Heat flux variations beneath central Greenland's ice due to anomalously thin lithosphere

At the Earth’s surface, heat fluxes from the interior1 are generally insignificant compared with those from the Sun and atmosphere2, except in areas permanently blanketed by ice. Modelling studies show that geothermal heat flux influences the internal thermal structure of ice sheets and the distribution of basal melt water3, and it should be taken into account in planning deep ice drilling campaigns and climate reconstructions4. Here we use a coupled ice–lithosphere model driven by climate and show that the oldest and thickest part of the Greenland Ice Sheet is strongly influenced by heat flow from the deep Earth. We find that the geothermal heat flux in central Greenland increases from west to east due to thinning of the lithosphere, which is only about 25–66% as thick as is typical for terrains of early Proterozoic age5. Complex interactions between geothermal heat flow and glaciation-induced thermal perturbations in the upper crust over glacial cycles lead to strong regional variations in basal ice conditions, with areas of rapid basal melting adjoining areas of extremely cold basal ice. Our findings demonstrate the role that the structure of the solid Earth plays in the dynamics of surface processes

Shock-transformation of whitlockite to merrillite and the implications for meteoritic phosphate

Meteorites represent the only samples available for study on Earth of a number of planetary bodies. The minerals within meteorites therefore hold the key to addressing numerous questions about our solar system. Of particular interest is the Ca-phosphate mineral merrillite, the anhydrous end-member of the merrillite–whitlockite solid solution series. For example, the anhydrous nature of merrillite in Martian meteorites has been interpreted as evidence of water-limited late-stage Martian melts. However, recent research on apatite in the same meteorites suggests higher water content in melts. One complication of using meteorites rather than direct samples is the shock compression all meteorites have experienced, which can alter meteorite mineralogy. Here we show whitlockite transformation into merrillite by shock-compression levels relevant to meteorites, including Martian meteorites. The results open the possibility that at least part of meteoritic merrillite may have originally been H(+)-bearing whitlockite with implications for interpreting meteorites and the need for future sample return

Clinical Outcomes in Duchenne Muscular Dystrophy: A Study of 5345 Patients from the TREAT-NMD DMD Global Database

BACKGROUND: Recent short-term clinical trials in patients with Duchenne Muscular Dystrophy (DMD) have indicated greater disease variability in terms of progression than expected. In addition, as average life-expectancy increases, reliable data is required on clinical progression in the older DMD population. OBJECTIVE: To determine the effects of corticosteroids on major clinical outcomes of DMD in a large multinational cohort of genetically confirmed DMD patients. METHODS: In this cross-sectional study we analysed clinical data from 5345 genetically confirmed DMD patients from 31 countries held within the TREAT-NMD global DMD database. For analysis patients were categorised by corticosteroid background and further stratified by age. RESULTS: Loss of ambulation in non-steroid treated patients was 10 years and in corticosteroid treated patients 13 years old (p = 0.0001). Corticosteroid treated patients were less likely to need scoliosis surgery (p < 0.001) or ventilatory support (p < 0.001) and there was a mild cardioprotective effect of corticosteroids in the patient population aged 20 years and older (p = 0.0035). Patients with a single deletion of exon 45 showed an increased survival in contrast to other single exon deletions. CONCLUSIONS: This study provides data on clinical outcomes of DMD across many healthcare settings and including a sizeable cohort of older patients. Our data confirm the benefits of corticosteroid treatment on ambulation, need for scoliosis surgery, ventilation and, to a lesser extent, cardiomyopathy. This study underlines the importance of data collection via patient registries and the critical role of multi-centre collaboration in the rare disease field

Melting at the base of the Greenland ice sheet explained by Iceland hotspot history

Ice-penetrating radar1,2,3 and ice core drilling4 have shown that large parts of the north-central Greenland ice sheet are melting from below. It has been argued that basal ice melt is due to the anomalously high geothermal flux1,4 that has also influenced the development of the longest ice stream in Greenland1. Here we estimate the geothermal flux beneath the Greenland ice sheet and identify a 1,200-km-long and 400-km-wide geothermal anomaly beneath the thick ice cover. We suggest that this anomaly explains the observed melting of the ice sheet’s base, which drives the vigorous subglacial hydrology3 and controls the position of the head of the enigmatic 750-km-long northeastern Greenland ice stream5. Our combined analysis of independent seismic, gravity and tectonic data6,7,8,9 implies that the geothermal anomaly, which crosses Greenland from west to east, was formed by Greenland’s passage over the Iceland mantle plume between roughly 80 and 35 million years ago. We conclude that the complexity of the present-day subglacial hydrology and dynamic features of the north-central Greenland ice sheet originated in tectonic events that pre-date the onset of glaciation in Greenland by many tens of millions of years