A lumpy back: extensive cutaneous collagenomas

A widespread form of eruptive collagenomas in a 12-year-old man is presented for the impressive iconography, challenging differential diagnosis, and histopathological considerations associated with such rare connective tissue disorders. Syndromic forms should be carefully investigated for the different course and prognosis. Treatment is a major unsolved issue as aesthetic concerns are significant, especially in young adults

Interstitial granulomatous drug reaction due to febuxostat

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CPU Support for CUDA

CUDA programming language perfectly matches the data parallel programming model and it is a very specific way of programming Graphics Processing Unit devices. On the other hand, the large amount of hardware not necessarily having a GPU is a resource that we would not like to left unused. Exploiting this resources arises the issue of guaranteeing performance portability, a major challenge faced today by the heterogeneous high performance programming community. The aim of this work is the development of an automatic translation tool from CUDA to C++. Operating at a source-to-source translation level we manipulate the Abstract Syntax Tree of the CUDA program to obtain the C++ version. To accomplish this synctactic analysis and transformation, we are relying on clang, a compiler front-end for the C/C++ languages family, that also handles CUDA syntax. Our approach consists in mapping each CUDA block to a CPU thread, and serialize the execution of each CUDA thread. After describing the implementation of this tool, we will show that we preserve a comparable performance running the translated code on the target architecture. We also point out how the use of the CUDA framework can be profitable targeting more than GPU architectures

Development of an instrumented anthropomorphic dummy for the study of impacts and falls in skiing

Abstract The development of anthropomorphic dummies to be used during impact and fall tests in skiing is presented. The dummies allow introducing in the impacts the realistic conditions of skiing equipment against the safety barriers; on the other side, the dummies can wear protective devices whose performance can be evaluated during full scale simulations. The concept, design, construction and calibration of the dummies during the INTERREG SkiProTech project are presented to explain the possibilities of applications of such devices in research

A nose for trouble.

A 63‑year‑old Caucasian non‑smoker presented with purplish, firm, slowly growing plaques on the nose, of 20 years duration. The bigger one involved the upper part of the nose in its entirety [Figure 1], while there were smaller ones on the left and right cheek. All the plaques were asymptomatic and did not worsen after sunlight exposure. His past medical history was unremarkable. Hematological and biochemical parameters were within normal limits. Histological examination revealed a diffuse mid‑dermal cellular infiltrate composed of neutrophils, eosinophils, plasma cells, and lymphocytes. A narrow Grenz zone was present. In the lower part of the reticular dermis, the mixed infiltrate was intermingled with a massive deposition of fascicled pattern collagen fibers and spindle cell

Aggregating Heterogeneous Computing Resources

The project's core objective is to develop a sophisticated web portal that acts as a comprehensive platform for optimizing resource allocation and improving system administration tasks. Key goals include streamlining resource management processes, enhancing resource utilization, monitoring hardware performance, and boosting system reliability. The envisioned web portal is designed to merge data from multiple sources into a unified interface, granting administrators a real-time overview of the diverse computing nodes within the openlab network. Automation will play a significant role, enabling the portal to gather data from internal lists and deployment tools, potentially utilizing scripts and databases for comprehensive machine information. This consolidated data could be harnessed to generate valuable reports and notifications about user expirations, thereby aiding administrators in effective resource management. Moreover, the web portal will offer manual functionalities, allowing administrators to manually add or remove non-managed machines, include extra users, and engage directly with specific machine users via broadcast emails. This flexibility contributes to the network's adaptability to changing project needs and resource demands. The significance of this project stems from its potential to enhance the efficiency and effectiveness of system administrators. By centralizing resource management through the portal, administrators can align resources with project requirements, minimize wastage, optimize workload distribution, and ultimately bolster system stability. These enhancements, in turn, foster a more resilient and dependable computing environment, pivotal for the successful execution of projects within the intricate openlab network

a nose for trouble

As clinicians we work in a world of evidence- based care, making diagnoses using history taking and examination skills. In his William Pickles lecture at the 2011 Spring General Meeting, Dr Terry Davies asked whether GPs sometimes put too much emphasis on the 'straight line science approach in their diagnoses' when often their initial 'hunch' is the correct one. I suggest that experienced clinicians sometimes make their judgements based not only on experience, but using all their senses including olfaction; they literally develop a 'nose for trouble'. In our everyday life we take our sense of smell for granted. In cities we are overwhelmed by sensory overload as we walk past fast-food outlets, coffee shops, bakeries, through throngs of shoppers smelling of soap, shampoo, aftershave, and perfume, and the ever-present smell of vehicle exhaust. There are many human smells that we simply do not register in our perfumed and deodorised world such as ear wax, sebum, menstrual blood, and even breath, while other smells we note and find offensive, such as stale sweat, flatus, and teenage boys' feet. However, which mother has not lingered over the head of her new baby, breathing in the very special smell of baby and milk? Sheep and cattle recognise their offspring by scent and I am certain that humans are able

Pseudoepitheliomatous keratotic and micaceous balanitis: low-risk human papilloma virus detection in two further cases

We report two cases of histologically documented pseudoepitheliomatous keratotic and micaceous balanitis in middle-aged male patients, which showed positivity for low-risk serotype human papillomavirus DNA. To our knowledge, only one other case has been documented. Further immunohistochemical proliferative markers were performed and compared to literature findings in penile epithelial proliferations. Evolution to invasive verrucous carcinoma has been associated with absence of HPV DNA. Thus, if confirmed by further studies, HPV testing should be included in pseudoepitheliomatous keratotic and micaceous balanitis assessment to address prognosis, and management

Atypical fibroxanthoma/pleomorphic dermal sarcoma of the scalp with aberrant expression of HMB-45: a pitfall in dermatopathology

Atypical fibroxanthoma (AFX) has been considered as the non-infiltrating precursor lesion of pleomorphic dermal sarcoma (PDS), which shows an aggressive clinical behavior, because of its extensive invasion of the deeper skin layers. Although these two tumors may represent two stages of the same disease, it can be difficult to differentiate between them, because of their similar clinical and histological features 1. Furthermore, they must be distinguished from a spindled variant of squamous carcinoma, melanoma and leiomyosarcoma 2. AFX/PDS still remains a diagnosis of exclusion, that needs to combine immunohistochemical markers for a definitive diagnosis. Usually AFX/PDS shows positivity for CD10, CD99, CD68, vimentin and lysozyme, while S100, HMB45, MART-1, cytokeratins, CD34, CD31, desmin and h-caldesmon are absent

Primary Localized Cutaneous Nodular Amyloidosis and Limited Cutaneous Systemic Sclerosis: Additional Cases with Dermatoscopic and Histopathological Correlation of Amyloid Deposition

Primary localized cutaneous nodular amyloidosis (PLCNA) is a rare condition due to the plasma cell proliferation and skin deposition of immunoglobulin light chains, without systemic amyloidosis or hematological dyscrasias. The association with autoimmune connective tissue diseases has been reported, especially with Sjogren's syndrome, and in a few cases with systemic sclerosis. Herein, we describe three cases of PLCNA occurring in women with a diagnosis of limited cutaneous systemic sclerosis and review the literature on the topic to highlight a stereotypical presentation. Moreover, we support the usefulness of dermoscopy, characterized by a yellow-orange waxy pattern surrounded by telangiectasias, for a rapid and non-invasive diagnostic assessment. Thus, when asymptomatic nodules occur on lower limbs of women affected with limited systemic sclerosis, and dermoscopy identifies yellow-orange blotches, a diagnosis of PLCNA can be considered and further confirmed by histopathology. Monitoring for systemic amyloidosis development is advisable, although the risk of progression is considered very low