Geometría 3d, Estructura y formación de la cuenca del Duero en el contexto geodinámico del orógeno pirenaico

The Duero foreland basin is characterized by a large synformal geometry formed by the lithospheric flexure and northward subduction of the Iberian crust underneath the Cantabrian-European crust. Basin structure is represented by high-angle faults that involve both basement and cover units, and that did not generate large amounts of horizontal displacement. The northern deformation front is represented by a series of S-directed faults that probably sole into middle-lower crustal levels. Growth strata within the basin interior indicate that basement faulting occurred during the uppermost Cretaceous to Paleocene, previous to the onset of the foreland stage, while the Orogen uplift and the northern deformation front activity took place mainly between the Eocene-Oligocene, locally protracting until Miocene times. The Duero Basin behaved as an orogenic scale buttress due to the lack of an inherited Late Jurassic-Early Cretaceous extensional architecture associated with the opening of the Bay of Biscay. Hence, most of the Alpine contraction had a major impact where Mesozoic extension was more important, like the North Iberian Margin and the system of Mesozoic extensional basins of the Pyrenean rif

Remdesivir in Very Old Patients (≥80 Years) Hospitalized with COVID-19: Real World Data from the SEMI-COVID-19 Registry

Background: Large cohort studies of patients with COVID-19 treated with remdesivir have reported improved clinical outcomes, but data on older patients are scarce. Objective: This work aims to assess the potential benefit of remdesivir in unvaccinated very old patients hospitalized with COVID-19; (2) Methods: This is a retrospective analysis of patients >= 80 years hospitalized in Spain between 15 July and 31 December 2020 (SEMI-COVID-19 Registry). Differences in 30-day all-cause mortality were adjusted using a multivariable regression analysis. (3) Results: Of the 4331 patients admitted, 1312 (30.3%) were >= 80 years. Very old patients treated with remdesivir (n: 140, 10.7%) had a lower mortality rate than those not treated with remdesivir (OR (95% CI): 0.45 (0.29-0.69)). After multivariable adjustment by age, sex, and variables associated with lower mortality (place of COVID-19 acquisition; degree of dependence; comorbidities; dementia; duration of symptoms; admission qSOFA; chest X-ray; D-dimer; and treatment with corticosteroids, tocilizumab, beta-lactams, macrolides, and high-flow nasal canula oxygen), the use of remdesivir remained associated with a lower 30-day all-cause mortality rate (adjusted OR (95% CI): 0.40 (0.22-0.61) (p < 0.001)). (4) Conclusions: Remdesivir may reduce mortality in very old patients hospitalized with COVID-19

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group

Robots in therapy for dementia patients

This paper presents the application developed for humanoid robots which are used in therapy of dementia patients, as a cognitive stimulation tool. It has been created using BICA, a component oriented framework for programming robot applications, which is also described. The developed robotherapy application includes the control software onboard the robot and some tools like the visual script generator or several monitoring tools to supervise the robot behavior along the sessions. The behavior of the robot along the therapy sessions is visually programmed in a session script that allows music playing, physical movements (dancing, exercises...), speech synthesis and interaction with the human monitor. The monitoring tools allow the therapist interaction with the robot through its buttons, a tablet or a Wiimote device. Experiments with real dementia patients have been performed in collaboration with a research center in neurological diseases. Initial results show a slight (or mild) improvement in neuropsychiatric symptoms over other traditional therapy methods.This work was supported by the project S2009/DPI-1559, RoboCity2030-II, from the Comunidad de Madrid, by the project PI10/02567 from the Spanish Ministry of Science and Innovation and project 231/2011 from IMSERSO

Geometría 3d, Estructura y formación de la cuenca del Duero en el contexto geodinámico del orógeno pirenaico

The Duero foreland basin is characterized by a large synformal geometry formed by the lithospheric flexure and northward subduction of the Iberian crust underneath the Cantabrian-European crust. Basin structure is represented by high-angle faults that involve both basement and cover units, and that did not generate large amounts of horizontal displacement. The northern deformation front is represented by a series of S-directed faults that probably sole into middle-lower crustal levels. Growth strata within the basin interior indicate that basement faulting occurred during the uppermost Cretaceous to Paleocene, previous to the onset of the foreland stage, while the Orogen uplift and the northern deformation front activity took place mainly between the Eocene-Oligocene, locally protracting until Miocene times. The Duero Basin behaved as an orogenic scale buttress due to the lack of an inherited Late Jurassic-Early Cretaceous extensional architecture associated with the opening of the Bay of Biscay. Hence, most of the Alpine contraction had a major impact where Mesozoic extension was more important, like the North Iberian Margin and the system of Mesozoic extensional basins of the Pyrenean rif

El sistema de yacimientos de mamíferos miocenos del Cerro de los Batallones, Cuenca de Madrid: estado actual y perspectivas

77 págs, 24 láms.The Cerro de los Batallones (Los Batallones Butte) is located in the central-northern area of the Madrid Basin, central Spain. Nine vertebrates localities containing a large variety of mammals of Upper Vallesian Age (Late Miocene) have been found associated with the sediments forming the butte. From bottom to top, these sediments consist of magnesian lutite beds (Unit I), paleosols formed of sepiolite and opal (Unit II), and siliclastic, marlstone and carbonate beds (Unit III). The set of ERT profiles developed in Los Batallones Butte have demonstrate that electrical imaging techniques are an estimable tool for the characterization and prospecting of fossil sites developed in fine-grained siliciclastic sequences. These localities contain an exceptionally rich, varied and well-preserved vertebrate fauna together with invertebrate and plant fossils. Carnivore species are strikingly well represented at Batallones 1 and 3, and large herbivore species, such as mastodons, rhinoceros and giraffes, at Batallones 2, 4, 5 and 10. The taphonomical studies, together with the morphological features shown by the sedimentary fills of the mammal localities, permit an overall interpretation of these deposits as vertebrate traps. The study of these localities should offer a significant contribution to our understanding of the formation pattern of trap-like paleontological sites - which so far have been typically reported in karstic-type systems -, as well as an important source of paleobiological information about numerous vertebrate groups.Nuestro sincero agradecimiento a la Comunidad de Madrid (Dirección General de Patrimonio Histórico Artístico) por su apoyo a lo largo de todos estos años. A la empresa TOLSA, SA por su inapreciable ayuda en todas las circunstancias. National Geographic Society financió la campaña de Batallones-1 del año 2001. Son muchos los compañeros y amigos que han participado en las excavaciones, y en los diferentes proyectos de investigación de estos yacimientos, a todos ellos nuestro más sincero agradecimiento y nuestros mejores deseos, con la esperanza de seguir contando con su valiosa colaboración. Este trabajo se ha realizado en el marco de los proyectos de investigación MEC 2005-03900/BTE y CGL2006-01773/BTE, y del Grupo de Investigación CAM-UCM 910607.Peer reviewe

La transformación social desde el protagonismo del estudiante y la convivencia escolar

La educación se constituye actualmente en una vigorosa herramienta de transformación social para fortalecer los contextos educativos en beneficio de las personas. Dicho cambio es posible de realizar impactando situaciones determinadas que en conjunto contribuyen a robustecer el conglomerado social. Este libro en un primer momento presenta los retos que la sociedad tiene en torno a la evolución social y a la asignación de desafíos específicos para los diferentes actores de la educación. Luego se presentan estrategias centradas en quienes aprenden con el propósito de generar transformaciones de sus propias realidades, al tiempo que pautas que puedan ser adoptadas por contextos análogos. La obra demuestra que desde entornos particulares se generan innovaciones sociales; gran parte del libro sistematiza experiencias exitosas de fortalecimiento de diferentes contextos educativos. Cada caso analizado evidencia que el mejoramiento continuo inicia en circunstancias concretas. Estas, en conjunto, contribuyen a que la sociedad en sí misma logre superar las dinámicas excluyentes tradicionalmente existentes. El texto en sí se plantea como un ejemplo de modificación educativa de la realidad

Endocarditis in patients with ascending aortic prosthetic graft: a case series from a national multicentre registry.

Endocarditis in patients with ascending aortic prosthetic graft (AAPG) is a life-threatening complication. The purpose of this study was to examine the clinical presentation and prognosis of patients with AAPG endocarditis included in a large prospective infectious endocarditis multicentre study. From January 2008 to April 2015, 3200 consecutive patients with infectious endocarditis according to the modified Duke criteria, were prospectively included in the 'Spanish Collaboration on Endocarditis Registry (GAMES)' registry. Twenty-seven definite episodes of endocarditis (0.8%) occurred in patients with AAPG. During the study period, 27 cases of endocarditis were detected in patients with AAPG. The median age of patients was 61 years [interquartile range (IQR) 51-68 years] and 23 (85.2%) patients were male. The median time from AAPG surgery to the episode of AAPG infection was 24 months (IQR 6-108 months). The most frequently isolated micro-organisms were coagulase-negative staphylococci and S. aureus (11 patients, 40.7%). Four patients (14.8%) underwent medical treatment, whereas surgery was performed in 21 (77.7%). Two patients (7.4%) died before surgery could be performed. The median hospital stay prior to surgery was 7 days (IQR 4-21 days). Surgery consisted of replacing previous grafts with a composite aortic graft (10 cases) or aortic homograft (2 patients), and removal of a large vegetation attached to the valve of a composite tube (1 case). Nine patients had an infected aortic valve prosthesis without evidence of involvement of the AAPG. Isolated redo-aortic valve replacement was performed in 8 (88.9%) of these patients. Reinfection occurring during 1 year of follow-up was not detected in any patient. Two patients (7.4%) died while awaiting surgery and 6 did so after surgery (22.2%). A New York Heart Association (NYHA) Class IV was associated with mortality in patients undergoing surgery (P Most cases of endocarditis in patients with AAPG occur late after initial surgery. Mortality rate of patients with AAPG endocarditis who undergo surgery is acceptable. NYHA Class IV before surgery is associated with an increased postoperative mortality