J., & Gu, C. (2012). Semilocal Convergence of a Class of Modified Super-Halley Methods in Banach Spaces. Journal of Optimization Theory and Applications, 153(3), 779-793. doi:10.1007/s10957-012-9985-9Argyros, I. K., & Magreñán, Á. A. (2015). A study on the local convergence and the dynamics of Chebyshev–Halley–type methods free from second derivative. Numerical Algorithms, 71(1), 1-23. doi:10.1007/s11075-015-9981-xWu, Q., & Zhao, Y. (2007). Newton–Kantorovich type convergence theorem for a family of new deformed Chebyshev method. Applied Mathematics and Computation, 192(2), 405-412. doi:10.1016/j.amc.2007.03.018Martínez, E., Singh, S., Hueso, J. L., & Gupta, D. K. (2016). Enlarging the convergence domain in local convergence studies for iterative methods in Banach spaces. Applied Mathematics and Computation, 281, 252-265. doi:10.1016/j.amc.2016.01.036Kumar, A., Gupta, D. K., Martínez, E., & Singh, S. (2018). Semilocal convergence of a Secant-type method under weak Lipschitz conditions in Banach spaces. Journal of Computational and Applied Mathematics, 330, 732-741. doi:10.1016/j.cam.2017.02.042Singh, S., Gupta, D. K., Martínez, E., & Hueso, J. L. (2016). Semilocal Convergence Analysis of an Iteration of Order Five Using Recurrence Relations in Banach Spaces. Mediterranean Journal of Mathematics, 13(6), 4219-4235. doi:10.1007/s00009-016-0741-

Research Productivity and Visualization of the All India Institute of Medical Sciences (AIIMS) Bhubaneswar during 2012-2019: A Scientometric Approach

The purpose of the present study is to evaluate the productivity of research at the Indian Institute of Medical Sciences (AIIMS), Bhubaneswar, in the first eight years (2012-2019) of its establishment. In this study, the authors used a number of Scientometric indices to assess research productivity. The results of the study showed that in the selected period of 2019, most research publications appear with an average growth rate of 46.43%. Most of the comments were written by five or more authors. In addition, R.R. Das is recognized as the most prolific author, and the Journal of Clinical and Diagnostic Research is one of the most popular sources of publications, with the largest number of publications with the help of scientists from AIIMS. The UK and AIIMS New Delhi are the countries and institutions that work best together. In addition, the study also found that the Indian Medical Research Council is the leading research institution with AIIMS Bhubaneswar. The title of Maiti R Metronomic Chemotherapy , published in the Journal of Pharmacology and Pharmacotherapeutics, received the most citations. this sentence is long and somewhat complicated. This study is useful for policymakers and stakeholders in medical institutions to improve their research prospects

Chlamydial virulence factor TarP mimics talin to disrupt the talin-vinculin complex

Vinculin is a central component of mechanosensitive adhesive complexes that form between cells and the extracellular matrix. A myriad of infectious agents mimic vinculin binding sites (VBS), enabling them to hijack the adhesion machinery and facilitate cellular entry. Here, we report the structural and biochemical characterisation of a VBS from the chlamydial virulence factor TarP. Whilst the affinities of isolated VBS peptides from TarP and talin for vinculin are similar, their behaviour in larger fragments is markedly different. In talin, VBS are cryptic and require mechanical activation to bind vinculin, whereas the TarP VBS are located in disordered regions, and so are constitutively active. We demonstrate that the TarP VBS can uncouple talin:vinculin complexes, which may lead to adhesion destabilisation

Research Productivity and Visualization of the All India Institute of Medical Sciences (AIIMS) Bhubaneswar during 2012-2019: A Scientometric Approach

Scientometric analysis of research results enable individuals and institutions to understand their current status and improve their performance. The present study evaluate the productivity of research at the Indian Institute of Medical Sciences (AIIMS), Bhubaneswar using scientometric parameters. Study revealed that most research publications appeared with an average growth rate of 46.43%. and R.R. Das was the most prolific author. Journal of Clinical and Diagnostic Research was found to be the most popular source of publications and AIIMS Bhubaneswar the leading research institution. The title of Maiti R 'Metronomic Chemotherapy' published in the Journal of Pharmacology and Pharmacotherapeutics, received the highest citations. The findings of the study will be of use to the policy makers to improve research in the the area

Talin Rod Domain Containing Protein 1 (TLNRD1) is a novel actin-bundling protein which promotes filopodia formation

Talin is a mechanosensitive adapter protein which couples integrins to the cytoskeleton and regulates integrin-mediated adhesion. Talin rod domain-containing protein-1 (TLNRD1) shares 22% homology with the R7R8 domains of talin, and is highly conserved throughout vertebrate evolution, however little is known about its function. Here we show that TLNRD1 is an α-helical protein which shares the same atypical topology as talin R7R8, but forms a novel antiparallel dimer arrangement. Actin co-sedimentation assays and electron microscopy reveal TLNRD1 is an actin-bundling protein that forms tight actin bundles. In addition, TLNRD1 binds to the same LD-motif containing proteins, RIAM and KANK, as talin, and thus may act in competition with talin. Filopodia are cell protrusions supported by tightly bundled actin filaments and TLNRD1 localises to filopodia tips, increases filopodia number and promotes cell migration in 2D. Together our results suggest that TLNRD1 has similar functionality to talin R7R8, serving as a nexus between the actin and microtubule cytoskeletons independent of adhesion complexes

Structure and N-acetylglucosamine binding of the distal domain of mouse adenovirus 2 fibre

15 pags, 8 figsMurine adenovirus 2 (MAdV-2) infects cells of the mouse gastrointestinal tract. Like human adenoviruses, it is a member of the genus Mastadenovirus, family Adenoviridae. The MAdV-2 genome has a single fibre gene that expresses a 787 residue-long protein. Through analogy to other adenovirus fibre proteins, it is expected that the carboxy-terminal virus-distal head domain of the fibre is responsible for binding to the host cell, although the natural receptor is unknown. The putative head domain has little sequence identity to adenovirus fibres of known structure. In this report, we present high-resolution crystal structures of the carboxy-terminal part of the MAdV-2 fibre. The structures reveal a domain with the typical adenovirus fibre head topology and a domain containing two triple ß-spiral repeats of the shaft domain. Through glycan microarray profiling, saturation transfer difference nuclear magnetic resonance spectroscopy, isothermal titration calorimetry and site-directed mutagenesis, we show that the fibre specifically binds to the monosaccharide N-acetylglucosamine (GlcNAc). The crystal structure of the complex reveals that GlcNAc binds between the AB and CD loops at the top of each of the three monomers of the MAdV-2 fibre head. However, infection competition assays show that soluble GlcNAc monosaccharide and natural GlcNAc-containing polymers do not inhibit infection by MAdV-2. Furthermore, site-directed mutation of the GlcNAc-binding residues does not prevent the inhibition of infection by soluble fibre protein. On the other hand, we show that the MAdV-2 fibre protein binds GlcNAc-containing mucin glycans, which suggests that the MAdV-2 fibre protein may play a role in viral mucin penetration in the mouse gut.This research was sponsored by grant BFU2014-53425-P (to M. J. v. R.), coordinated grants CTQ2015-64597-P-C02-01 and CTQ2015-64597-P-C02-02 (to J. J. B. and F. J. C., respectively), grant BFU2015-70052-R (to M. M.) and the Spanish Adenovirus Network (AdenoNet, BIO2015-68990-REDT), all from the Spanish Agencia Estatal de Investigación. Financial support to M. M. from the CIBER of Respiratory Diseases (CIBERES) from the Spanish Institute of Health Carlos III is also acknowledged. These grants are co-financed by the European Regional Development Fund of the European Union. A. K. S. and T. H. N. were recipients of pre-doctoral fellowships from La Caixa and CSIC-VAST, respectively. The expression vectors were designed and created in Hungary, and this was financed by the Hungarian Scientific Research Fund (OTKA K100163). M. K. thanks Enterprise Ireland for a Commercialisation Fund grant (CF/2015/0089), A. K. acknowledges the National University of Ireland for a Cancer Care West Hardiman PhD scholarship and L. J. acknowledges the EU FP7 programme in support of the GlycoHIT consortium (grant no. 260600). This work was supported by R01 AI104920 (to J. G. S.) from the National Institute for Allergy and Infectious Diseases (www.niaid.nih.gov). S. S. W. was also supported by the Helen Riaboff Whiteley Endowment to the University of Washington and by Public Health Service, National Research Service Awards T32 AI083203 from the National Institute for Allergy and Infectious Diseases and T32 GM007270 from the National Institute of General Medical Sciences

Talin rod domain-containing protein 1 (TLNRD1) is a novel actin-bundling protein which promotes filopodia formation

Talin is a mechanosensitive adapter protein that couples integrins to the cytoskeleton. Talin rod domain-containing protein 1 (TLNRD1) shares 22% homology with the talin R7R8 rod domains, and is highly conserved throughout vertebrate evolution, although little is known about its function. Here we show that TLNRD1 is an α-helical protein structurally homologous to talin R7R8. Like talin R7R8, TLNRD1 binds F-actin, but because it forms a novel antiparallel dimer, it also bundles F-actin. In addition, it binds the same LD motif-containing proteins, RIAM and KANK, as talin R7R8. In cells, TLNRD1 localizes to actin bundles as well as to filopodia. Increasing TLNRD1 expression enhances filopodia formation and cell migration on 2D substrates, while TLNRD1 down-regulation has the opposite effect. Together, our results suggest that TLNRD1 has retained the diverse interactions of talin R7R8, but has developed distinct functionality as an actin-bundling protein that promotes filopodia assembly

Talin rod domain–containing protein 1 (TLNRD1) is a novel actin-bundling protein which promotes filopodia formation

Talin is a mechanosensitive adapter protein that couples integrins to the cytoskeleton. Talin rod domain–containing protein 1 (TLNRD1) shares 22% homology with the talin R7R8 rod domains, and is highly conserved throughout vertebrate evolution, although little is known about its function. Here we show that TLNRD1 is an α-helical protein structurally homologous to talin R7R8. Like talin R7R8, TLNRD1 binds F-actin, but because it forms a novel antiparallel dimer, it also bundles F-actin. In addition, it binds the same LD motif–containing proteins, RIAM and KANK, as talin R7R8. In cells, TLNRD1 localizes to actin bundles as well as to filopodia. Increasing TLNRD1 expression enhances filopodia formation and cell migration on 2D substrates, while TLNRD1 down-regulation has the opposite effect. Together, our results suggest that TLNRD1 has retained the diverse interactions of talin R7R8, but has developed distinct functionality as an actin-bundling protein that promotes filopodia assembly