Activity and content of antioxidant enzymes in prostate tumors

To investigate the antioxidant enzyme system in blood of men with benign hyperplasia of prostate (BHP) and with prostate adenocarcinoma (CaP). Methods: The spectrophotometrical methods were applied to study content and activity changes of superoxide-dismutase (SOD), catalase (CAT), ceruloplasmin (Cp), tripeptide glutathione (GSH), glutathione-peroxidase (GSH-Px), and glutathione-reductase (GR). Lipid peroxidation was evaluated using thiobarbituric acid (TBA)-test. Blood plasma and erythrocytes of men with prostate tumors served as the material for the studies; n = 15 for each group. Results: SOD activity was increased in BHP (24.65 ± 1.20 U/µl) and decreased in CaP (11.45 ± 0.89 U/µl), CAT activity remained unaltered in BHP (12.41 ± 0.85 mcat/ml) and was slightly declined in CaP (9.52 ± 0.56 mcat/ml). Cp was increased in both kind of tumors, especially in CaP (54.27 ± 7.22 mg%), as well as GSH (0.736 ± 0.07 µM/l) and GR (0.031 ± 0.002 µM/g.Hemogl/min). GSH-Px was sharply increased in BHP (0.67 ± 0.05 µM/g.Hemogl/min) and reduced in CaP (0.16 ± 0.01 µM/g.Hemogl/min). Conclusion: The development of BHP reflects relatively weakly on blood system as activity and content of antioxidant enzymes are not revealing marked changes in this disease. The significant changes are revealed in case of CaP, showing the reduced functional state of blood antioxidant enzyme system.Цель: исследование системы антиоксидантных ферментов в крови больных c доброкачественной гиперплазией простаты (ДГП) и аденокарциномой простаты (АКП). Методы: изменения содержания и активности супероксид-дисмутазы (СОД), каталазы (КАТ), церулоплазмина (ЦП), трипептида глютатиона (ВГ), глутатион-пероксидазы (ГП) и глутатион-редуктазы (ГР) были изучены спектрофотометрическими методами. Перекисное окисление липидов оценивали с помощью тиобарбитуровой кислоты (TBК-тест). Материалом для исследовании служили плазма крови и эритроциты больных с опухолями простаты, n = 15 для каждой группы. Результаты: активность СОД повышалась в ДГП (24,65 ± 1,20 ед./мкл) и снижалась в АКП (11,45 ± 0,89 ед./мкл). Активность КАТ оставалась неизмененной в ДГП (12,41 ± 0,85 мкат/мл) и слегка снижалась в АКП (9,52 ± 0,56 мкат/мл). Содержание ЦП повышалось в обоих типах опухолей, в особенности в АКП (54,27 ± 7,22 mg%), так же как ВГ (0,736 ± 0,07 мкM/л) и ГР (0,031 ± 0,002 мкМ/г.гемогл/мин). Активность ГП резко возрастала в ДГП (0,67 ± 0,05 мкМ/г.гемогл/мин) и снижалась в АКП (0,16 ± 0,01 мкМ/г.гемогл/мин). Выводы: развитие ДГП сравнительно слабо отражается на системе крови, так как содержание и активность антиоксидантных ферментов не показывают заметных изменении при этой болезни. Значительные изменения были выявлены в группе больных с АКП, что указывало на подавление функционального состояния системы антиоксидантных ферментов крови

Modern trends and challenges of development of global aluminum industry

This article overviews complex study into modern trends and challenges of development of global aluminum industry. Dynamics, structure, and segmentation of global aluminum market are discussed in terms of systematic analysis. On this basis strategic map of the industry has been plotted and five forces of competition on global aluminum market have been determined which will influence directly on functioning and development of aluminum producing companies

Description of the Vitis vinifera L. phenotypic variability in eno-carpological traits by a Euro-Asiatic collaborative network among ampelographic collections

The grapevine intra-specific variability captured an increasing interest during the last decades, as demonstrated by the number of recently funded European projects focused on the grapevine biodiversity preservation. However, nowadays, crop plants are mainly characterized by genotyping methods. The present work summarizes the phenotype data collected among 20 ampelographic collections spread in 15 countries, covering mostly of the viticultural areas in the Euro-Asiatic range: from Portugal to Armenia and from Cyprus to Luxembourg. Together with agro-climatic characterization of the experimental site, in two years, about 2400 accessions were described, following a common experimental protocol mainly focused on the carpological and oenological traits, obtaining a general overview of the distribution of the considered phenotypic traits in the cultivated Vitis vinifera species. The most replicated cultivars were selected and, for the subset of these reference cultivars, their behavior in the different environmental conditions over sites and years was described by ANOVA methods

Description of the vitis vinifera L. Phenotypic variability in eno-carpological traits by a Euro-Asiatic collaborative network among ampelographic collections

The grapevine intra-specific variability captured an increasing interest during the last decades, as demonstrated by the number of recently funded European projects focused on the grapevine biodiversity preservation. However, nowadays, crop plants are mainly characterized by genotyping methods. The present work summarizes the phenotype data collected among 20 ampelographic collections spread over 15 countries, covering most of the viticultural areas in the Euro-Asiatic region: from Portugal to Armenia and from Cyprus to Luxembourg. Together with agro-climatic characterization of the experimental site, over two years about 2,400 accessions were described. A common experimental protocol mainly focused on the carpological and oe-nological traits was followed, obtaining a general overview of the distribution of the considered phenotypic traits in the cultivated Vitis vinifera species. The most replicated cultivars were selected and, for the subset of these reference cultivars, their behavior in the different environmental conditions over sites and years was described by ANOVA methods

КОМПЛЕКСНАЯ ДИАГНОСТИКА И КОРРЕКЦИЯ НАРУШЕНИЙ СНА У ДЕТЕЙ

The article is devoted to the actual problem of modern pediatrics and neurology ― a comprehensive diagnosis and correction of sleep disorders in children. Detail the features of the clinical manifestations of sleep disorders in childhood (insomnia and parasomnia), great attention is paid to sleep apnea syndrome as a risk factor for somatic and psychopathological disorders in children. Highlight the current capabilities of complex instrumental diagnosis of sleep disorders with the use of highly effective methods of polysomnography and pulse oximetry. The actual dimensions as non-drug and drug treatment of sleep disorders in children, taking into account the pathogenetic features of their occurrence. From the standpoint of evidence-based medicine demonstrate efficient methods of herbal medicine, developed on the basis of traditional Chinese recipes, as well as modern nootropics and magnesium preparations. It is shown that sleep disorders in children not only lead to a deterioration of emotional mood, cognitive function, health and school performance, but also are associated with increasing risk of somatic disorders, which determines the need for timely diagnosis and comprehensive differentiated medical and psychological data correction of pathological conditions, taking into account the neurophysiological and biochemical mechanisms of their development, as well as polymorphism of clinical manifestations, in order to increase the effectiveness of treatment and quality of life of patients.  Статья посвящена актуальной проблеме современной педиатрии и неврологии ― комплексной диагностике и коррекции нарушений сна у детей. Подробно рассмотрены особенности клинических проявлений расстройств сна в детском возрасте (инсомний и парасомний), большое внимание уделено синдрому обструктивного апноэ сна как фактору риска развития соматических и психопатологических нарушений у детей. Освещены современные возможности комплексной инструментальной диагностики расстройств сна с применением высокоэффективных методов полисомнографии и пульсоксиметрии, а также актуальные аспекты как немедикаментозной, так и лекарственной терапии нарушений сна в детском возрасте с учетом патогенетических особенностей их возникновения. С позиций доказательной медицины продемонстрирована высокая эффективность способов фитотерапии, разработанных на основе традиционных китайских рецептов, а также современных ноотропных средств и препаратов магния. Показано, что расстройства сна у детей не только приводят к ухудшению эмоционального настроя, когнитивных функций, работоспособности и школьной успеваемости, но и сопряжены с нарастающим риском развития соматических нарушений, что определяет необходимость проведения своевременной диагностики и комплексной дифференцированной медико-психологической коррекции данных патологических состояний с учетом нейрофизиологических и биохимических механизмов их развития, а также полиморфизма клинических проявлений с целью повышения эффективности лечения и улучшения качества жизни пациентов.

"Комп'ютерне моделювання і керування в техніці та технологіях КМКТТ-2021", Дев’ята міжнародна науково-практична конференція

Definitions of traffic flow components are presented, including ratios and practical application models, which provide a basis for studying the "behavior" of individual vehicles moving in a common flow. The theory of traffic flows is one of the newest theories in the field of traffic organization theories. But, although this field has been introduced recently, with its help substantial results have been obtained.Определения транспортных компонентов потока представлены, включая отношения и модели практического применения, которые обеспечивают основание для изучения «поведения» отдельных транспортных средств, перемещающихся в общий поток Теория транспортных потоков – одна из новейших теорий в области транспортных организационных теорий. Но, хотя эта область была недавно введена, с ее помощью были получены, существенные результаты

The second Universal Periodic Review of the Russian Federation

The article analyses the fulfilling of the second Universal periodic Review by the Russian Federation as an international obligation. It expresses also the achievements in the ground of human rights protection by Russian Federation and the claims from the international community to Russia

Protection of human rights within the Tribunal of the Southern African Development Community (SADC)

The article deals with human rights protection within the Southern African Development Community (SADC). The Tribunal of SADC was the main body in the ground of human rights protection in the sub-region. Unfortunately, It was shutdown in 2010 because of the discordances between the heads of States and Governments and the Tribunal. This situation occurred because of the massive complains against the Republic of Zimbabwe, alleging human rights violations

The International Law System

The doctrinal approaches are examined both in Russian and Western doctrines concerning the problem of international law system at modern stage. The article touches upon fundamental bases in the field of law theory. The following concepts are analyzed, for example international law system, legal system. There is also comparative analysis between the concepts. The are many questions that are analyzed: what is the definition of the international law system, what are the features of the international law system, what are the further development of the international law system. In the conclusion authors offer their own definition of the international law system