Budjetoinnin ja ennustamisen toimintamallien kehittäminen kohdeyrityksessä

Tutkimus käsittelee budjetoinnin ja ennustamisen toimintamallien kehittämistä kohdeyrityksessä. Tutkimuksen tavoitteena oli tutkia, miten mahdollistavan johtamisen periaatteita voidaan hyödyntää budjetoinnin ja ennustamisen toimintamallien kehittämisessä sekä kehittää suunnittelutieteellisellä tutkimusmenetelmällä artefakti tehostamaan budjetoinnin ja ennustamisen toteuttamista

SiMEA : a Framework for simulating neurons on Multi-Electrode Array

Proceeding volume: 38A Multi-Electrode Array (MEA) is a practical device for recording the extracellular activity of in-vitro biological culture. Such culture - for instance neurons - is prone to mistakes leading to irrelevant recordings or no recording at all. Additionally, with the expenses generated by in-vitro culture, minimizing risks is a must. This paper proposes a framework designed and implemented for simulating the spatial positioning of neuronal cultures on a MEA. The framework serves as a sandbox for researchers to simulate the model of their MEA experiments before its eventual in-vitro implementation. The framework enables simulating the density of the plated culture, the death of cells over time, choosing diverse reconstructed morphologies of cells, and simulating their spiking activity in interaction with Brian2 simulator.Peer reviewe

Serum matrix metalloproteinase 8 and tissue inhibitor of metalloproteinase 1 : Potential markers for malignant transformation of recurrent respiratory papillomatosis and for prognosis of laryngeal cancer

Background Biomarkers that could predict malignant transformation of recurrent respiratory papillomatosis (RRP) would be useful in patient follow-up. We investigated whether serum matrix metalloproteinase 8 (MMP-8) and tissue inhibitor of metalloproteinase 1 (TIMP-1) could predict malignant transformation of RRP and whether they associate with survival in laryngeal squamous cell carcinoma (LSCC) without preexisting RRP. Methods We analyzed serum MMP-8 (S-MMP-8) and serum TIMP-1 (s-TIMP-1) in 114 patients: 55 were treated for RRP and 59 for LSCC without preexisting RRP. Five patients with RRP developed LSCC during follow-up. Results Elevated S-MMP-8 level in RRP was associated with malignant transformation (P = .01). Compared to patients with RRP, S-MMP-8 in patients with LSCC was significantly higher (P <.001). Increased S-TIMP-1 level in LSCC was associated with poor overall survival (P = .02) and recurrence-free survival (P = .05). Conclusion In RRP, high S-MMP-8 may predict malignant transformation. In LSCC, elevated S-TIMP-1 is connected to poor survival.Peer reviewe

Action-Oriented Programming Model: Collective Executions and Interactions in the Fog

Today’s dominant design for the Internet of Things (IoT) is a Cloud-based system, where devices transfer their data to a back-end and in return receive instructions on how to act. This view is challenged when delays caused by communication with the back-end become an obstacle for the IoT applications with e.g., stringent timing constraints. In contrast, Fog Computing approaches, where devices communicate and orchestrate their operations collectively and closer to the origin of data, lack adequate tools for programming secure interactions between humans and their proximate devices at the network edge. This paper fills the gap by applying Action-Oriented Programming (AcOP) model for this task. While originally the AcOP model was proposed for Cloud-based infrastructures, presently it is re-designed around the notion of coalescence and disintegration, which enable the devices to collectively and autonomously execute their operations in the Fog by serving humans in a peer-to-peer fashion. The Cloud’s role has been minimized—it is being leveraged as a development and deployment platform.Peer reviewe

Diffractive W and Z production at the Fermilab Tevatron

We report on a measurement of the fraction of events with a W or Z boson which are produced diffractively in ¯pp collisions at √s=1.96  TeV, using data from 0.6  fb−1 of integrated luminosity collected with the CDF II detector equipped with a Roman-pot spectrometer that detects the ¯p from ¯p+p→¯p+[X+W/Z]. We find that (1.00±0.11)% of Ws and (0.88±0.22)% of Zs are produced diffractively in a region of antiproton or proton fractional momentum loss ξ of 0.03<ξ<0.10 and 4-momentum transferred squared t of −1<t<0  (GeV/c)2, where we account for the events in which the proton scatters diffractively while the antiproton dissociates, ¯p+p→[X+W/Z]+p, by doubling the measured proton dissociation fraction. We also report on searches for W and Z production in double Pomeron exchange, p+¯p→p+[X+W/Z]+¯p, and on exclusive Z production, ¯p+p→¯p+Z+p. No signal is seen above background for these processes, and comparisons are made with expectations.We thank the Fermilab staff and the technical staffs of the participating institutions for their vital contributions. This work was supported by the U.S. Department of Energy and National Science Foundation; the Italian Istituto Nazionale di Fisica Nucleare; the Ministry of Education, Culture, Sports, Science, and Technology of Japan; the Natural Sciences and Engineering Research Council of Canada; the National Science Council of the Republic of China; the Swiss National Science Foundation; the A.P. Sloan Foundation; the Bundesministerium für Bildung und Forschung, Germany; the World Class University Program, the National Research Foundation of Korea; the Science and Technology Facilities Council and the Royal Society, UK; the Institut National de Physique Nucleaire et Physique des Particules/CNRS; the Russian Foundation for Basic Research; the Ministerio de Ciencia e Innovación, and Programa Consolider-Ingenio 2010, Spain; the Slovak Research and Development Agency; and the Academy of Finland

Observation of the baryonic flavor-changing neutral current decay Λb0→Λμ+μ-

We report the first observation of the baryonic flavor-changing neutral current decay Λb0→Λμ+μ- with 24 signal events and a statistical significance of 5.8 Gaussian standard deviations. This measurement uses a pp̅ collisions data sample corresponding to 6.8  fb-1 at √s=1.96  TeV collected by the CDF II detector at the Tevatron collider. The total and differential branching ratios for Λb0→Λμ+μ- are measured. We find B(Λb0→Λμ+μ-)=[1.73±0.42(stat)±(syst)]×10-6. We also report the first measurement of the differential branching ratio of Bs0→ϕμ+μ-, using 49 signal events. In addition, we report branching ratios for B+→K+μ+μ-, B0→K0μ+μ-, and B→K*(892)μ+μ- decays.We thank the Fermilab staff and the technical staffs of the participating institutions for their vital contributions. This work was supported by the U.S. Department of Energy and National Science Foundation; the Italian Istituto Nazionale di Fisica Nucleare; the Ministry of Education, Culture, Sports, Science and Technology of Japan; the Natural Sciences and Engineering Research Council of Canada; the National Science Council of the Republic of China; the Swiss National Science Foundation; the A.P. Sloan Foundation; the Bundesministerium für Bildung und Forschung, Germany; the World Class University Program, the National Research Foundation of Korea; the Science and Technology Facilities Council and the Royal Society, UK; the Institut National de Physique Nucleaire et Physique des Particules/CNRS; the Russian Foundation for Basic Research; the Ministerio de Ciencia e Innovación, and Programa ConsoliderIngenio 2010, Spain; the Slovak R&D Agency; and the Academy of Finland