Learning from Live Coding

The pace of engagement with new digital technologies in music education is proving to be slow. A key issue - and a major barrier to entry - is teacher skills and confidence to work with technology creatively. Following a concerted campaign from the technology industry, in spring 2013 the UK government agreed to introduce the subject of computing into the national curriculum for all children at the age of five. This chapter describes, interprets and theorises the digital skills and engagement with live coding performance in music

Modeling the cost of bird strikes to US civil aircraft

The objective of our analysis is to develop a model of damage costs that arise from collisions between aircraft and birds, based on data drawn from the Federal Aviation Administration National Wildlife Strike Database (NWSD). We develop a two-part model, composed of two separate statistical models, that accounts for the effects of aircraft mass category, engine type, component of the aircraft struck, and the size and number of birds struck. Our results indicate the size of bird, number of birds, and engine ingestions are the largest determinants of strike-related costs. More generally, our result is a model that provides a better understanding of the determinants of damage costs and that can be used to interpolate the substantial amount of missing data on damage costs that currently exists within the NWSD. A more complete accounting of damage costs will allow a better understanding of how damage costs vary geographically and temporally and, thus, enable more efficient allocation of management resources across airports and seasons

A comparison of three methods for estimating call densities of migrating bowhead whales using passive acoustic monitoring

TAM thanks partial support by Centro de Estatistica e Aplicações, Universidade de Lisboa (funded by FCT—Fundação para a Ciência e a Tecnologia, Portugal, through the project UID/MAT/00006/2013).Various methods for estimating animal density from visual data, including distance sampling (DS) and spatially explicit capture-recapture (SECR), have recently been adapted for estimating call density using passive acoustic monitoring (PAM) data, e.g., recordings of animal calls. Here we summarize three methods available for passive acoustic density estimation: plot sampling, DS, and SECR. The first two require distances from the sensors to calling animals (which are obtained by triangulating calls matched among sensors), but SECR only requires matching (not localizing) calls among sensors. We compare via simulation what biases can arise when assumptions underlying these methods are violated. We use insights gleaned from the simulation to compare the performance of the methods when applied to a case study: bowhead whale call data collected from arrays of directional acoustic sensors at five sites in the Beaufort Sea during the fall migration 2007–2014. Call detections were manually extracted from the recordings by human observers simultaneously scanning spectrograms of recordings from a given site. The large discrepancies between estimates derived using SECR and the other two methods were likely caused primarily by the manual detection procedure leading to non-independent detections among sensors, while errors in estimated distances between detected calls and sensors also contributed to the observed patterns. Our study is among the first to provide a direct comparison of the three methods applied to PAM data and highlights the importance that all assumptions of an analysis method need to be met for correct inference.Publisher PDFPeer reviewe

Live Coding, Live Notation, Live Performance

This paper/demonstration explores relationships between code, notation including representation, visualisation and performance. Performative aspects of live coding activities are increasingly being investigated as the live coding movement continues to grow and develop. Although live instrumental performance is sometimes included as an accompaniment to live coding, it is often not a fully integrated part of the performance, relying on improvisation and/or basic indicative forms of notation with varying levels of sophistication and universality. Technologies are developing which enable the use of fully explicit music notations as well as more graphic ones, allowing more fully integrated systems of code in and as performance which can also include notations of arbitrary complexity. This itself allows the full skills of instrumental musicians to be utilised and synchronised in the process. This presentation/demonstration presents work and performances already undertaken with these technologies, including technologies for body sensing and data acquisition in the translation of the movements of dancers and musicians into synchronously performable notation, integrated by live and prepared coding. The author together with clarinetist Ian Mitchell present a short live performance utilising these techniques, discuss methods for the dissemination and interpretation of live generated notations and investigate how they take advantage of instrumental musicians’ training-related neuroplasticity skills

Do Wealth and Inequality Associate with Health in a Small-Scale Subsistence Society?

In high-income countries, one’s relative socio-economic position and economic inequality may affect health and well-being, arguably via psychosocial stress. We tested this in a small-scale subsistence society, the Tsimane, by associating relative household wealth (n = 871) and community-level wealth inequality (n = 40, Gini = 0.15–0.53) with a range of psychological variables, stressors, and health outcomes (depressive symptoms [n = 670], social conflicts [n = 401], non-social problems [n = 398], social support [n = 399], cortisol [n = 811], body mass index [n = 9,926], blood pressure [n = 3,195], self-rated health [n = 2523], morbidities [n = 1542]) controlling for community-average wealth, age, sex, household size, community size, and distance to markets. Wealthier people largely had better outcomes while inequality associated with more respiratory disease, a leading cause of mortality. Greater inequality and lower wealth were associated with higher blood pressure. Psychosocial factors did not mediate wealth-health associations. Thus, relative socio-economic position and inequality may affect health across diverse societies, though this is likely exacerbated in high-income countries

Helminth Infection is Associated with Dampened Cytokine Responses to Viral and Bacterial Stimulations in Tsimane Forager-Horticulturalists

Background Soil-transmitted helminths (STHs) and humans share long co-evolutionary histories over which STHs have evolved strategies to permit their persistence by downregulating host immunity. Understanding the interactions between STHs and other pathogens can inform our understanding of human evolution and contemporary disease patterns. Methodology We worked with Tsimane forager-horticulturalists in the Bolivian Amazon, where STHs are prevalent. We tested whether STHs and eosinophil levels—likely indicative of infection in this population—are associated with dampened immune responses to in vitro stimulation with H1N1 and lipopolysaccharide (LPS) antigens. Whole blood samples (n = 179) were treated with H1N1 vaccine and LPS and assayed for 13 cytokines (INF-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12p70, IL-13, GM-CSF and TNF-ɑ). We evaluated how STHs and eosinophil levels affected cytokine responses and T helper (Th) 1 and Th2-cytokine suite responses to stimulation. Results Infection with Ascaris lumbricoides was significantly (P ≤ 0.05) associated with lower response of some cytokines to H1N1 and LPS in women. Eosinophils were significantly negatively associated with some cytokine responses to H1N1 and LPS, with the strongest effects in women, and associated with a reduced Th1- and Th2-cytokine response to H1N1 and LPS in women and men. Conclusions and implications Consistent with the ‘old friends’ and hygiene hypotheses, we find that STHs were associated with dampened cytokine responses to certain viral and bacterial antigens. This suggests that STH infections may play an essential role in immune response regulation and that the lack of STH immune priming in industrialized populations may increase the risk of over-reactive immunity. Lay Summary: Indicators of helminth infection were associated with dampened cytokine immune responses to in vitro stimulation with viral and bacterial antigens in Tsimane forager-horticulturalists in the Bolivian Amazon, consistent with the ‘old friends’ and hygiene hypotheses

The N2K Consortium. IV. New temperatures and metallicities for 100,000+ FGK dwarfs

We have created a framework to facilitate the construction of specialized target lists for radial velocity surveys that are biased toward stars that (1) possess planets and (2) are easiest to observe with current detection techniques. We use a procedure that uniformly estimates fundamental stellar properties of Tycho 2 stars, with errors, using spline functions of broadband photometry and proper motion found in Hipparcos/Tycho 2 and 2MASS. We provide estimates of temperature and distance for 2.4 million Tycho 2 stars that lack trigonometric distances. For stars that appear to be FGK dwarfs according to estimated temperature and absolute magnitude, we also derive [Fe/H] and identify unresolved binary systems with mass ratios between 1.25 and 3. Our spline function models are trained on the unique Valenti & Fischer (2005) set, composed of 1000 dwarfs with precise stellar parameters estimated from HIRES spectroscopy. For FGK dwarfs with V photometric error less than 0.05 magnitudes, or V < 9, our temperature model gives a one-sigma error of +58.7/-65.9 K and our metallicity model gives a one-sigma error of +0.13/-0.14 dex. Our estimates of distance and spectral type enable us to isolate 354,822 Tycho 2 dwarfs, 321,996 of which are absent from Hipparcos, with giant and subgiant contamination at 2.6% and 7.2%, respectively. 2,500 of these FGK dwarfs are bright (V 0.2). Our metallicity estimates have been used to identify targets for N2K (Fischer et al. 2005), a large-scale radial velocity search for Hot Jupiters, which has published the detection of 4 Hot Jupiters with one transit. The broadband filtering outlined here is the first screening tier for N2K; the second tier is a low-resolution spectroscopy program headed by S.E. Robinson (astro-ph/0510150).Comment: 32 pages, 8 figures, accepted by ApJS in October 2005. Data files temporarily stored at http://www.ucolick.org/~ammons/tycho_parameter

Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls.

This corrects the article DOI: 10.1038/sdata.2017.179

Low-Level Laser Therapy Activates NF-kB via Generation of Reactive Oxygen Species in Mouse Embryonic Fibroblasts

Background Despite over forty years of investigation on low-level light therapy (LLLT), the fundamental mechanisms underlying photobiomodulation at a cellular level remain unclear. Methodology/Principal Findings In this study, we isolated murine embryonic fibroblasts (MEF) from transgenic NF-kB luciferase reporter mice and studied their response to 810 nm laser radiation. Significant activation of NF-kB was observed at fluences higher than 0.003 J/cm2 and was confirmed by Western blot analysis. NF-kB was activated earlier (1 hour) by LLLT compared to conventional lipopolysaccharide treatment. We also observed that LLLT induced intracellular reactive oxygen species (ROS) production similar to mitochondrial inhibitors, such as antimycin A, rotenone and paraquat. Furthermore, we observed similar NF-kB activation with these mitochondrial inhibitors. These results, together with inhibition of laser induced NF-kB activation by antioxidants, suggests that ROS play an important role in the laser induced NF-kB signaling pathways. However, LLLT, unlike mitochondrial inhibitors, induced increased cellular ATP levels, which indicates that LLLT also upregulates mitochondrial respiration. Conclusion We conclude that LLLT not only enhances mitochondrial respiration, but also activates the redox-sensitive NFkB signaling via generation of ROS. Expression of anti-apoptosis and pro-survival genes responsive to NFkB could explain many clinical effects of LLLT.National Institutes of Health (U.S.) (grant R01AI050875)Center for Integration of Medicine and Innovative Technology (DAMD17-02-2-0006)United States. Dept. of Defense (CDMRP Program in TBI, W81XWH-09-1-0514)United States. Air Force Office of Scientific Research (FA9950-04-1-0079