17 research outputs found
Monocyte Gene Expression Signature of Patients with Early Onset Coronary Artery Disease
- Author
- A Tone
- AC Strang
- AJ Lavoie
- Alison H. Goodall
- AP Bijnens
- Augusto Rendon
- Brigitte M. Sondermeijer
- CA Argmann
- DJ Smyth
- Esther E. Creemers
- F Antohe
- GS Berenson
- Hanneke Basart
- J Gu
- J Rangel
- J Wong
- J Wong
- J Wong
- John J. P. Kastelein
- KA Hunt
- Kees Hovingh
- M Nakayama
- Massimo Federici
- Mieke D. Trip
- ML Fitzgerald
- MN Di Minno
- MR O'Byrne
- NA Watkins
- Nicholas A. Watkins
- NJ Samani
- P Gaede
- P Libby
- S Mosig
- S Sivapalaratnam
- SA Green
- Sara J. Pinto-Sietsma
- SH Schirmer
- SR Heckbert
- Stepanie Maiwald
- Suthesh Sivapalaratnam
- T Zeller
- TT Tuomisto
- TW Chittenden
- Unni Krishnan
- WD Patino
- Willem H. Ouwehand
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
The burden of cardiovascular disease (CVD) cannot be fully addressed by therapy targeting known pathophysiological pathways. Even with stringent control of all risk factors CVD events are only diminished by half. A number of additional pathways probably play a role in the development of CVD and might serve as novel therapeutic targets. Genome wide expression studies represent a powerful tool to identify such novel pathways. We compared the expression profiles in monocytes from twenty two young male patients with premature familial CAD with those from controls matched for age, sex and smoking status, without a family history of CVD. Since all patients were on statins and aspirin treatment, potentially affecting the expression of genes in monocytes, twelve controls were subsequently treated with simvastatin and aspirin for 6 and 2 weeks, respectively
QCD and strongly coupled gauge theories : challenges and perspectives
- Author
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- Publication date
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- Field of study
We highlight the progress, current status, and open challenges of QCD-driven physics, in theory and in experiment. We discuss how the strong interaction is intimately connected to a broad sweep of physical problems, in settings ranging from astrophysics and cosmology to strongly coupled, complex systems in particle and condensed-matter physics, as well as to searches for physics beyond the Standard Model. We also discuss how success in describing the strong interaction impacts other fields, and, in turn, how such subjects can impact studies of the strong interaction. In the course of the work we offer a perspective on the many research streams which flow into and out of QCD, as well as a vision for future developments.Peer reviewe
A new ACE on the table: ACE2 expression in human atherosclerosis.
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- Publication date
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- Field of study
A new ACE on the table:ACE2 expression in human atherosclerosis.
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- Publication date
- 01/01/2005
- Field of study
A new ACE on the table:ACE2 expression in human atherosclerosis.
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- Publication date
- 01/01/2005
- Field of study
A new ACE on the table:ACE2 expression in human atherosclerosis.
- Publication venue
- Publication date
- 01/01/2005
- Field of study
The longitudinal and transverse distributions of the pion wave function from the present experimental data on the pion–photon transition form factor
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- AP Bakulev
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- AV Pimikov
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- W Lucha
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- 'Springer Science and Business Media LLC'
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- Field of study
Implications of conspecific background noise for features of blue tit, Cyanistes caeruleus, communication networks at dawn
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- A Poesel
- AP Møller
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- B Kempenaers
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- PK McGregor
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- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Plasminogen activator inhibitor-1 (PAI-1) antigen
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- EK Kruithof
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- F andreotti
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- RR Schleef
- T Urano
- TH Ngo
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- WP Fay
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/1999
- Field of study