Free vibration analysis of multi-cracked micro beams based on Modified Couple Stress Theory

In this article, the size effect on the dynamic behavior of a simply supported multi-cracked microbeam is studied based on the Modified Couple Stress Theory (MCST).  At first, based on the MCST, the equivalent torsional stiffness spring for every open edge crack at its location is calculated; in this regard, the Stress Intensity Factor (SIF) is also considered for all open edge cracks. Hamilton’s principle has been used in order to achieve the governing equations of motion of the system and associated boundary conditions are derived based on the MCST. Then the natural frequencies of multi-cracked microbeamare analytically determined. After that, the Numerical solutions have been presented for the microbeam with two open edge cracks. Finally, the variation of the first three natural frequencies of the system is investigated versus different values of the depth and the location of two cracks and the material length scale parameter. The obtained results express that the natural frequencies of the system increase by increasing the material length scale parameter and decrease by moving away from the simply supported of the beam and node points, in addition to increasing the number of cracks and cracks depth

Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018: a systematic review and modelling study

Background: Seasonal influenza virus is a common cause of acute lower respiratory infection (ALRI) in young children. In 2008, we estimated that 20 million influenza-virus-associated ALRI and 1 million influenza-virus-associated severe ALRI occurred in children under 5 years globally. Despite this substantial burden, only a few low-income and middle-income countries have adopted routine influenza vaccination policies for children and, where present, these have achieved only low or unknown levels of vaccine uptake. Moreover, the influenza burden might have changed due to the emergence and circulation of influenza A/H1N1pdm09. We aimed to incorporate new data to update estimates of the global number of cases, hospital admissions, and mortality from influenza-virus-associated respiratory infections in children under 5 years in 2018. Methods: We estimated the regional and global burden of influenza-associated respiratory infections in children under 5 years from a systematic review of 100 studies published between Jan 1, 1995, and Dec 31, 2018, and a further 57 high-quality unpublished studies. We adapted the Newcastle-Ottawa Scale to assess the risk of bias. We estimated incidence and hospitalisation rates of influenza-virus-associated respiratory infections by severity, case ascertainment, region, and age. We estimated in-hospital deaths from influenza virus ALRI by combining hospital admissions and in-hospital case-fatality ratios of influenza virus ALRI. We estimated the upper bound of influenza virus-associated ALRI deaths based on the number of in-hospital deaths, US paediatric influenza-associated death data, and population-based childhood all-cause pneumonia mortality data in six sites in low-income and lower-middle-income countries. Findings: In 2018, among children under 5 years globally, there were an estimated 109·5 million influenza virus episodes (uncertainty range [UR] 63·1–190·6), 10·1 million influenza-virus-associated ALRI cases (6·8–15·1); 870 000 influenza-virus-associated ALRI hospital admissions (543 000–1 415 000), 15 300 in-hospital deaths (5800–43 800), and up to 34 800 (13 200–97 200) overall influenza-virus-associated ALRI deaths. Influenza virus accounted for 7% of ALRI cases, 5% of ALRI hospital admissions, and 4% of ALRI deaths in children under 5 years. About 23% of the hospital admissions and 36% of the in-hospital deaths were in infants under 6 months. About 82% of the in-hospital deaths occurred in low-income and lower-middle-income countries. Interpretation: A large proportion of the influenza-associated burden occurs among young infants and in low-income and lower middle-income countries. Our findings provide new and important evidence for maternal and paediatric influenza immunisation, and should inform future immunisation policy particularly in low-income and middle-income countries. Funding: WHO; Bill & Melinda Gates Foundation.Fil: Wang, Xin. University of Edinburgh; Reino UnidoFil: Li, You. University of Edinburgh; Reino UnidoFil: O'Brien, Katherine L.. University Johns Hopkins; Estados UnidosFil: Madhi, Shabir A.. University of the Witwatersrand; SudáfricaFil: Widdowson, Marc Alain. Centers for Disease Control and Prevention; Estados UnidosFil: Byass, Peter. Umea University; SueciaFil: Omer, Saad B.. Yale School Of Public Health; Estados UnidosFil: Abbas, Qalab. Aga Khan University; PakistánFil: Ali, Asad. Aga Khan University; PakistánFil: Amu, Alberta. Dodowa Health Research Centre; GhanaFil: Azziz-Baumgartner, Eduardo. Centers for Disease Control and Prevention; Estados UnidosFil: Bassat, Quique. University Of Barcelona; EspañaFil: Abdullah Brooks, W.. University Johns Hopkins; Estados UnidosFil: Chaves, Sandra S.. Centers for Disease Control and Prevention; Estados UnidosFil: Chung, Alexandria. University of Edinburgh; Reino UnidoFil: Cohen, Cheryl. National Institute For Communicable Diseases; SudáfricaFil: Echavarría, Marcela Silvia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. CEMIC-CONICET. Centro de Educaciones Médicas e Investigaciones Clínicas "Norberto Quirno". CEMIC-CONICET; ArgentinaFil: Fasce, Rodrigo A.. Public Health Institute; ChileFil: Gentile, Angela. Gobierno de la Ciudad de Buenos Aires. Hospital General de Niños "Ricardo Gutiérrez"; ArgentinaFil: Gordon, Aubree. University of Michigan; Estados UnidosFil: Groome, Michelle. University of the Witwatersrand; SudáfricaFil: Heikkinen, Terho. University Of Turku; FinlandiaFil: Hirve, Siddhivinayak. Kem Hospital Research Centre; IndiaFil: Jara, Jorge H.. Universidad del Valle de Guatemala; GuatemalaFil: Katz, Mark A.. Clalit Research Institute; IsraelFil: Khuri Bulos, Najwa. University Of Jordan School Of Medicine; JordaniaFil: Krishnan, Anand. All India Institute Of Medical Sciences; IndiaFil: de Leon, Oscar. Universidad del Valle de Guatemala; GuatemalaFil: Lucero, Marilla G.. Research Institute For Tropical Medicine; FilipinasFil: McCracken, John P.. Universidad del Valle de Guatemala; GuatemalaFil: Mira-Iglesias, Ainara. Fundación Para El Fomento de la Investigación Sanitaria; EspañaFil: Moïsi, Jennifer C.. Agence de Médecine Préventive; FranciaFil: Munywoki, Patrick K.. No especifíca;Fil: Ourohiré, Millogo. No especifíca;Fil: Polack, Fernando Pedro. Fundación para la Investigación en Infectología Infantil; ArgentinaFil: Rahi, Manveer. University of Edinburgh; Reino UnidoFil: Rasmussen, Zeba A.. National Institutes Of Health; Estados UnidosFil: Rath, Barbara A.. Vienna Vaccine Safety Initiative; AlemaniaFil: Saha, Samir K.. Child Health Research Foundation; BangladeshFil: Simões, Eric A.F.. University of Colorado; Estados UnidosFil: Sotomayor, Viviana. Ministerio de Salud de Santiago de Chile; ChileFil: Thamthitiwat, Somsak. Thailand Ministry Of Public Health; TailandiaFil: Treurnicht, Florette K.. University of the Witwatersrand; SudáfricaFil: Wamukoya, Marylene. African Population & Health Research Center; KeniaFil: Lay-Myint, Yoshida. Nagasaki University; JapónFil: Zar, Heather J.. University of Cape Town; SudáfricaFil: Campbell, Harry. University of Edinburgh; Reino UnidoFil: Nair, Harish. University of Edinburgh; Reino Unid

Global burden of respiratory infections associated with seasonal influenza in children under 5 years in 2018: a systematic review and modelling study

BackgroundSeasonal influenza virus is a common cause of acute lower respiratory infection (ALRI) in young children. In 2008, we estimated that 20 million influenza-virus-associated ALRI and 1 million influenza-virus-associated severe ALRI occurred in children under 5 years globally. Despite this substantial burden, only a few low-income and middle-income countries have adopted routine influenza vaccination policies for children and, where present, these have achieved only low or unknown levels of vaccine uptake. Moreover, the influenza burden might have changed due to the emergence and circulation of influenza A/H1N1pdm09. We aimed to incorporate new data to update estimates of the global number of cases, hospital admissions, and mortality from influenza-virus-associated respiratory infections in children under 5 years in 2018.MethodsWe estimated the regional and global burden of influenza-associated respiratory infections in children under 5 years from a systematic review of 100 studies published between Jan 1, 1995, and Dec 31, 2018, and a further 57 high-quality unpublished studies. We adapted the Newcastle-Ottawa Scale to assess the risk of bias. We estimated incidence and hospitalisation rates of influenza-virus-associated respiratory infections by severity, case ascertainment, region, and age. We estimated in-hospital deaths from influenza virus ALRI by combining hospital admissions and in-hospital case-fatality ratios of influenza virus ALRI. We estimated the upper bound of influenza virus-associated ALRI deaths based on the number of in-hospital deaths, US paediatric influenza-associated death data, and population-based childhood all-cause pneumonia mortality data in six sites in low-income and lower-middle-income countries.FindingsIn 2018, among children under 5 years globally, there were an estimated 109·5 million influenza virus episodes (uncertainty range [UR] 63·1–190·6), 10·1 million influenza-virus-associated ALRI cases (6·8–15·1); 870 000 influenza-virus-associated ALRI hospital admissions (543 000–1 415 000), 15 300 in-hospital deaths (5800–43 800), and up to 34 800 (13 200–97 200) overall influenza-virus-associated ALRI deaths. Influenza virus accounted for 7% of ALRI cases, 5% of ALRI hospital admissions, and 4% of ALRI deaths in children under 5 years. About 23% of the hospital admissions and 36% of the in-hospital deaths were in infants under 6 months. About 82% of the in-hospital deaths occurred in low-income and lower-middle-income countries.InterpretationA large proportion of the influenza-associated burden occurs among young infants and in low-income and lower middle-income countries. Our findings provide new and important evidence for maternal and paediatric influenza immunisation, and should inform future immunisation policy particularly in low-income and middle-income countries.</div

Equivalent Stiffness Calculation of a Journal Bearing by Analytical Approach for Vibrational Modeling

More equipment which is used in the mechanical industry has rotating shafts. In the design of the rotating shaft, vibration prediction of the system is very important to reduce and prevent vibrations of the system. One of the important elements that have a more efficacy on the results of the vibration simulation of the rotating shaft is modeling of the bearings. The journal bearings are of great importance in the industries. In this study, firstly, the pressure equation of the lubricant film is derived in any position (angle) using Reynolds hydrodynamic theory for one-dimensional flow. Then using the definition of stiffness and its relationship with the force and pressure, the equivalent stiffness of the journal bearing lubricant film is calculated based on the angle by an analytical approach. Finally, with the solution of governing equations, equivalent stiffness is calculated for a sample journal bearing. Also, the calculated stiffness is validated and error factors of the results are studied. The obtained analytical equations can be helped the designer of the journal bearings to understand the stiffness behavior of the journal bearing versus the angular position and also system parameters of the bearing. The obtained results show that the journal bearing stiffness is directly related with the lubricant viscosity, the angular velocity, the length, and the second power of the journal radius. Also, the journal bearing stiffness is inversely related with the third power of the radial clearance of journal bearing

A Circular Biorefinery-Integrating Wastewater Treatment with the Generation of an Energy Precursor and an Organic Fertilizer

A circular (close-loop) biorefinery, which integrates wastewater treatment with the generation of an energy precursor and organic fertilizer, tested at the level of a pilot plant treating 54,000 L per day (LPD) of sewage, is described. In the biorefinery’s first stage, sewage was treated in a novel SHEFROL® (sheet-flow-root-level) bioreactor at a very rapid rate, indicated by a hydraulic retention time of a mere 6 h, to a level that met the prevailing national standards for the discharge of treated sewage. The main bioagent of the reactor—water hyacinth—was then processed for the generation of energy precursors. For this, volatile fatty acids (VFA) were extracted in a simple batch reactor operating at ambient temperature and pressure. The ‘spent’ weeds were then converted into organic fertilizer, also at ambient temperature and pressure, by the high-rate vermicomposting process earlier reported by the authors. In this manner, wastewater treatment, energy production, and the generation of a fertilizer were achieved rapidly and efficiently, creating a circular close-loop system that required very little energy and materials and generated almost zero net waste

A Circular Biorefinery-Integrating Wastewater Treatment with the Generation of an Energy Precursor and an Organic Fertilizer

A circular (close-loop) biorefinery, which integrates wastewater treatment with the generation of an energy precursor and organic fertilizer, tested at the level of a pilot plant treating 54,000 L per day (LPD) of sewage, is described. In the biorefinery&rsquo;s first stage, sewage was treated in a novel SHEFROL&reg; (sheet-flow-root-level) bioreactor at a very rapid rate, indicated by a hydraulic retention time of a mere 6 h, to a level that met the prevailing national standards for the discharge of treated sewage. The main bioagent of the reactor&mdash;water hyacinth&mdash;was then processed for the generation of energy precursors. For this, volatile fatty acids (VFA) were extracted in a simple batch reactor operating at ambient temperature and pressure. The &lsquo;spent&rsquo; weeds were then converted into organic fertilizer, also at ambient temperature and pressure, by the high-rate vermicomposting process earlier reported by the authors. In this manner, wastewater treatment, energy production, and the generation of a fertilizer were achieved rapidly and efficiently, creating a circular close-loop system that required very little energy and materials and generated almost zero net waste

Potential prosthetic arterio-venous graft dissection: A rare case

Arterio-venous fistulas (AVFs) are recommended as the first line vascular access option in patients requiring hemodialysis in end-stage renal disease (ESRD). Prosthetic grafts have been used successfully as an alternative in cases where AVF is not feasible. We present a rare case of dissection of the prosthetic graft. Knowledge and recognition of this complication is important in making correct diagnosis and deciding appropriate treatment

Alleviation of Cadmium Adverse Effects by Improving Nutrients Uptake in Bitter Gourd through Cadmium Tolerant Rhizobacteria

Cadmium is acute toxicity inducing heavy metal that significantly decreases the yield of crops. Due to high water solubility, it reaches the plant tissue and disturbs the uptake of macronutrients. Low uptake of nutrients in the presence of cadmium is a well-documented fact due to its antagonistic relationship with those nutrients, i.e., potassium. Furthermore, cadmium stressed plant produced a higher amount of endogenous stress ethylene, which induced negative effects on yield. However, inoculation of 1-amino cyclopropane-1-carboxylate deaminase (ACCD), producing plant growth promoting rhizobacteria (PGPR), can catabolize this stress ethylene and immobilized heavy metals to mitigate cadmium adverse effects. We conducted a study to examine the influence of ACCD PGPR on nutrients uptake and yield of bitter gourd under cadmium toxicity. Cadmium tolerant PGPRs, i.e., Stenotrophomonas maltophilia and Agrobacterium fabrum were inoculated solely and in combination with recommended nitrogen, phosphorus, and potassium fertilizers (RNPKF) applied under different concentration of soil cadmium (2 and 5 mg kg&minus;1 soil). Results showed that A. fabrum with RNPKF showed significant positive response towards an increase in the number of bitter gourds per plant (34% and 68%), fruit length (19% and 29%), bitter gourd yield (26.5% and 21.1%), N (48% and 56%), and K (72% and 55%) concentration from the control at different concentrations of soil cadmium (2 and 5 mg kg&minus;1 soil), respectively. In conclusion, we suggest that A. fabrum with RNPKF can more efficaciously enhance N, K, and yield of bitter gourd under cadmium toxicity