Coupling of dynamical micromagnetism and a stationary spin drift-diffusion equation: A step towards a fully self-consistent spintronics framework

This is the author accepted manuscript. The final version is available from Elsevier via the DOI in this record.We consider the coupling of the Landau-Lifshitz-Gilbert equation with a quasilinear diffusion equation to describe the interplay of magnetization and spin accumulation in magnetic-nonmagnetic multilayer structures. For this problem, we propose and analyze a convergent finite element integrator, where, in contrast to prior work, we consider the stationary limit for the spin diffusion. Numerical experiments underline that the new approach is more effective, since it leads to the same experimental results as for the model with time-dependent spin diffusion, but allows for larger time-steps of the numerical integrator.The authors acknowledge support from the Vienna Science and Technology Fund (WWTF) under grant MA14-44 (GH, DP, DS), from the Austrian Science Fund (FWF) under grant W1245 (DP, MR), from TU Wien through the innovative projects initiative (DP, MR), from the Austrian Federal Ministry of Science, Research and Economy and the National Foundation for Research, Technology and Development (CA, DS), through the EPSRC grant EP/K008412/1 (GH), from the Royal Society under grant UF080837 (GH)

A Conserved LIR Motif in Connexins Mediates Ubiquitin-Independent Binding to LC3/GABARAP Proteins

This research was supported by the European Regional Development Fund (ERDF) through the Operational Program for Competitiveness Factors (COMPETE) [under the projects PAC “NETDIAMOND” POCI-01-0145-FEDER-016385; HealthyAging2020 CENTRO-01-0145-FEDER-000012-N2323; POCI-01-0145-FEDER-007440, CENTRO-01-0145-FEDER-032179, CENTRO-01-0145-FEDER-032414,FCTUID/NEU/04539/2013 and ID/NEU/04539/2019]. This research is based upon work from COST Action (PROTEOSTASIS BM1307), supported by COST (European Cooperation in Science and Technology).S.C. was supported by Action BM1307 – 39607 from COST Action PROTEOSTASIS BM1307, T.M.R.-R. was supported by PD/BD/52294/2013 from Fundação para a Ciência e a Tecnologia (FCT). C.A. was supported by a DOC Fellowship of the Austrian Academy of Sciences.Gap junctions (GJ) are specialized cell-cell contacts formed by connexins (Cxs), which provide direct communication between adjacent cells. Cx43 ubiquitination has been suggested to induce the internalization of GJs, as well as the recruitment of the autophagy receptor p62 to mediate binding to LC3B and degradation by macroautophagy. In this report, we describe a functional LC3 interacting region (LIR), present in the amino terminal of most Cx protein family members, which can mediate the autophagy degradation of Cx43 without the need of ubiquitin. Mutation of the LIR motif on Cx37, Cx43, Cx46 and Cx50 impairs interaction with LC3B and GABARAP without compromising protein ubiquitination. Through in vitro protein-protein interaction assays, we demonstrate that this LIR motif is required for the binding of Cx43 to LC3B and GABARAP. Overall, our findings describe an alternative mechanism whereby Cxs interact with LC3/GABARAP proteins, envisioning a new model for the autophagy degradation of connexins.publishersversionpublishe

Lack of an association of miR-938 SNP in IDDM10 with human type 1 diabetes

MicroRNAs (miRNAs) are a newly discovered type of small non-protein coding RNA that function in the inhibition of effective mRNA translation, and may serve as susceptibility genes for various disease developments. The SNP rs12416605, located in human type 1 diabetes IDDM10 locus, changes the seeding sequence (UGU[G/A]CCC) of miRNA miR-938 and potentially alters miR-938 targets, including IL-16 and IL-17A. In an attempt to test whether miR-938 may be a susceptibility gene for IDDM10, we assessed the possible association of the miR-938 SNP with T1D in an American Caucasian cohort of 622 patients and 723 healthy controls by TaqMan assay. Our current data do not support the association between the SNP in miR-938 and type 1 diabetes

A review of sustainable and intensified techniques for extraction of food and natural products

This review presents innovative extraction techniques and their role in promoting sustainable ingredients for the food, cosmetic and pharmaceutical industries

Kane County water resources investigations : final report on geologic investigations

Kane County Water Resources Department, Contract No. 02-279Ope

FIP200 claw domain binding to p62 promotes autophagosome formation at ubiquitin condensates

The autophagy cargo receptor p62 facilitates the condensation of misfolded, ubiquitin-positive proteins and their degradation by autophagy, but the molecular mechanism of p62 signaling to the core autophagy machinery is unclear. Here, we show that disordered residues 326-380 of p62 directly interact with the C-terminal region (CTR) of FIP200. Crystal structure determination shows that the FIP200 CTR contains a dimeric globular domain that we designated the "Claw" for its shape. The interaction of p62 with FIP200 is mediated by a positively charged pocket in the Claw, enhanced by p62 phosphorylation, mutually exclusive with the binding of p62 to LC3B, and it promotes degradation of ubiquitinated cargo by autophagy. Furthermore, the recruitment of the FIP200 CTR slows the phase separation of ubiquitinated proteins by p62 in a reconstituted system. Our data provide the molecular basis for a crosstalk between cargo condensation and autophagosome formation

Compactifications and algebraic completions of Limit groups

In this paper we consider the existence of dense embeddings of Limit groups in locally compact groups generalizing earlier work of Breuillard, Gelander, Souto and Storm [GBSS] where surface groups were considered. Our main results are proved in the context of compact groups and algebraic groups over local fields. In addition we prove a generalization of the classical Baumslag lemma which is a useful tool for generating eventually faithful sequences of homomorphisms. The last section is dedicated to correct a mistake from [BGSS] and to get rid of the even genus assumption.Comment: v2: Substantial changes to sections 7 and 8.2. Typos corrected. References added. v3: Acknowledgement correcte

Understood at Last?: A Memetic Analysis of Beethoven’s ‘Bloody Fist’

As a singular moment in the western canon, the opening of the recapitulation in the first movement of Beethoven’s Ninth Symphony has prompted a variety of structural and expressive readings. This paper explores its intertextual connections with Mozart’s Don Giovanni from a memetic perspective, outlining certain extra musical interpretations, including some related to Susan McClary’s controversial reading of the passage, one might infer from the strong musical connections

Unified treatment of spin torques using a coupled magnetisation dynamics and three-dimensional spin current solver

A three-dimensional spin current solver based on a generalised spin drift-diffusion description, including the bulk and interfacial spin Hall effects, is integrated with a magnetisation dynamics solver. The resulting model is shown to simultaneously reproduce the spin-orbit torques generated using the spin Hall effect, spin pumping torques generated by magnetisation dynamics in multilayers, as well as the spin transfer torques acting on magnetisation regions with spatial gradients, whilst field-like and spin-like torques are reproduced in a spin valve geometry. Two approaches to modelling interfaces are analysed, one based on the spin mixing conductance and the other based on continuity of spin currents where the spin dephasing length governs the absorption of transverse spin components. In both cases analytical formulas are derived for the spin-orbit torques in a heavy metal / ferromagnet bilayer geometry, showing in general both field-like and damping-like torques are generated. The limitations of the analytical approach are discussed, showing that even in a simple bilayer geometry, due to the non-uniformity of the spin currents, a full three-dimensional treatment is required. The model is further applied to the analysis of the spin Hall angle in Pt by reproducing published experimental ferromagnetic resonance data in the bilayer geometry